omeprazole has been researched along with Bone Loss, Osteoclastic in 9 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Omeprazole is an inhibitor of gastric H+,K(+)-ATPase." | 1.29 | Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans. ( Abe, K; Furukawa, Y; Katano, K; Mizunashi, K, 1993) |
| "The effects of such treatments on bone resorption were assessed by quantitative scanning electron microscopy." | 1.28 | Modularity of osteoclast behaviour and "mode-specific" inhibition of osteoclast function. ( Zaidi, M, 1990) |
| "Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase." | 1.27 | Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro. ( Tuukkanen, J; Väänänen, HK, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sheraly, AR | 1 |
| Lickorish, D | 1 |
| Sarraf, F | 1 |
| Davies, JE | 1 |
| Malnick, SD | 1 |
| Gottesfeld, F | 1 |
| Walpart, A | 1 |
| Keter, D | 1 |
| Lurie, Y | 1 |
| Beergabel, M | 1 |
| Kocsis, I | 1 |
| Arató, A | 1 |
| Bodánszky, H | 1 |
| Szönyi, L | 1 |
| Szabó, A | 1 |
| Tulassay, T | 1 |
| Vásárhelyi, B | 1 |
| Mizunashi, K | 1 |
| Furukawa, Y | 1 |
| Katano, K | 1 |
| Abe, K | 1 |
| Persson, P | 1 |
| Gagnemo-Persson, R | 1 |
| Chen, D | 1 |
| Axelson, J | 1 |
| Nylander, AG | 1 |
| Johnell, O | 1 |
| Häkanson, R | 1 |
| Nemoto, R | 1 |
| Satou, S | 1 |
| Mochizuki, T | 1 |
| Okabe, K | 1 |
| Zaidi, M | 1 |
| Hall, TJ | 1 |
| Chambers, TJ | 1 |
| Tuukkanen, J | 1 |
| Väänänen, HK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Effects of Lansoprazole Usage on Bone Turnover Markers in Children With Gastroesophageal Reflux or Gastroesophageal Reflux Disease[NCT04814316] | 60 participants (Actual) | Observational | 2019-12-02 | Completed | |||
| Correlation Between Peri-implantitis and Assumptions of Medications: a Retrospective Study[NCT04783974] | 270 participants (Actual) | Observational | 2021-02-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for omeprazole and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Short-term omeprazole treatment does not influence biochemical parameters of bone turnover in children.
Topics: Adolescent; Alkaline Phosphatase; Anti-Ulcer Agents; Bone Resorption; Calcium; Child; Collagen; Coll | 2002 |
8 other studies available for omeprazole and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Use of gastrointestinal proton pump inhibitors to regulate osteoclast-mediated resorption of calcium phosphate cements in vivo.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acid Phosphatase; Animals; Bone Cements; Bone Resorption; C | 2009 |
Nonhealing gastric ulcer caused by chronic alendronate administration.
Topics: Abdominal Pain; Aged; Alendronate; Anti-Ulcer Agents; Bone Resorption; Drug Administration Schedule; | 2002 |
Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Body Weight; Bone Resorption; Calcium; Ch | 1993 |
Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible?
Topics: Animals; Bone and Bones; Bone Density; Bone Resorption; Calcium; Gastrectomy; Gastric Acid; Male; Om | 1993 |
Response of MBT-2 bladder carcinoma-induced osteolysis to various agents.
Topics: Alendronate; Animals; Bone Neoplasms; Bone Resorption; Calcitonin; Cyclosporine; Diphosphonates; Fem | 1992 |
Modularity of osteoclast behaviour and "mode-specific" inhibition of osteoclast function.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Bone Resorption; Cell Movement; Cells, Cultured; Colchi | 1990 |
Na+/H+ antiporter is the primary proton transport system used by osteoclasts during bone resorption.
Topics: Adenosine Triphosphatases; Amiloride; Animals; Animals, Newborn; Biological Transport; Bone Resorpti | 1990 |
Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.
Topics: Adenosine Triphosphatases; Animals; Benzimidazoles; Bone Resorption; Calcium; H(+)-K(+)-Exchanging A | 1986 |