olopatadine-hydrochloride and Dermatitis--Allergic-Contact

Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.

Topics: Animals; Dermatitis, Allergic Contact; Dibenzoxepins; Disease Models, Animal; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Immunoglobulin E; Indoles; Interleukin-4; Interleukin-5; Interleukin-6; Mice; Mice, Inbred C57BL; Olopatadine Hydrochloride; Picryl Chloride; Piperazines; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4

Allergic contact dermatitis to Alstroemeria has been well documented; however, occupational allergy to this decorative flower has never been reported in the literature.. We describe a florist with complaints of a sense of throat tightness, allergic rhinoconjunctivitis, urticaria, and facial angioedema attributable to the handling of this popular flower.. An allergy skin testing by the puncture technique and a challenge test are performed in a private office. A staff member is used as a control for the skin testing. Main outcome measures are the subject's clinical symptoms.. The allergy skin testing reveals positive response to Alstroemeria (Peruvian lily), but negative to Stargazer lily, solidago, and few other flower extracts. In the challenge test, the subject develops conjunctival injection, postnasal drip with nasal congestion, and cough.. This is the first report of a type I allergic reaction to Alstroemeria and illustrate the ease of in-office performance of skin testing and challenge to flowering plants.

Topics: Adult; Anti-Allergic Agents; Dermatitis, Allergic Contact; Dibenzoxepins; Diphenhydramine; Humans; Lilium; Male; Occupational Diseases; Olopatadine Hydrochloride; Prednisone; Skin Tests

To evaluate skin tests with clinical ocular allergy and to compare cutaneous hypersensitivity and seasonal allergic conjunctivitis in children.. A 10-year-old girl presented a typical seasonal allergic conjunctivitis, never treated and the onset occurred one year before. She was skin tested for the allergy. Complete blood tests were also performed. An ocular treatment was given: olopatadine over 45 days.. She showed a complete cutaneous anergy including histamine and codeine controls. Radioallergosorbent tests (RAST) found numerous great positivity to different allergens. Within 30 days under ocular treatment, she recovered completely from symptoms and clinical signs.. Clinical typical seasonal ocular allergy in children with cutaneous anergy should be explored further or at least treated. Cutaneous hypersensitivity should be evaluated more precisely with a larger study comparing results in general allergy and in ocular allergy where the anergy seems to be more frequent.

Topics: Child; Conjunctivitis, Allergic; Dermatitis, Allergic Contact; Dibenzoxepins; Female; Histamine H1 Antagonists; Humans; Immune Tolerance; Olopatadine Hydrochloride; Ophthalmic Solutions; Radioallergosorbent Test; Skin Tests