oligonucleotide-5320 and Disease-Models--Animal

oligonucleotide-5320 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for oligonucleotide-5320 and Disease-Models--Animal

Article	Year
Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:8 Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate. Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Disease Models, Animal; Dose-Response Relationship, Drug; HIV-1; Humans; Mice; Mice, SCID; Oligodeoxyribonucleotides; T-Lymphocytes; Thionucleotides; Virus Replication	1998

Article

Year

Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320.

Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:8

Viral replication was inhibited in a dose-dependent manner after administration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/Liv mice. Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate.

Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-HIV Agents; Disease Models, Animal; Dose-Response Relationship, Drug; HIV-1; Humans; Mice; Mice, SCID; Oligodeoxyribonucleotides; T-Lymphocytes; Thionucleotides; Virus Replication

1998