omeprazole has been researched along with Cancer of Pancreas in 24 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on the clinical signs, diagnosis and 8-year course in a 54-year-old female patient with myeloma and gastrinoma with liver metastasis and associated Cushing syndrome treated for the last 3 years with the new H+/K+-ATPase inhibitor omeprazole which has successfully suppressed the massive gastric acid hypersecretion." | 8.77 | [Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma]. ( Kummer, H; Schaub, N; Schlup, M; Wegmann, W, 1988) |
| "Evolution of gastrinoma tumoral mass, fasting serum gastrin concentrations, and gastric endocrine cells has been analyzed in 21 patients with the Zollinger-Ellison syndrome committed to long-term omeprazole treatment (up to 7." | 7.68 | Gastric endocrine cell evolution in patients with Zollinger-Ellison syndrome. Influence of gastrinoma growth and long-term omeprazole treatment. ( Bonfils, S; Cadiot, G; Lehy, T; Mignon, M; Ruszniewski, P, 1993) |
| " Although the number of cases treated with omeprazole are too few to draw firm conclusions, it would appear that proton pump inhibitors are useful and should be considered for cases of gastrinoma managed medically." | 4.83 | Canine gastrinoma: a case study and literature review of therapeutic options. ( Hughes, SM, 2006) |
| "We report on the clinical signs, diagnosis and 8-year course in a 54-year-old female patient with myeloma and gastrinoma with liver metastasis and associated Cushing syndrome treated for the last 3 years with the new H+/K+-ATPase inhibitor omeprazole which has successfully suppressed the massive gastric acid hypersecretion." | 4.77 | [Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma]. ( Kummer, H; Schaub, N; Schlup, M; Wegmann, W, 1988) |
| "Evolution of gastrinoma tumoral mass, fasting serum gastrin concentrations, and gastric endocrine cells has been analyzed in 21 patients with the Zollinger-Ellison syndrome committed to long-term omeprazole treatment (up to 7." | 3.68 | Gastric endocrine cell evolution in patients with Zollinger-Ellison syndrome. Influence of gastrinoma growth and long-term omeprazole treatment. ( Bonfils, S; Cadiot, G; Lehy, T; Mignon, M; Ruszniewski, P, 1993) |
| "Gastrinomas are gastrin-secreting pancreatic tumours rarely diagnosed in cats." | 1.72 | Combined surgical and medical management of a cat with gastrinoma. ( Mazepa, ASW; Myers-Nodes, J, 2022) |
| "Treatment of highly invasive Panc1 pancreatic cancer cells with TCDD, omeprazole, and seven other AhR-active pharmaceuticals showed that only omeprazole and tranilast, but not TCDD, inhibited invasion in a Boyden chamber assay." | 1.42 | Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. ( Jin, UH; Kim, SB; Safe, S, 2015) |
| "Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial." | 1.37 | Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. ( Ellinger, S; Henne-Bruns, D; Klapperstueck, T; Knippschild, U; Kreyes, A; Landfester, K; Udelnow, A; Walther, P; Wohlrab, J; Würl, P, 2011) |
| "Calcium gluconate was injected directly into the arteries supplying the pancreas and liver after standard selective angiography." | 1.33 | Localization of gastrinomas by selective intra-arterial calcium injection in patients on proton pump inhibitor or H2 receptor antagonist therapy. ( Bloom, SR; Dhillo, WS; Jackson, JE; Jayasena, CN; Lynn, JA; Meeran, K; Todd, JF, 2005) |
| "Cushing's syndrome was the result of ectopic adrenocorticotropic hormone production by a large cystic gastrin-producing tumour of the pancreatic tail." | 1.30 | Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome. ( Basenau, D; Becker, H; Horstmann, O; Raddatz, D; Ramadori, G, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Myers-Nodes, J | 1 |
| Mazepa, ASW | 1 |
| Zhao, R | 1 |
| Lin, S | 1 |
| Han, M | 1 |
| Lin, Z | 1 |
| Yu, M | 1 |
| Peng, L | 1 |
| Jin, UH | 2 |
| Karki, K | 1 |
| Kim, SB | 2 |
| Safe, S | 2 |
| Hayashi, T | 1 |
| Ishiwatari, H | 1 |
| Ihara, H | 1 |
| Kawano, Y | 1 |
| Takada, K | 1 |
| Miyanishi, K | 1 |
| Kobune, M | 1 |
| Takimoto, R | 1 |
| Sonoda, T | 1 |
| Takayama, T | 1 |
| Kato, J | 1 |
| Niitsu, Y | 1 |
| Wong, H | 1 |
| Yau, T | 1 |
| Chan, P | 1 |
| Ng, IO | 1 |
| Chan, G | 1 |
| Hui, P | 1 |
| Law, WL | 1 |
| Lo, CM | 1 |
| Hedley, AJ | 1 |
| Epstein, RJ | 1 |
| Familiar, C | 1 |
| Antón, T | 1 |
| Moraga, I | 1 |
| Ramos, A | 1 |
| Marco, A | 1 |
| Udelnow, A | 1 |
| Kreyes, A | 1 |
| Ellinger, S | 1 |
| Landfester, K | 1 |
| Walther, P | 1 |
| Klapperstueck, T | 1 |
| Wohlrab, J | 1 |
| Henne-Bruns, D | 1 |
| Knippschild, U | 1 |
| Würl, P | 1 |
| Scherübl, H | 1 |
| Schaaf, L | 1 |
| Raue, F | 1 |
| Faiss, S | 1 |
| Zeitz, M | 1 |
| Dhillo, WS | 1 |
| Jayasena, CN | 1 |
| Jackson, JE | 1 |
| Lynn, JA | 1 |
| Bloom, SR | 2 |
| Meeran, K | 1 |
| Todd, JF | 1 |
| Hughes, SM | 1 |
| Becker, HD | 1 |
| Ashley, SW | 1 |
| Cheung, LY | 1 |
| Jensen, RT | 2 |
| Fraker, DL | 1 |
| Hammond, PJ | 1 |
| Cadiot, G | 1 |
| Lehy, T | 1 |
| Ruszniewski, P | 1 |
| Bonfils, S | 1 |
| Mignon, M | 1 |
| Altschul, M | 1 |
| Simpson, KW | 1 |
| Dykes, NL | 1 |
| Mauldin, EA | 1 |
| Reubi, JC | 1 |
| Cummings, JF | 1 |
| Raddatz, D | 1 |
| Horstmann, O | 1 |
| Basenau, D | 1 |
| Becker, H | 1 |
| Ramadori, G | 1 |
| Mai, AL | 1 |
| Mai, KT | 1 |
| McDonald, JM | 1 |
| Longnecker, DS | 1 |
| Bell, RH | 1 |
| Pisegna, JR | 1 |
| Norton, JA | 1 |
| Slimak, GG | 1 |
| Metz, DC | 1 |
| Maton, PN | 1 |
| Gardner, JD | 1 |
| Sakakibara, T | 1 |
| Inoue, K | 1 |
| Koizumi, T | 1 |
| Inoue, A | 1 |
| Kitanaka, H | 1 |
| Kaneko, E | 1 |
| Zuckerman, S | 1 |
| Schaub, N | 1 |
| Schlup, M | 1 |
| Kummer, H | 1 |
| Wegmann, W | 1 |
5 reviews available for omeprazole and Cancer of Pancreas
| Article | Year |
|---|---|
[About a case of multiple endocrine neoplasia type 1. Review of some clinical manifestations and treatment controversies].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Carcinoid Tumor; Combined Modality Therapy; Duodenal Neopla | 2011 |
Canine gastrinoma: a case study and literature review of therapeutic options.
Topics: Animals; Anti-Ulcer Agents; Antineoplastic Agents; Dog Diseases; Dogs; Fatal Outcome; Female; Gastri | 2006 |
[Zollinger-Ellison syndrome].
Topics: Benzimidazoles; Calcium; Cimetidine; Diarrhea; Duodenal Ulcer; Female; Fluorouracil; Gastrectomy; Ga | 1984 |
New directions in the management of Zollinger-Ellison syndrome: a case study and review.
Topics: Adult; Combined Modality Therapy; Female; Gastrinoma; Histamine H2 Antagonists; Humans; Omeprazole; | 1989 |
[Long-term suppression of acid secretion with omeprazole use in metastatic gastrinoma].
Topics: Female; Gastric Juice; Gastrinoma; Humans; Liver Neoplasms; Middle Aged; Neoplasms, Multiple Primary | 1988 |
2 trials available for omeprazole and Cancer of Pancreas
| Article | Year |
|---|---|
Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms.
Topics: Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Aged; Aged, 80 and over; Anti-Ulcer Agents; Ant | 2009 |
Effects of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome.
Topics: Adult; Aged; Cimetidine; Dose-Response Relationship, Drug; Duodenal Neoplasms; Famotidine; Female; F | 1992 |
17 other studies available for omeprazole and Cancer of Pancreas
| Article | Year |
|---|---|
Combined surgical and medical management of a cat with gastrinoma.
Topics: Animals; Cat Diseases; Cats; Duodenal Neoplasms; Female; Gastrinoma; Gastrins; Omeprazole; Pancreati | 2022 |
Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study.
Topics: Digestive System Neoplasms; Gastrointestinal Neoplasms; Genome-Wide Association Study; Humans; Mende | 2023 |
Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study.
Topics: Digestive System Neoplasms; Gastrointestinal Neoplasms; Genome-Wide Association Study; Humans; Mende | 2023 |
Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study.
Topics: Digestive System Neoplasms; Gastrointestinal Neoplasms; Genome-Wide Association Study; Humans; Mende | 2023 |
Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study.
Topics: Digestive System Neoplasms; Gastrointestinal Neoplasms; Genome-Wide Association Study; Humans; Mende | 2023 |
Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.
Topics: Cell Line, Tumor; Cell Movement; Humans; JNK Mitogen-Activated Protein Kinases; Neoplasm Invasivenes | 2018 |
Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Female; Humans; Neoplasm Invasiven | 2015 |
PPI-delayed diagnosis of gastrinoma: oncologic victim of pharmacologic success.
Topics: Anti-Ulcer Agents; Appendectomy; Barrett Esophagus; Delayed Diagnosis; Gastrinoma; Gastroesophageal | 2010 |
Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cathepsin D; Cell Line, Tumor; Cell | 2011 |
[Hereditary neuroendocrine gastroenteropancreatic tumors and multiple endocrine neoplasia type 1].
Topics: Anti-Ulcer Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormon | 2004 |
Localization of gastrinomas by selective intra-arterial calcium injection in patients on proton pump inhibitor or H2 receptor antagonist therapy.
Topics: Adult; Blood Specimen Collection; Calcium Gluconate; Female; Gastrinoma; Hepatic Veins; Histamine H2 | 2005 |
The SSAT-AGA (Society for Surgery of the Alimentary Tract-American Gastroenterological Association). New Orleans, May 20-23, 1984.
Topics: Animals; Benzimidazoles; Colitis, Ulcerative; Colon; Common Bile Duct; Crohn Disease; Digestive Syst | 1984 |
Zollinger-Ellison syndrome. Advances in treatment of gastric hypersecretion and the gastrinoma.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Blood Chemical Analysis; Combined Modali | 1994 |
Gut neuroendocrine tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dacarbazine; Diazoxide; Etoposide; Fluoro | 1994 |
Gastric endocrine cell evolution in patients with Zollinger-Ellison syndrome. Influence of gastrinoma growth and long-term omeprazole treatment.
Topics: Adult; Aged; APUD Cells; Chi-Square Distribution; Chronic Disease; Female; Gastrinoma; Gastrins; Hum | 1993 |
Evaluation of somatostatin analogues for the detection and treatment of gastrinoma in a dog.
Topics: Animals; Anti-Ulcer Agents; Antineoplastic Agents, Hormonal; Dog Diseases; Dogs; Dose-Response Relat | 1997 |
Cushing's syndrome due to ectopic adrenocorticotropic hormone production by a non-metastatic gastrinoma after long-term conservative treatment of Zollinger-Ellison syndrome.
Topics: Adrenocorticotropic Hormone; Aged; Anti-Ulcer Agents; Cushing Syndrome; Female; Gastrinoma; Gastrins | 1998 |
Fine-needle aspiration biopsy of an intra-abdominal inflammatory mass secondary to a penetrating duodenal ulcer mimicking neoplasm.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Biopsy, Needle; Clarithromycin; Diagnosis, Dif | 2001 |
Effect of hypergastrinemia on pancreatic carcinogenesis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenoma; Animals; Anti-Ulcer Agents; Azaserine; Carcinoma i | 2002 |
[A case of Zollinger-Ellison syndrome successfully treated with an H+-K+ ATPase inhibitor].
Topics: Adenosine Triphosphatases; Gastrinoma; Gastrins; H(+)-K(+)-Exchanging ATPase; Humans; Male; Middle A | 1989 |