olivomycins and Lymphoma--Non-Hodgkin

Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Ehrlich Tumor; Child; Choriocarcinoma; Culture Techniques; Dactinomycin; Female; Hodgkin Disease; Humans; Leukemia, Experimental; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Neoplasms; Olivomycins; Polycythemia; Pregnancy; Sarcoma 180; Tonsillar Neoplasms; USSR; Wilms Tumor

Diacarb or lasix in combination with olivomycin increased the antibiotic antiblastomic activity and toxicity when used for the course treatment of mice with transplanted lymphosarcoma LIO-I. The chemotherapeutic indices of such combinations did not differ from those of olivomycin used alone. Diacarb decreased excretion of olivomycin with the urine in healthy mice, while lasix increased it.

Topics: Acetazolamide; Animals; Diuresis; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Female; Furosemide; Kinetics; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasms, Experimental; Olivomycins; Rats

The pharmacokinetics of C14-olivomycin after its single intravenous administration to mice with lymphosarcome (LIO-I) was studied. It was shown that according to the specific radioactivity the organs may be placed in the following order: I hour after the antibiotic administration-the blood, liver, spleen, thymus, tumor, muscle; 3 hour after the administration-the liver, spleen, thymus, blood, tumor, muscle. Accumulation of olivomycin in the mouse organs was mainly in direct dependence on the dose of the antibiotic administered. Chromatography of the substances extraceted with ethylacetate from the urine collected at various periods after C14-olivomycin administration showed the presence of a new radioactive product (Rf 0.35-0.37) in addition to the unchanged antibiotic (Rf 0.53). Bioautographic analysis of the chromatograms showed that the product of C14-olivomycin conversion preserved its biological activity. The analysis of the substances extracted with ethylacetate from the liver, spleen and tumors 3 hours after the antibiotic administration reveiled (except of the liver) the presence of a spot with Rf corresponding to that of the initial drug.

Topics: Animals; Autoradiography; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Chromatography, Paper; Dose-Response Relationship, Drug; Injections, Intravenous; Kinetics; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasm Transplantation; Olivomycins; Radiochemistry; Sarcoma, Experimental; Scintillation Counting; Spectrophotometry; Time Factors

Combined use of rubomycin and olivomycin with diacarb in treatment of rats with Pliss lymphosarcoma increased the antiblastomic activity of the antibiotics. The antitumor effect of rubomycin and olivomycin was increased by diacarb in the same degree as that of dipin, a synthetic cytostatic.

Topics: Animals; Antibiotics, Antineoplastic; Diuretics; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Female; Lymphoma, Non-Hodgkin; Neoplasm Transplantation; Olivomycins; Piperazines; Rats; Skin Neoplasms; Time Factors

Topics: Animals; Carbon Isotopes; Liver; Lymphoma, Non-Hodgkin; Mice; Mitochondria, Liver; Neoplasm Transplantation; Nucleoproteins; Olivomycins; Sarcoma, Experimental; Spleen; Subcellular Fractions

Topics: Animals; Antibiotics, Antineoplastic; Lymphoma, Non-Hodgkin; Mice; Neoplasm Transplantation; Olivomycins; Sarcoma, Experimental

Topics: Animals; Antibiotics, Antineoplastic; Depression, Chemical; Female; Lymphoma, Non-Hodgkin; Male; Mice; Olivomycins; Sarcoma, Experimental; Seasons

Topics: Animals; Antibiotics, Antineoplastic; Depression, Chemical; Drug Synergism; Lymphoma, Non-Hodgkin; Male; Mice; Olivomycins; Organ Size; Spleen; Stimulation, Chemical

Topics: Anti-Bacterial Agents; Antineoplastic Agents; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Olivomycins; Pharmacology; Research; Sarcoma; Sarcoma, Experimental

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Olivomycins; Pharmacology; Research; Sarcoma 180; Thiotepa; Toxicology

Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chemistry, Pharmaceutical; Lymphoma; Lymphoma, Non-Hodgkin; Mice; Neoplasms; Olivomycins; Pharmacology; Research; Sarcoma; Sarcoma, Experimental; Toxicology

Topics: Anti-Bacterial Agents; Antineoplastic Agents; Dysgerminoma; Female; Fibrosarcoma; Humans; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasms; Olivomycins; Ovarian Neoplasms; Sarcoma; Stomach Neoplasms; Uterine Cervical Neoplasms

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Busulfan; Cytostatic Agents; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Methylthiouracil; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Olivomycins; Pharmacology; Research; Thiotepa