oleuropein-aglycone and Alzheimer-Disease

Topics: Acetates; Alzheimer Disease; Animals; Autophagy; Cyclopentane Monoterpenes; Humans; Pyrans; TOR Serine-Threonine Kinases

(1) Background: Autophagy, the major cytoplasmic process of substrate turnover, declines with age, contributing to proteostasis decline, accumulation of harmful protein aggregates, damaged mitochondria and to ROS production. Accordingly, abnormalities in the autophagic flux may contribute to many different pathophysiological conditions associated with ageing, including neurodegeneration. Recent data have shown that extra-virgin olive oil (EVOO) polyphenols stimulate cell defenses against plaque-induced neurodegeneration, mainly, through autophagy induction. (2) Methods: We carried out a set of in vitro experiments on SH-SY5Y human neuroblastoma cells exposed to toxic Aβ

Topics: Acetates; Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Cell Line; Cyclopentane Monoterpenes; Diet, Mediterranean; Humans; Mitochondria; Models, Neurological; Nerve Degeneration; Neurons; Olive Oil; Peptide Fragments; Phenylethyl Alcohol; Polyphenols; Proteasome Endopeptidase Complex; Pyrans; Reactive Oxygen Species; Ubiquitin