Page last updated: 2024-11-01

omeprazole and Deficiency, Magnesium

omeprazole has been researched along with Deficiency, Magnesium in 19 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Research Excerpts

ExcerptRelevanceReference
" Etiologic investigations led to the discovery of Giardiasis lamblia on duodenal biopsies and a long-term treatment with proton pump inhibitors (PPI) (omeprazole followed by esomeprazole), both being recently described as causal factors of hypomagnesemic hypoparathyroidism."3.74[Chronic use of proton-pump inhibitors associated with giardiasis: A rare cause of hypomagnesemic hypoparathyroidism?]. ( Caron, J; Durlach, V; François, M; Lévy-Bohbot, N, 2008)
"Two cases of severe hypomagnesaemia in adult long-term users of the PPI omeprazole, presenting with hypocalcaemic seizures."3.74Severe hypomagnesaemia in long-term users of proton-pump inhibitors. ( Cundy, T; Dissanayake, A, 2008)
"The enteral bioavailability of magnesium firmly bound to a fire-proof, inert SiO2-Al2O3 matrix (ground magnesia boats) was studied in magnesium-deficient albino Sprague-Dawley rats, with and without blocking gastric hydrochloric acid secretion with omeprazole."1.29Erythema formation in magnesium-deficient albino rats. A non-invasive model for the screening of anti-inflammatory agents and oral mineral supplements. ( Abele, C; Classen, CU; Classen, HG; Friedberg, KD; Haubold, W; Schimatschek, HF, 1993)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's4 (21.05)29.6817
2010's13 (68.42)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Isse, N1
Hashimoto, M1
Koh, ZY1
Lim, SWM1
Lim, WS1
Semb, S1
Helgstrand, F1
Hjørne, F1
Bytzer, P1
van den Berg, S1
Scheer, MLJ1
Holman, ND1
Thongon, N1
Penguy, J1
Kulwong, S1
Khongmueang, K1
Thongma, M1
Eberhard, J1
Macdonald, A1
Cundy, T2
François, M1
Lévy-Bohbot, N1
Caron, J1
Durlach, V1
Shabajee, N1
Lamb, EJ1
Sturgess, I1
Sumathipala, RW1
Doornebal, J1
Bijlsma, R1
Brouwer, RM1
Gato Diez, A1
Córdoba Soriano, JG1
Mora Escudero, I1
Fernández-Fernández, FJ2
Sesma, P2
Caínzos-Romero, T2
Ferreira, L1
Ferreira-González, L1
Callejas Díaz, A1
Montero Hernández, E1
Gil Navarro, M1
Tutor-Ureta, P1
Yebra Bango, M1
Vargas Núñez, JA1
Gutiérrez Macías, A1
Ibarmia Lahuerta, J1
Alvarez De Castro, M1
Lizarralde Palacios, E1
Swaminathan, K1
Wilson, J1
Famularo, G1
Minisola, G1
Bravi, MC1
Colucci, P1
Gasbarrone, L1
Bai, JP1
Hausman, E1
Lionberger, R1
Zhang, X1
Dissanayake, A1
Classen, CU1
Abele, C1
Schimatschek, HF1
Friedberg, KD1
Classen, HG1
Haubold, W1

Other Studies

19 other studies available for omeprazole and Deficiency, Magnesium

ArticleYear
Omeprazole-induced hypomagnesaemia, causing renal tubular acidosis with hypokalaemia, hypocalcaemia, hyperlactacidaemia and hyperammonaemia.
    BMJ case reports, 2020, Jul-08, Volume: 13, Issue:7

    Topics: Acidosis, Renal Tubular; Aged; Humans; Hyperammonemia; Hyperlactatemia; Hypocalcemia; Hypokalemia; M

2020
An Interesting Case of "Refractory" Hypomagnesemia.
    Journal of the American Medical Directors Association, 2017, 07-01, Volume: 18, Issue:7

    Topics: Aged, 80 and over; Gastric Mucosa; Gastroesophageal Reflux; Humans; Magnesium Deficiency; Male; Omep

2017
Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication.
    World journal of gastroenterology, 2017, Oct-07, Volume: 23, Issue:37

    Topics: Administration, Oral; Aged; Fundoplication; Gastroesophageal Reflux; Humans; Infusions, Intravenous;

2017
[Severe hypomagnesaemia due to proton pump inhibitor use].
    Nederlands tijdschrift voor geneeskunde, 2018, Aug-03, Volume: 162

    Topics: Aged; Female; Humans; Magnesium Deficiency; Omeprazole; Proton Pump Inhibitors

2018
Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats.
    Pflugers Archiv : European journal of physiology, 2016, Volume: 468, Issue:11-12

    Topics: Animals; Anti-Ulcer Agents; Cation Transport Proteins; Claudins; Duodenum; Intestinal Absorption; Ma

2016
Severe proton pump inhibitor-induced hypomagnesaemia in a mother and daughter.
    Internal medicine journal, 2017, Volume: 47, Issue:3

    Topics: Aged, 80 and over; Female; Humans; Magnesium Deficiency; Middle Aged; Mothers; Nuclear Family; Omepr

2017
[Chronic use of proton-pump inhibitors associated with giardiasis: A rare cause of hypomagnesemic hypoparathyroidism?].
    Annales d'endocrinologie, 2008, Volume: 69, Issue:5

    Topics: Deglutition Disorders; Duodenum; Esomeprazole; Female; Giardiasis; Humans; Hypocalcemia; Hypoparathy

2008
Omeprazole and refractory hypomagnesaemia.
    BMJ (Clinical research ed.), 2008, Jul-10, Volume: 337

    Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Chronic Disease; Female; Humans; Hypocalcemia; Hypokalem

2008
[An unknown but potentially serious side effect of proton pump inhibitors: hypomagnesaemia].
    Nederlands tijdschrift voor geneeskunde, 2009, Volume: 153

    Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Female; Humans; Hypocalcemia; Hypokalemia; Hypoparathyro

2009
[Severe hypomagnesaemia due to long-term treatment with omeprazole].
    Medicina clinica, 2011, Jan-29, Volume: 136, Issue:2

    Topics: Aged; Enzyme Inhibitors; Humans; Magnesium Deficiency; Male; Omeprazole; Severity of Illness Index

2011
[Hypomagnesemia related to the use of omeprazole with negative result for mutation in the TRPM6 gene].
    Medicina clinica, 2011, Jul-09, Volume: 137, Issue:4

    Topics: Aged; Alcoholism; Esophagitis, Peptic; Famotidine; Histamine H2 Antagonists; Humans; Intestinal Abso

2011
Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole.
    The Netherlands journal of medicine, 2010, Volume: 68, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Ulcer Agents; Famotidine; Histamine H2 Antagonis

2010
[Omeprazole and hypomagnesemia].
    Revista clinica espanola, 2011, Volume: 211, Issue:6

    Topics: Enzyme Inhibitors; Humans; Magnesium Deficiency; Male; Middle Aged; Omeprazole

2011
[Severe hypomagnesemia related to omeprazole].
    Revista clinica espanola, 2011, Volume: 211, Issue:9

    Topics: Aged, 80 and over; Anti-Ulcer Agents; Humans; Magnesium Deficiency; Male; Middle Aged; Omeprazole

2011
Elusive cause of hypomagnesaemia.
    BMJ (Clinical research ed.), 2011, Sep-30, Volume: 343

    Topics: Anti-Ulcer Agents; Humans; Hydroxycholecalciferols; Infusions, Intravenous; Magnesium Compounds; Mag

2011
Tetany, hypomagnesemia, and proton-pump inhibitors.
    The American journal of medicine, 2012, Volume: 125, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Biomarkers; Female; Humans; Hypoparathyroidism; Magnesium;

2012
Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1. Oral absorption of magnesium.
    Molecular pharmaceutics, 2012, Dec-03, Volume: 9, Issue:12

    Topics: Administration, Oral; Computer Simulation; Homeostasis; Humans; Intestinal Absorption; Magnesium; Ma

2012
Severe hypomagnesaemia in long-term users of proton-pump inhibitors.
    Clinical endocrinology, 2008, Volume: 69, Issue:2

    Topics: Aged; Female; Gastroesophageal Reflux; Humans; Hypocalcemia; Magnesium Deficiency; Male; Middle Aged

2008
Erythema formation in magnesium-deficient albino rats. A non-invasive model for the screening of anti-inflammatory agents and oral mineral supplements.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Biological Availability; Cromolyn Sodium; Diet; Disease Models, A

1993