omeprazole has been researched along with Cirrhosis, Liver in 30 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duthaler, U | 1 |
| Bachmann, F | 1 |
| Suenderhauf, C | 1 |
| Grandinetti, T | 1 |
| Pfefferkorn, F | 1 |
| Haschke, M | 1 |
| Hruz, P | 1 |
| Bouitbir, J | 1 |
| Krähenbühl, S | 1 |
| Ellakany, AR | 1 |
| Elgendy, DI | 1 |
| Alshenawy, HA | 1 |
| Abdel Ghaffar, AE | 1 |
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Wang, J | 7 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Li, Y | 6 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 3 |
| Cheng, J | 1 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Chen, K | 2 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 2 |
| Chen, Y | 4 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Liu, C | 3 |
| Lin, Y | 1 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 2 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
| Kaleka, CC | 1 |
| Amaro, JT | 1 |
| Cohen, M | 1 |
| Huang, W | 1 |
| Li, T | 1 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Yang, Y | 3 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 2 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
| Ge, JB | 1 |
| Milheiro, SA | 1 |
| Gonçalves, J | 1 |
| Lopes, RMRM | 1 |
| Madureira, M | 1 |
| Lobo, L | 1 |
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| Nogueira, F | 1 |
| Fontinha, D | 1 |
| Prudêncio, M | 1 |
| M Piedade, MF | 1 |
| Pinto, SN | 1 |
| Florindo, PR | 1 |
| Moreira, R | 1 |
| Castillo-Lora, J | 1 |
| Delley, MF | 1 |
| Laga, SM | 1 |
| Mayer, JM | 1 |
| Sutjarit, N | 1 |
| Thongon, N | 1 |
| Weerachayaphorn, J | 1 |
| Piyachaturawat, P | 1 |
| Suksamrarn, A | 1 |
| Suksen, K | 1 |
| Papachristou, DJ | 1 |
| Blair, HC | 1 |
| Hu, Y | 1 |
| Shen, P | 1 |
| Zeng, N | 1 |
| Wang, L | 3 |
| Yan, D | 1 |
| Cui, L | 1 |
| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 1 |
| Ye, W | 1 |
| Guo, P | 1 |
| Rahimi, S | 1 |
| Singh, MP | 1 |
| Gupta, J | 1 |
| Nakanishi, I | 1 |
| Ohkubo, K | 1 |
| Shoji, Y | 1 |
| Fujitaka, Y | 1 |
| Shimoda, K | 1 |
| Matsumoto, KI | 1 |
| Fukuhara, K | 1 |
| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
| Berry, JD | 1 |
| Bedlack, R | 1 |
| Mathews, D | 1 |
| Agnese, W | 1 |
| Apple, S | 1 |
| Meloncelli, S | 1 |
| Divizia, M | 1 |
| Germani, G | 1 |
| Adefegha, SA | 1 |
| Bottari, NB | 1 |
| Leal, DB | 1 |
| de Andrade, CM | 1 |
| Schetinger, MR | 1 |
| Martínez-Velasco, A | 1 |
| Perez-Ortiz, AC | 1 |
| Antonio-Aguirre, B | 1 |
| Martínez-Villaseñor, L | 1 |
| Lira-Romero, E | 1 |
| Palacio-Pastrana, C | 1 |
| Zenteno, JC | 1 |
| Ramirez, I | 1 |
| Zepeda-Palacio, C | 1 |
| Mendoza-Velásquez, C | 1 |
| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
| Schladweiler, MC | 1 |
| Phillips, P | 1 |
| Harmon, M | 1 |
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| Richards, J | 1 |
| George, I | 1 |
| Haykal-Coates, N | 1 |
| Gilmour, MI | 1 |
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| Farraj, AK | 1 |
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| Shaheen, MY | 1 |
| Basudan, AM | 1 |
| Niazy, AA | 1 |
| van den Beucken, JJJP | 1 |
| Jansen, JA | 1 |
| Alghamdi, HS | 1 |
| Gao, Q | 2 |
| Guo, X | 1 |
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| Jia, X | 1 |
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| Lu, C | 2 |
| Zhu, H | 2 |
| Melku, M | 1 |
| Abebe, G | 1 |
| Teketel, A | 1 |
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| Kassa, E | 1 |
| Damtie, D | 1 |
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| Ahmed, MFE | 1 |
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| Wang, YF | 1 |
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| Liu, LP | 1 |
| Li, XX | 1 |
| Zhou, CL | 1 |
| Chen, WM | 1 |
| Wei, KL | 1 |
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| Chang, TS | 1 |
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| Chiu, WN | 1 |
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| Lu, SN | 1 |
| Hung, CH | 1 |
| Alakavuklar, MA | 1 |
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| Luo, KL | 1 |
| Underwood, RS | 1 |
| Greenwald, I | 1 |
| Elashiry, MM | 1 |
| Elashiry, M | 1 |
| Zeitoun, R | 1 |
| Elsayed, R | 1 |
| Tian, F | 1 |
| Saber, SE | 1 |
| Elashry, SH | 1 |
| Tay, FR | 1 |
| Cutler, CW | 1 |
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| Maciel, M | 1 |
| Poole, ST | 1 |
| Jobling, MG | 1 |
| Rollenhagen, JE | 1 |
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| McVeigh, AL | 1 |
| Gregory, MJ | 1 |
| Maves, RC | 1 |
| Prouty, MG | 1 |
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| Palevsky, PM | 1 |
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| Thiessen Philbrook, H | 1 |
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| Shi-Li, L | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| In Vivo Determination of Cytochrome P450 Activities in Patients With Liver Cirrhosis[NCT03337945] | 48 participants (Actual) | Interventional | 2018-04-04 | Completed | |||
| [NCT01458990] | 60 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Analysis at baseline will be compared to that at 2 weeks. This will be specifically, changes in those with PPI withdrawal compared to those with PPI initiation (NCT01458990)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| PPI Initiation | 0 |
| PPI Withdrawal | 0 |
Analysis at baseline will be compared to that at 2 weeks using Multitagged sequencing. Number of patients with overgrowth of oral microbiota in their stool after PPI therapy withdrawal or initiation were specifically analyzed. (NCT01458990)
Timeframe: 2 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| PPI Inititation | 45 |
| PPI Withdrawal | 15 |
2 reviews available for omeprazole and Cirrhosis, Liver
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Helicobacter pylori infection in patients with liver cirrhosis: facts and fictions.
Topics: Ammonia; Anti-Ulcer Agents; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; | 2003 |
11 trials available for omeprazole and Cirrhosis, Liver
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Fungal dysbiosis in cirrhosis.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Cross-Sectional Studies; Dysbiosis; Female; Follow-Up Studie | 2018 |
Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
Topics: Arginine; Biomarkers; Case-Control Studies; Feces; Female; Gastrins; Hippurates; Humans; Intestines; | 2014 |
In vivo metabolic activity of CYP2C19 and CYP3A in relation to CYP2C19 genetic polymorphism in chronic liver disease.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome | 2005 |
Reversal of migraine symptoms by Helicobacter pylori eradication therapy in patients with hepatitis-B-related liver cirrhosis.
Topics: Adult; Amoxicillin; Clarithromycin; Drug Therapy, Combination; Female; Follow-Up Studies; Helicobact | 2007 |
Effect of Helicobacter pylori eradication and antisecretory maintenance therapy on peptic ulcer recurrence in cirrhotic patients: a prospective, cohort 2-year follow-up study.
Topics: Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Cohort Studies; Endoscopy; Follow-Up Studies; Greece | 2008 |
Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Injections, Intrave | 1993 |
Pharmacokinetics of pantoprazole in man.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adolescent; Adult; Aged; Anti-Ulcer A | 1996 |
Rabeprazole: pharmacokinetics in patients with stable, compensated cirrhosis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Benzimidazoles; Chronic Disease; Enzyme Inhibitors; | 1999 |
Helicobacter pylori eradication with dual and low-dose triple therapy in patients with liver cirrhosis.
Topics: Amoxicillin; Drug Administration Schedule; Female; Helicobacter Infections; Helicobacter pylori; Hum | 1999 |
Pharmacokinetics of clarithromycin in Helicobacter pylori eradication therapy in patients with liver cirrhosis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromy | 2000 |
18 other studies available for omeprazole and Cirrhosis, Liver
| Article | Year |
|---|---|
Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently.
Topics: Caffeine; Child; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochr | 2022 |
Assessment of the potential therapeutic effects of omeprazole in Schistosoma mansoni infected mice.
Topics: Animals; Drug Therapy, Combination; Granuloma; Liver Cirrhosis; Male; Mice; Omeprazole; Parasite Egg | 2019 |
Proton pump inhibitor use is associated with a variety of infections in patients with liver cirrhosis.
Topics: Bacterial Infections; Case-Control Studies; Databases, Factual; Female; Germany; Humans; Liver Cirrh | 2020 |
Experimental osteoporosis and its correction.
Topics: Albumins; Alkaline Phosphatase; Animals; Bone and Bones; Bone Density; Calcium; Carbon Tetrachloride | 2014 |
Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.
Topics: Animals; Gastric Mucosa; Glycoproteins; Hypertension, Portal; Liver Cirrhosis; Male; Nitric Oxide; O | 2014 |
[Osteoporosis correction in experiment].
Topics: Allografts; Animals; Anti-Ulcer Agents; Bone Density Conservation Agents; Disease Models, Animal; Fe | 2014 |
Proton Pump Inhibitors Increase Risk for Hepatic Encephalopathy in Patients With Cirrhosis in A Population Study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administrative Claims, Healthcare; Adult; Aged; Case-Contro | 2017 |
Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Extracellular Space; Furosemide; Liver; Liv | 2010 |
Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Animals; Bacteria; Bacterial Infections; Cohor | 2012 |
Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations.
Topics: Acute Disease; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Combined Modal | 2012 |
Pharmacokinetics of omeprazole in patients with liver cirrhosis and extrahepatic portal venous obstruction.
Topics: Administration, Oral; Adult; Biological Availability; Capsules; Chromatography, High Pressure Liquid | 2003 |
Cholelithiasis and hepatic fibrosis in a standardbred mare.
Topics: Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; Biopsy; Blood Cell Count; Blood Chemical Analysis | 2006 |
Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients.
Topics: Adult; Aged; Alkylating Agents; Anti-Bacterial Agents; Anti-Ulcer Agents; China; Clarithromycin; Fem | 2008 |
Pharmacokinetics of lansoprazole in patients with renal or liver disease of varying severity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Administration, Oral; Adult; Aged; Female; Half | 1993 |
Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection.
Topics: Ammonia; Amoxicillin; Anti-Ulcer Agents; Ascites; Chronic Disease; Diuretics; Helicobacter Infection | 1998 |
Helicobacter pylori, hyperammonemia and subclinical portosystemic encephalopathy: effects of eradication.
Topics: Aged; Ammonia; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combination; | 1999 |
Bleeding from staple line erosion after esophageal transection: effect of omeprazole.
Topics: Adult; Aged; Depression, Chemical; Drug Evaluation; Esophageal and Gastric Varices; Esophagus; Femal | 1992 |
Effect of omeprazole on nocturnal intragastric pH in cirrhotics with inadequate antisecretory response to ranitidine.
Topics: Female; Gastric Acid; Gastric Acidity Determination; Gastritis; Humans; Hydrogen-Ion Concentration; | 1991 |