omeprazole has been researched along with Alloxan Diabetes in 9 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Stress induced gastric ulcer is a serious health problem in diabetic patients." | 5.48 | Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. ( Abd El Motteleb, DM; Elshazly, SM; Ibrahim, IAAE, 2018) |
| "Omeprazole treatment had no significant effect on lowering the blood glucose levels of diabetic mice, when compared to control, although it improved the antihyperglycemic actions of exendin-4." | 5.39 | Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. ( Bahekar, R; Detroja, J; Dhanesha, N; Gandhi, T; Jain, M; Joharapurkar, A; Kshirsagar, S; Patel, K; Patel, V, 2013) |
| "Stress induced gastric ulcer is a serious health problem in diabetic patients." | 1.48 | Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. ( Abd El Motteleb, DM; Elshazly, SM; Ibrahim, IAAE, 2018) |
| "Omeprazole treatment had no significant effect on lowering the blood glucose levels of diabetic mice, when compared to control, although it improved the antihyperglycemic actions of exendin-4." | 1.39 | Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice. ( Bahekar, R; Detroja, J; Dhanesha, N; Gandhi, T; Jain, M; Joharapurkar, A; Kshirsagar, S; Patel, K; Patel, V, 2013) |
| "Omeprazole was administered intravenously (20 mg/kg) and orally (40 mg/kg) to DMIA and DMIS rats and their respective controls." | 1.34 | Changes in omeprazole pharmacokinetics in rats with diabetes induced by alloxan or streptozotocin: faster clearance of omeprazole due to induction of hepatic CYP1A2 and 3A1. ( Lee, DY; Lee, I; Lee, MG; Shin, HS, 2007) |
| "We compared the gastric toxic effect of aspirin (ASA) in both normal and diabetic rats, with that of NCX-4016, a derivative of ASA with nitric oxide (NO) releasing moiety." | 1.31 | Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. ( Fujita, A; Takeuchi, K; Tashima, K; Umeda, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Lagunas-Rangel, FA | 1 |
| Koshelev, D | 1 |
| Nedorubov, A | 1 |
| Kosheleva, L | 1 |
| Trukhan, V | 1 |
| Rabinovitch, A | 1 |
| Schiöth, HB | 1 |
| Levit, S | 1 |
| Elshazly, SM | 1 |
| Abd El Motteleb, DM | 1 |
| Ibrahim, IAAE | 1 |
| Castillo, GM | 1 |
| Nishimoto-Ashfield, A | 1 |
| Banerjee, AA | 1 |
| Landolfi, JA | 1 |
| Lyubimov, AV | 1 |
| Bolotin, EM | 1 |
| Patel, V | 1 |
| Joharapurkar, A | 1 |
| Dhanesha, N | 1 |
| Kshirsagar, S | 1 |
| Detroja, J | 1 |
| Patel, K | 2 |
| Gandhi, T | 1 |
| Bahekar, R | 1 |
| Jain, M | 1 |
| Phadatare, PD | 1 |
| Chandrashekhar, VM | 1 |
| Lee, DY | 1 |
| Lee, MG | 1 |
| Shin, HS | 1 |
| Lee, I | 1 |
| Tashima, K | 1 |
| Fujita, A | 1 |
| Umeda, M | 1 |
| Takeuchi, K | 1 |
| Ayan, S | 1 |
| Sarioglu, Y | 1 |
| Yildirim, S | 1 |
| Gökce, G | 1 |
| Bagcivan, I | 1 |
| Minhas, S | 1 |
| Cartledge, JJ | 1 |
9 other studies available for omeprazole and Alloxan Diabetes
| Article | Year |
|---|---|
Triple drug therapy with GABA, sitagliptin, and omeprazole prevents type 1 diabetes onset and promotes its reversal in non-obese diabetic mice.
Topics: Animals; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dipeptidyl-Peptidase | 2022 |
Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Body Weight; Cyclooxygenase 2; Diabetes Mellitus, | 2018 |
Omeprazole and PGC-formulated heparin binding epidermal growth factor normalizes fasting blood glucose and suppresses insulitis in multiple low dose streptozotocin diabetes model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Carriers; Gastrins; Heparin-binding EG | 2013 |
Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Ex | 2013 |
Influence of esomeprazole on hypoglycemic activity of oral antidiabetic agents in rats and rabbits.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Evaluation, Prec | 2011 |
Changes in omeprazole pharmacokinetics in rats with diabetes induced by alloxan or streptozotocin: faster clearance of omeprazole due to induction of hepatic CYP1A2 and 3A1.
Topics: Alloxan; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Di | 2007 |
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; | 2000 |
Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erect | 2001 |
Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum.
Topics: Animals; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Enzyme Inhibitors; Humans; Male; | 2001 |