oligomycins and Neuronal-Ceroid-Lipofuscinoses

oligomycins has been researched along with Neuronal-Ceroid-Lipofuscinoses* in 1 studies

Other Studies

1 other study(ies) available for oligomycins and Neuronal-Ceroid-Lipofuscinoses

Article	Year
A disrupted homologue of the human CLN3 or juvenile neuronal ceroid lipofuscinosis gene in Saccharomyces cerevisiae: a model to study Batten disease. Cellular and molecular neurobiology, 1999, Volume: 19, Issue:5 1. In order to investigate the biological function of the human CLN3 gene that is defective in Batten disease, we created a yeast strain by PCR-targeted disruption of the yeast gene (YHC3), which is a homologue of the human CLN3 gene. 2. The phenotypic characterization revealed that the yhc3 delta mutants are more sensitive to combined heat and alkaline stress than the wild-type strains as determined by inhibition of cell proliferation. 3. This suggests that the yhc3 delta mutant is a good model to investigate the biological function of human CLN3 gene in mammalian cells and to understand the pathophysiology of juvenile Batten disease. Topics: Alkalosis; Antineoplastic Agents; Cyclins; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Membrane Glycoproteins; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Oligomycins; Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	1999

Article

Year

A disrupted homologue of the human CLN3 or juvenile neuronal ceroid lipofuscinosis gene in Saccharomyces cerevisiae: a model to study Batten disease.

Cellular and molecular neurobiology, 1999, Volume: 19, Issue:5

1. In order to investigate the biological function of the human CLN3 gene that is defective in Batten disease, we created a yeast strain by PCR-targeted disruption of the yeast gene (YHC3), which is a homologue of the human CLN3 gene. 2. The phenotypic characterization revealed that the yhc3 delta mutants are more sensitive to combined heat and alkaline stress than the wild-type strains as determined by inhibition of cell proliferation. 3. This suggests that the yhc3 delta mutant is a good model to investigate the biological function of human CLN3 gene in mammalian cells and to understand the pathophysiology of juvenile Batten disease.

Topics: Alkalosis; Antineoplastic Agents; Cyclins; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Membrane Glycoproteins; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Oligomycins; Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

1999