omeprazole has been researched along with Carcinoid Tumor in 34 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Investigative studies showed evidence for marked and sustained hypergastrinemia increasing on chronic dosing which was capable of restoring gastric acid secretion and pH to near control values." | 5.27 | Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole. ( Betton, GR; Buckley, P; Dormer, CS; Pert, P; Price, CA; Wells, T, 1988) |
| "Gastric ECL-cell hyperplasia and carcinoids (ECLoma) develop after 1 year in rats treated with omeprazole or 2 months in Mastomys treated with loxtidine." | 3.78 | Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine. ( Chen, D; Kidd, M; Modlin, IM; Vigen, RA; Zhao, CM, 2012) |
| "Based on the experience from more than 10,000 individuals omeprazole has been found to be safe and is well tolerated." | 3.76 | Omeprazole: long-term safety. ( Arnold, R; Koop, H, 1989) |
| " However, the consequences of very long-term use of proton pump inhibitors remain unknown." | 2.41 | Problems associated with the clinical use of proton pump inhibitors. ( Gillen, D; McColl, KE, 2001) |
| " The lack of significant adverse effects has revealed a degree of tolerability that, to write a review of the adverse effects, poses a difficult task." | 2.39 | A comparative overview of the adverse effects of antiulcer drugs. ( Piper, DW, 1995) |
| "argyrophilic gastric carcinoids." | 2.38 | Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis. ( Rindi, G; Silini, E; Solcia, E; Villani, L, 1993) |
| "ECL-cell hyperplasia and carcinoids which occur during application of very high doses of omeprazole in rats are not caused by a direct effect of omeprazole." | 2.38 | [Risk for developing tumors in therapy with the proton pump inhibitor omeprazole]. ( Arnold, R; Eissele, R, 1993) |
| " The safety of chronic administration of these drugs has come into question, however." | 2.38 | The gastrin hypothesis. Implications for antisecretory drug selection. ( Karnes, WE; Walsh, JH, 1990) |
| "Gastric carcinoids are slow growing neuroendocrine tumours arising from enterochromaffin-like (ECL) cells in the corpus of stomach." | 1.46 | Deletion of ( Choi, EK; Hayes, MM; Kang, AJ; Merchant, JL; Sundaresan, S, 2017) |
| "However, no carcinoid tumors were observed, possibly because the strain of mastomys studied does not produce carcinoids spontaneously." | 1.28 | The effect of omeprazole-induced hypergastrinemia on the oxyntic mucosa of mastomys. ( Brenna, E; Håkanson, R; Sandvik, AK; Sundler, F; Waldum, HL, 1991) |
| "Neuroendocrine cell (carcinoid) tumours have been reported in the acid-secreting part of the stomach of rodents after long-term administration of a range of potent chemically diverse antisecretory agents." | 1.28 | Potential hazards of long-term acid suppression. ( Selway, SA, 1990) |
| " Investigative studies showed evidence for marked and sustained hypergastrinemia increasing on chronic dosing which was capable of restoring gastric acid secretion and pH to near control values." | 1.27 | Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole. ( Betton, GR; Buckley, P; Dormer, CS; Pert, P; Price, CA; Wells, T, 1988) |
| "Omeprazole is a long acting inhibitor of gastric acid secretion in different species including rat and dog." | 1.27 | Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa. ( Carlsson, E; Larsson, H; Mattsson, H; Ryberg, B; Sundell, G, 1986) |
| "The tumours could be defined as carcinoids of enterochromaffin-like (ECL) cell origin." | 1.27 | Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. ( Havu, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.59) | 18.7374 |
| 1990's | 16 (47.06) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 4 (11.76) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Vigil, NH | 1 |
| Hamann, DJ | 1 |
| Nandy, N | 1 |
| Hanson, JA | 1 |
| Strickland, RG | 1 |
| McCarthy, DM | 1 |
| Sundaresan, S | 1 |
| Kang, AJ | 1 |
| Hayes, MM | 1 |
| Choi, EK | 1 |
| Merchant, JL | 1 |
| Familiar, C | 1 |
| Antón, T | 1 |
| Moraga, I | 1 |
| Ramos, A | 1 |
| Marco, A | 1 |
| Vigen, RA | 1 |
| Kidd, M | 1 |
| Modlin, IM | 1 |
| Chen, D | 1 |
| Zhao, CM | 1 |
| Barbato, A | 1 |
| Panizzolo, C | 1 |
| Landi, L | 1 |
| Semenzato, R | 1 |
| Rugge, M | 1 |
| Attila, T | 1 |
| Santharam, R | 1 |
| Blom, D | 1 |
| Komorowski, R | 1 |
| Koch, TR | 1 |
| Solcia, E | 2 |
| Rindi, G | 2 |
| Silini, E | 1 |
| Villani, L | 1 |
| Piper, DW | 1 |
| Yeomans, ND | 1 |
| Freston, JW | 1 |
| Arnold, R | 3 |
| Eissele, R | 1 |
| Haga, Y | 1 |
| Nakatsura, T | 1 |
| Shibata, Y | 1 |
| Sameshima, H | 1 |
| Nakamura, Y | 1 |
| Tanimura, M | 1 |
| Ogawa, M | 1 |
| Hixson, R | 1 |
| Christmas, D | 1 |
| Dawson, R | 1 |
| Manson, JM | 1 |
| Waldum, HL | 2 |
| Daniels, IR | 1 |
| Gillen, D | 1 |
| McColl, KE | 1 |
| Brenna, E | 1 |
| Håkanson, R | 1 |
| Sundler, F | 1 |
| Sandvik, AK | 1 |
| Miederer, SE | 1 |
| Berlin, RG | 1 |
| Cadiot, G | 1 |
| Lehy, T | 1 |
| Ruszniewski, P | 1 |
| Sobhani, I | 1 |
| Vallot, T | 1 |
| Mignon, M | 1 |
| Bonfils, SJ | 1 |
| Selway, SA | 1 |
| Karnes, WE | 1 |
| Walsh, JH | 1 |
| Havu, N | 2 |
| Elm, G | 1 |
| Goldfain, D | 1 |
| le Bodic, MF | 1 |
| Lavergne, A | 1 |
| Galian, A | 1 |
| Modigliani, R | 1 |
| Koop, H | 2 |
| Betton, GR | 1 |
| Dormer, CS | 1 |
| Wells, T | 1 |
| Pert, P | 1 |
| Price, CA | 1 |
| Buckley, P | 1 |
| Carlsson, E | 1 |
| Larsson, H | 1 |
| Mattsson, H | 1 |
| Ryberg, B | 1 |
| Sundell, G | 1 |
11 reviews available for omeprazole and Carcinoid Tumor
| Article | Year |
|---|---|
Solitary Gastric Carcinoid Tumor Associated with Long-Term Use of Omeprazole: A Case Report and Review of the Literature.
Topics: Aged; Carcinoid Tumor; Endoscopy, Digestive System; Humans; Male; Omeprazole; Proton Pump Inhibitors | 2016 |
[About a case of multiple endocrine neoplasia type 1. Review of some clinical manifestations and treatment controversies].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Carcinoid Tumor; Combined Modality Therapy; Duodenal Neopla | 2011 |
Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis.
Topics: Animals; Carcinoid Tumor; Enterochromaffin Cells; Gastric Acid; Gastric Mucosa; Gastrins; Gastritis; | 1993 |
A comparative overview of the adverse effects of antiulcer drugs.
Topics: Antacids; Anti-Ulcer Agents; Carcinoid Tumor; Cimetidine; Humans; Misoprostol; Omeprazole; Ranitidin | 1995 |
Omeprazole: short- and long-term safety.
Topics: Animals; Carcinoid Tumor; DNA; Double-Blind Method; Drug Interactions; Humans; Lysosomes; Omeprazole | 1994 |
[Risk for developing tumors in therapy with the proton pump inhibitor omeprazole].
Topics: Animals; Carcinogenicity Tests; Carcinoid Tumor; Esophagitis, Peptic; Humans; Omeprazole; Peptic Ulc | 1993 |
Problems associated with the clinical use of proton pump inhibitors.
Topics: Animals; Anti-Ulcer Agents; Carcinoid Tumor; Gastric Acid; Gastritis, Atrophic; Helicobacter Infecti | 2001 |
[Anomalies of fundic argyrophil cell proliferation (enterochromaffin-like cells) in Zollinger-Ellison syndrome].
Topics: Carcinoid Tumor; Enterochromaffin Cells; Female; Gastrins; Humans; Male; Omeprazole; Pyloric Antrum; | 1991 |
[From acid secretion inhibition to enterochromaffin-like cell proliferation. Traps on the path].
Topics: Adenocarcinoma; Carcinoid Tumor; Enterochromaffin Cells; Gastric Mucosa; Gastrins; Gastritis, Atroph | 1991 |
The gastrin hypothesis. Implications for antisecretory drug selection.
Topics: Achlorhydria; Animals; Carcinoid Tumor; Cell Transformation, Neoplastic; Enterochromaffin Cells; Gas | 1990 |
Omeprazole: long-term safety.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Carcinoid Tumor; Clinical Trials as | 1989 |
4 trials available for omeprazole and Carcinoid Tumor
| Article | Year |
|---|---|
Omeprazole: short- and long-term safety.
Topics: Animals; Carcinoid Tumor; DNA; Double-Blind Method; Drug Interactions; Humans; Lysosomes; Omeprazole | 1994 |
Omeprazole.
Topics: Animals; Carcinoid Tumor; Clinical Trials as Topic; Gastric Acid; Gastroesophageal Reflux; Humans; O | 1990 |
Qualitative studies of gastric endocrine cells in patients treated long-term with omeprazole.
Topics: Biopsy; Carcinoid Tumor; Cell Division; Cell Transformation, Neoplastic; Enterochromaffin Cells; Eso | 1989 |
Omeprazole: long-term safety.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Carcinoid Tumor; Clinical Trials as | 1989 |
21 other studies available for omeprazole and Carcinoid Tumor
| Article | Year |
|---|---|
Allergic contact dermatitis masquerading as carcinoid syndrome.
Topics: Aged; Carcinoid Tumor; Chromogranin A; Dermatitis, Allergic Contact; Diagnosis, Differential; Female | 2021 |
Deletion of
Topics: Adenocarcinoma; Adult; Animals; Benzodiazepines; Carcinogenesis; Carcinoid Tumor; Cell Line, Tumor; | 2017 |
Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine.
Topics: Animals; Anti-Ulcer Agents; Autophagy; Carcinoid Tumor; Enterochromaffin-like Cells; Female; Histami | 2012 |
Asthma-like syndrome in a teenager.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba | 2003 |
Multifocal gastric carcinoid tumor in a patient with pernicious anemia receiving lansoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anemia, Pernicious; Biopsy, Needle; Carcinoid Tumor; Female | 2005 |
Omeprazole, hypergastrinemia, and gastric carcinoid tumors.
Topics: Carcinoid Tumor; Esophagitis, Peptic; Gastrins; Humans; Omeprazole; Stomach Neoplasms | 1994 |
[What are the indications for proton pump inhibitors? R. Arnold, Marburg, elaborates on the clinical aspects of the controversy regarding lansoprazole. Interview by Gerrit Lichtenberg].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Carcinogenicity Tests; Carcinoi | 1994 |
Human gastric carcinoid detected during long-term antiulcer therapy of H2 receptor antagonist and proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Carcinoid Tumor; Famotidine; Hist | 1998 |
Use of omeprazole in life-threatening metabolic alkalosis.
Topics: Alkalosis; Carcinoid Tumor; Duodenal Neoplasms; Duodenal Ulcer; Fatal Outcome; Humans; Male; Middle | 1999 |
Omeprazole in oesophageal reflux disease.
Topics: Anti-Ulcer Agents; Carcinoid Tumor; Female; Gastroesophageal Reflux; Humans; Middle Aged; Omeprazole | 2000 |
The safety of proton pump inhibitors.
Topics: Carcinoid Tumor; Cell Transformation, Neoplastic; Enzyme Inhibitors; Gastric Acid; Humans; Omeprazol | 2001 |
Omeprazole, its isomers, and the carcinoid question.
Topics: Animals; Anti-Ulcer Agents; Carcinoid Tumor; Female; Humans; Omeprazole; Rats; Species Specificity; | 2001 |
The effect of omeprazole-induced hypergastrinemia on the oxyntic mucosa of mastomys.
Topics: Animals; Carcinoid Tumor; Enterochromaffin Cells; Female; Gastric Mucosa; Gastrins; Histamine; Histi | 1991 |
[Comment on the contribution: "Effect of omeprazole on serum gastrin levels: influence of age and sex" by Koop et al].
Topics: Age Factors; Carcinoid Tumor; Esophagitis, Peptic; Female; Gastrins; Humans; Male; Middle Aged; Omep | 1991 |
Omeprazole: gastrin and gastric data (August 1991)
Topics: Achlorhydria; Animals; Carcinoid Tumor; Gastrins; Humans; Omeprazole; Rats; Stomach Neoplasms | 1991 |
Potential hazards of long-term acid suppression.
Topics: Animals; Carcinoid Tumor; Female; Gastric Acid; Gastric Mucosa; Gastrins; Histamine H2 Antagonists; | 1990 |
Gastric carcinoid tumours in patients with Zollinger-Ellison syndrome on long-term omeprazole.
Topics: Carcinoid Tumor; Humans; Long-Term Care; Male; Middle Aged; Omeprazole; Stomach Neoplasms; Zollinger | 1989 |
Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole.
Topics: Animals; Carcinogens; Carcinoid Tumor; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; | 1988 |
[Omeprazole long-term therapy: how great is the risk of developing a carcinoid tumor?].
Topics: Carcinoid Tumor; Follow-Up Studies; Gastric Mucosa; Humans; Long-Term Care; Omeprazole; Risk Factors | 1988 |
Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Carcinoid Tumor; Dogs; Female; Gastric Acid; Gastric Muc | 1986 |
Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion.
Topics: Animals; Carcinoid Tumor; Chromaffin System; Enterochromaffin Cells; Female; Gastric Mucosa; Gastrin | 1986 |