olprinone has been researched along with Disease Models, Animal in 16 studies
olprinone: RN refers to HCl; structure given in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The phosphodiesterase III inhibitor olprinone has been confirmed to improve myocardial function and increase cerebral blood flow; therefore, if olprinone exerts direct neuroprotective effects against global cerebral ischemia to the same degree as cilostazol, olprinone could be useful for cerebral resuscitation after cardiac arrest." | 7.76 | The effects of the phosphodiesterase inhibitor olprinone on global cerebral ischemia. ( Fujikawa, K; Inoue, K; Kakihana, Y; Kanmura, Y; Matsunaga, A; Miyata, A; Nagayama, T; Okayama, N; Takeyama, M, 2010) |
| "This study was performed in order to assess the effects of olprinone, a phosphodiesterase III inhibitor, on hepatic oxygen delivery (DO2H), oxygen consumption (VO2H), and mitochondrial oxidation in the liver of a porcine endotoxemia model." | 7.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| " We also demonstrated that intraperitoneal administration of olprinone improves diaphragmatic fatigability and inhibits an increase in myeloperoxidase activity induced by abdominal sepsis." | 7.72 | Olprinone improves diaphragmatic contractility and fatigability during abdominal sepsis in a rat model. ( Hagiwara, S; Iwasaka, H; Kira, S; Kitano, T; Miyakawa, H; Noguchi, T; Oishi, K, 2004) |
| "We investigated the short-term effects of a phosphodiesterase III inhibitor (Olprinone) on hemodynamics and thoracic duct lymph flow in anesthetized open-chest sheep with heart failure induced by endothelin-1 (cardiogenic shock)." | 7.71 | Effect of phosphodiesterase III inhibitor (Olprinone) on thoracic duct lymph flow in anesthetized sheep with experimentally induced heart failure by endothelin-1. ( Inagaki, M; Ishikawa, S; Mitsui, T; Onizuka, M; Sato, Y; Tomoyasu, M; Yamamoto, T, 2002) |
| " The administration of olprinone (phosphodiesterase III inhibitor) improves the liver blood flow circulation in a porcine model of endotoxemia." | 7.71 | The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia. ( Isowaki, S; Kakihana, Y; Kanmura, Y; Nagata, E; Tobo, K, 2001) |
| "We concluded that TWBCP with olprinone reduces myocardial reperfusion injury by reducing oxidant-mediated lipid peroxidation, and it accelerates prompt and persistent LV functional recovery with suppression of reperfusion arrhythmia." | 3.78 | Reversal of oxidant-mediated biochemical injury and prompt functional recovery after prolonged single-dose crystalloid cardioplegic arrest in the infantile piglet heart by terminal warm-blood cardioplegia supplemented with phosphodiesterase III inhibitor. ( Abe, T; Hashimoto, K; Kinouchi, K; Ko, Y; Morita, K; Nagahori, R; Shinohara, G, 2012) |
| "The phosphodiesterase III inhibitor olprinone has been confirmed to improve myocardial function and increase cerebral blood flow; therefore, if olprinone exerts direct neuroprotective effects against global cerebral ischemia to the same degree as cilostazol, olprinone could be useful for cerebral resuscitation after cardiac arrest." | 3.76 | The effects of the phosphodiesterase inhibitor olprinone on global cerebral ischemia. ( Fujikawa, K; Inoue, K; Kakihana, Y; Kanmura, Y; Matsunaga, A; Miyata, A; Nagayama, T; Okayama, N; Takeyama, M, 2010) |
| "This study was performed in order to assess the effects of olprinone, a phosphodiesterase III inhibitor, on hepatic oxygen delivery (DO2H), oxygen consumption (VO2H), and mitochondrial oxidation in the liver of a porcine endotoxemia model." | 3.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| " We also demonstrated that intraperitoneal administration of olprinone improves diaphragmatic fatigability and inhibits an increase in myeloperoxidase activity induced by abdominal sepsis." | 3.72 | Olprinone improves diaphragmatic contractility and fatigability during abdominal sepsis in a rat model. ( Hagiwara, S; Iwasaka, H; Kira, S; Kitano, T; Miyakawa, H; Noguchi, T; Oishi, K, 2004) |
| "We investigated the short-term effects of a phosphodiesterase III inhibitor (Olprinone) on hemodynamics and thoracic duct lymph flow in anesthetized open-chest sheep with heart failure induced by endothelin-1 (cardiogenic shock)." | 3.71 | Effect of phosphodiesterase III inhibitor (Olprinone) on thoracic duct lymph flow in anesthetized sheep with experimentally induced heart failure by endothelin-1. ( Inagaki, M; Ishikawa, S; Mitsui, T; Onizuka, M; Sato, Y; Tomoyasu, M; Yamamoto, T, 2002) |
| " The administration of olprinone (phosphodiesterase III inhibitor) improves the liver blood flow circulation in a porcine model of endotoxemia." | 3.71 | The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia. ( Isowaki, S; Kakihana, Y; Kanmura, Y; Nagata, E; Tobo, K, 2001) |
| "Treatment with olprinone reduced the numbers of polymorphonuclears in the BAL fluid, decreased the formation of most oxidation markers in the lungs, reduced lung edema and prevented a decrease in TAS in the lung homogenate compared to non-treated animals." | 1.38 | Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. ( Calkovska, A; Drgova, A; Mokra, D; Pullmann, R, 2012) |
| "Sevoflurane/olprinone treatment attenuated the bronchoconstriction induced by the highest dose of Ach with RL being significantly lower (0." | 1.37 | Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs. ( Iwasaki, S; Watanabe, A; Yamakage, M; Zhou, J, 2011) |
| "Olprinone treatment (0." | 1.36 | Olprinone attenuates the acute inflammatory response and apoptosis after spinal cord trauma in mice. ( Bramanti, P; Cuzzocrea, S; Esposito, E; Impellizzeri, D; Mazzon, E; Paterniti, I, 2010) |
| "Olprinone was applied locally to the sciatic nerves of rats, and nerve regeneration activity was examined in relation to heat shock protein (HSP)27 expression." | 1.35 | Local application of olprinone for promotion of peripheral nerve regeneration. ( Ikeda, K; Sugimoto, N; Tomita, K; Tsubouchi, H, 2009) |
| "Olprinone inhibited the increase in the IL-8 levels resulting from the incubation of HK-2 with TNF-alpha." | 1.34 | Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure. ( Anas, C; Maruyama, S; Matsuo, S; Ono, Y; Ozaki, T; Yamamoto, T; Zu Gotoh, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Narita, M | 2 |
| Hatano, E | 2 |
| Ikai, I | 1 |
| Miyagawa-Hayashino, A | 1 |
| Yanagida, A | 2 |
| Nagata, H | 2 |
| Asechi, H | 2 |
| Taura, K | 2 |
| Uemoto, S | 2 |
| Tsubouchi, H | 1 |
| Ikeda, K | 1 |
| Sugimoto, N | 1 |
| Tomita, K | 1 |
| Okayama, N | 2 |
| Matsunaga, A | 1 |
| Kakihana, Y | 3 |
| Fujikawa, K | 1 |
| Inoue, K | 1 |
| Nagayama, T | 1 |
| Takeyama, M | 1 |
| Miyata, A | 1 |
| Kanmura, Y | 3 |
| Esposito, E | 1 |
| Mazzon, E | 1 |
| Paterniti, I | 1 |
| Impellizzeri, D | 1 |
| Bramanti, P | 1 |
| Cuzzocrea, S | 1 |
| Yamanaka, K | 1 |
| Kitamura, K | 1 |
| Nitta, T | 1 |
| Zhou, J | 1 |
| Iwasaki, S | 1 |
| Watanabe, A | 1 |
| Yamakage, M | 1 |
| Kinouchi, K | 1 |
| Morita, K | 1 |
| Ko, Y | 1 |
| Nagahori, R | 1 |
| Shinohara, G | 1 |
| Abe, T | 1 |
| Hashimoto, K | 1 |
| Mokra, D | 2 |
| Drgova, A | 2 |
| Pullmann, R | 2 |
| Calkovska, A | 2 |
| Kopincova, J | 1 |
| Tomoyasu, M | 1 |
| Onizuka, M | 1 |
| Inagaki, M | 1 |
| Sato, Y | 1 |
| Yamamoto, T | 2 |
| Ishikawa, S | 1 |
| Mitsui, T | 1 |
| Miyakawa, H | 1 |
| Oishi, K | 1 |
| Hagiwara, S | 1 |
| Kira, S | 1 |
| Kitano, T | 1 |
| Iwasaka, H | 1 |
| Noguchi, T | 1 |
| Kuniyoshi, T | 1 |
| Isowaki, S | 2 |
| Nagata, E | 2 |
| Tobo, K | 2 |
| Kaminosono, T | 1 |
| Hashiguchi, T | 1 |
| Tahara, M | 1 |
| Kawamae, H | 1 |
| Anas, C | 1 |
| Ozaki, T | 1 |
| Maruyama, S | 1 |
| Zu Gotoh, M | 1 |
| Ono, Y | 1 |
| Matsuo, S | 1 |
16 other studies available for olprinone and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A phosphodiesterase III inhibitor protects rat liver from sinusoidal obstruction syndrome through heme oxygenase-1 induction.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Combined Modality Therapy; Disease Models, Ani | 2009 |
Local application of olprinone for promotion of peripheral nerve regeneration.
Topics: Animals; Axonal Transport; Disease Models, Animal; Female; Ganglia, Spinal; HSP27 Heat-Shock Protein | 2009 |
The effects of the phosphodiesterase inhibitor olprinone on global cerebral ischemia.
Topics: Animals; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Cell Hypoxia; Cell Survival; Ce | 2010 |
Olprinone attenuates the acute inflammatory response and apoptosis after spinal cord trauma in mice.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Humans; Imidazoles; Male; Mice; Neutrophil In | 2010 |
Olprinone attenuates excessive shear stress through up-regulation of endothelial nitric oxide synthase in a rat excessive hepatectomy model.
Topics: Animals; Apoptosis; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Hepatectomy; Hepat | 2011 |
Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs.
Topics: Acetylcholine; Airway Resistance; Anesthetics, Inhalation; Animals; Bronchial Hyperreactivity; Bronc | 2011 |
Reversal of oxidant-mediated biochemical injury and prompt functional recovery after prolonged single-dose crystalloid cardioplegic arrest in the infantile piglet heart by terminal warm-blood cardioplegia supplemented with phosphodiesterase III inhibitor.
Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Biomarkers; Cyclic AMP; Disease Models, Animal; Hea | 2012 |
Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bronchoalveolar Lavage Fluid; Disease Models, Anima | 2012 |
Anti-inflammatory treatment in dysfunction of pulmonary surfactant in meconium-induced acute lung injury.
Topics: Acetylcysteine; Acute Lung Injury; Aminophylline; Animals; Anti-Inflammatory Agents; Antioxidants; B | 2013 |
Effect of phosphodiesterase III inhibitor (Olprinone) on thoracic duct lymph flow in anesthetized sheep with experimentally induced heart failure by endothelin-1.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiac Output; Central Venous Pressure; Cyclic Nucleo | 2002 |
Olprinone improves diaphragmatic contractility and fatigability during abdominal sepsis in a rat model.
Topics: Abdomen; Analysis of Variance; Animals; Cardiotonic Agents; Cecum; Diaphragm; Disease Models, Animal | 2004 |
Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Electron Transport Complex IV; Endotoxemia; Endotoxins; Hemoglobins | 2005 |
Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acute Kidney Injury; Animals; Blood Flow Velocity; Blood Urea N | 2007 |
The effects of olprinone (a phosphodiesterase III inhibitor) on hepatic vascular bed in a porcine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Imidazoles; Liver Circulation; Oxygen; Phosphodiestera | 2001 |