oleuropein and Drug-Related-Side-Effects-and-Adverse-Reactions

The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.. 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg. After 1 day, animals were sacrificed and the liver tissue sections stained with H&E, toluidine blue and tryptase for immunohistochemical study.. There was no statistically significant difference between ALT, AST and albumin averages of the oleuropein and control groups (p> 0.05). The tryptase average of the control group was higher than the tryptase average of the oleuropein group and this difference was statistically significant (p=0.003). The T. blue average in the oleuropein group was higher than the control group. However, there was no statistically significant difference between groups (p=0.482).. Rocuronium adverse effects, like hypersensitivity and anaphylaxis, may limit routine use of this substance. The use of oleuropein reduced the number of inflammatory cells and prevented degranulation.

Topics: Alanine Transaminase; Anesthesia, General; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Cell Aggregation; Cell Degranulation; Chromatography, High Pressure Liquid; Diet Therapy; Drug-Related Side Effects and Adverse Reactions; Immunohistochemistry; Iridoid Glucosides; Iridoids; Liver; Male; Mast Cells; Neuromuscular Nondepolarizing Agents; Pre-Exposure Prophylaxis; Rabbits; Random Allocation; Reproducibility of Results; Rocuronium; Serum Albumin