Page last updated: 2024-11-01

omeprazole and Anesthesia

omeprazole has been researched along with Anesthesia in 11 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"Pre-anesthetic administration of 2 PO doses of omeprazole at a dosage of 1."6.84Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. ( Belafsky, PC; Della Maggiore, A; Fulton, A; Garcia, RS; Marks, SL; Osborn, JM; Pierce, T; Pypendop, BH; Walker, VJ, 2017)
"Effect of omeprazole, a gastric proton pump inhibitor, on gastric secretion during anesthesia and surgery was evaluated in 39 elective surgical patients ranged in age from 18 to 69 years."3.69[A gastric proton pump inhibitor as preanesthetic medication]. ( Hashimoto, Y; Kubota, T; Kudo, A; Matsuki, A; Murakawa, T; Taguchi, S; Takagi, Y, 1994)
"Pre-anesthetic administration of 2 PO doses of omeprazole at a dosage of 1."2.84Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. ( Belafsky, PC; Della Maggiore, A; Fulton, A; Garcia, RS; Marks, SL; Osborn, JM; Pierce, T; Pypendop, BH; Walker, VJ, 2017)
" Cmax (maximum serum concentration) and AUC (area under the serum concentration-time curve) for (+)-lansoprazole were 5-6 times greater than those for (-)-lansoprazole, whereas for (+)-5-hydroxylansoprazole both values were significantly smaller than those for the (-) enantiomer."1.30Pharmacokinetic differences between lansoprazole enantiomers in rats. ( Arimori, K; Katsuki, H; Nakano, M; Yasuda, K, 1998)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (54.55)18.2507
2000's4 (36.36)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garcia, RS1
Belafsky, PC1
Della Maggiore, A1
Osborn, JM1
Pypendop, BH1
Pierce, T1
Walker, VJ1
Fulton, A1
Marks, SL1
Yenişehirli, A1
Naseri, E1
Czuprynski, CJ1
Faith, NG1
Steinberg, H1
Neudeck, B1
Paterson, AC1
Lockhart, SM1
Baker, J1
Neumann, G1
Baldwin, GS1
Shulkes, A1
Melo, JR1
de Araújo, GK1
da Luz, MM1
da Conceição, SA1
Lisboa, FA1
Moraes-Santos, T1
Cunha-Melo, JR1
Coruzzi, G1
Adami, M1
Bertaccini, G1
Murakawa, T1
Kudo, A1
Kubota, T1
Hashimoto, Y1
Takagi, Y1
Taguchi, S1
Matsuki, A1
Davies, PR1
Ogg, TW1
Arimori, K1
Yasuda, K1
Katsuki, H1
Nakano, M1
Kawano, S1
Tanimura, H1
Sato, N1
Tsuji, S1
Takei, Y1
Ogihara, T1
Nagano, K1
Fusamoto, H1
Kamada, T1
Fändriks, L1
Jönson, C1

Trials

1 trial available for omeprazole and Anesthesia

ArticleYear
Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH.
    Journal of veterinary internal medicine, 2017, Volume: 31, Issue:3

    Topics: Administration, Oral; Anesthesia; Animals; Anti-Ulcer Agents; Cat Diseases; Cats; Esophagus; Female;

2017

Other Studies

10 other studies available for omeprazole and Anesthesia

ArticleYear
Omeprazole, lansoprazole and pantoprazole had no effect on blood pressure and electrocardiogram of anesthetized rat.
    Pharmacological research, 2008, Volume: 58, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anesthesia; Animals; Blood Pressure; Dose-Response Relation

2008
Sodium pentobarbital anesthesia transiently enhances the severity of infection following intragastric, but not intravenous, inoculation of Listeria monocytogenes in mice.
    Microbial pathogenesis, 2003, Volume: 35, Issue:2

    Topics: Anesthesia; Animals; Anti-Ulcer Agents; Antidiarrheals; Cell Culture Techniques; Cell Line; Cimetidi

2003
Identity and regulation of stored and secreted progastrin-derived peptides in sheep.
    Endocrinology, 2004, Volume: 145, Issue:11

    Topics: Anesthesia; Animals; Anti-Ulcer Agents; Chromatography; Consciousness; Gastrins; Mass Spectrometry;

2004
Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats.
    Toxicon : official journal of the International Society on Toxinology, 2006, Volume: 48, Issue:5

    Topics: Acute Disease; Anesthesia; Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Ant

2006
Gastric antisecretory activity of lansoprazole in different experimental models: comparison with omeprazole.
    General pharmacology, 1995, Volume: 26, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anesthesia; Animals; Anti-Ulcer Agents; Cats; Female; Gastr

1995
[A gastric proton pump inhibitor as preanesthetic medication].
    Masui. The Japanese journal of anesthesiology, 1994, Volume: 43, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anesthesia; Gastric Acidity Determination; Gastric Mu

1994
Omeprazole in outpatient surgery.
    Acta anaesthesiologica Scandinavica, 1993, Volume: 37, Issue:3

    Topics: Ambulatory Surgical Procedures; Anesthesia; Humans; Hydrogen-Ion Concentration; Omeprazole; Pneumoni

1993
Pharmacokinetic differences between lansoprazole enantiomers in rats.
    The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anesthesia; Animals; Anti-Ulcer Agents; Area Under Curve; C

1998
Effects of proton pump inhibitor on gastric mucosa hemodynamics and tissue oxygenation in anesthetized rats.
    European journal of pharmacology, 1992, Jan-28, Volume: 211, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anesthesia; Animals; Benzimidazoles; Gastric Mucosa; Hemody

1992
Effects of acute administration of omeprazole or ranitidine on basal and vagally stimulated gastric acid secretion and alkalinization of the duodenum in anaesthetized cats.
    Acta physiologica Scandinavica, 1990, Volume: 138, Issue:2

    Topics: Anesthesia; Animals; Bicarbonates; Cats; Duodenum; Electric Stimulation; Female; Gastric Acid; Gastr

1990