omeprazole and Disease Models, Animal studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
"In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)."	8.02	Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021)
"Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia (PPE), is a major side effect of capecitabine."	8.02	Use of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome. ( Hiromoto, S; Inoue, M; Kawashiri, T; Kobayashi, D; Mine, K; Shimazoe, T; Uchida, M; Yamanaka, N, 2021)
" Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats."	7.79	Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013)
"The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats."	7.78	Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012)
" Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice."	7.77	Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model."	7.76	Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010)
"The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 microg/kg) (12 ml/rat/day) or intraperitoneally (10 microg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]."	7.75	Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole. ( Anic, T; Batelja, L; Berkopic, L; Blagaic Boban, A; Brcic, L; Cesarec, V; Coric, M; Dolovski, Z; Drmic, D; Ilic, S; Ivica, M; Klicek, R; Kocman, I; Kolenc, D; Lovric Bencic, M; Mise, S; Radic, B; Seiwerth, S; Sever, M; Sikiric, P; Skorjanec, S; Staresinic, M; Tonkic, A; Zoricic, I, 2009)
"The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied."	7.74	Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008)
"Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels."	7.74	Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008)
"Evaluation of prophylactic effects of omeprazole and/or vitamin E on the formation of free oxygen radicals (FOR) and bowel histopathology in the newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC)."	7.74	Protective effects of vitamin E and omeprazole on the hypoxia/reoxygenation induced intestinal injury in newborn rats. ( Ariturk, E; Aydin, O; Bernay, F; Bicakci, U; Cadir, FO; Kilicoglu-Aydin, B; Rizalar, R; Tander, B, 2008)
"We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology."	7.73	Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005)
"To clarify the effector sites of lansoprazole in the colonic mucosa during the formation of colitis, dextran sulfate sodium-induced colitis was induced by the oral administration of 3% aqueous solution for 3 and 7 days."	7.73	Lansoprazole binding to the neutrophils in dextran sulfate sodium-induced rat colitis. ( Arakawa, T; Asada, M; Atsuda, K; Hibi, N; Higuchi, K; Matsui, H; Nakamura, M; Tsuchimoto, K; Watanabe, T, 2005)
"Daily oral administration of cimetidine or omeprazole markedly accelerated the healing of acetic acid-induced gastric ulcers in rats with a limited food intake time."	7.69	Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion. ( Inaguma, K; Ito, M; Segami, T; Suzuki, Y, 1994)
"The effects of cimetidine, omeprazole and atropine sulfate on the healing of acetic acid-induced gastric ulcers in rats with limited food intake time (9:00-10:00 a."	7.69	Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. ( Ito, M; Kojima, R; Segami, T; Suzuki, Y; Tsukahara, T, 1994)
"The determinants of gastric aminopyrine clearance were studied in a canine hemorrhagic shock model."	7.67	Induction of anacidity restores gastric aminopyrine clearance in canine hemorrhagic shock. ( Blum, AL; Fimmel, CJ; Hinder, RA, 1988)
"Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats."	7.67	Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989)
"Omeprazole (OMZ) is a proton pump inhibitor that is used to reduce gastric acid secretion, but little is known about its possible liver protective effects."	5.72	Omeprazole Increases Survival Through the Inhibition of Inflammatory Mediaters in Two Rat Sepsis Models. ( Hashimoto, Y; Hatta, M; Kaibori, M; Kotsuka, M; Nakatake, R; Nishizawa, M; Okumura, T; Okuyama, T; Sekimoto, M; Yoshida, T, 2022)
"Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels."	5.62	The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021)
" The CGA is well absorbed orally, and its effects on gastric ulcer have not been previously reported."	5.39	Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. ( de Melo, IL; de Oliveira e Silva, AM; Farsky, SH; Machado, ID; Mancini-Filho, J; Santin, JR; Shimoyama, AT, 2013)
"Chronic gastric ulcers were produced in male Wistar rats, weighing 180 g, by the application of 100% acetic acid."	5.28	Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. ( Eastwood, GL; Kuwayama, H; Matsuo, Y, 1991)
" pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma."	4.81	[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001)
" In humans, omeprazole is a common drug used to mitigate Gastroesophageal Reflux Disease."	4.31	Intrauterine exposure to omeprazole increases the risk of teeth morphological anomalies in the offspring of a murine model. ( Ezequiel, BS; Frítola, M; Martins, CCN; Morimoto, J; Salles, MJS; Sestario, CS, 2023)
"In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)."	4.02	Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021)
"Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia (PPE), is a major side effect of capecitabine."	4.02	Use of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome. ( Hiromoto, S; Inoue, M; Kawashiri, T; Kobayashi, D; Mine, K; Shimazoe, T; Uchida, M; Yamanaka, N, 2021)
"We used two well-established mouse models of gastric ulcer (GU) induced by oral administration of EtOH (80% solution in water) or diclofenac (30 mg/kg, p."	4.02	AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice. ( Binienda, A; Fichna, J; Kordek, R; Majchrzak, K; Małecka-Panas, E; Salaga, M; Zatorski, H; Zielińska, M, 2021)
"This study evaluates the effectiveness of gastric acid secretion inhibitors (omeprazole and ranitidine), gastric mucosal protectants (sucralfate) and anthelmintics (mebendazole and flubendazole) in treating anisakiasis in Wistar rats."	4.02	Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model. ( Arrebola, F; Gómez-Mateos, M; González, JM; Navarro, MC; Romero, MC; Valero, A, 2021)
" Aspirin 150 mg/kg was used to induce gastric ulcer in all groups except normal control."	3.81	Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice. ( Ali, A; Aslam, B; Javed, I; Khaliq, T; Majeed, W; Muhammad, F; Raza, A, 2015)
"Osteoporosis is simulated in rats by chronic administration of omeprazole or serotonin for 6 months; investigated bone status in the model of liver fibrosis and the administration of serotonin against liver fibrosis."	3.80	[Osteoporosis correction in experiment]. ( Puzikov, AM, 2014)
" Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats."	3.79	Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. ( Agrawal, M; Madhur, G; Mishra, V; Narender, T; Onasanwo, SA; Palit, G; Pandey, HP; Rastogi, P, 2013)
" Peganine hydrochloride was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats."	3.79	Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. ( Barthwal, MK; Khaliq, T; Mishra, V; Narender, T; Palit, G; Pandey, HP; Singh, VK; Tiwari, S, 2013)
" They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min."	3.78	Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. ( Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA, 2012)
"The aim of this study which was structured with the objective of determination of the optimum protective therapy against the long term NSAID therapy-induced ulcers was to compare the gastro-protective effects of various antiulcer drugs (ranitidine, omeprazole, bismuth and misoprostol) alone or in combination with each other in different doses on indomethacin-induced gastric ulcers in rats."	3.78	Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. ( Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M, 2012)
"Ample of evidence proved the gastroprotective effect of thymoquinone (TQ), the main constituent of Nigella sativa oil; however, the full mechanistic cassette on the gastric ulcer etiopathogenesis is not fully elucidated."	3.78	Thymoquinone: Novel gastroprotective mechanisms. ( Hanan, el-A; Magdy, MA; Nabila, el-M, 2012)
" Therefore, we examined the potential of the green tea-derived polyphenol epigallocatechin gallate (EGCG) to treat indomethacin-induced stomach ulcers in mice."	3.77	Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"The healing activity of black tea (BT) and BT fermented with Candida parapsilosis and kombucha culture, designated as CT and KT respectively against the indomethacin-induced stomach ulceration has been studied in a mouse model."	3.76	Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G, 2010)
"Bisabolangelone is the main anti-ulcer active compound of Angelica polymorpha, and remarkably preventive and therapeutic action on gastric ulcer."	3.75	The anti-ulcer activities of bisabolangelone from Angelica polymorpha. ( Cai, Z; Cheng, F; Dan, F; Guo, Z; Wang, J; Yang, J; Zhu, L; Zou, K, 2009)
"The healing rate of gastrocutaneous fistula in rat (2-mm-diameter stomach defect, 3-mm-diameter skin defect) validates macro/microscopically and biomechanically a direct skin wound/stomach ulcer relation, and identifies a potential therapy consisting of: (i) stable gastric pentadecapeptide BPC 157 [in drinking water (10 microg/kg) (12 ml/rat/day) or intraperitoneally (10 microg/kg, 10 ng/kg, 10 pg/kg)], (ii) atropine (10 mg/kg), ranitidine (50 mg/kg), and omeprazole (50 mg/kg), (iii) 6-alpha-methylprednisolone (1 mg/kg) [intraperitoneally, once daily, first application at 30 min following surgery; last 24 h before sacrifice (at postoperative days 1, 2, 3, 7, 14, and 21)]."	3.75	Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole. ( Anic, T; Batelja, L; Berkopic, L; Blagaic Boban, A; Brcic, L; Cesarec, V; Coric, M; Dolovski, Z; Drmic, D; Ilic, S; Ivica, M; Klicek, R; Kocman, I; Kolenc, D; Lovric Bencic, M; Mise, S; Radic, B; Seiwerth, S; Sever, M; Sikiric, P; Skorjanec, S; Staresinic, M; Tonkic, A; Zoricic, I, 2009)
"Evaluation of prophylactic effects of omeprazole and/or vitamin E on the formation of free oxygen radicals (FOR) and bowel histopathology in the newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC)."	3.74	Protective effects of vitamin E and omeprazole on the hypoxia/reoxygenation induced intestinal injury in newborn rats. ( Ariturk, E; Aydin, O; Bernay, F; Bicakci, U; Cadir, FO; Kilicoglu-Aydin, B; Rizalar, R; Tander, B, 2008)
"The healing activity of the methanol extract of the spice rampatri, Myristica malabarica, (RM) and omeprazole against indometacin-induced stomach ulceration has been studied in a mouse model."	3.74	Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Maity, B, 2007)
"The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats."	3.74	Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). ( Gopalakrishnan, G; Kavimani, S; Malairajan, P; Narasimhan, S; Veni, KJ, 2007)
"Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels."	3.74	Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. ( Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S, 2008)
"The healing activity of malabaricone B and malabaricone C, the major antioxidant constituents of the spice Myristica malabarica against the indomethacin-induced gastric ulceration in mice has been studied."	3.74	Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. ( Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK, 2008)
"To investigate the protective effects of sildenafil citrate (SC) on indomethacin-induced gastric ulcer in a rat model."	3.74	The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. ( Atamanalap, SS; Aydinli, B; Başoğlu, M; Gündoğdu, C; Gürsan, N; Kiziltunç, A; Oren, D; Oztürk, G; Polat, KY; Süleyman, H; Yildirgan, MI, 2007)
" The extract at 400 mg/kg body weight, once daily, orally has a significant effect in cold restraint (CRU, 2 h cold restraint stress), aspirin (ASA, 150 mg/kg body weight, orally), alcohol (AL, 1 ml/200 gm of absolute alcohol) and pyloric ligation (PL, 4h ligation) induced gastric ulcer models as it showed protection index of 71."	3.73	Allophylus serratus: a plant with potential anti-ulcerogenic activity. ( Dharmani, P; Maurya, R; Mishra, PK; Palit, G; Singh Chauhan, V, 2005)
"We utilized a newborn rat model of hypoxia/reoxygenation (H/R) that resembles human necrotizing enterocolitis (NEC) to investigate the effects of omeprazole and/or gentamicin on the formation of free oxygen radicals (FOR) and bowel histopathology."	3.73	Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. ( Aritürk, E; Aydin, BK; Aydin, O; Bernay, F; Biçakçi, U; Eren, Z; Rizalar, R; Tander, B, 2005)
"To clarify the effector sites of lansoprazole in the colonic mucosa during the formation of colitis, dextran sulfate sodium-induced colitis was induced by the oral administration of 3% aqueous solution for 3 and 7 days."	3.73	Lansoprazole binding to the neutrophils in dextran sulfate sodium-induced rat colitis. ( Arakawa, T; Asada, M; Atsuda, K; Hibi, N; Higuchi, K; Matsui, H; Nakamura, M; Tsuchimoto, K; Watanabe, T, 2005)
" Three models of acute gastric damage (ethanol, hemorrhagic shock, and indomethacin) were examined and treatment was also carried out with the antiulcer drugs omeprazole, ranitidine, and misoprostol, to show the advantages of this histomorphometric approach."	3.71	Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. ( Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A, 2001)
"We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats."	3.70	Anti-ulcer effects of antioxidants: effect of probucol. ( Ishihara, M; Ito, M; Suzuki, Y, 1998)
"Daily oral administration of cimetidine or omeprazole markedly accelerated the healing of acetic acid-induced gastric ulcers in rats with a limited food intake time."	3.69	Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion. ( Inaguma, K; Ito, M; Segami, T; Suzuki, Y, 1994)
"The effects of cimetidine, omeprazole and atropine sulfate on the healing of acetic acid-induced gastric ulcers in rats with limited food intake time (9:00-10:00 a."	3.69	Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. ( Ito, M; Kojima, R; Segami, T; Suzuki, Y; Tsukahara, T, 1994)
" Omeprazole, which blocks the terminal step of acid secretion--the proton pump, can produce long-lasting achlorhydria."	3.67	Effect of omeprazole on acute gastric stress ulceration in cervical cord transected rats. ( Hardy, KJ; MacLellan, DG; Shulkes, A, 1987)
"Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats."	3.67	Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. ( Niida, H; Okabe, S; Okada, M; Takeuchi, K, 1989)
"The determinants of gastric aminopyrine clearance were studied in a canine hemorrhagic shock model."	3.67	Induction of anacidity restores gastric aminopyrine clearance in canine hemorrhagic shock. ( Blum, AL; Fimmel, CJ; Hinder, RA, 1988)
" Minor adverse events include headache, diarrhoea, dizziness, pruritus and rash."	2.39	Safety of proton pump inhibitors--an overview. ( Arnold, R, 1994)
"Neuropathic pain is well known to occur after damage to the somatosensory system."	1.72	Modulation of Aryl Hydrocarbon Receptor Expression Alleviated Neuropathic Pain in a Chronic Constriction Nerve Injury Animal Model. ( Pan, HC; Pan, LY; Sheehan, J; Sheu, ML; Yang, MY, 2022)
"Omeprazole (OMZ) is a proton pump inhibitor that is used to reduce gastric acid secretion, but little is known about its possible liver protective effects."	1.72	Omeprazole Increases Survival Through the Inhibition of Inflammatory Mediaters in Two Rat Sepsis Models. ( Hashimoto, Y; Hatta, M; Kaibori, M; Kotsuka, M; Nakatake, R; Nishizawa, M; Okumura, T; Okuyama, T; Sekimoto, M; Yoshida, T, 2022)
"Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels."	1.62	The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021)
"Treatment with omeprazole reduced endothelium-dependent aortic responses to acetylcholine without causing hypertension."	1.43	Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction. ( de Angelis, CD; Guimarães, DA; Oliveira-Paula, GH; Pinheiro, LC; Portella, RL; Tanus-Santos, JE, 2016)
"Omeprazole is a proton pump inhibitor used in the treatment of peptic ulcer disease and gastrosophageal reflux disease and acts by irreversibly blocking ATP4A, a P-type H+/K+ ATPase in gastric parietal cells."	1.42	Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. ( Ichihashi, M; Karaman-Jurukovska, N; Matsui, MS; Muizzuddin, N; Niki, Y; Petris, MJ; Yarosh, DB, 2015)
"Omeprazole (OM) is a proton pump inhibitor that is used to treat humans with gastric acid related disorders."	1.42	Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. ( Jiang, W; Moorthy, B; Patel, A; Shivanna, B; Wang, L; Welty, SE; Zhang, S, 2015)
" The CGA is well absorbed orally, and its effects on gastric ulcer have not been previously reported."	1.39	Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. ( de Melo, IL; de Oliveira e Silva, AM; Farsky, SH; Machado, ID; Mancini-Filho, J; Santin, JR; Shimoyama, AT, 2013)
"Indomethacin was orally administered to induce an acute gastric injury (3, 10 and 30mg/kg)."	1.38	Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. ( Castañeda-Hernández, G; Chávez-Piña, AE; Jiménez-Andrade, JM; Pineda-Peña, EA, 2012)
"Gastric ulcer was induced by administering alcohol (or) acetylsalicylic acid (or) hypothermic restraint stress to rats pretreated with HAEPD (200 mg/kgbwt for 30 day)."	1.38	Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. ( Geetha, A; Megala, J, 2012)
"Arbutin did not produce significant inhibition of NO."	1.38	Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. ( Abdelwahab, SI; Abdulla, MA; Ali, HM; Hadi, AH; Salga, MS; Taha, MM, 2012)
"However, AUC(0-3) for DPG/TS under hypochlorhydria was almost identical to that of DPG in normal rats."	1.38	Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012)
" Pharmacokinetic profiling of orally dosed DPG or DPG with 60% loading of FA (DPG/FA60) was carried out in omeprazole-treated rats as a hypochlorhydric model."	1.38	Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012)
"Omeprazole treatment did not result in mucosal injury or inflammation; however, there were marked shifts in numbers and types of enteric bacteria, including a significant reduction (∼80%) of jejunal Actinobacteria and Bifidobacteria spp."	1.37	Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. ( Bercik, P; Bolla, M; Collins, SM; de Palma, G; Denou, E; Jury, J; McKnight, W; Ongini, E; Syer, S; Verdu, E; Vong, L; Wallace, JL, 2011)
"Omeprazole, 10 mg/kg, was given i."	1.36	Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression. ( Chung, JW; Hahm, KB; Hong, KS; Kim, JH; Kim, YJ; Lee, JS, 2010)
"Omeprazole (100 mg/kg) was given p."	1.36	Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. ( Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K, 2010)
"Omeprazole was administered to the oesophagitis rats for 10 days."	1.35	Experimental oesophagitis in the rat is associated with decreased voluntary movement. ( Iizuka, S; Koseki, J; Matsumoto, T; Miwa, H; Oshima, T; Sakurai, J; Tomita, T, 2009)
"Esophageal squamous cell carcinoma developed in INK4a/Arf+/- mice (7."	1.35	Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. ( Chen, X; Hao, J; Liu, B; Yang, CS, 2009)
"Omeprazole pretreatment ameliorated DMP-777-induced parietal cell loss as well as foveolar hyperplasia."	1.33	Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. ( Car, BD; Goldenring, JR; Nomura, S; Ogawa, M, 2006)
"Stress gastric ulcer is a serious complication, but the mechanism involved is not fully clarified."	1.33	Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats. ( Chen, L; Geng, B; Ke, Y; Lou, LX; Pan, CS; Qi, YF; Tang, CS; Wang, X; Yu, F; Zhang, J, 2006)
"Omeprazole was dosed intravenously and orally in a crossover fashion to age-matched CF-KO and wild-type male and female mice."	1.32	Altered pharmacokinetics of omeprazole in cystic fibrosis knockout mice relative to wild-type mice. ( Ali, SY; Smith, PC; Tallman, MN, 2004)
"Ebrotidine is a new H2 receptor antagonist that potentiates the gastric mucosal barrier."	1.31	Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. ( Arroyo, MT; Lanas, A; Sáinz, R, 2000)
"Duodenoesophageal reflux was induced in 60 rats by performing a duodenesophagostomy."	1.31	Adenocarcinoma of the rat esophagus in the presence of a proton pump inhibitor: a pilot study. ( Barry, P; Burn, J; Falk, G; Moore, KH, 2001)
"None of the rats developed esophageal cancer, but esophageal mucosal hyperplasia was more pronounced in rats receiving omeprazole."	1.30	Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux. ( Adrian, TE; Hinder, RA; Perdikis, G; Profanter, C; Smyrk, T; Wetscher, GJ, 1999)
"The enteral bioavailability of magnesium firmly bound to a fire-proof, inert SiO2-Al2O3 matrix (ground magnesia boats) was studied in magnesium-deficient albino Sprague-Dawley rats, with and without blocking gastric hydrochloric acid secretion with omeprazole."	1.29	Erythema formation in magnesium-deficient albino rats. A non-invasive model for the screening of anti-inflammatory agents and oral mineral supplements. ( Abele, C; Classen, CU; Classen, HG; Friedberg, KD; Haubold, W; Schimatschek, HF, 1993)
"Chronic gastric ulcers were produced in male Wistar rats, weighing 180 g, by the application of 100% acetic acid."	1.28	Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. ( Eastwood, GL; Kuwayama, H; Matsuo, Y, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (3.13)	18.7374
1990's	15 (11.72)	18.2507
2000's	50 (39.06)	29.6817
2010's	44 (34.38)	24.3611
2020's	15 (11.72)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Melanole, a Nigella Sativa (Black Seed) Extract for the Treatment of Gastroesophageal Reflux Disease[NCT02587910]			Phase 2/Phase 3	170 participants (Anticipated)	Interventional	2015-10-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Safety of proton pump inhibitors--an overview. Alimentary pharmacology & therapeutics, 1994, Volume: 8 Suppl 1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Benzimidazoles; Cytochrome P-450 Enzyme System; Di	1994
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:4 Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer	2001

Article	Year
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr	2020
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. European journal of medicinal chemistry, 2021, Mar-05, Volume: 213 Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dos	2021
Omeprazole Increases Survival Through the Inhibition of Inflammatory Mediaters in Two Rat Sepsis Models. Shock (Augusta, Ga.), 2022, 03-01, Volume: 57, Issue:3 Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Galactosamine; Hepatectomy; Hepatocytes; I	2022
Intrauterine exposure to omeprazole increases the risk of teeth morphological anomalies in the offspring of a murine model. Odontology, 2023, Volume: 111, Issue:2 Topics: Animals; Disease Models, Animal; Female; Gastroesophageal Reflux; Humans; Mice; Odontogenesis; Omepr	2023
Modulation of Aryl Hydrocarbon Receptor Expression Alleviated Neuropathic Pain in a Chronic Constriction Nerve Injury Animal Model. International journal of molecular sciences, 2022, Sep-24, Volume: 23, Issue:19 Topics: Animals; Constriction; Constriction, Pathologic; Crush Injuries; Disease Models, Animal; Hyperalgesi	2022
The Proton Pump Inhibitor Omeprazole Does Not Promote Clostridioides difficile Colonization in a Murine Model. mSphere, 2019, 11-20, Volume: 4, Issue:6 Topics: Animals; Carrier State; Clostridioides difficile; Clostridium Infections; Cluster Analysis; Disease	2019
Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model. Digestive diseases and sciences, 2021, Volume: 66, Issue:1 Topics: Acute Disease; Animals; Anisakiasis; Anthelmintics; Anti-Ulcer Agents; Antinematodal Agents; Disease	2021
Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice. Digestive diseases and sciences, 2020, Volume: 65, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Gastric Emptyin	2020
Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. The Journal of allergy and clinical immunology, 2020, Volume: 146, Issue:4 Topics: Allergens; Animals; Cell Degranulation; Cells, Cultured; Cytokines; Disease Models, Animal; Food Hyp	2020
Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite. Biochemical pharmacology, 2020, Volume: 177 Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Gast	2020
Effect of prolonged omeprazole administration on segmental intestinal Mg World journal of gastroenterology, 2020, Mar-21, Volume: 26, Issue:11 Topics: Animals; Cation Transport Proteins; Colon; Disease Models, Animal; Drug Administration Schedule; Duo	2020
Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation. Nutrients, 2020, Aug-07, Volume: 12, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dinoprostone; Disease Models, Animal; Endothelin-1; Et	2020
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. European journal of pharmacology, 2021, Feb-05, Volume: 892 Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N	2021
Use of omeprazole, the proton pump inhibitor, as a potential therapy for the capecitabine-induced hand-foot syndrome. Scientific reports, 2021, 04-26, Volume: 11, Issue:1 Topics: Animals; Capecitabine; Disease Models, Animal; Hand-Foot Syndrome; Mice; Mice, Inbred ICR; Omeprazol	2021
Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms. Journal of ethnopharmacology, 2021, Oct-05, Volume: 278 Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Female;	2021
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice. Molecules (Basel, Switzerland), 2021, May-15, Volume: 26, Issue:10 Topics: Administration, Oral; Animals; Catalase; Diclofenac; Disease Models, Animal; Ethanol; Male; Mice; Om	2021
The Protective Effect of Omeprazole Against Traumatic Brain Injury: An Experimental Study. World neurosurgery, 2017, Volume: 104 Topics: Animals; Brain; Brain Contusion; Disease Models, Animal; Male; Methylprednisolone; Omeprazole; Oxida	2017
Comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats. World journal of gastroenterology, 2017, Aug-28, Volume: 23, Issue:32 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Fibroblast Growth Factor 2; Gastri	2017
The effect of Astragaloside IV on ethanol-induced gastric mucosal injury in rats: Involvement of inflammation. International immunopharmacology, 2017, Volume: 52 Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Disease Models, Animal; Ethanol; Gast	2017
Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells. Chemico-biological interactions, 2019, Jan-05, Volume: 297 Topics: Acute Kidney Injury; Animals; Cell Survival; Cells, Cultured; Cisplatin; Disease Models, Animal; Hum	2019
Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats. BioMed research international, 2019, Volume: 2019 Topics: Aluminum Hydroxide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygena	2019
The effect of Heweijiangni-decoction on esophageal morphology in a rat model of OVA-induced visceral hypersensitivity followed by acid exposure. Cellular and molecular biology (Noisy-le-Grand, France), 2019, Jun-30, Volume: 65, Issue:5 Topics: Animals; Desmosomes; Disease Models, Animal; Drugs, Chinese Herbal; Esophagus; Extracellular Space;	2019
Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Apr-15, Volume: 20, Issue:6 Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fruit; Gastric Acid; G	2013
Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy. Biochimica et biophysica acta, 2013, Volume: 1830, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechols; Disease Models, Anim	2013
Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Oct-15, Volume: 20, Issue:13 Topics: Alcohols; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Cold Temperature; Disease Mo	2013
[Effect of schemes second line quadruple therapy on interactions of some protective factors in gastric mucosal tissue in experimental ulcer]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2013, Issue:5 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Drug Therapy	2013
Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats. World journal of gastroenterology, 2014, Feb-28, Volume: 20, Issue:8 Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Esophagus; F	2014
Efficacy and pharmacological mechanism of pronase-enhanced low-dose antibiotics for Helicobacter pylori eradication. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:6 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Disease Models, Anim	2014
Effect of rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis. Neurogastroenterology and motility, 2014, Volume: 26, Issue:7 Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drugs, Chinese Herbal; Esophagitis	2014
Instantaneous enteric nano-encapsulation of omeprazole: pharmaceutical and pharmacological evaluation. International journal of pharmaceutics, 2014, Jul-01, Volume: 468, Issue:1-2 Topics: Animals; Anti-Ulcer Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Disease M	2014
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2013, Dec-20, Volume: 28, Issue:2 Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Indomethacin; Ma	2013
Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. The Journal of investigative dermatology, 2015, Volume: 135, Issue:3 Topics: Adenosine Triphosphatases; Animals; Cation Transport Proteins; Cell Line, Tumor; Cells, Cultured; Co	2015
[Osteoporosis correction in experiment]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2014, Issue:2 Topics: Allografts; Animals; Anti-Ulcer Agents; Bone Density Conservation Agents; Disease Models, Animal; Fe	2014
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice. World journal of gastroenterology, 2015, Jul-21, Volume: 21, Issue:27 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Catalase; Clostridium butyricum; Cold Temperature; Disease Mo	2015
Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice. Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 148, Issue:1 Topics: Animals; Animals, Newborn; Anti-Ulcer Agents; Basic Helix-Loop-Helix Transcription Factors; Biomarke	2015
Histopathological evaluation of gastro protective effect of Berberis vulgaris (Zereshk) seeds against aspirin induced ulcer in albino mice. Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:6 Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Berberis; Cell Proliferatio	2015
Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction. Redox biology, 2016, Volume: 9 Topics: Animals; Biomarkers; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activatio	2016
Effect of Roux-en-Y surgery and medical intervention on Barrett's-type changes: an in vivo model. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2008, Volume: 21, Issue:8 Topics: Anastomosis, Roux-en-Y; Animals; Barrett Esophagus; Disease Models, Animal; Gastroesophageal Reflux;	2008
Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin, on experimental reflux oesophagitis in rats. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 Topics: alpha-Tocopherol; Animals; Antioxidants; Catalase; Collagen; Disease Models, Animal; Esophagitis, Pe	2008
Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole. Digestive diseases and sciences, 2009, Volume: 54, Issue:1 Topics: Adrenal Cortex Hormones; Animals; Anti-Ulcer Agents; Atropine; Cutaneous Fistula; Disease Models, An	2009
N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:2 Topics: Aminopyridines; Animals; Anti-Ulcer Agents; Benzopyrans; Disease Models, Animal; Dogs; Enzyme Inhibi	2009
Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model. International journal of cancer, 2009, Mar-15, Volume: 124, Issue:6 Topics: Acetylcysteine; Adenocarcinoma; alpha-Tocopherol; Animals; Disease Models, Animal; Esophageal Neopla	2009
Effects of a one-week treatment with acid gastric inhibitors on Helicobacter pylori-infected mice. Scandinavian journal of gastroenterology, 2008, Volume: 43, Issue:8 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Dru	2008
Experimental oesophagitis in the rat is associated with decreased voluntary movement. Neurogastroenterology and motility, 2009, Volume: 21, Issue:3 Topics: Animals; Anti-Ulcer Agents; Claudin-3; Claudin-4; Disease Models, Animal; Esophagitis, Peptic; Esoph	2009
Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats. Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:5 Topics: Analysis of Variance; Animals; Ascorbic Acid; Biopsy, Needle; Disease Models, Animal; Dose-Response	2009
Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:2 Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Anti-Inflammatory Agents; Anti-Ulcer Age	2009
The anti-ulcer activities of bisabolangelone from Angelica polymorpha. Journal of ethnopharmacology, 2009, Jun-22, Volume: 123, Issue:2 Topics: Angelica; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Gast	2009
Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis. Peptides, 2009, Volume: 30, Issue:8 Topics: Animals; Bombesin; Disease Models, Animal; Gastric Mucosa; Gastritis; Indomethacin; Lipid Peroxidati	2009
Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. BMC gastroenterology, 2009, Jul-23, Volume: 9 Topics: Adenocarcinoma; Animals; Anti-Ulcer Agents; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibi	2009
Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma. The Journal of allergy and clinical immunology, 2009, Volume: 124, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Asthma; Cell Line, Tumor; Disease Models, Animal;	2009
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology, 2010, Volume: 138, Issue:2 Topics: Animals; Atrophy; Calcium; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dogs; Epithe	2010
Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:8-9 Topics: Acids; Animals; Anti-Ulcer Agents; Disease Models, Animal; Female; Fruit; Gastric Mucosa; Guinea Pig	2010
[Modeling osteoporosis]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2010, Issue:4 Topics: Animals; Bone and Bones; Disease Models, Animal; Female; Omeprazole; Osteoporosis; Ovariectomy; Prot	2010
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1 Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer A	2010
Osteogenic activity of locally applied small molecule drugs in a rat femur defect model. Journal of biomedicine & biotechnology, 2010, Volume: 2010 Topics: Alendronate; Animals; Bone Density; Disease Models, Animal; Femur; Lovastatin; Male; Omeprazole; Org	2010
Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression. Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:8 Topics: Animals; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Disease Models,	2010
Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:4 Topics: Animals; Anti-Ulcer Agents; Bismuth; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergi	2012
Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice. Pharmacological reports : PR, 2011, Volume: 63, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Catechin; Disease	2011
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology, 2011, Volume: 141, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Actinobacteria; Animals; Anti-Inflammatory Agents, Non-Ster	2011
Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action. Food & function, 2010, Volume: 1, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Ferment	2010
[Changes of NO-ergic activity in the salivary glands of rats under conditions of omeprazole-induced hypergastrinemia]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2011, Volume: 57, Issue:3 Topics: Animals; Disease Models, Animal; Gastric Mucosa; Gastrins; Male; Nitric Oxide; Nitric Oxide Synthase	2011
Gastroprotective effect of Senecio candicans DC on experimental ulcer models. Journal of ethnopharmacology, 2012, Mar-06, Volume: 140, Issue:1 Topics: Adenosine Triphosphatases; Alkaloids; Animals; Anti-Ulcer Agents; Antioxidants; Biphenyl Compounds;	2012
Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. International journal of pharmaceutics, 2012, Apr-15, Volume: 426, Issue:1-2 Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Biological Availability; Chemistry, P	2012
Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. Journal of ethnopharmacology, 2012, May-07, Volume: 141, Issue:1 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Arbutin; Aspirin; Cell Line; Cytoprotection; Disease Model	2012
Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. Journal of ethnopharmacology, 2012, Jul-13, Volume: 142, Issue:2 Topics: Animals; Anti-Ulcer Agents; Aspirin; Carbohydrate Metabolism; Cell Proliferation; Cold Temperature;	2012
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. International journal of pharmaceutics, 2012, Sep-15, Volume: 434, Issue:1-2 Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Benzenesulfonates; Biological Availab	2012
Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:11 Topics: Animals; Anti-Ulcer Agents; Benzophenones; Disease Models, Animal; Dose-Response Relationship, Drug;	2012
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. Pharmaceutical biology, 2012, Volume: 50, Issue:12 Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotecti	2012
Thymoquinone: Novel gastroprotective mechanisms. European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzoquinones; Cytoprotection; Disease Models, Animal; Gas	2012
Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. European journal of pharmacology, 2012, Dec-15, Volume: 697, Issue:1-3 Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cytoprotection; Dinoprostone; Disease Models, Anim	2012
Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Carbenoxolone; Ch	2013
Hydrogen-potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro. International journal of urology : official journal of the Japanese Urological Association, 2002, Volume: 9, Issue:11 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Disease Models, Animal; Enzyme Inhibitors; H(+)-K(	2002
Rabeprazole treatment attenuated Helicobacter pylori-associated gastric mucosal lesion formation in Mongolian gerbils. Journal of gastroenterology and hepatology, 2003, Volume: 18, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Analysis of Variance; Animals; Anti-Ulcer Agents; Benzimida	2003
Gastric transitional zones, areas where Helicobacter treatment fails: results of a treatment trial using the Sydney strain mouse model. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:7 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Disease Models, Anim	2003
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA. Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Diseas	2004
Altered pharmacokinetics of omeprazole in cystic fibrosis knockout mice relative to wild-type mice. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9 Topics: Administration, Oral; Animals; Cross-Over Studies; Disease Models, Animal; Drug Evaluation, Preclini	2004
Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils. Journal of gastroenterology, 2005, Volume: 40, Issue:1 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Carcinogenicity Tests; Cell Prolifer	2005
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Animals; Anti-Ulcer Agents; Cell Line	2005
Allophylus serratus: a plant with potential anti-ulcerogenic activity. Journal of ethnopharmacology, 2005, Jul-14, Volume: 99, Issue:3 Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Cold Temperature; Disease Models, Animal;	2005
Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage. World journal of gastroenterology, 2005, Jul-14, Volume: 11, Issue:26 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce	2005
Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/ reoxygenation induced intestinal injury in newborn rats. Pediatric surgery international, 2005, Volume: 21, Issue:10 Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Enteroc	2005
A novel gastric lesion model induced in rats by partial gastric vascular ligation. Inflammopharmacology, 2005, Volume: 13, Issue:1-3 Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship	2005
Lansoprazole binding to the neutrophils in dextran sulfate sodium-induced rat colitis. Inflammopharmacology, 2005, Volume: 13, Issue:1-3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Infective Agents; Apoptosis; Autoradiography;	2005
[Antibacterial activity of a Chinese herbal medicine, Gosyuyu (Wu-Chu-Yu), against Helicobacter pylori]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 11 Topics: Alkaloids; Animals; Chromatography, Thin Layer; Disease Models, Animal; Dose-Response Relationship,	2005
Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Digestive diseases and sciences, 2006, Volume: 51, Issue:3 Topics: Analysis of Variance; Animals; Azetidines; Disease Models, Animal; Drug Interactions; Gastric Acid;	2006
Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats. Life sciences, 2006, Oct-04, Volume: 79, Issue:19 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Apoptosis; Caspase 12; Caspases; Disease Models, A	2006
Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). Journal of ethnopharmacology, 2007, Mar-21, Volume: 110, Issue:2 Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Ligation; Male; Medici	2007
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Mod	2007
Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration. The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:11 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug;	2007
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action. European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease	2008
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2007, Volume: 13, Issue:4 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease M	2007
Biochemical and histopathologic effects of omeprazole and vitamin E in rats with corrosive esophageal burns. Pediatric surgery international, 2008, Volume: 24, Issue:5 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Burns, Chemical; Disease Models, Animal; Drug Therapy, Com	2008
Effect of some natural products either alone or in combination on gastritis induced in experimental rats. Digestive diseases and sciences, 2008, Volume: 53, Issue:7 Topics: Administration, Oral; Analysis of Variance; Animals; Curcuma; Disease Models, Animal; Fatty Acids, O	2008
Protective effects of vitamin E and omeprazole on the hypoxia/reoxygenation induced intestinal injury in newborn rats. Pediatric surgery international, 2008, Volume: 24, Issue:7 Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Ulcer Agents; Antioxidants; Disease Models, An	2008
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice. Digestive diseases and sciences, 2008, Volume: 53, Issue:11 Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catechols; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston	2008
Remodeling the hypergastrinemia model. Gastroenterology, 1995, Volume: 109, Issue:4 Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Gastrins; Humans; Omeprazole; Rats	1995
Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time. European journal of pharmacology, 1994, Oct-03, Volume: 263, Issue:3 Topics: Acetates; Acetic Acid; Administration, Oral; Analysis of Variance; Animals; Atropine; Cimetidine; Di	1994
Cimetidine and omeprazole accelerate gastric ulcer healing by an increase in gastrin secretion. European journal of pharmacology, 1994, Oct-03, Volume: 263, Issue:3 Topics: Analysis of Variance; Animals; Cimetidine; Disease Models, Animal; Drug Interactions; Drug Synergism	1994
Antiulcerogenicity of the flavonoid fraction from Bidens aurea: comparison with ranitidine and omeprazole. Journal of ethnopharmacology, 1994, Volume: 42, Issue:3 Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cold Temperature; Disease Models, Animal; Female; Flavono	1994
Erythema formation in magnesium-deficient albino rats. A non-invasive model for the screening of anti-inflammatory agents and oral mineral supplements. Arzneimittel-Forschung, 1993, Volume: 43, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Cromolyn Sodium; Diet; Disease Models, A	1993
Depletion of enterochromaffin-like cell histamine increases histidine decarboxylase and chromogranin A mRNA levels in rat stomach by a gastrin-independent mechanism. Scandinavian journal of gastroenterology, 1996, Volume: 31, Issue:10 Topics: Animals; Anti-Ulcer Agents; Culture Techniques; Disease Models, Animal; Enterochromaffin Cells; Enzy	1996
A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life sciences, 1996, Volume: 59, Issue:19 Topics: Animals; Anti-Ulcer Agents; Antibodies, Monoclonal; CD18 Antigens; Disease Models, Animal; Gastric A	1996
Relevance of the ferret model of Helicobacter-induced gastritis to evaluation of antibacterial therapies. The American journal of gastroenterology, 1996, Volume: 91, Issue:11 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Disease Models, Anim	1996
Evaluation of experimental therapeutics in a new mouse model of Helicobacter felis utilizing 16S rRNA polymerase chain reaction for detection. Scandinavian journal of gastroenterology, 1997, Volume: 32, Issue:4 Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Disease Models, Animal; Drug Therapy, Combination	1997
Oral SIV, SHIV, and HIV type 1 infection. AIDS research and human retroviruses, 1998, Volume: 14 Suppl 1 Topics: Adult; AIDS Vaccines; Animals; Animals, Newborn; Disease Models, Animal; HIV Infections; HIV-1; Huma	1998
Anti-ulcer effects of antioxidants: effect of probucol. European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3 Topics: Acetic Acid; Acute Disease; Animals; Anti-Ulcer Agents; Antioxidants; Chronic Disease; Cimetidine; D	1998
Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux. Digestive diseases and sciences, 1999, Volume: 44, Issue:6 Topics: Adenocarcinoma; Animals; Anti-Ulcer Agents; Disease Models, Animal; Duodenogastric Reflux; Esophagea	1999
Establishment of surgically induced chronic acid reflux esophagitis in rats. Scandinavian journal of gastroenterology, 1999, Volume: 34, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Disease Models, Animal; Enzyme	1999
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. European journal of gastroenterology & hepatology, 2000, Volume: 12, Issue:3 Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 A	2000
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-. European journal of pharmacology, 2001, Jan-05, Volume: 411, Issue:1-2 Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship,	2001
Evaluation of the gastroprotective activity of cordatin, a diterpene isolated from Aparisthmium cordatum (Euphorbiaceae). Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diterpe	2000
Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis. Cancer research, 2001, Jan-15, Volume: 61, Issue:2 Topics: Adenoma; Adenomatous Polyposis Coli; Adenomatous Polyposis Coli Protein; Animals; Bromodeoxyuridine;	2001
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Digestive diseases and sciences, 2001, Volume: 46, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease	2001
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice. Life sciences, 2001, Mar-09, Volume: 68, Issue:16 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo	2001
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, Volume: 8, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce	2001
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor. Digestion, 2001, Volume: 63, Issue:3 Topics: Animals; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Fibroblast Growth Factors	2001
Adenocarcinoma of the rat esophagus in the presence of a proton pump inhibitor: a pilot study. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2001, Volume: 14, Issue:1 Topics: Adenocarcinoma; Animals; Disease Models, Animal; Esophageal Neoplasms; Esophagostomy; Gastroesophage	2001
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. Toxicology and applied pharmacology, 2001, Jul-01, Volume: 174, Issue:1 Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Mis	2001
Antiulcerogenic effect of Hippophae rhamnoides L. Phytotherapy research : PTR, 2001, Volume: 15, Issue:7 Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprost	2001
Effect of hypergastrinemia on pancreatic carcinogenesis. American journal of surgery, 2002, Volume: 183, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenoma; Animals; Anti-Ulcer Agents; Azaserine; Carcinoma i	2002
Effects of sucralfate, lansoprazole, and cimetidine on the delayed healing by hydrocortisone sodium phosphate of chronic gastric ulcers in the rat. The American journal of medicine, 1991, Aug-08, Volume: 91, Issue:2A Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidi	1991
Healing process of duodenal ulcers induced by indomethacin plus histamine in rats. Digestion, 1989, Volume: 42, Issue:4 Topics: Animals; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydr	1989
Indomethacin-induced gastric antral ulcers in hamsters. Gastroenterology, 1988, Volume: 95, Issue:4 Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal	1988
Induction of anacidity restores gastric aminopyrine clearance in canine hemorrhagic shock. Digestion, 1988, Volume: 40, Issue:1 Topics: Aminopyrine; Animals; Disease Models, Animal; Dogs; Female; Gastric Acid; Gastric Mucosa; Male; Omep	1988
Effect of omeprazole on acute gastric stress ulceration in cervical cord transected rats. Digestive diseases and sciences, 1987, Volume: 32, Issue:4 Topics: Achlorhydria; Animals; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; F	1987

omeprazole and Disease Models, Animal

Research Excerpts

Research

Studies (128)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Abrams, RPM	1
Yasgar, A	1
Teramoto, T	1
Lee, MH	1
Dorjsuren, D	1
Eastman, RT	1
Malik, N	1
Zakharov, AV	1
Li, W	1
Bachani, M	1
Brimacombe, K	1
Steiner, JP	1
Hall, MD	1
Balasubramanian, A	1
Jadhav, A	1
Padmanabhan, R	1
Simeonov, A	1
Nath, A	1
Chen, LZ	1
Shu, HY	1
Wu, J	1
Yu, YL	1
Ma, D	1
Huang, X	1
Liu, MM	1
Liu, XH	1
Shi, JB	1
Kotsuka, M	1
Hashimoto, Y	1
Nakatake, R	1
Okuyama, T	1
Hatta, M	1
Yoshida, T	1
Okumura, T	1
Nishizawa, M	1
Kaibori, M	1
Sekimoto, M	1
Frítola, M	1
Sestario, CS	1
Martins, CCN	1
Ezequiel, BS	1
Morimoto, J	1
Salles, MJS	1
Sheu, ML	1
Pan, LY	1
Sheehan, J	1
Yang, MY	1
Pan, HC	1
Tomkovich, S	1
Lesniak, NA	1
Li, Y	2
Bishop, L	1
Fitzgerald, MJ	1
Schloss, PD	1
Gómez-Mateos, M	1
Arrebola, F	1
Navarro, MC	1
Romero, MC	1
González, JM	1
Valero, A	1
Satoh, H	1
Akiba, Y	1
Urushidani, T	1
Kanagaratham, C	1
El Ansari, YS	1
Sallis, BF	1
Hollister, BA	1
Lewis, OL	1
Minnicozzi, SC	1
Oyoshi, MK	1
Rosen, R	1
Nurko, S	1
Fiebiger, E	1
Oettgen, HC	1
Sanches-Lopes, JM	1
Ferreira, GC	1
Pinheiro, LC	2
Kemp, R	1
Tanus-Santos, JE	2
Suksridechacin, N	1
Kulwong, P	1
Chamniansawat, S	1
Thongon, N	1
Yu, L	1
Li, R	1
Liu, W	1
Zhou, Y	1
Qin, Y	1
Chen, Y	1
Xu, Y	1
AbdelAziz, EY	1
Tadros, MG	1
Menze, ET	1
Hiromoto, S	1
Kawashiri, T	1
Yamanaka, N	1
Kobayashi, D	1
Mine, K	1
Inoue, M	1
Uchida, M	1
Shimazoe, T	1
da Luz, BB	1
Maria-Ferreira, D	1
Dallazen, JL	1
de Oliveira, AF	1
Queiroz Telles, JE	1
Beltrame, OC	1
Cipriani, TR	1
de Paula Werner, MF	1
Zatorski, H	1
Salaga, M	1
Zielińska, M	1
Majchrzak, K	1
Binienda, A	1
Kordek, R	1
Małecka-Panas, E	1
Fichna, J	1
Özay, R	1
Türkoğlu, ME	1
Gürer, B	1
Dolgun, H	1
Evirgen, O	1
Ergüder, Bİ	1
Hayırlı, N	1
Gürses, L	1
Şekerci, Z	1
Nur Azlina, MF	1
Qodriyah, HMS	1
Chua, KH	1
Kamisah, Y	1
Qin, S	1
Huang, K	1
Fang, Z	1
Yin, J	2
Dai, R	1
Gao, H	1
Zhang, S	2
Hu, T	1
Qu, X	1
Zhai, J	1
Zhang, Y	2
Tao, L	1
Song, Y	1
Fang, YF	1
Xu, WL	1
Wang, L	2
Lian, QW	1
Qiu, LF	1
Zhou, H	1
Chen, SJ	1
Jia, BY	1
Xie, CE	1
Wang, ZB	1
Pei, WJ	1
Li, XH	1
Shi, L	1
Liu, JL	1
Han, YF	1
Tan, X	1
Ding, PH	1
Sun, ZM	1
Yuan, WJ	1
Li, JX	1
Mishra, V	3
Agrawal, M	1
Onasanwo, SA	1
Madhur, G	1
Rastogi, P	1
Pandey, HP	2
Palit, G	4
Narender, T	2
Yadav, SK	2
Adhikary, B	2
Bandyopadhyay, SK	6
Chattopadhyay, S	6
Singh, VK	1
Tiwari, S	1
Khaliq, T	2
Barthwal, MK	1
Iakubov, AV	1
Pulatova, NI	1
Khamraev, AA	1
Zamora, Z	1
Molina, V	1
Mas, R	1
Ravelo, Y	1
Perez, Y	1
Oyarzabal, A	1
Liu, KY	1
Du, FC	1
Fu, Q	1
Zhang, WJ	1
Sun, HW	1
Gan, le L	1
Yue, ZY	1
Zou, QM	1
Guo, G	1
Kondo, T	1
Oshima, T	2
Koseki, J	2
Hattori, T	1
Kase, Y	1
Tomita, T	2
Fukui, H	1
Watari, J	1
Miwa, H	2
Bendas, ER	1
Abdelbary, AA	1
Adewoye, EO	1
Salami, AT	1
Matsui, MS	1
Petris, MJ	1
Niki, Y	1
Karaman-Jurukovska, N	1
Muizzuddin, N	1
Ichihashi, M	1
Yarosh, DB	1
Puzikov, AM	1
Wang, FY	1
Liu, JM	1
Luo, HH	1
Liu, AH	1
Jiang, Y	1
Shivanna, B	1
Patel, A	1
Jiang, W	1
Welty, SE	1
Moorthy, B	1
Majeed, W	1
Aslam, B	1
Javed, I	1
Muhammad, F	1
Ali, A	1
Raza, A	1
Oliveira-Paula, GH	1
Portella, RL	1
Guimarães, DA	1
de Angelis, CD	1
Koak, Y	1
Davies, SE	1
Winslet, M	1
Rao, CV	1
Vijayakumar, M	1
Skorjanec, S	1
Dolovski, Z	1
Kocman, I	1
Brcic, L	1
Blagaic Boban, A	1
Batelja, L	1
Coric, M	1
Sever, M	1
Klicek, R	1
Berkopic, L	1
Radic, B	1
Drmic, D	1
Kolenc, D	1
Ilic, S	1
Cesarec, V	1
Tonkic, A	1
Zoricic, I	2
Mise, S	2
Staresinic, M	1
Ivica, M	1
Lovric Bencic, M	1
Anic, T	2
Seiwerth, S	2
Sikiric, P	2
Mori, H	1
Tonai-Kachi, H	1
Ochi, Y	1
Taniguchi, Y	1
Ohshiro, H	1
Takahashi, N	1
Aihara, T	1
Hirao, A	1
Kato, T	1
Sakakibara, M	1
Kurebayashi, Y	1
Hao, J	2
Zhang, B	1
Liu, B	2
Lee, M	1
Hao, X	1
Reuhl, KR	1
Chen, X	2
Yang, CS	2
Medhi, B	1
Prakash, A	1
Sakurai, J	1
Matsumoto, T	1
Iizuka, S	1
Ishiyama, F	1
Iijima, K	1
Asanuma, K	1
Ara, N	1
Yoshitake, J	1
Abe, Y	1
Koike, T	1
Imatani, A	1
Ohara, S	1
Shimosegawa, T	1
Dutra, RC	1
Fava, MB	1
Alves, CC	1
Ferreira, AP	1
Barbosa, NR	1
Wang, J	1
Zhu, L	1
Zou, K	1
Cheng, F	1
Dan, F	1
Guo, Z	1
Cai, Z	1
Yang, J	1
Petronilho, F	1
Araújo, JH	1
Steckert, AV	1
Rezin, GT	1
Ferreira, GK	1
Roesler, R	1
Schwartsmann, G	1
Dal-Pizzol, F	1
Streck, EL	1
Cortes, JR	1
Rivas, MD	1
Molina-Infante, J	1
Gonzalez-Nuñez, MA	1
Perez-G, M	1
Masa, JF	1
Sanchez, JF	1
Zamorano, J	1
Waghray, M	1
Zavros, Y	1
Saqui-Salces, M	1
El-Zaatari, M	1
Alamelumangapuram, CB	1
Todisco, A	1
Eaton, KA	1
Merchant, JL	1
Lakshmi, V	1
Singh, N	1
Shrivastva, S	1
Mishra, SK	1
Dharmani, P	2
Lychkova, AE	1
Petrakov, AV	1
Khomeriki, SG	1
Amagase, K	2
Ochi, A	1
Sugihara, T	1
Kato, S	2
Takeuchi, K	4
Cottrell, JA	1
Vales, FM	1
Schachter, D	1
Wadsworth, S	1
Gundlapalli, R	1
Kapadia, R	1
O'Connor, JP	1
Kim, YJ	1
Lee, JS	1
Hong, KS	1
Chung, JW	1
Kim, JH	1
Hahm, KB	1
Kirchhoff, P	1
Socrates, T	1
Sidani, S	1
Duffy, A	1
Breidthardt, T	1
Grob, C	1
Viehl, CT	1
Beglinger, C	1
Oertli, D	1
Geibel, JP	1
Izzettin, FV	1
Sancar, M	1
Okuyan, B	1
Apikoglu-Rabus, S	1
Cevikbas, U	1
Wallace, JL	1
Syer, S	1
Denou, E	1
de Palma, G	1
Vong, L	1
McKnight, W	1
Jury, J	1
Bolla, M	1
Bercik, P	1
Collins, SM	1
Verdu, E	1
Ongini, E	1
Banerjee, D	4
Hassarajani, SA	1
Maity, B	2
Narayan, G	1
Sukhomlyn, AA	1
Berehova, TV	1
Neporada, KS	1
Hariprasath, L	1
Raman, J	1
Nanjian, R	1
Onoue, S	2
Inoue, R	2
Taniguchi, C	2
Kawabata, Y	2
Yamashita, K	2
Wada, K	3
Yamauchi, Y	2
Yamada, S	2
Taha, MM	1
Salga, MS	1
Ali, HM	1
Abdulla, MA	1
Abdelwahab, SI	1
Hadi, AH	1
Megala, J	1
Geetha, A	1
Niero, R	2
Dal Molin, MM	1
Silva, S	1
Damian, NS	1
Maia, LO	1
Delle Monache, F	1
Cechinel Filho, V	1
de Andrade, SF	2
Hisam, EE	1
Zakaria, ZA	1
Mohtaruddin, N	1
Rofiee, MS	1
Hamid, HA	1
Othman, F	1
Magdy, MA	1
Hanan, el-A	1
Nabila, el-M	1
Pineda-Peña, EA	1
Jiménez-Andrade, JM	1
Castañeda-Hernández, G	1
Chávez-Piña, AE	1
Shimoyama, AT	1
Santin, JR	1
Machado, ID	1
de Oliveira e Silva, AM	1
de Melo, IL	1
Mancini-Filho, J	1
Farsky, SH	1
Bagcivan, I	1
Gökçe, G	1
Ayan, S	1
Yildirim, S	1
Saraç, B	1
Kiliçarslan, H	1
Sarioglu, Y	1
Suzuki, H	1
Miyazawa, M	1
Nagahashi, S	1
Sato, M	1
Bessho, M	1
Nagata, H	1
Miura, S	1
Ishii, H	1
van Zanten, SJ	1
Kolesnikow, T	1
Leung, V	1
O'Rourke, JL	1
Lee, A	1
Batista, LM	1
de Almeida, AB	2
de Pietro Magri, L	1
Toma, W	3
Calvo, TR	1
Vilegas, W	1
Souza Brito, AR	2
Tallman, MN	1
Ali, SY	1
Smith, PC	1
Maruta, F	1
Sugiyama, A	1
Ishizone, S	1
Miyagawa, S	1
Ota, H	1
Katsuyama, T	1
Rodríguez, JA	1
Theoduloz, C	1
Sánchez, M	1
Yáñez, T	1
Razmilic, I	1
Schmeda-Hirschmann, G	1
Mishra, PK	1
Maurya, R	1
Singh Chauhan, V	1
Blandizzi, C	2
Fornai, M	1
Colucci, R	1
Natale, G	2
Lubrano, V	1
Vassalle, C	1
Antonioli, L	1
Lazzeri, G	2
Del Tacca, M	2
Biçakçi, U	3
Tander, B	3
Aritürk, E	3
Aydin, BK	1
Aydin, O	3
Rizalar, R	3
Eren, Z	1
Bernay, F	3
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Fujimura, T	1
Okabe, S	3
Nakamura, M	1
Asada, M	1
Atsuda, K	1
Matsui, H	1
Watanabe, T	2
Higuchi, K	2
Arakawa, T	2
Hibi, N	1
Tsuchimoto, K	1
Tominaga, K	1
Hamasaki, N	1
Tanigawa, T	1
Sasaki, E	1
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Oshitani, N	1
Ishii, E	1
Tezuka, Y	1
Nagaoka, T	1
Kadota, S	1
Ogawa, M	1
Nomura, S	1
Car, BD	1
Goldenring, JR	1
Lou, LX	1
Geng, B	1
Yu, F	1
Zhang, J	1
Pan, CS	1
Chen, L	1
Qi, YF	1
Ke, Y	1
Wang, X	1
Tang, CS	1
Malairajan, P	1
Gopalakrishnan, G	1
Narasimhan, S	1
Veni, KJ	1
Kavimani, S	1
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Noldin, VF	1
Filho, VC	1
Bauri, AK	2
Guha, RK	1
Aydinli, B	1
Yildirgan, MI	1
Oztürk, G	1
Atamanalap, SS	1
Polat, KY	1
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Süleyman, H	2
Kiziltunç, A	1
Gürsan, N	1
Oren, D	1
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Kilicoglu-Aydin, B	2
Ayyildiz, SH	1
Elseweidy, MM	1
Younis, NN	1
Amin, RS	1
Abdallah, FR	1
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Yousif, ZA	1
Cadir, FO	1
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Maliakkal, B	1
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Luk, G	1
Ito, M	3
Segami, T	2
Tsukahara, T	1
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Suzuki, Y	5
Inaguma, K	1
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La Casa, C	1
Motilva, V	1
Arnold, R	1
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Schimatschek, HF	1
Friedberg, KD	1
Classen, HG	1
Haubold, W	1
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Lindström, E	1
Chen, D	1
Monstein, HJ	1
Boketoft, A	1
Håkanson, R	1
Kamisaki, Y	1
Kitano, M	1
Kishimoto, Y	1
Nakamoto, K	1
Itoh, T	1
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Ewing, PJ	1
Mitten, MJ	1
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Tanaka, SK	1
Smith, JG	1
Kong, L	1
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Gill, CJ	1
Flattery, AM	1
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Ruprecht, RM	1
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Montefiori, DC	1
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Kashiwagi, H	1
Chen, G	1
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Lee, SS	1
Lim, H	1
Lee, DH	1
Hiruma-Lima, CA	2
Gracioso, JD	1
de Paula, AC	1
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Muller, AH	2
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Watson, SA	1
Smith, AM	1
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Gracioso, JS	1
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Paula, AC	1
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