omeprazole has been researched along with Achlorhydria in 55 studies
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The increase in the concentration of TFF1/pS2 in gastric secretions during chronic omeprazole-induced achlorhydria may be important in preventing tissue injury and promoting repair in response to an increased luminal bacterial population." | 7.71 | Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach. ( Alderman, BM; Cook, GA; Giraud, AS; Kang, B; Nicoll, AJ, 2001) |
| "We estimated fasting and peptone meal stimulated plasma gastrin in nine patients (seven female) with pernicious anaemia and achlorhydria, before and on the final day of 4 weeks' dosing with omeprazole 40 mg daily." | 7.69 | Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria. ( Ardill, JE; Banerjee, S; Beattie, AD; McColl, KE, 1995) |
| "The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria." | 7.68 | Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria. ( Bartsch, H; Béréziat, JC; Calmels, S; Ohshima, H, 1991) |
| " Achlorhydria was induced in rats by the gastric H+/K+ ATPase inhibitor, omeprazole (100 mumol/kg)." | 7.67 | Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. ( Brand, SJ; Stone, D, 1988) |
| "Absorption of ketoconazole is impaired in patients with achlorhydria." | 5.08 | Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole. ( Chin, TW; Fong, IW; Loeb, M, 1995) |
| "Based on the experience from more than 10,000 individuals omeprazole has been found to be safe and is well tolerated." | 3.76 | Omeprazole: long-term safety. ( Arnold, R; Koop, H, 1989) |
| " However, studies to date have failed to show a similar association with omeprazole, a proton pump inhibitor that also produces achlorhydria." | 3.72 | Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia. ( Brannon, MA; Carloss, EA; Sharma, VR, 2004) |
| " Therefore, we investigated how the chronic gastritis in mice made hypochlorhydric by either gastrin deficiency or omeprazole treatment modulates epithelial cell function." | 3.71 | Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. ( Ferguson, A; Merchant, JL; Rieder, G; Samuelson, LC; Zavros, Y, 2002) |
| " We also determined the forms of EGF present in the gastric juice of patients under basal conditions, patients taking the acid suppressant omeprazole, patients with achlorhydria, and volunteers undergoing intragastric neutralization with NaHCO3 (n = 6 per group)." | 3.69 | Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice. ( Batten, JJ; Calam, J; Calnan, DP; Hansen, HF; Marchbank, T; Playford, RJ; Royston, P, 1995) |
| " The ratio of lactulose to mannitol excreted was normal in both atrophic gastritis and omeprazole-treated groups." | 3.69 | Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. ( Golner, B; Kowdley, KV; Pedrosa, MC; Perrone, G; Russell, RM; Saltzman, JR; Sepe, T, 1994) |
| "We estimated fasting and peptone meal stimulated plasma gastrin in nine patients (seven female) with pernicious anaemia and achlorhydria, before and on the final day of 4 weeks' dosing with omeprazole 40 mg daily." | 3.69 | Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria. ( Ardill, JE; Banerjee, S; Beattie, AD; McColl, KE, 1995) |
| "The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria." | 3.68 | Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria. ( Bartsch, H; Béréziat, JC; Calmels, S; Ohshima, H, 1991) |
| " Omeprazole, which blocks the terminal step of acid secretion--the proton pump, can produce long-lasting achlorhydria." | 3.67 | Effect of omeprazole on acute gastric stress ulceration in cervical cord transected rats. ( Hardy, KJ; MacLellan, DG; Shulkes, A, 1987) |
| " Achlorhydria was induced in rats by the gastric H+/K+ ATPase inhibitor, omeprazole (100 mumol/kg)." | 3.67 | Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. ( Brand, SJ; Stone, D, 1988) |
| "Quinine levels were measured fluorometrically from 100 microL samples after simple extraction." | 2.70 | A modification of the quininium resin test for assessing gastric acidity. ( Hurwitz, A; Parsonnet, J; Passaro, DJ; Triadafilopoulos, G, 2002) |
| "Drug-induced hypochlorhydria causes high duodenal bacterial counts in the elderly but, in the short term, this bacterial overgrowth is not associated with malabsorption." | 2.69 | Drug-induced hypochlorhydria causes high duodenal bacterial counts in the elderly. ( Dowling, RH; Gainsborough, N; Pereira, SP, 1998) |
| "To examine the effect of iatrogenic hypochlorhydria on intragastric acetaldehyde production from ethanol after a moderate dose of alcohol, and to relate the findings to the changes in gastric flora." | 2.69 | Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol. ( Färkkilä, M; Jousimies-Somer, H; Nuutinen, H; Salaspuro, M; Tillonen, J; Väkeväinen, S, 2000) |
| "Thus, hypochlorhydria could be an important risk factor for mineral malabsorption and the development of marginal mineral status." | 2.68 | Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans. ( Pedrosa, M; Russell, RR; Saltzman, JR; Sepe, TE; Serfaty-Lacrosniere, C; Voytko, D; Wood, RJ, 1995) |
| "During hypochlorhydria the mean oral-caecal transit time was 4." | 2.67 | The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation. ( Moncrieff, J; Snyman, JR; Sommers, DK; van Wyk, M, 1992) |
| "To investigate the effects of hypochlorhydria and acidic drink ingestion on protein-bound vitamin B12 absorption in elderly subjects." | 2.67 | Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. ( Dallal, GE; Golner, BB; Kemp, JA; Pedrosa, MC; Russell, RM; Saltzman, JR, 1994) |
| " Moderate hypergastrinaemia occurs in some patients, especially if an omeprazole dosage of 40 mg/day is needed." | 2.39 | Risk-benefit assessment of omeprazole in the treatment of gastrointestinal disorders. ( Creutzfeldt, W, 1994) |
| "Since hypochlorhydria can induce hypergastrinemia, and gastrin has a trophic effect on some gastrointestinal cells, states that cause elevated plasma gastrin levels are of interest in terms of effects on cell growth and function." | 2.39 | Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis. ( Borch, K; Brand, SJ; Carlsson, E; Creutzfeldt, W; Freston, JW; Håkanson, R; Olbe, L; Solcia, E; Walsh, JH; Wolfe, MM, 1995) |
| "To date, however, no cases of carcinoid tumor have been attributed to the use of omeprazole in humans." | 2.38 | The gastrin hypothesis. Implications for antisecretory drug selection. ( Karnes, WE; Walsh, JH, 1990) |
| "Conclusions: Prolonged gastric juice hypochlorhydria led to depletion of antioxidant protection enzymes." | 1.62 | ACTIVITY OF SUPEROXIDE DISMUTASE AND CATALASE IN THE GASTRIC MUCOSA OF RATS UNDER THE PROLONGED ADMINISTRATION OF OMEPRAZOL AND COMBINATION OF OMEPRAZOLE AND MULTIPROBIOTICS. ( Akarchuk, VVM; Koval, AA; Pylypenko, SV, 2021) |
| " The present study aimed to develop a novel amorphous solid dispersion (ASD) of CAR with acidic counter ions for pH modifications in microenvironment to improve the pharmacokinetic properties under hypochlorhydric conditions." | 1.48 | Amorphous solid dispersions of carvedilol along with pH-modifiers improved pharmacokinetic properties under hypochlorhydoria. ( Halder, S; Onoue, S; Sato, H; Seto, Y; Tabata, A, 2018) |
| "The aim of this study was to develop new dipyridamole (DP) salts with pH-independent solubility for improving oral bioavailability under hypochlorhydria." | 1.39 | New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions. ( Inoue, R; Kato, M; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K, 2013) |
| "We examined 27 patients with hypochlorhydria or achlorhydria based on a predefined basal acid output (BAO) measurement of less than 5." | 1.39 | Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome. ( Metz, DC; Shah, P; Singh, MH; Yang, YX, 2013) |
| " Pharmacokinetic profiling of orally dosed DPG or DPG with 60% loading of FA (DPG/FA60) was carried out in omeprazole-treated rats as a hypochlorhydric model." | 1.38 | Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012) |
| "However, AUC(0-3) for DPG/TS under hypochlorhydria was almost identical to that of DPG in normal rats." | 1.38 | Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012) |
| "Thus, gastric hypochlorhydria would be expected to enhance the susceptibility to prion infection by the oral route." | 1.37 | Inhibitors of gastric acid secretion increase the risk of prion infection in mice. ( Benestad, SL; Martinsen, TC; Moldal, T; Waldum, HL, 2011) |
| "A prolonged GA inhibitor-induced hypochlorhydria has been suggested as a risk factor for severe gastrointestinal infections." | 1.33 | Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. ( Canani, RB; Cirillo, P; Guarino, A; Malamisura, B; Manguso, F; Morelli, L; Passariello, A; Roggero, P; Romano, C; Terrin, G, 2006) |
| "Although profound hypochlorhydria is considered to be an important risk factor for development of gastric cancer, long-term effect of Helicobacter pylori eradication on its reversibility remains uncertain." | 1.32 | Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria. ( Iijima, K; Imatani, A; Koike, T; Ohara, S; Sekine, H; Shimosegawa, T, 2004) |
| "After induction of achlorhydria, however, neither the amount of alpha-amidated gastrin nor the total progastrin product increased in the fat/fat mice." | 1.31 | Impaired feedback of gastric functions in carboxypeptidase E-deficient mice. ( Friis-Hansen, L; Rehfeld, JF, 2000) |
| "Whether such treatment will result in vitamin B12 deficiency is controversial." | 1.30 | Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. ( Gibril, F; Jensen, RT; Sutliff, VE; Termanini, B; Venzon, DJ; Yu, F, 1998) |
| " During dosing with omeprazole, basal gastric acid output diminished by 94%, and pentagastrin-stimulated acid output by 97%." | 1.28 | Repeated high oral doses of omeprazole do not affect intrinsic factor secretion: proof of a selective mode of action. ( Den Hollander, W; Festen, HP; Meuwissen, SG; Tuynman, HA, 1989) |
| "Chronic achlorhydria distinctly reduced somatostatin responses to isoproterenol, whereas potent stimulation was observed in controls." | 1.27 | Influence of chronic drug-induced achlorhydria by substituted benzimidazoles on the endocrine stomach in rats. ( Arnold, R; Eissele, R; Koop, H; Steinbach, F; Tuch, K; Willemer, S, 1987) |
| " Achlorhydria, induced by omeprazole at a dosage of 250-500 times that required for effective acid inhibition in man and animals, therefore resulted in reciprocal changes in gastrin and somatostatin cells." | 1.27 | Gastric regulatory peptides in rats with reduced acid secretion. ( Allen, JM; Bishop, AE; Bloom, SR; Carlsson, E; Daly, MJ; Larsson, H; Polak, JM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (18.18) | 18.7374 |
| 1990's | 25 (45.45) | 18.2507 |
| 2000's | 11 (20.00) | 29.6817 |
| 2010's | 8 (14.55) | 24.3611 |
| 2020's | 1 (1.82) | 2.80 |
| Authors | Studies |
|---|---|
| Pylypenko, SV | 2 |
| Koval, AA | 2 |
| Korinchak, LM | 1 |
| Akarchuk, VVM | 1 |
| Halder, S | 1 |
| Tabata, A | 1 |
| Seto, Y | 1 |
| Sato, H | 1 |
| Onoue, S | 4 |
| Taniguchi, C | 3 |
| Inoue, R | 3 |
| Kato, M | 1 |
| Yamashita, K | 3 |
| Kawabata, Y | 3 |
| Wada, K | 3 |
| Yamada, S | 3 |
| Shah, P | 1 |
| Singh, MH | 1 |
| Yang, YX | 1 |
| Metz, DC | 1 |
| Manko, AM | 1 |
| Neporada, KS | 1 |
| Sukhomlyn, AA | 1 |
| Ghasemzadeh, J | 1 |
| Beregova, TV | 1 |
| Yankovskiy, DS | 1 |
| Martinsen, TC | 1 |
| Benestad, SL | 1 |
| Moldal, T | 1 |
| Waldum, HL | 1 |
| Yamauchi, Y | 2 |
| Hage, E | 1 |
| Hendel, L | 1 |
| Gustafsen, J | 1 |
| Hendel, J | 1 |
| Iijima, K | 1 |
| Sekine, H | 1 |
| Koike, T | 1 |
| Imatani, A | 1 |
| Ohara, S | 1 |
| Shimosegawa, T | 1 |
| Sharma, VR | 1 |
| Brannon, MA | 1 |
| Carloss, EA | 1 |
| Canani, RB | 1 |
| Cirillo, P | 1 |
| Roggero, P | 1 |
| Romano, C | 1 |
| Malamisura, B | 1 |
| Terrin, G | 1 |
| Passariello, A | 1 |
| Manguso, F | 1 |
| Morelli, L | 1 |
| Guarino, A | 1 |
| Lai, KC | 1 |
| Cheng, CH | 1 |
| Leung, PS | 1 |
| Chin, TW | 1 |
| Loeb, M | 1 |
| Fong, IW | 1 |
| Simon, B | 1 |
| Eissele, R | 4 |
| Czornik, M | 1 |
| Swarovsky, B | 1 |
| Arnold, R | 6 |
| Saltzman, JR | 3 |
| Kemp, JA | 1 |
| Golner, BB | 1 |
| Pedrosa, MC | 2 |
| Dallal, GE | 1 |
| Russell, RM | 3 |
| Playford, RJ | 1 |
| Marchbank, T | 1 |
| Calnan, DP | 1 |
| Calam, J | 1 |
| Royston, P | 1 |
| Batten, JJ | 1 |
| Hansen, HF | 1 |
| Rantala, A | 1 |
| Ovaska, J | 1 |
| Freston, JW | 1 |
| Borch, K | 1 |
| Brand, SJ | 2 |
| Carlsson, E | 2 |
| Creutzfeldt, W | 2 |
| Håkanson, R | 1 |
| Olbe, L | 1 |
| Solcia, E | 1 |
| Walsh, JH | 2 |
| Wolfe, MM | 1 |
| Kowdley, KV | 1 |
| Sepe, T | 1 |
| Golner, B | 1 |
| Perrone, G | 1 |
| Miyazaki, Y | 1 |
| Shinomura, Y | 1 |
| Yasunaga, Y | 1 |
| Higashimoto, Y | 1 |
| Kanayama, S | 1 |
| Aoki, T | 1 |
| Okuda, Y | 1 |
| Narita, T | 1 |
| Miwa, K | 1 |
| Miyazaki, I | 1 |
| Serfaty-Lacrosniere, C | 1 |
| Wood, RJ | 1 |
| Voytko, D | 1 |
| Pedrosa, M | 1 |
| Sepe, TE | 2 |
| Russell, RR | 1 |
| Banerjee, S | 1 |
| Ardill, JE | 1 |
| Beattie, AD | 1 |
| McColl, KE | 1 |
| Termanini, B | 1 |
| Gibril, F | 1 |
| Sutliff, VE | 1 |
| Yu, F | 1 |
| Venzon, DJ | 1 |
| Jensen, RT | 1 |
| Pereira, SP | 1 |
| Gainsborough, N | 1 |
| Dowling, RH | 1 |
| Paiva, SA | 1 |
| Booth, SL | 1 |
| Camilo, ME | 1 |
| O'Brien, ME | 1 |
| Davidson, KW | 1 |
| Sadowski, JA | 1 |
| Friis-Hansen, L | 1 |
| Rehfeld, JF | 1 |
| Viani, F | 1 |
| Siegrist, HH | 1 |
| Pignatelli, B | 1 |
| Cederberg, C | 1 |
| Idström, JP | 1 |
| Verdu, EF | 1 |
| Fried, M | 1 |
| Blum, AL | 1 |
| Armstrong, D | 1 |
| Väkeväinen, S | 1 |
| Tillonen, J | 1 |
| Salaspuro, M | 1 |
| Jousimies-Somer, H | 1 |
| Nuutinen, H | 1 |
| Färkkilä, M | 1 |
| Zavros, Y | 1 |
| Rieder, G | 1 |
| Ferguson, A | 1 |
| Samuelson, LC | 1 |
| Merchant, JL | 1 |
| Kang, B | 1 |
| Alderman, BM | 1 |
| Nicoll, AJ | 1 |
| Cook, GA | 1 |
| Giraud, AS | 1 |
| Passaro, DJ | 1 |
| Hurwitz, A | 1 |
| Triadafilopoulos, G | 1 |
| Parsonnet, J | 1 |
| Read, MA | 1 |
| Read, DM | 1 |
| Kapuscinski, M | 1 |
| Shulkes, A | 2 |
| Sommers, DK | 1 |
| van Wyk, M | 1 |
| Snyman, JR | 1 |
| Moncrieff, J | 1 |
| Patberg, H | 1 |
| Koop, H | 5 |
| Krack, W | 1 |
| Lorenz, W | 1 |
| McKnight, AT | 1 |
| Griffith, JL | 1 |
| Cummings, OW | 1 |
| Hirschowitz, BI | 1 |
| Cataldi, R | 1 |
| Meeroff, M | 1 |
| Calmels, S | 2 |
| Béréziat, JC | 2 |
| Ohshima, H | 2 |
| Bartsch, H | 2 |
| Berlin, RG | 1 |
| Wormsley, KG | 1 |
| Rosskopf, B | 1 |
| Adler, G | 1 |
| Karnes, WE | 1 |
| Festen, HP | 1 |
| Tuynman, HA | 1 |
| Den Hollander, W | 1 |
| Meuwissen, SG | 1 |
| Willemer, S | 1 |
| Steinbach, F | 1 |
| Tuch, K | 1 |
| Stone, D | 1 |
| Cadiot, G | 1 |
| Lehy, T | 1 |
| Bonfils, S | 1 |
| Friedman, G | 1 |
| Bishop, AE | 1 |
| Allen, JM | 1 |
| Daly, MJ | 2 |
| Larsson, H | 1 |
| Bloom, SR | 1 |
| Polak, JM | 1 |
| MacLellan, DG | 1 |
| Hardy, KJ | 1 |
| Pottage, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis[NCT01524757] | 48 participants (Anticipated) | Interventional | 2012-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for omeprazole and Achlorhydria
| Article | Year |
|---|---|
Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis.
Topics: Achlorhydria; Animals; Gastric Mucosa; Gastrins; Humans; Intestinal Mucosa; Omeprazole; Rats | 1995 |
Risk-benefit assessment of omeprazole in the treatment of gastrointestinal disorders.
Topics: Achlorhydria; Animals; Gastrointestinal Diseases; Humans; Omeprazole; Risk Factors | 1994 |
Is hypergastrinaemia dangerous for man?
Topics: Achlorhydria; Gastric Acid; Gastric Mucosa; Gastrins; Humans; Omeprazole | 1991 |
The gastrin hypothesis. Implications for antisecretory drug selection.
Topics: Achlorhydria; Animals; Carcinoid Tumor; Cell Transformation, Neoplastic; Enterochromaffin Cells; Gas | 1990 |
Omeprazole: long-term safety.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Carcinoid Tumor; Clinical Trials as | 1989 |
Omeprazole.
Topics: Achlorhydria; Animals; Duodenal Ulcer; Humans; Omeprazole; Rats; Zollinger-Ellison Syndrome | 1987 |
10 trials available for omeprazole and Achlorhydria
| Article | Year |
|---|---|
Effects of an acidic beverage (Coca-Cola) on absorption of ketoconazole.
Topics: Achlorhydria; Adult; Carbonated Beverages; Female; Gastric Acid; Humans; Hydrogen-Ion Concentration; | 1995 |
Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption.
Topics: Absorption; Achlorhydria; Administration, Oral; Aged; Aged, 80 and over; Female; Gastric Acid; Gastr | 1994 |
Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans.
Topics: Achlorhydria; Adult; Aged; Anti-Ulcer Agents; Calcium; Female; Food Analysis; Humans; Hydrogen-Ion C | 1995 |
Drug-induced hypochlorhydria causes high duodenal bacterial counts in the elderly.
Topics: Achlorhydria; Age Factors; Aged; Aged, 80 and over; Anti-Ulcer Agents; Bacteria, Aerobic; Bacteria, | 1998 |
Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole.
Topics: 1-Carboxyglutamic Acid; Achlorhydria; Adult; Aged; Bacteria; Biomarkers; Cross-Over Studies; Diet; D | 1998 |
Hypochlorhydria induced by a proton pump inhibitor leads to intragastric microbial production of acetaldehyde from ethanol.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetaldehyde; Achlorhydria; Adult; Anti-Ulcer Agents; Bacte | 2000 |
A modification of the quininium resin test for assessing gastric acidity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Adult; Anti-Ulcer Agents; Benzimidazoles; Fem | 2002 |
The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation.
Topics: Achlorhydria; Adult; Delayed-Action Preparations; Gastrointestinal Transit; Humans; Intestinal Absor | 1992 |
Omeprazole: long-term safety.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Carcinoid Tumor; Clinical Trials as | 1989 |
[Therapeutic achlorhydria: for which diseases, when and for how long?].
Topics: Achlorhydria; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Esophagitis, Peptic; Hi | 1988 |
40 other studies available for omeprazole and Achlorhydria
| Article | Year |
|---|---|
Influence of opefera on the colon motility of rats in the conditions of prolonged gastric juice hypoacidity.
Topics: Achlorhydria; Animals; Colon; Gastric Juice; Humans; Omeprazole; Rats | 2019 |
ACTIVITY OF SUPEROXIDE DISMUTASE AND CATALASE IN THE GASTRIC MUCOSA OF RATS UNDER THE PROLONGED ADMINISTRATION OF OMEPRAZOL AND COMBINATION OF OMEPRAZOLE AND MULTIPROBIOTICS.
Topics: Achlorhydria; Animals; Catalase; Gastric Mucosa; Male; Omeprazole; Superoxide Dismutase | 2021 |
Amorphous solid dispersions of carvedilol along with pH-modifiers improved pharmacokinetic properties under hypochlorhydoria.
Topics: Achlorhydria; Administration, Oral; Animals; Antihypertensive Agents; Carbazoles; Carvedilol; Drug L | 2018 |
New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions.
Topics: Achlorhydria; Administration, Oral; Animals; Biological Availability; Dipyridamole; Humans; Hydrogen | 2013 |
Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.
Topics: Achlorhydria; Adolescent; Adult; Aged; Anti-Ulcer Agents; Esomeprazole; False Positive Reactions; Fe | 2013 |
Experimental correction of metabolic changes in mouth at long-term hypoacidity by multiprobiotic "Symbiter acidophilic".
Topics: Achlorhydria; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Juice; Gastric Mucosa; Gastrins; Gl | 2014 |
Inhibitors of gastric acid secretion increase the risk of prion infection in mice.
Topics: Achlorhydria; Animals; Brain Chemistry; Disease Susceptibility; Female; Gastric Acid; Hydrogen-Ion C | 2011 |
Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria.
Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Biological Availability; Chemistry, P | 2012 |
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.
Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Benzenesulfonates; Biological Availab | 2012 |
Histopathology of the gastric oxyntic mucosa in two different patient groups during long-term treatment with omeprazole.
Topics: Achlorhydria; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cell Division; Drug Administration Schedul | 2003 |
Long-term effect of Helicobacter pylori eradication on the reversibility of acid secretion in profound hypochlorhydria.
Topics: Achlorhydria; Aged; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Drug Therapy, Combinat | 2004 |
Effect of omeprazole on oral iron replacement in patients with iron deficiency anemia.
Topics: Achlorhydria; Administration, Oral; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Anti-Ulcer Age | 2004 |
Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.
Topics: Achlorhydria; Acute Disease; Anti-Ulcer Agents; Child, Preschool; Community-Acquired Infections; Gas | 2006 |
The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas.
Topics: Achlorhydria; Acute Disease; Animals; Autocrine Communication; Ceruletide; Food Deprivation; Gastric | 2007 |
Effect of gastrin receptor blockade on gastrin and histidine decarboxylase gene expression in rats during achlorhydria.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Blotting, Northern; Chromogranin A; | 1995 |
Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice.
Topics: Achlorhydria; Acids; Animals; Bicarbonates; Digestion; Drug Stability; Epidermal Growth Factor; Fema | 1995 |
Association between medically induced achlorhydria of the stomach and a severe postoperative infection? A report of two cases.
Topics: Achlorhydria; Adult; Aged; Bacteria, Anaerobic; Bacterial Infections; Duodenal Ulcer; Gastrectomy; H | 1994 |
Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects.
Topics: Achlorhydria; Aged; Bacteria; Carbohydrates; Colony-Forming Units Assay; Fats; Feces; Female; Gastri | 1994 |
Effect of antrectomy and drug-induced achlorhydria on urinary excretion of N-terminal big gastrin immunoreactivity in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Benzimidazoles; Female; Gastrectomy; | 1993 |
Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria.
Topics: Achlorhydria; Administration, Oral; Aged; Aged, 80 and over; Anemia, Pernicious; Anti-Ulcer Agents; | 1995 |
Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome.
Topics: Achlorhydria; Adenosine Triphosphatases; Adolescent; Adult; Aged; Anti-Ulcer Agents; Drug Monitoring | 1998 |
Impaired feedback of gastric functions in carboxypeptidase E-deficient mice.
Topics: Achlorhydria; Animals; Base Sequence; Carboxypeptidase H; Carboxypeptidases; Chromogranin A; Chromog | 2000 |
The effect of intra-gastric acidity and flora on the concentration of N-nitroso compounds in the stomach.
Topics: Achlorhydria; Adult; Carcinogens; Enzyme Inhibitors; Female; Humans; Hydrogen-Ion Concentration; Mal | 2000 |
Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice.
Topics: Achlorhydria; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; B-Lymphocytes; Bacteriological Tech | 2002 |
Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach.
Topics: Achlorhydria; Animals; Gastric Mucosa; Growth Substances; Male; Mucins; Muscle Proteins; Neuropeptid | 2001 |
Achlorhydria induced changes in gastrin, somatostatin, H+/K(+)-ATPase and carbonic anhydrase in the sheep.
Topics: Achlorhydria; Animals; Base Sequence; Blotting, Northern; Carbonic Anhydrases; Chromatography, Gel; | 1992 |
Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Enterochromaffin Cells; Gastrins; Hi | 1992 |
Development of sustained achlorhydria in a patient with the Zollinger-Ellison syndrome treated with omeprazole.
Topics: Achlorhydria; Atrophy; Female; Gastric Mucosa; Humans; Middle Aged; Omeprazole; Zollinger-Ellison Sy | 1991 |
[Reply to the critique by Drs. Díaz de Rojas y Castelló Tapias].
Topics: Achlorhydria; Depression, Chemical; Gastric Acid; Humans; Omeprazole; Peptic Ulcer | 1991 |
Bacterial formation of N-nitroso compounds in the rat stomach after omeprazole-induced achlorhydria.
Topics: Achlorhydria; Animals; Bacteria; Gastric Mucosa; Male; Nitrosamines; Nitroso Compounds; Omeprazole; | 1991 |
Bacterial formation of N-nitroso compounds from administered precursors in the rat stomach after omeprazole-induced achlorhydria.
Topics: Achlorhydria; Animals; Escherichia coli; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Morpholin | 1991 |
Omeprazole: gastrin and gastric data (August 1991)
Topics: Achlorhydria; Animals; Carcinoid Tumor; Gastrins; Humans; Omeprazole; Rats; Stomach Neoplasms | 1991 |
Proliferation of endocrine cells in the rat stomach caused by drug-induced achlorhydria.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Cell Count; Enterochromaffin Cells; | 1991 |
Repeated high oral doses of omeprazole do not affect intrinsic factor secretion: proof of a selective mode of action.
Topics: Achlorhydria; Gastric Acid; Humans; Intrinsic Factor; Male; Omeprazole; Pentagastrin; Perfusion; Phe | 1989 |
Influence of chronic drug-induced achlorhydria by substituted benzimidazoles on the endocrine stomach in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Benzimidazoles; Female; Gastric Acid | 1987 |
Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria.
Topics: Achlorhydria; Animals; Gastrins; Gene Expression Regulation; Male; Omeprazole; Pyloric Antrum; Rats; | 1988 |
Action of somatostatin analogue (SMS 201-995) on the growth-promoting effect resulting from sustained achlorhydria in rat gastric mucosa, with special reference to endocrine cell behaviour.
Topics: Achlorhydria; Animals; Endocrine Glands; Female; Gastric Acid; Gastric Mucosa; Gastrins; Octreotide; | 1988 |
Gastric regulatory peptides in rats with reduced acid secretion.
Topics: Achlorhydria; Animals; Gastrectomy; Gastric Acid; Gastric Fundus; Gastrins; Gastrointestinal Hormone | 1986 |
Effect of omeprazole on acute gastric stress ulceration in cervical cord transected rats.
Topics: Achlorhydria; Animals; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; F | 1987 |
Antisecretory drugs and gastric cancer.
Topics: Achlorhydria; Animals; Benzimidazoles; Humans; Mice; Omeprazole; Rats; Stomach Neoplasms; Triazoles | 1985 |