oleuropein and Metabolic-Diseases

The overall health beneficial action of olive oil phenolic components is well established. Recent studies have elucidated the biological effects of two isolated compounds, namely oleuropein and hydroxytyrosol, with particular attention on their antioxidant activity. Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders. The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.

Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Humans; Iridoid Glucosides; Iridoids; Metabolic Diseases; Olive Oil; Phenylethyl Alcohol; Plant Oils