omeprazole has been researched along with Cell Transformation, Neoplastic in 9 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of 64 patients with an endoscopically diagnosed gastric adenoma and H pylori infection, 32 were treated with omeprazole and antibiotics to eradicate the infection, and 32 were not." | 5.09 | Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma. ( Arai, K; Kobayashi, R; Mori, M; Ohki, I; Saito, K, 2000) |
| " The safety of chronic administration of these drugs has come into question, however." | 2.38 | The gastrin hypothesis. Implications for antisecretory drug selection. ( Karnes, WE; Walsh, JH, 1990) |
| " This study aimed to develop an animal model to examine the effects of long-term use of PPI in vivo." | 1.56 | Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats. ( Chang, HW; Chang, VHS; Chien, LN; Chu, PG; Dong, F; Jia, W; Lin, IH; Liu, YR; Wu, MJ; Xie, G; Yang, YSH; Yen, Y, 2020) |
| "Omeprazole, 10 mg/kg, was given i." | 1.36 | Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression. ( Chung, JW; Hahm, KB; Hong, KS; Kim, JH; Kim, YJ; Lee, JS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, YSH | 1 |
| Chang, HW | 1 |
| Lin, IH | 1 |
| Chien, LN | 1 |
| Wu, MJ | 1 |
| Liu, YR | 1 |
| Chu, PG | 1 |
| Xie, G | 1 |
| Dong, F | 1 |
| Jia, W | 1 |
| Chang, VHS | 1 |
| Yen, Y | 1 |
| Kim, YJ | 1 |
| Lee, JS | 1 |
| Hong, KS | 1 |
| Chung, JW | 1 |
| Kim, JH | 1 |
| Hahm, KB | 1 |
| Hamaguchi, K | 1 |
| Ogawa, K | 1 |
| Katsube, T | 1 |
| Konno, S | 1 |
| Aiba, M | 1 |
| Ma, Q | 1 |
| Lu, AY | 1 |
| Saito, K | 1 |
| Arai, K | 1 |
| Mori, M | 1 |
| Kobayashi, R | 1 |
| Ohki, I | 1 |
| Morgner, A | 1 |
| Miehlke, S | 1 |
| Fischbach, W | 1 |
| Schmitt, W | 1 |
| Müller-Hermelink, H | 1 |
| Greiner, A | 1 |
| Thiede, C | 1 |
| Schetelig, J | 1 |
| Neubauer, A | 1 |
| Stolte, M | 1 |
| Ehninger, G | 1 |
| Bayerdörffer, E | 1 |
| Waldum, HL | 1 |
| Karnes, WE | 1 |
| Walsh, JH | 1 |
| Solcia, E | 1 |
| Rindi, G | 1 |
| Havu, N | 1 |
| Elm, G | 1 |
2 reviews available for omeprazole and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
Topics: Amines; Animals; Anti-Ulcer Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformat | 2007 |
The gastrin hypothesis. Implications for antisecretory drug selection.
Topics: Achlorhydria; Animals; Carcinoid Tumor; Cell Transformation, Neoplastic; Enterochromaffin Cells; Gas | 1990 |
2 trials available for omeprazole and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma.
Topics: Adenoma; Aged; Aged, 80 and over; Amoxicillin; Carcinoma; Cell Transformation, Neoplastic; Clarithro | 2000 |
Qualitative studies of gastric endocrine cells in patients treated long-term with omeprazole.
Topics: Biopsy; Carcinoid Tumor; Cell Division; Cell Transformation, Neoplastic; Enterochromaffin Cells; Eso | 1989 |
5 other studies available for omeprazole and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats.
Topics: Administration, Oral; alpha-Tocopherol; Animals; Bile Duct Neoplasms; Bile Ducts; Cell Transformatio | 2020 |
Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression.
Topics: Animals; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Disease Models, | 2010 |
Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer? Comparison of mucosal lesions in the residual stomach before and after Helicobacter pylori eradication.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenocarcinoma; Aged; Amoxicillin; Anti-Bacterial Agents; A | 2004 |
Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Ulcer Agents; Cell Transformation, Neoplastic; Fem | 2001 |
The safety of proton pump inhibitors.
Topics: Carcinoid Tumor; Cell Transformation, Neoplastic; Enzyme Inhibitors; Gastric Acid; Humans; Omeprazol | 2001 |