olivomycins and Testicular-Neoplasms

Clinical trials of the combination of olivomycin with cyclophosphamide were performed on 41 patients with testicle tumours of heterogenous structure. Objective effects were observed in 70.7 per cent of the cases, an effect higher than 50 per cent was recorded in 46.3 per cent of the patients and complete regression of the tumours was achieved in 17.1 per cent of the cases. The combination of olivomycin with cyclophosphamide was well tolerated by the patients. The most frequent side effects of the combination were leucopenia, thrombocytopenia, nausea and vomiting.

Topics: Adult; Clinical Trials as Topic; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Drug Tolerance; Humans; Male; Olivomycins; Testicular Neoplasms; Time Factors

Sixty two patients with metastases of testicular teratoblastoma were subjected to combination chemotherapy. Forty nine patients were treated with an association of bleomycin and vincaalkaloids. An objective effect was gained in 77.5%. Ten patients were treated with a combination of bleomycin, vinblastine, natulane, dactinomycin, an effect being gained in 60% of the patients. The treatment with cis-diamini-dichloroplatinum was effective in 8 of 11 patients (72.7%). In 6 of 10 patients treated with olivomycin and cyclophosphane the effect was obtained (in 60%), when they were resistant to bleomycin combinations. Evidence is presented of high-effectiveness of the combinations including bleomycin as well as of the effect of cis-diamini-dichloroplatinum in treatment of testicular teratoblastomas. With pharmaceutical resistance to bleomycin it is recommended to continue olivomycin and cyclophosphane chemotherapy.

Topics: Adolescent; Adult; Aged; Bleomycin; Choriocarcinoma; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Dactinomycin; Drug Evaluation; Drug Therapy, Combination; Dysgerminoma; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Metastasis; Neoplasms, Germ Cell and Embryonal; Olivomycins; Procarbazine; Teratoma; Testicular Neoplasms; Vinblastine; Vincristine

Topics: Antibiotics, Antineoplastic; Biopsy; Cell Nucleus; Culture Media; Culture Techniques; Dactinomycin; Humans; Kidney Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Neoplasms; Olivomycins; Peripheral Nervous System Neoplasms; Plicamycin; Testicular Neoplasms; Wilms Tumor

Topics: Adult; Antibiotics, Antineoplastic; Cyclophosphamide; Dactinomycin; Depression, Chemical; Dysgerminoma; Humans; Male; Melphalan; Methotrexate; Neoplasm Metastasis; Olivomycins; Teratoma; Testicular Neoplasms

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgerminoma; Humans; Male; Melphalan; Methotrexate; Olivomycins; Teratoma; Testicular Neoplasms