omeprazole and Gastrointestinal Hemorrhage studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Research Excerpts

Excerpt	Relevance	Reference
"To assess the impact of prophylactic omeprazole with background dual anti-platelet therapy on patient-reported symptoms of dyspepsia compared to placebo."	9.20	The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; McIntosh, AI; Schnitzer, TJ; Vardi, M, 2015)
"A total of 101 patients who had peptic ulcer bleeding based on endoscopic findings of nonbleeding visible vessels or fresh adherent clots were randomly assigned to receive omeprazole (40 mg p."	9.10	Comparison of oral omeprazole and endoscopic ethanol injection therapy for prevention of recurrent bleeding from peptic ulcers with nonbleeding visible vessels or fresh adherent clots. ( Jung, HK; Jung, SA; Kim, DY; Lee, HC; Moon, IH; Son, HY; Yi, SY; Yoo, K, 2002)
" pylori-positive patients with peptic ulcer bleeding (n = 101) were randomized to receive either a regular dose (20 mg/day for 3 days) (n = 51) or a high dose of omeprazole (80 mg bolus + 8 mg/h infusion/day for 3 days) (n = 50)."	9.10	Effect of short-term treatment with regular or high doses of omeprazole on the detection of Helicobacter pylori in bleeding peptic ulcer patients. ( Julkunen, R; Miettinen, P; Palmu, A; Udd, M, 2003)
"The use of omeprazole is more effective than cimetidine in increasing intragastric pH and reducing rebleeding episodes in patients with bleeding peptic ulcers after successful endoscopic therapy."	9.08	A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. ( Lee, FY; Lin, HJ; Lo, WC; Perng, CL; Tseng, GY, 1998)
"Aspirin is indicated for primary and secondary prevention of cardiovascular diseases (CVD) by major guidelines."	8.95	Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. ( Bliden, K; Chaudhary, R; Gurbel, PA; Sharma, T; Tantry, U, 2017)
"Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent."	7.71	Lansoprazole-induced thrombocytopenia. ( Anderson, CG; Zlabek, JA, 2002)
"We retrospectively investigated the efficacy of high dose omeprazole compared to a combined therapy of famotidine, pirenzepine and antacid for acute upper gastrointestinal hemorrhage (AUGIH) also adjuvant to endoscopic injection therapy if indicated."	7.69	[High-dose omeprazole versus famotidine, pirenzepine and antacid in therapy of acute upper gastrointestinal hemorrhage in a retrospective comparison]. ( Busam, J; Garbe, WE, 1994)
"Patients with intracerebral hemorrhage (ICH) are at high risk for severe stress-related upper gastrointestinal (UGI) bleeding, which is predictive of higher mortality."	6.78	A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage. ( Fei, Z; Gao, DK; Hu, SJ; Li, B; Lin, W; Liu, BL; Zhang, L; Zhang, X, 2013)
"Cimetidine treatment was successful for seven years but dose reduction was followed by intractable hemorrhage which did not respond to H2-receptor antagonists."	5.27	Long term management of hemorrhagic esophagitis with cimetidine and omeprazole. ( Bonnin, M; Hetzel, DJ, 1986)
"To assess the impact of prophylactic omeprazole with background dual anti-platelet therapy on patient-reported symptoms of dyspepsia compared to placebo."	5.20	The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; McIntosh, AI; Schnitzer, TJ; Vardi, M, 2015)
" Patients with Helicobacter pylori infection and a history of peptic ulcer were assigned dual antiplatelet combination with omeprazole."	5.17	Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting. ( Chen, G; Du, Y; Hang, L; Ma, B, 2013)
" The aim of this study was to compare therapeutic effects of oral omeprazole and intravenous cimetidine on reducing rebleeding rates, duration of hospitalization, and the need for blood transfusion in duodenal ulcer patients."	5.12	A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer. ( Fattahi, E; Khaleghian, F; Khoshbaten, M; Naderi, N; Rezailashkajani, M, 2006)
" pylori-positive patients with peptic ulcer bleeding (n = 101) were randomized to receive either a regular dose (20 mg/day for 3 days) (n = 51) or a high dose of omeprazole (80 mg bolus + 8 mg/h infusion/day for 3 days) (n = 50)."	5.10	Effect of short-term treatment with regular or high doses of omeprazole on the detection of Helicobacter pylori in bleeding peptic ulcer patients. ( Julkunen, R; Miettinen, P; Palmu, A; Udd, M, 2003)
"A total of 101 patients who had peptic ulcer bleeding based on endoscopic findings of nonbleeding visible vessels or fresh adherent clots were randomly assigned to receive omeprazole (40 mg p."	5.10	Comparison of oral omeprazole and endoscopic ethanol injection therapy for prevention of recurrent bleeding from peptic ulcers with nonbleeding visible vessels or fresh adherent clots. ( Jung, HK; Jung, SA; Kim, DY; Lee, HC; Moon, IH; Son, HY; Yi, SY; Yoo, K, 2002)
"The use of omeprazole is more effective than cimetidine in increasing intragastric pH and reducing rebleeding episodes in patients with bleeding peptic ulcers after successful endoscopic therapy."	5.08	A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. ( Lee, FY; Lin, HJ; Lo, WC; Perng, CL; Tseng, GY, 1998)
"Aspirin has been the mainstay for secondary prevention of coronary artery disease to decrease early recurrence and severity of recurrent cardiovascular events."	4.95	Usefulness of PA32540 in Protecting the Gastric Layer While Providing Secondary Prevention for Coronary Artery Disease. ( Haseeb, S; Kagolanu, D; Lam, P; Munnangi, S; Sayedy, N; Shah, S; Stephenson, K; Viswanathan, P, 2017)
"Aspirin is indicated for primary and secondary prevention of cardiovascular diseases (CVD) by major guidelines."	4.95	Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. ( Bliden, K; Chaudhary, R; Gurbel, PA; Sharma, T; Tantry, U, 2017)
" Key search terms included pantoprazole, omeprazole, proton-pump inhibitors, gastrointestinal hemorrhage, histamine(2)-receptor antagonists, ranitidine, and cimetidine."	4.82	Intravenous proton-pump inhibitors versus H2-antagonists for treatment of GI bleeding. ( Huggins, RM; Latour, JK; Scates, AC, 2003)
", omeprazole, misoprostol, and high-dose famotidine) in the prevention of NSAID-induced gastroduodenal ulcers will also be effective in this setting."	3.71	Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. ( Lanas, AI, 2001)
"Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent."	3.71	Lansoprazole-induced thrombocytopenia. ( Anderson, CG; Zlabek, JA, 2002)
"We studied the recurrence of upper gastrointestinal bleeding (UGIB) in a cohort of patients who had an episode of peptic ulcer bleed, and we investigated the effect of maintenance treatment with cimetidine, omeprazole, and ranitidine."	3.70	Secondary prevention of upper gastrointestinal bleeding associated with maintenance acid-suppressing treatment in patients with peptic ulcer bleed. ( García Rodríguez, LA; Ruigómez, A, 1999)
"We retrospectively investigated the efficacy of high dose omeprazole compared to a combined therapy of famotidine, pirenzepine and antacid for acute upper gastrointestinal hemorrhage (AUGIH) also adjuvant to endoscopic injection therapy if indicated."	3.69	[High-dose omeprazole versus famotidine, pirenzepine and antacid in therapy of acute upper gastrointestinal hemorrhage in a retrospective comparison]. ( Busam, J; Garbe, WE, 1994)
"Diarrhea was common (8/20 omeprazole, 5/17 placebo), hematochezia was rare (1/20 omeprazole, 1/17 placebo); melena was not observed."	3.30	Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion. ( Guadiano, P; Lewis, MJ; Mehra, JM; Moore, GE; Steiner, JM; Tolbert, MK, 2023)
"Randomized patients with available aspirin dosing information in COGENT (N = 3,752) were divided into "low-dose" (≤ 100 mg) and "high-dose" (>100 mg) aspirin groups."	2.82	Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. ( Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M, 2016)
"Patients with intracerebral hemorrhage (ICH) are at high risk for severe stress-related upper gastrointestinal (UGI) bleeding, which is predictive of higher mortality."	2.78	A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage. ( Fei, Z; Gao, DK; Hu, SJ; Li, B; Lin, W; Liu, BL; Zhang, L; Zhang, X, 2013)
" However, a randomized controlled trial that compared clopidogrel alone with the combination of clopidogrel and omeprazole found no increase in adverse cardiovascular outcomes and a reduction in the rate of adverse gastrointestinal outcomes attributable to omeprazole."	2.48	Recent safety concerns with proton pump inhibitors. ( Chen, J; Howden, CW; Leontiadis, GI; Yuan, YC, 2012)
" As there are specific characteristics of these patients that could alter the pharmacokinetics of the drugs, studies need to be performed to determine the most suitable dose and dosage interval."	2.46	Pharmacokinetics of intravenous omeprazole in critically ill paediatric patients. ( López-Herce, J; Solana, MJ, 2010)
" Administration of immediate-release omeprazole at bedtime results in a rapid and sustained elevation of gastric pH, and seems to provide better night time control of gastric acidity than that observed with conventional morning dosing of delayed-release proton pump inhibitors."	2.43	Review of immediate-release omeprazole for the treatment of gastric acid-related disorders. ( Castell, D, 2005)
" Intravenous pantoprazole is especially distinguished in its lack of clinically relevant drug interactions, and it requires no dosage adjustment for patients with renal insufficiency or with mild to moderate hepatic dysfunction."	2.41	Potential uses of intravenous proton pump inhibitors to control gastric acid secretion. ( Metz, DC, 2000)
" Another advantage over the histamine 2 receptor antagonists is that pantoprazole does not require dosage adjustment in patients with renal impairment."	2.41	Intravenous pantoprazole: a new tool for acutely ill patients who require acid suppression. ( Trépanier, EF, 2000)
" This suggests that for stress ulcer prophylaxis, intermittent dosing with an intravenous proton pump inhibitor may be an alternative to high-dose continuous infusions of a histamine-2-receptor antagonist."	2.41	Stress-related mucosal disease in the critically ill patient: risk factors and strategies to prevent stress-related bleeding in the intensive care unit. ( Steinberg, KP, 2002)
"Cotreatment with omeprazole did not reduce indomethacin-induced intestinal bleeding."	1.42	Suppression of contractile activity in the small intestine by indomethacin and omeprazole. ( Bhattarai, D; Dial, EJ; Lichtenberger, LM; Phan, TM; Uray, K, 2015)
" The incidence of adverse side effects was 3."	1.37	Comparison of the efficacy and safety between generic intravenous omeprazole (Zefxon) and original omeprazole (Losec) in the adjunct treatment of non-variceal upper gastrointestinal bleeding in Siriraj Hospital. ( Lohsiriwat, D; Lohsiriwat, V; Saejong, R; Thamlikitkul, V; Tongsai, S, 2011)
"Omeprazole treatment did not result in mucosal injury or inflammation; however, there were marked shifts in numbers and types of enteric bacteria, including a significant reduction (∼80%) of jejunal Actinobacteria and Bifidobacteria spp."	1.37	Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. ( Bercik, P; Bolla, M; Collins, SM; de Palma, G; Denou, E; Jury, J; McKnight, W; Ongini, E; Syer, S; Verdu, E; Vong, L; Wallace, JL, 2011)
"(1) The majority of trauma admissions are at high risk for developing gastrointestinal haemorrhage."	1.36	Gastroprotection in trauma patients receiving non-steroidal anti-inflammatory drugs. ( Chan, JK; Graham, A; Phoenix, G; Sharma, S; Sleat, G, 2010)
" The ulcers scarred after the long-term administration of a proton pump inhibitor (PPI), but recurred after the suspension."	1.35	Recurrent peptic ulcer disease in a pediatric patient with type 1 neurofibromatosis and primary ciliary dyskinesia. ( Di Stefano, V; Francavilla, R; Lionetti, E; Pavone, L; Principi, MB; Ruggieri, M, 2009)
"Especially patients with severe sepsis or septic shock are prone to develop lesions of the upper gastrointestinal tract with consecutive bleeding."	1.35	[Stress ulcer prophylaxis in septic patients. Evidence-based overview]. ( Elke, G; Schädler, D; Scholz, J; Weiler, N; Zick, G, 2008)
"Exploration found volvulus and a gangrenous segment of the distal ileum."	1.32	Massive gastrointestinal bleeding in infants with ascariasis. ( Chedphaopan, J; Mitamun, W; Patrapinyokul, S; Sangkhathat, S; Wudhisuthimethawee, P, 2003)
"A patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel."	1.31	Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. ( Meijer, K; Peters, FT; van der Meer, J, 2001)
"We compared the gastric toxic effect of aspirin (ASA) in both normal and diabetic rats, with that of NCX-4016, a derivative of ASA with nitric oxide (NO) releasing moiety."	1.31	Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. ( Fujita, A; Takeuchi, K; Tashima, K; Umeda, M, 2000)
"Pretreatment with omeprazole (30 mg/kg s."	1.30	Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. ( Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K, 1999)
"Omeprazole does increase intragastric pH in bleeding peptic ulcer patients with H."	1.30	Will Helicobacter pylori affect short-term rebleeding rate in peptic ulcer bleeding patients after successful endoscopic therapy? ( Chang, FY; Hsieh, YH; Lee, FY; Lee, SD; Lin, HJ; Perng, CL; Tseng, GY, 1999)
"Lansoprazole was more potent than omeprazole, famotidine and ranitidine in inhibiting gastric mucosal lesions and hemorrhagic shock- or stress-induced bleeding."	1.29	[Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion]. ( Asano, S; Inada, I; Inatomi, N; Murakami, I; Satoh, H, 1996)
" All healed with further omeprazole and healing persisted with long-term administration (20 mg/day)."	1.28	Bleeding from staple line erosion after esophageal transection: effect of omeprazole. ( Burroughs, AK; Hobbs, KE; Kaye, GL; McCormick, PA; McIntyre, N; Siringo, S, 1992)
"Timoprazole was an active antisecretory agent when given subcutaneously (ED50 10 mg/kg), but was not cytoprotective when given by this route."	1.27	Timoprazole is a unique cytoprotective agent in the rat. ( Davis, JP; Lancaster, C; Nezamis, JE; Nichols, NM; Ochoa, R; Rush, BD; Ruwart, MJ, 1984)
"Cimetidine treatment was successful for seven years but dose reduction was followed by intractable hemorrhage which did not respond to H2-receptor antagonists."	1.27	Long term management of hemorrhagic esophagitis with cimetidine and omeprazole. ( Bonnin, M; Hetzel, DJ, 1986)

Research

Studies (177)

Authors

Clinical Trials (12)

Trial Overview

Trial Outcomes

Number of Participants With Healed Peptic Ulcer

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (2.26)	18.7374
1990's	39 (22.03)	18.2507
2000's	81 (45.76)	29.6817
2010's	46 (25.99)	24.3611
2020's	7 (3.95)	2.80

Authors	Studies
Azzopardi, M	1
Paris, JL	1
Sladden, D	1
Hao, W	1
Piao, L	1
Sun, M	1
Zeng, F	1
Abu El-Ella, SS	1
El-Mekkawy, MS	1
Mohamed Selim, A	1
Mehra, JM	1
Tolbert, MK	1
Guadiano, P	1
Steiner, JM	1
Moore, GE	1
Lewis, MJ	1
Rak, MB	1
Moyers, TD	1
Price, JM	1
Whittemore, JC	1
Roa Colomo, A	1
García Robles, A	1
Ruiz Escolano, E	1
Levy, AN	1
Ali, N	1
Andrici, J	1
Hamilton, MJ	1
Parton, JR	1
Ritchie, J	1
Tseng, ZF	1
Hsu, PI	1
Peng, NJ	1
Kao, SS	1
Tsay, FW	1
Cheng, JS	1
Chen, WC	1
Tsai, KF	1
Tang, SY	1
Chuah, SK	1
Shie, CB	1
Kagolanu, D	1
Sayedy, N	1
Haseeb, S	1
Shah, S	1
Lam, P	1
Munnangi, S	1
Viswanathan, P	1
Stephenson, K	1
Chintalapati, SP	1
Patel, A	1
Conjeevaram, H	1
Deregnaucourt, D	1
Buche, S	1
Coopman, S	1
Basraoui, D	1
Turck, D	1
Delaporte, E	1
Ma, B	1
Hang, L	1
Chen, G	1
Du, Y	1
Lichtenberger, LM	2
Bhattarai, D	1
Phan, TM	2
Dial, EJ	2
Uray, K	1
Batgi, H	1
Akbal, E	1
Koçak, E	1
Akyürek, Ö	1
Köklü, S	1
Dönmez, M	1
Güneş, F	1
Vardi, M	1
Cryer, BL	4
Cohen, M	4
Lanas, A	8
Schnitzer, TJ	4
Lapuerta, P	4
Goldsmith, MA	4
Laine, L	6
Doros, G	3
Liu, Y	3
McIntosh, AI	1
Cannon, CP	4
Bhatt, DL	4
Ford, NF	1
Vaduganathan, M	2
Hsieh, WH	2
Shook, TL	3
Sharma, T	1
Bliden, K	1
Chaudhary, R	1
Tantry, U	1
Gurbel, PA	1
Tseng, GY	3
Jeng, TK	1
Yang, HB	1
Lin, HJ	5
Davidkov, L	1
Evstatiev, I	1
Chirkov, A	1
Castelluccio, MS	1
Hermida, R	1
Ayunta, H	1
Manzotti, L	1
Cháves, E	1
Romo, R	1
Perelstein, G	1
Gao, QP	1
Sun, Y	1
Sun, YX	1
Wang, LF	1
Fu, L	1
Tai, CK	1
Butt, MA	1
Mohammed, UA	1
Ballinger, AB	1
Ono, S	1
Kato, M	1
Ono, Y	1
Nakagawa, M	1
Nakagawa, S	1
Shimizu, Y	1
Asaka, M	1
van Werkum, JW	1
ten Berg, JM	1
Bredenoord, AJ	1
Lionetti, E	1
Francavilla, R	1
Ruggieri, M	1
Di Stefano, V	1
Principi, MB	1
Pavone, L	1
Hennekens, C	1
Bretagne, JF	1
Juhász, M	1
Herszényi, L	1
Tulassay, Z	1
Solana, MJ	2
López-Herce, J	2
Chan, JK	1
Sleat, G	1
Sharma, S	1
Phoenix, G	1
Graham, A	1
Rahme, E	1
Bernatsky, S	1
Amaral, MC	1
Favas, C	1
Alves, JD	1
Riso, N	1
Riscado, MV	1
Fan, H	1
Zheng, Z	1
Feng, W	1
Wang, W	1
Song, Y	1
Lin, Y	1
Hu, S	1
Morini, S	1
Zullo, A	1
Contant, CF	1
Scirica, BM	1
Murphy, SA	1
Southworth, MR	1
Temple, R	1
Këlliçi, I	1
Kraja, B	1
Mone, I	1
Prifti, S	1
Juurlink, DN	1
Sadek, A	1
Ford, AC	1
Owens, SL	1
Parnell, NK	1
Mumtaz, K	1
Kamani, L	1
Hamid, S	1
Abid, S	1
Shah, HA	1
Jafri, W	1
Kinsey, SG	1
Nomura, DK	1
O'Neal, ST	1
Long, JZ	1
Mahadevan, A	1
Cravatt, BF	1
Grider, JR	1
Lichtman, AH	1
Wallace, JL	1
Syer, S	1
Denou, E	1
de Palma, G	1
Vong, L	1
McKnight, W	1
Jury, J	1
Bolla, M	1
Bercik, P	1
Collins, SM	1
Verdu, E	1
Ongini, E	1
Harmsze, AM	1
de Boer, A	1
Boot, H	1
Deneer, VH	1
Heringa, M	1
Mol, PG	1
Schalekamp, T	1
Verduijn, MM	1
Verheugt, FW	1
le Comte, M	1
Amariles, P	1
Holguín, H	1
Ceballos, M	1
Abraham, NS	1
Harrison, RW	1
Mahaffey, KW	1
Chen, J	1
Yuan, YC	1
Leontiadis, GI	1
Howden, CW	2
Lohsiriwat, D	1
Saejong, R	1
Lohsiriwat, V	1
Tongsai, S	1
Thamlikitkul, V	1
Sakurada, T	1
Kawashima, J	1
Ariyama, S	1
Kani, K	1
Takabayashi, H	1
Ohno, S	1
Kato, S	1
Yakabi, K	1
Takayama, S	1
Izuhara, C	1
Yamada, N	1
Yamanaka, S	1
Hashimoto, E	1
Kaneko, S	1
Takeuchi, K	3
Lim, YJ	1
Graham, DY	1
Liu, BL	1
Li, B	1
Zhang, X	1
Fei, Z	1
Hu, SJ	1
Lin, W	1
Gao, DK	1
Zhang, L	1
Sánchez, A	1
Sánchez, C	1
Urbano, J	1
López, D	1
Carrillo, A	1
Wee, EW	1
Varghese, NM	1
Tung, ML	1
Low, HC	1
Hrabovský, V	1
Mendlová, A	1
Zadák, Z	1
Bláha, V	1
Hyšpler, R	1
Tichá, A	1
Svagera, Z	1
Lo, GH	1
Perng, DS	1
Chang, CY	1
Tai, CM	1
Wang, HM	1
Lin, HC	1
Jung, HK	1
Son, HY	1
Jung, SA	1
Yi, SY	1
Yoo, K	1
Kim, DY	1
Moon, IH	1
Lee, HC	1
Zhou, Y	1
Qiao, L	1
Wu, J	1
Hu, H	1
Xu, C	1
Yang, YX	1
Lewis, JD	1
Huggins, RM	1
Scates, AC	1
Latour, JK	1
Baskhaeva, RG	1
Udd, M	1
Miettinen, P	1
Palmu, A	1
Julkunen, R	1
Rodrigo, L	1
Márquez, JL	1
Bajador, E	2
Pérez-Roldan, F	1
Cabrol, J	1
Quintero, E	1
Montoro, M	1
Gomollón, F	2
Santolaria, S	1
Lorente, S	1
Cucala, M	1
Nuevo, J	1
Ferrández, A	1
Sung, JJ	4
Chan, FK	2
Lau, JY	4
Yung, MY	1
Leung, WK	2
Wu, JC	2
Ng, EK	1
Chung, SC	2
Jensen, DM	2
Pisegna, JR	2
Pais, SA	1
Yang, R	1
Oviedo, JA	1
Wolfe, MM	2
Sangkhathat, S	1
Patrapinyokul, S	1
Wudhisuthimethawee, P	1
Chedphaopan, J	1
Mitamun, W	1
van Rensburg, CJ	1
Hartmann, M	1
Thorpe, A	1
Venter, L	1
Theron, I	1
Lühmann, R	1
Wurst, W	1
Maltz, C	1
Tanaka, A	1
Hayashi, Y	1
Kubo, Y	1
Enns, R	1
Andrews, CN	1
Fishman, M	1
Hahn, M	1
Atkinson, K	1
Kwan, P	1
Levy, A	1
Arasaradnam, RP	1
Donnelly, MT	1
Shaheen, NJ	1
Stuart, E	1
Schmitz, SM	1
Mitchell, KL	1
Fried, MW	1
Zacks, S	1
Russo, MW	1
Galanko, J	1
Shrestha, R	1
Hata, M	2
Shiono, M	2
Sekino, H	2
Furukawa, H	2
Sezai, A	2
Iida, M	3
Yoshitake, I	2
Hattori, T	2
Wakui, S	2
Soeda, M	1
Taoka, M	2
Negishi, N	2
Sezai, Y	2
Conrad, SA	1
Gabrielli, A	1
Margolis, B	1
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Miura, M	1
Morozumi, K	1
Ishida, H	1
Takahashi, S	1
Glazunov, VK	1
Rumiantsev, GV	1
Buka, GIu	1
Brikman, AE	1
Sumishevskiĭ, EV	1
Kondrat'eva, AB	1
Castell, D	1
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Triadafilopoulos, G	1
Khoshbaten, M	1
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Rezailashkajani, M	1
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Lyakhovetskiy, A	1
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Hammar, CH	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease[NCT00557921]	Phase 3	5,000 participants (Anticipated)	Interventional	2007-12-31	Terminated (stopped due to Terminated by Sponsor)
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]		228 participants (Actual)	Interventional	2012-01-31	Completed
Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744]		101 participants (Actual)	Interventional	2012-07-31	Completed
The Efficacy and Safety of Proton Pump Inhibitor ( in Patients With Moderate Bleeding Risk and Coronary Artery Disease Undergoing Percutaneous Coronary: A Randomised, Open ,Compared With Control[NCT05820048]	Phase 4	300 participants (Anticipated)	Interventional	2023-05-01	Not yet recruiting
A Randomized, Controlled Trial of Ligation Plus Vasoconstrictor vs.Ligation Plus Proton Pump Inhibitor in the Control of Acute Esophageal Variceal Bleeding[NCT01112852]	Phase 4	118 participants (Actual)	Interventional	2006-12-31	Completed
Comparative Effectiveness Research: Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails to Treat the Patients With Acute Variceal Bleeding[NCT02311608]		1,320 participants (Anticipated)	Observational	2014-02-28	Recruiting
Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot[NCT02536989]	Phase 4	40 participants (Actual)	Interventional	2009-03-31	Completed
Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery[NCT00839488]	Phase 4	6 participants (Actual)	Interventional	2008-04-30	Terminated (stopped due to the chief of GS left the hopsital and the successor did't want to keep on this study)
Administration of Intravenous Proton Pump Inhibitor Prior to Endoscopy [APPE] in Patients With Upper Gastrointestinal Bleeding; a Double-Blind Placebo-Controlled Randomised Study.[NCT00164866]	Phase 4	638 participants	Interventional	2004-02-29	Completed
Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage: A Double-Blind, Randomized, Placebo-Controlled Trial[NCT02903017]	Phase 4	114 participants (Actual)	Interventional	2016-09-30	Completed
Laparoscopic Revision Gastric Bypass Surgery for Perforated Marginal Ulcer: A 10 Year Experience[NCT01041196]		30 participants (Actual)	Observational	2009-01-31	Completed
The Effect of Using Preendoscopic Proton Pump Inhibitors in Upper Gastrointestinal System Bleeding on Patient Prognosis[NCT05467358]		1,100 participants (Actual)	Observational	2021-07-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Number of Participants With Ulcer Recurrence

Intervention	participants (Number)
Histamine-2 Receptor Antagonist Group	106
Placebo Group	101

Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month

Article	Year
Usefulness of PA32540 in Protecting the Gastric Layer While Providing Secondary Prevention for Coronary Artery Disease. The American journal of cardiology, 2017, Oct-01, Volume: 120, Issue:7 Topics: Administration, Oral; Aspirin; Coronary Artery Disease; Double-Blind Method; Drug Combinations; Gast	2017
Clopidogrel and Genotyping. The Journal of invasive cardiology, 2015, Volume: 27, Issue:8 Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Gastroint	2015
Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease. Expert opinion on pharmacotherapy, 2017, Volume: 18, Issue:1 Topics: Aspirin; Cardiovascular Diseases; Coronary Artery Disease; Gastrointestinal Diseases; Gastrointestin	2017
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 2. Use of intravenous omeprazole in gastrointestinal patients before endoscopy. Emergency medicine journal : EMJ, 2008, Volume: 25, Issue:11 Topics: Anti-Ulcer Agents; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Humans; Infusio	2008
Proton pump inhibitor and clopidogrel interaction: fact or fiction? The American journal of gastroenterology, 2010, Volume: 105, Issue:1 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therap	2010
Proton pump inhibitor and clopidogrel interaction: fact or fiction? The American journal of gastroenterology, 2010, Volume: 105, Issue:1 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therap	2010
Proton pump inhibitor and clopidogrel interaction: fact or fiction? The American journal of gastroenterology, 2010, Volume: 105, Issue:1 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therap	2010
Proton pump inhibitor and clopidogrel interaction: fact or fiction? The American journal of gastroenterology, 2010, Volume: 105, Issue:1 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therap	2010
[Prevention of GI bleeding due to antiplatelet agents: a labyrinth!]. Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Comb	2009
Current standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist. Digestion, 2010, Volume: 81, Issue:1 Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Interactions; Dr	2010
Pharmacokinetics of intravenous omeprazole in critically ill paediatric patients. European journal of clinical pharmacology, 2010, Volume: 66, Issue:4 Topics: Child; Critical Illness; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Infusions,	2010
[Interaction between clopidogrel and proton pump inhibitors]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:28 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therap	2011
Prescribing proton pump inhibitor and clopidogrel together: current state of recommendations. Current opinion in gastroenterology, 2011, Volume: 27, Issue:6 Topics: Clopidogrel; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Gastrointestinal Hemo	2011
Clopidogrel and PPI interaction: clinically relevant or not? Current cardiology reports, 2012, Volume: 14, Issue:1 Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female;	2012
Recent safety concerns with proton pump inhibitors. Journal of clinical gastroenterology, 2012, Volume: 46, Issue:2 Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Fractures, Spontaneous; Gastrointestinal	2012
Prevention and treatment of stress ulcers in critically ill patients. Seminars in gastrointestinal disease, 2003, Volume: 14, Issue:1 Topics: Aged; Anti-Ulcer Agents; Cimetidine; Critical Illness; Female; Gastric Mucosa; Gastrointestinal Hemo	2003
Intravenous proton-pump inhibitors versus H2-antagonists for treatment of GI bleeding. The Annals of pharmacotherapy, 2003, Volume: 37, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Cimetidine; Drug Administration Schedule; E	2003
Treatment and prevention of aspirin-induced gastroduodenal ulcers and gastrointestinal bleeding. Expert opinion on drug safety, 2002, Volume: 1, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Dru	2002
Treating patients with acute gastrointestinal bleeding or rebleeding. Pharmacotherapy, 2003, Volume: 23, Issue:10 Pt 2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Benzimidazoles; Clinical Trials a	2003
Diagnostic and therapeutic options in the management of nonvariceal upper gastrointestinal bleeding. Current gastroenterology reports, 2003, Volume: 5, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Diathermy; Endoscopy, Ga	2003
Gastroprotection by coxibs: what do the Celecoxib Long-Term Arthritis Safety Study and the Vioxx Gastrointestinal Outcomes Research Trial tell us? Rheumatic diseases clinics of North America, 2003, Volume: 29, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase Inhibitors; Di	2003
Proton pump inhibitors for acute upper GI bleeding. Drug and therapeutics bulletin, 2004, Volume: 42, Issue:6 Topics: Acute Disease; Aged; Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Humans; Middle Aged; Omeprazole	2004
Acute endoscopic intervention in non-variceal upper gastrointestinal bleeding. Postgraduate medical journal, 2005, Volume: 81, Issue:952 Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cautery; Combined Modality Therapy; Emergency Tre	2005
Review of immediate-release omeprazole for the treatment of gastric acid-related disorders. Expert opinion on pharmacotherapy, 2005, Volume: 6, Issue:14 Topics: Administration, Oral; Anti-Ulcer Agents; Circadian Rhythm; Dosage Forms; Drug Administration Schedul	2005
Review article: prevention of stress-related mucosal bleeding with proton-pump inhibitors. Alimentary pharmacology & therapeutics, 2005, Volume: 22 Suppl 3 Topics: Critical Illness; Enzyme Inhibitors; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Omeprazole	2005
Review article: the role of antisecretory therapy in the management of non-variceal upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics, 2005, Volume: 22 Suppl 3 Topics: Administration, Oral; Endoscopy, Gastrointestinal; Enzyme Inhibitors; Gastrointestinal Hemorrhage; H	2005
Clinical review: gastrointestinal bleeding after percutaneous coronary intervention: a deadly combination. QJM : monthly journal of the Association of Physicians, 2008, Volume: 101, Issue:6 Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Coronary Thrombosis; Enzyme Inhibitors; Gastrointest	2008
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract. The Gastroenterologist, 1994, Volume: 2, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Digestive System; Gastrointestinal H	1994
Acid pump blockers: what are their current therapeutic roles? Bailliere's clinical gastroenterology, 1993, Volume: 7, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Duodenal Ulcer; Gastroesophageal Reflux;	1993
Antisecretory therapy for bleeding peptic ulcer. JAMA, 1998, Sep-09, Volume: 280, Issue:10 Topics: Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Omeprazole; Peptic	1998
[Recent progress in the drug therapy for gastrointestinal bleeding]. Nihon rinsho. Japanese journal of clinical medicine, 1998, Volume: 56, Issue:9 Topics: Anti-Ulcer Agents; Cimetidine; Gastric Acidity Determination; Gastrointestinal Hemorrhage; Histamine	1998
Use of proton-pump inhibitors in complicated ulcer disease and upper gastrointestinal tract bleeding. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Dec-01, Volume: 56, Issue:23 Suppl 4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi	1999
[Antisecretory drugs and prophylaxis of secondary gastrointestinal effects associated with the consumption of non steroid anti-inflammatory drugs]. Medicina clinica, 2000, Volume: 114 Suppl 2 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Enzyme Inhibitors; Female; Gastrointesti	2000
Potential uses of intravenous proton pump inhibitors to control gastric acid secretion. Digestion, 2000, Volume: 62, Issue:2-3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Gastric Acid; Gastric Ac	2000
Intravenous pantoprazole: a new tool for acutely ill patients who require acid suppression. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2000, Volume: 14 Suppl D Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Enzyme Inhibitors; Esophagitis, Peptic; Gas	2000
Intravenous omeprazole after endoscopic treatment of bleeding peptic ulcers. Gut, 2001, Volume: 49, Issue:5 Topics: Anti-Ulcer Agents; Chemotherapy, Adjuvant; Double-Blind Method; Endoscopy, Gastrointestinal; Gastroi	2001
Nonvariceal upper gastrointestinal bleeding. Endoscopy, 2002, Volume: 34, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Endoscopy, Gastrointestinal; Gastrointes	2002
Stress-related mucosal disease in the critically ill patient: risk factors and strategies to prevent stress-related bleeding in the intensive care unit. Critical care medicine, 2002, Volume: 30, Issue:6 Suppl Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Critical Illness; Gastric Mucosa; Gastroint	2002
Intravenous proton pump inhibitors in the critical care setting. Critical care medicine, 2002, Volume: 30, Issue:6 Suppl Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Canada; Critical Care; Gastrointestinal Hem	2002

Article	Year
Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion. Journal of veterinary internal medicine, 2023, Volume: 37, Issue:2 Topics: Animals; Diarrhea; Dog Diseases; Dogs; Gastrointestinal Hemorrhage; Intervertebral Disc; Interverteb	2023
Clinicopathologic and gastrointestinal effects of administration of prednisone, prednisone with omeprazole, or prednisone with probiotics to dogs: A double-blind randomized trial. Journal of veterinary internal medicine, 2023, Volume: 37, Issue:2 Topics: Animals; Dog Diseases; Dogs; Double-Blind Method; Gastrointestinal Hemorrhage; Glucocorticoids; Omep	2023
Omeprazole vs famotidine for the prevention of gastroduodenal injury in high-risk users of low-dose aspirin: A randomized controlled trial. Journal of the Chinese Medical Association : JCMA, 2021, Jan-01, Volume: 84, Issue:1 Topics: Aged; Aged, 80 and over; Aspirin; Famotidine; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; H	2021
Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting. The West Indian medical journal, 2013, Volume: 62, Issue:2 Topics: Angiography; Aspirin; Breath Tests; Carotid Arteries; Carotid Stenosis; Clopidogrel; Drug Interactio	2013
The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. Alimentary pharmacology & therapeutics, 2015, Volume: 42, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Double-Blind Method; Drug The	2015
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. Journal of the American College of Cardiology, 2016, Apr-12, Volume: 67, Issue:14 Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia;	2016
Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. The American journal of medicine, 2016, Volume: 129, Issue:9 Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Gastr	2016
Early use of omeprazole benefits patients with acute myocardial infarction. Journal of thrombosis and thrombolysis, 2009, Volume: 28, Issue:3 Topics: Adult; Anti-Ulcer Agents; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Humans; Incidenc	2009
Effects of preoperative administration of omeprazole on bleeding after endoscopic submucosal dissection: a prospective randomized controlled trial. Endoscopy, 2009, Volume: 41, Issue:4 Topics: Administration, Oral; Aged; Anti-Ulcer Agents; Drug Administration Schedule; Female; Follow-Up Studi	2009
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Dru	2010
Role of intravenous omeprazole on non-variceal upper gastrointestinal bleeding after endoscopic treatment: a comparative study. Medicinski arhiv, 2010, Volume: 64, Issue:6 Topics: Antacids; Anti-Ulcer Agents; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Hista	2010
Comparison of adjuvant therapies by an H2-receptor antagonist and a proton pump inhibitor after endoscopic treatment in hemostatic management of bleeding gastroduodenal ulcers. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2012, Volume: 24, Issue:2 Topics: Chemotherapy, Adjuvant; Enzyme Inhibitors; Famotidine; Female; Gastrointestinal Hemorrhage; Hemostas	2012
A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage. Journal of neurosurgery, 2013, Volume: 118, Issue:1 Topics: Adult; Aged; Anti-Ulcer Agents; Cerebral Hemorrhage; Cimetidine; Female; Gastrointestinal Hemorrhage	2013
0.5 mg/kg versus 1 mg/kg of intravenous omeprazole for the prophylaxis of gastrointestinal bleeding in critically ill children: a randomized study. The Journal of pediatrics, 2013, Volume: 162, Issue:4 Topics: Anti-Ulcer Agents; Child; Child, Preschool; Critical Illness; Female; Gastric Acidity Determination;	2013
Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding. Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Combined Modality Therapy; Esophageal and Gast	2013
Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding. Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Combined Modality Therapy; Esophageal and Gast	2013
Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding. Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Combined Modality Therapy; Esophageal and Gast	2013
Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding. Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Combined Modality Therapy; Esophageal and Gast	2013
Comparison of oral omeprazole and endoscopic ethanol injection therapy for prevention of recurrent bleeding from peptic ulcers with nonbleeding visible vessels or fresh adherent clots. The American journal of gastroenterology, 2002, Volume: 97, Issue:7 Topics: Administration, Oral; Endoscopy, Gastrointestinal; Enzyme Inhibitors; Ethanol; Female; Gastrointesti	2002
Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study. Journal of gastroenterology and hepatology, 2002, Volume: 17, Issue:9 Topics: Adult; Aged; Drug Evaluation; Enzyme Inhibitors; Esophageal and Gastric Varices; Female; Gastrointes	2002
Effect of short-term treatment with regular or high doses of omeprazole on the detection of Helicobacter pylori in bleeding peptic ulcer patients. Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:6 Topics: Anti-Ulcer Agents; Diagnostic Techniques, Digestive System; Dose-Response Relationship, Drug; Double	2003
The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Annals of internal medicine, 2003, Aug-19, Volume: 139, Issue:4 Topics: Anti-Ulcer Agents; Combined Modality Therapy; Endoscopy, Gastrointestinal; Female; Follow-Up Studies	2003
Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: a randomized, controlled trial. Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Double-Blind Method; Esophageal and Gastric	2005
Prospective randomized trial for optimal prophylactic treatment of the upper gastrointestinal complications after open heart surgery. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Cardiac Surgical Procedu	2005
Randomized, double-blind comparison of immediate-release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients. Critical care medicine, 2005, Volume: 33, Issue:4 Topics: Administration, Oral; Aged; Anti-Ulcer Agents; Cimetidine; Critical Care; Dosage Forms; Double-Blind	2005
A prospective randomized trial of either famotidine or omeprazole for the prevention of bleeding after endoscopic mucosal resection and the healing of endoscopic mucosal resection-induced ulceration. Alimentary pharmacology & therapeutics, 2005, Volume: 21 Suppl 2 Topics: Aged; Anti-Ulcer Agents; Cost-Benefit Analysis; Endoscopy, Gastrointestinal; Famotidine; Female; Gas	2005
A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer. BMC gastroenterology, 2006, Jan-11, Volume: 6 Topics: Administration, Oral; Adult; Aged; Anti-Ulcer Agents; Blood Transfusion; Cimetidine; Duodenal Ulcer;	2006
Proton pump inhibition prevents gastrointestinal bleeding in ultramarathon runners: a randomised, double blinded, placebo controlled study. British journal of sports medicine, 2006, Volume: 40, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Benzimidazoles; Double-Blind Method; Feces; Female;	2006
Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection: a prospective randomized controlled trial. Alimentary pharmacology & therapeutics, 2006, Sep-01, Volume: 24, Issue:5 Topics: Anti-Ulcer Agents; Famotidine; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Hum	2006
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Intravenous administration of lansoprazole: a preliminary study of dose ranging and efficacy in upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics, 1995, Volume: 9 Suppl 1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agen	1995
[Does the antisecretory agent used affect the evolution of upper digestive hemorrhage?]. Revista espanola de enfermedades digestivas, 1995, Volume: 87, Issue:6 Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Emergencies; Female; Gastrointestinal Hemorrhage	1995
Omeprazole in the management of sclerotherapy-induced esophageal ulcers resistant to H2 blocker treatment. Journal of gastroenterology, 1995, Volume: 30, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Drug Resistance; Esophageal and Gastric Varices; Esophageal Diseases	1995
[Lansoprazole versus ranitidine in the prevention of early recurrences of digestive hemorrhages from gastroduodenal ulcers. Randomized double-blind multicenter study]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Double-B	1994
[Omeprazole and cimetidine in the treatment of upper digestive hemorrhage]. Revista espanola de enfermedades digestivas, 1994, Volume: 86, Issue:6 Topics: Cimetidine; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Omeprazole; Prospective	1994
Prophylaxis of acute gastroduodenal bleeding after renal transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:5 Topics: Acute Disease; Adult; Aged; Anti-Ulcer Agents; Duodenal Ulcer; Female; Gastrointestinal Hemorrhage;	1997
A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Archives of internal medicine, 1998, Jan-12, Volume: 158, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Blood Transfusion; Cimetidine; Female	1998
Intravenous eradication therapy for bleeding gastroduodenal ulcer associated with Helicobacter pylori infection. Revista espanola de enfermedades digestivas, 2000, Volume: 92, Issue:6 Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Administration Schedule; Fem	2000
Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. The New England journal of medicine, 2001, Mar-29, Volume: 344, Issue:13 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Drug The	2001
Drug treatments in upper gastrointestinal bleeding: value of endoscopic findings as surrogate end points. Gut, 2001, Volume: 49, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Antifibrinolytic Agents; Blood Transfusi	2001
Omeprazole versus ranitidine in the medical treatment of acute upper gastrointestinal bleeding: assessment by early repeat endoscopy. International journal of clinical practice, 2001, Volume: 55, Issue:10 Topics: Acute Disease; Adult; Aged; Anti-Ulcer Agents; Endoscopy, Digestive System; Female; Gastrointestinal	2001
The potential clinical role of intravenous omeprazole. Digestion, 1992, Volume: 51 Suppl 1 Topics: Critical Illness; Decision Trees; Female; Gastric Acidity Determination; Gastrointestinal Hemorrhage	1992
Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ (Clinical research ed.), 1992, Jan-18, Volume: 304, Issue:6820 Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Endoscopy, Gastrointestin	1992
Abolition by omeprazole of aspirin induced gastric mucosal injury in man. Gut, 1990, Volume: 31, Issue:5 Topics: Adult; Aspirin; Double-Blind Method; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Ga	1990

Article	Year
Prophylactic use of proton pump inhibitors post-cardiac surgery. British journal of hospital medicine (London, England : 2005), 2021, Oct-02, Volume: 82, Issue:10 Topics: Cardiac Surgical Procedures; Gastrointestinal Hemorrhage; Humans; Omeprazole; Proton Pump Inhibitors	2021
Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen. Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:1(Special) Topics: Adolescent; Blood Urea Nitrogen; Child; Child, Preschool; Creatinine; Drug Therapy, Combination; Fem	2022
Stress ulcer prophylaxis for critically ill children: routine use needs to be re-examined. Anales de pediatria, 2022, Volume: 96, Issue:5 Topics: Acute Disease; Child; Critical Illness; Gastrointestinal Hemorrhage; Humans; Omeprazole; Peptic Ulce	2022
Black esophagus, is it as bad as it seems? Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:10 Topics: Alcoholism; Colonic Pseudo-Obstruction; Esophagitis; Esophagoscopy; Food, Formulated; Gastrointestin	2019
It's What's Up Front That Counts-Part Two: Esophageal Crohn's Disease Complicated by Recurrent Upper Gastrointestinal Bleeding. Digestive diseases and sciences, 2019, Volume: 64, Issue:12 Topics: Adalimumab; Anti-Bacterial Agents; Anti-Inflammatory Agents; Budesonide; Colonoscopy; Colostomy; Con	2019
Acute upper gastrointestinal bleed in the puerperium following weight reduction surgery. BMJ case reports, 2020, Oct-30, Volume: 13, Issue:10 Topics: Acute Disease; Adult; Bariatric Surgery; Female; Gastrointestinal Hemorrhage; Gastroscopy; Humans; I	2020
Gastric and duodenal ischaemia after transarterial chemoembolisation for hepatocellular carcinoma: an unexpected but significant complication. BMJ case reports, 2018, Feb-21, Volume: 2018 Topics: Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Duodenum; Gastrointestinal Hemorrhage; Hu	2018
[Pyoderma gangrenosum with lung involvement treated with infliximab]. Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:5 Topics: Adolescent; Adrenal Cortex Hormones; Analgesics; Antibodies, Monoclonal; Colectomy; Colitis, Ulcerat	2013
Suppression of contractile activity in the small intestine by indomethacin and omeprazole. American journal of physiology. Gastrointestinal and liver physiology, 2015, May-01, Volume: 308, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Enteritis; Gastrointestinal Hemorrhage	2015
Treatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models. Wiener klinische Wochenschrift, 2016, Volume: 128, Issue:Suppl 8 Topics: Animals; Anti-Ulcer Agents; Gastritis; Gastrointestinal Hemorrhage; Hemostatics; Male; Omeprazole; P	2016
Is there a role for intravenous omeprazole in patients with duodenal diverticular bleeding after successful initial endoscopic hemostasis? Gastrointestinal endoscopy, 2008, Volume: 68, Issue:2 Topics: Combined Modality Therapy; Diverticulum; Dose-Response Relationship, Drug; Drug Administration Sched	2008
[Upper gastrointestinal bleeding after cardiac surgery and invasive cardiology procedures--prophylaxis and therapy]. Khirurgiia, 2005, Issue:3 Topics: Anti-Ulcer Agents; Cardiac Surgical Procedures; Coronary Angiography; Gastrointestinal Hemorrhage; H	2005
[Upper gastrointestinal bleeding of infrequent cause]. Acta gastroenterologica Latinoamericana, 2008, Volume: 38, Issue:2 Topics: Acute Disease; Aged, 80 and over; Ampicillin; Anti-Ulcer Agents; Esophagitis; Fatal Outcome; Gastroi	2008
Acute gastrointestinal bleeding. Firstly, improve availability of endoscopy. BMJ (Clinical research ed.), 2008, Nov-03, Volume: 337 Topics: Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Omeprazole; Proton Pump Inhibit	2008
Proton pump inhibitors and clopidogrel: a difficult dilemma. American heart journal, 2009, Volume: 157, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage	2009
Recurrent peptic ulcer disease in a pediatric patient with type 1 neurofibromatosis and primary ciliary dyskinesia. Minerva pediatrica, 2009, Volume: 61, Issue:5 Topics: Adult; Age Factors; Anti-Ulcer Agents; Child, Preschool; Ciliary Motility Disorders; Female; Follow-	2009
Gastroprotection in trauma patients receiving non-steroidal anti-inflammatory drugs. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 2010, Volume: 8, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-	2010
NSAIDs and risk of lower gastrointestinal bleeding. Lancet (London, England), 2010, Jul-17, Volume: 376, Issue:9736 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Celecoxib; Coloni	2010
Stress-related mucosal disease: incidence of bleeding and the role of omeprazole in its prophylaxis. European journal of internal medicine, 2010, Volume: 21, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Female; Gastric Mucosa; Gastrointesti	2010
Risk factors and prevention of upper gastrointestinal hemorrhage after a coronary artery bypass grafting operation. Surgery today, 2010, Volume: 40, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Confidence Intervals; Coronary Artery Bypass; Coronary Artery Diseas	2010
[Does dual antiplatelet therapy always require gastroprotection? Gastroprotection with proton pump inhibitors is advisable for all patients who need dual antiplatelet therapy]. Giornale italiano di cardiologia (2006), 2010, Volume: 11, Issue:6 Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclo	2010
Interaction of clopidogrel and omeprazole. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Comb	2010
In brief: Clopidogrel and omeprazole. The Medical letter on drugs and therapeutics, 2010, Nov-29, Volume: 52, Issue:1352 Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Gastrointes	2010
Clopidogrel with or without omeprazole in coronary disease. The New England journal of medicine, 2011, 02-17, Volume: 364, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Cardiovascular Diseases; Chemistry, Pharmaceutical; Clopido	2011
Clopidogrel with or without omeprazole in coronary disease. The New England journal of medicine, 2011, 02-17, Volume: 364, Issue:7 Topics: Clopidogrel; Coronary Artery Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Gastrointest	2011
What is the evidence? Portosystemic shunt in a dog. Journal of the American Veterinary Medical Association, 2011, Apr-01, Volume: 238, Issue:7 Topics: Animals; Anti-Ulcer Agents; Diet; Dog Diseases; Dogs; Evidence-Based Medicine; Gastrointestinal Hemo	2011
Impact of a bleeding care pathway in the management of acute upper gastrointestinal bleeding. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2011, Volume: 30, Issue:2 Topics: Acute Disease; Adult; Aged; Case-Control Studies; Critical Pathways; Endoscopy; Female; Gastrointest	2011
Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3 Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Cannabinoid Recept	2011
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 2011, Volume: 141, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Actinobacteria; Animals; Anti-Inflammatory Agents, Non-Ster	2011
[Clinical importance of the clopidogrel - omeprazole interaction: a question to solve]. Atencion primaria, 2012, Volume: 44, Issue:3 Topics: Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Gastrointestinal Hemorrhage; Hu	2012
Comparison of the efficacy and safety between generic intravenous omeprazole (Zefxon) and original omeprazole (Losec) in the adjunct treatment of non-variceal upper gastrointestinal bleeding in Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2011, Volume: 94, Issue:11 Topics: Aged; Endoscopy, Digestive System; Female; Gastrointestinal Hemorrhage; Humans; Infusions, Intraveno	2011
Low dose or high dose of proton pump inhibitor for ulcer bleeding? European journal of internal medicine, 2012, Volume: 23, Issue:3 Topics: Female; Gastrointestinal Hemorrhage; Hemostasis, Endoscopic; Humans; Male; Omeprazole; Proton Pump I	2012
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:1 Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastr	2012
In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine. Digestion, 2012, Volume: 86, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis	2012
Endoscopic and endoscopic ultrasound (EUS) features of annular pancreas: duodenal ulceration and a dilated bile duct. Endoscopy, 2012, Volume: 44 Suppl 2 UCTN Topics: Aged; Anti-Ulcer Agents; Bile Duct Diseases; Bile Ducts; Colonic Pseudo-Obstruction; Dilatation, Pat	2012
Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations. Wiener klinische Wochenschrift, 2012, Volume: 124, Issue:23-24 Topics: Acute Disease; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Combined Modal	2012
[Therapeutic tactics for treating patient with duodenal ulcer complicated my hemorrhage]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2003, Issue:1 Topics: Drug Therapy, Combination; Duodenal Ulcer; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Hu	2003
Celecoxib versus diclofenac and omeprazole to prevent recurrent ulcer bleeding. The New England journal of medicine, 2003, Jun-12, Volume: 348, Issue:24 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase 2; Cyclooxygen	2003
Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole. Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin;	2003
Treatment of patients at high risk for recurrent bleeding from a peptic ulcer. Annals of internal medicine, 2003, Aug-19, Volume: 139, Issue:4 Topics: Anti-Ulcer Agents; Combined Modality Therapy; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrha	2003
Summaries for patients. Combination treatment for peptic ulcers at high risk for recurrent bleeding. Annals of internal medicine, 2003, Aug-19, Volume: 139, Issue:4 Topics: Anti-Ulcer Agents; Combined Modality Therapy; Endoscopy, Gastrointestinal; Female; Gastrointestinal	2003
Massive gastrointestinal bleeding in infants with ascariasis. Journal of pediatric surgery, 2003, Volume: 38, Issue:11 Topics: Animals; Anthelmintics; Ascariasis; Ascaris lumbricoides; Blood Transfusion; Child, Preschool; Combi	2003
Intragastric pH during continuous infusion with pantoprazole in patients with bleeding peptic ulcer. The American journal of gastroenterology, 2003, Volume: 98, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Benzimid	2003
Dosage of intravenous pantoprazole. The American journal of gastroenterology, 2003, Volume: 98, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Gastrointestinal Hemorrh	2003
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility. Digestive diseases and sciences, 2004, Volume: 49, Issue:2 Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinopro	2004
Management options for patients with ulcer hemorrhage. Annals of internal medicine, 2004, May-18, Volume: 140, Issue:10 Topics: Anti-Ulcer Agents; Combined Modality Therapy; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrha	2004
Description of prescribing practices in patients with upper gastrointestinal bleeding receiving intravenous proton pump inhibitors: a multicentre evaluation. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2004, Volume: 18, Issue:9 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Aged; Aged, 80 and over; Anti-Ulcer Agents;	2004
[Application of the proton pump inhibitors in treatment of an acute gastro-intestinal bleeding of the ulcer etiology]. Klinichna khirurhiia, 2005, Issue:6 Topics: Acute Disease; Adult; Aged; Female; Gastrointestinal Hemorrhage; Humans; Injections, Intravenous; Ma	2005
Clinical implications of immediate-release PPI therapy in the management of GERD and upper GI bleeding. Introduction. Alimentary pharmacology & therapeutics, 2005, Volume: 22 Suppl 3 Topics: Enzyme Inhibitors; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Humans; Omeprazole; Proton	2005
Proton-pump inhibitors for upper-gastrointestinal bleeding. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Feb-01, Volume: 63, Issue:3 Topics: Enzyme Inhibitors; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Infusions, Intrave	2006
Proton-pump inhibitors for upper-gastrointestinal bleeding. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, Feb-01, Volume: 63, Issue:3 Topics: Enzyme Inhibitors; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Infusions, Intrave	2006
Efficacy of a proton pump inhibitor given in the early postoperative period to relieve symptoms of hiatal hernia after open heart surgery. Surgery today, 2006, Volume: 36, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Benzimidazoles; Cardiac Sur	2006
[Gastric protection and treatment with low-dose aspirin]. Medicina clinica, 2006, Feb-18, Volume: 126, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal;	2006
Effects of rabeprazole or famotidine during cardiac surgery on perioperative gastric and esophageal pH readings. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 2006, Volume: 54, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzimidazoles;	2006
Late-onset life threatening hemorrhage of omeprazole-resistant duodenal ulcer managed by interventional radiology: report of a case. Internal medicine (Tokyo, Japan), 2006, Volume: 45, Issue:14 Topics: Aged; Angiography; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Drug	2006
Pre-endoscopic proton pump inhibitor therapy reduces recurrent adverse gastrointestinal outcomes in patients with acute non-variceal upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics, 2006, Oct-15, Volume: 24, Issue:8 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Administration, Oral; Aged; Aged, 80 and ove	2006
[Platelet inhibition and gastric problems]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-04, Volume: 127, Issue:1 Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Hum	2007
Pre-endoscopic PPI therapy reduces recurrent adverse outcomes in acute non-variceal upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics, 2007, Feb-01, Volume: 25, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Administration, Oral; Aged; Aged, 80 and ove	2007
Gastrointestinal bleeding in a toddler secondary to chronic renal failure and hyper-gastrinemia. Indian journal of pediatrics, 2008, Volume: 75, Issue:1 Topics: Anemia, Hypochromic; Anti-Ulcer Agents; Child, Preschool; Drug Therapy, Combination; Duodenal Ulcer;	2008
Upper gastrointestinal bleeding in patients with acute coronary syndromes: clinical predictors and prophylactic role of proton pump inhibitors. Journal of clinical gastroenterology, 2008, Volume: 42, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Female; Fibrinolytic Agents;	2008
Cost-effectiveness analysis of high-dose omeprazole infusion before endoscopy for patients with upper-GI bleeding. Gastrointestinal endoscopy, 2008, Volume: 67, Issue:7 Topics: Adult; Aged; Cohort Studies; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Dose-	2008
[Stress ulcer prophylaxis in septic patients. Evidence-based overview]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2008, Volume: 43, Issue:5 Topics: Anti-Ulcer Agents; Cimetidine; Duodenal Ulcer; Evidence-Based Medicine; Gastric Acid; Gastrointestin	2008
Timoprazole is a unique cytoprotective agent in the rat. Digestion, 1984, Volume: 30, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Benzimidazoles; Ethanol	1984
Upper gastrointestinal bleeding: a complication of "inlet patch mucosa" in the upper esophagus. Endoscopy, 1995, Volume: 27, Issue:3 Topics: Adult; Biopsy, Needle; Endoscopy, Digestive System; Esophageal Diseases; Gastric Mucosa; Gastrointes	1995
[Generalized convulsive crisis during the intravenous administration of omeprazole at high doses]. Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:4 Topics: Aged; Aged, 80 and over; Female; Gastrointestinal Hemorrhage; Humans; Injections, Intravenous; Omepr	1994
Haemorrhagic gastritis in two patients treated with all-trans-retinoic acid in acute promyelocytic leukaemia. Australian and New Zealand journal of medicine, 1994, Volume: 24, Issue:3 Topics: Aged; Female; Gastritis; Gastrointestinal Hemorrhage; Humans; Leukemia, Promyelocytic, Acute; Male;	1994
[High-dose omeprazole versus famotidine, pirenzepine and antacid in therapy of acute upper gastrointestinal hemorrhage in a retrospective comparison]. Zeitschrift fur Gastroenterologie, 1994, Volume: 32, Issue:2 Topics: Aged; Aged, 80 and over; Aluminum Hydroxide; Antacids; Dose-Response Relationship, Drug; Drug Admini	1994
[Cystic lymphangioma of the duodenum revealed by digestive hemorrhage and associated with exudative enteropathy]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9 Topics: Aged; Duodenal Neoplasms; Gastrointestinal Hemorrhage; Humans; Jejunal Neoplasms; Kidney Neoplasms;	1993
[Endoscopic and pharmacologic treatment with omeprazole of upper digestive hemorrhage]. Minerva gastroenterologica e dietologica, 1993, Volume: 39, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Endoscopy, Gastrointestinal; Female; Gast	1993
Omeprazole and refractory stress-induced gastric mucosal hemorrhage. Critical care medicine, 1993, Volume: 21, Issue:9 Topics: Bias; Deamino Arginine Vasopressin; Gastric Acidity Determination; Gastrointestinal Hemorrhage; Huma	1993
A prospective study of simplified omeprazole suspension for the prophylaxis of stress-related mucosal damage. Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Burn Units; Female; Gastric Mucosa; G	1996
[Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Disease; Animals; Anti-Ulcer Agents; Famotidine; Gast	1996
[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Dru	1996
Massively bleeding gastric pouch ulcer after silastic ring vertical gastroplasty successfully treated endoscopically: a report of two cases. Obesity surgery, 1997, Volume: 7, Issue:2 Topics: Anti-Ulcer Agents; Epinephrine; Ethanol; Female; Gastrointestinal Hemorrhage; Gastroplasty; Hemostas	1997
Omeprazole for bleeding PUD: do we finally have evidence for effective medical therapy? The American journal of gastroenterology, 1998, Volume: 93, Issue:9 Topics: Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Humans; Omeprazole; Peptic Ulcer; Prospective Studie	1998
One-week low-dose triple therapy is effective in treating Helicobacter pylori-infected patients with bleeding peptic ulcers. Journal of the Formosan Medical Association = Taiwan yi zhi, 1998, Volume: 97, Issue:11 Topics: Adult; Aged; Clarithromycin; Drug Therapy, Combination; Female; Follow-Up Studies; Gastrointestinal	1998
Omeprazole and bleeding peptic ulcer, or "how case-control studies can tell you what you suspected all along". Epidemiology (Cambridge, Mass.), 1999, Volume: 10, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Case-Control Studies; Confounding Factor	1999
Secondary prevention of upper gastrointestinal bleeding associated with maintenance acid-suppressing treatment in patients with peptic ulcer bleed. Epidemiology (Cambridge, Mass.), 1999, Volume: 10, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidi	1999
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. Arzneimittel-Forschung, 1999, Volume: 49, Issue:4 Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalas	1999
[Images in medicine. Giant gastric ulcer revealed by anemia]. Presse medicale (Paris, France : 1983), 1999, Jun-12, Volume: 28, Issue:21 Topics: Aged; Anemia; Female; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Omeprazole; Radiography; Sto	1999
Omeprazole and risk of recurrent bleeding. Epidemiology (Cambridge, Mass.), 1999, Volume: 10, Issue:6 Topics: Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Humans; Omeprazole; Secondary Prevention	1999
Will Helicobacter pylori affect short-term rebleeding rate in peptic ulcer bleeding patients after successful endoscopic therapy? The American journal of gastroenterology, 1999, Volume: 94, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Blood Transfusion; Confidence Intervals; Duodenal	1999
Optimal acid suppression therapy in critically ill patients. Annals of internal medicine, 2000, Jun-06, Volume: 132, Issue:11 Topics: Anti-Ulcer Agents; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Omeprazole; Raniti	2000
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. Life sciences, 2000, Aug-18, Volume: 67, Issue:13 Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa;	2000
Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents;	2001
Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2001, Volume: 12, Issue:3 Topics: Angiodysplasia; Blood Transfusion; Combined Modality Therapy; Deamino Arginine Vasopressin; Estrogen	2001
Preventing upper gastrointestinal bleeding in patients with Helicobacter pylori infection. The New England journal of medicine, 2001, Jul-05, Volume: 345, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastrointestinal Hemorrhage; He	2001
The novel use of an intravenous proton pump inhibitor in a patient with short bowel syndrome. Journal of clinical gastroenterology, 2002, Volume: 34, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Benzimidazoles; Gastrointestinal Hemorrh	2002
Proton pump inhibitors and gastric acid secretion. The American journal of gastroenterology, 2001, Volume: 96, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Enzyme Inhibitors; Gastric Acid; Gastrointe	2001
Lansoprazole-induced thrombocytopenia. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Gastrointestina	2002
Pantoprazole IV (Protonix IV). The Medical letter on drugs and therapeutics, 2002, Apr-29, Volume: 44, Issue:1129 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Benzimidazoles; Clinical Trials as Topic; Drug Approval; Fe	2002
[Upper gastrointestinal complications in uremic patients with dialysis]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50 Suppl Topics: Benzamidines; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Guanidines; H	1992
Use of intravenous omeprazole in emergency cases of gastroduodenal hemorrhage. The American journal of gastroenterology, 1992, Volume: 87, Issue:9 Topics: Duodenal Diseases; Emergencies; Female; Gastrointestinal Hemorrhage; Humans; Injections, Intravenous	1992
Omeprazole for acute upper gastrointestinal bleeding. BMJ (Clinical research ed.), 1992, Feb-08, Volume: 304, Issue:6823 Topics: Gastric Acid; Gastric Acidity Determination; Gastrointestinal Hemorrhage; Humans; Omeprazole	1992
Bleeding from staple line erosion after esophageal transection: effect of omeprazole. Hepatology (Baltimore, Md.), 1992, Volume: 15, Issue:6 Topics: Adult; Aged; Depression, Chemical; Drug Evaluation; Esophageal and Gastric Varices; Esophagus; Femal	1992
Therapeutic use of omeprazole for refractory stress-induced gastric mucosal hemorrhage. Critical care medicine, 1992, Volume: 20, Issue:6 Topics: Adult; Critical Illness; Disseminated Intravascular Coagulation; Gastrointestinal Hemorrhage; Humans	1992
Acute haemorrhagic gastritis controlled by omeprazole. Lancet (London, England), 1989, Apr-08, Volume: 1, Issue:8641 Topics: Acute Disease; Gastritis; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Omeprazole	1989
Life-threatening gastrointestinal hemorrhage with omeprazole. Digestive diseases and sciences, 1988, Volume: 33, Issue:6 Topics: Administration, Oral; Adult; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Omeprazole; Zol	1988
Long term management of hemorrhagic esophagitis with cimetidine and omeprazole. Australian and New Zealand journal of medicine, 1986, Volume: 16, Issue:2 Topics: Anemia; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Esophagitis; Gastrointestinal Hemorrhage; Hum	1986

omeprazole and Gastrointestinal Hemorrhage