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omeprazole and Epilepsy

omeprazole has been researched along with Epilepsy in 3 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin."3.74[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]. ( Fernández, FA; Garcés, FJ; Pintor, E; Quesada, R, 2007)
"Omeprazole was given as a single oral dose before and after 3 weeks of treatment of five patients with CBZ (400-600 mg daily)."2.68Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19. ( Bertilsson, L; Chang, M; Tomson, T; Tybring, G; Widén, J, 1997)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fernández, FA1
Pintor, E1
Quesada, R1
Garcés, FJ1
Bertilsson, L1
Tybring, G1
Widén, J1
Chang, M1
Tomson, T1
Andersson, T1
Lagerström, PO1
Unge, P1

Trials

1 trial available for omeprazole and Epilepsy

ArticleYear
Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytoch

1997

Other Studies

2 other studies available for omeprazole and Epilepsy

ArticleYear
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
    Actas dermo-sifiliograficas, 2007, Volume: 98, Issue:7

    Topics: Adenocarcinoma; Aged; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Combined Modality Therapy;

2007
A study of the interaction between omeprazole and phenytoin in epileptic patients.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:4

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Omeprazole; Phenytoin; Time F

1990
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