Compounds > oleic acid

oleic acid and Fatty Liver, Nonalcoholic

oleic acid has been researched along with Fatty Liver, Nonalcoholic in 121 studies

Research

Studies (121)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (0.83)29.6817
2010's67 (55.37)24.3611
2020's53 (43.80)2.80

Authors

AuthorsStudies
Lu, Y; Lu, Z; Lv, F; Sun, J; Tang, C; Tao, J1
Chang, YS; Zhang, YL; Zhou, SS1
Jia, J; Li, C; Wang, W; Wei, Y; Yan, B; Zhang, R; Zhang, X1
Chen, H; Ma, J; Nie, T; Shan, A; Zhang, P1
An, HJ; Cominguez, DC; Kang, YM; Kim, S; Nugroho, A; Park, YJ1
Birner-Gruenberger, R; Darnhofer, B; Gindlhuber, J; Liesinger, L; Schinagl, M; Schittmayer, M; Tomin, T1
Baishya, G; Billu, A; G Raghu, K; Gogoi, P; Nisha, P; Poornima, MS; Sindhu, G; Sruthi, CR1
Huang, W; Li, F; Li, X; Ma, Y; Sun, X; Wang, Y; Xu, M; Yu, D; Zhang, Y; Zou, J1
Choi, SE; Han, SJ; Hwang, Y; Jung, H; Kang, Y; Kemper, JK; Kim, HJ; Lee, G; Lee, KW; Lee, SJ; Park, S; Shin, TH; Son, Y; Song, HK1
An, T; Dou, L; Huang, X; Li, H; Li, J; Man, Y; Shen, T; Tang, W; Zhang, X1
Abe, H; Kakisaka, K; Kanazawa, J; Suzuki, Y; Takikawa, Y; Wang, T; Yonezawa, T1
An, W; Li, L; Lin, W; Xie, P; Zhan, Y; Zhang, C; Zhang, J; Zhang, X1
Chen, CH; Guo, BC; Hsu, MC; Hu, PA; Lee, TS1
Chu, K; Feng, R; Hu, X; Li, W; Liu, L; Wang, G; Zhang, L; Zhao, N1
Chen, C; Gan, YW; Lao, XQ; Lei, SH; Li, YL; Ming, Y; Ran, LS; Wang, HL; Wang, L; Wang, X; Wu, LJ; Wu, YZ; Xiong, R; Zhang, HM; Zhao, CY; Zheng, CM1
Frandsen, HS; Hagensen, CE; Mikkelsen, KL; Rogowska-Wrzesinska, A; Smith, LE; Sun, L; Thulesen, AP; Vej-Nielsen, JM; Yang, F1
Kim, HA; Kim, HJ; Lee, YH; You, M1
He, Y; Li, Y; Wang, C; Wen, S; Xu, C; Yuan, X; Zhou, L1
Chen, J; Fu, N; Hu, Y; Liu, W; Tang, Q; Tian, Y; Yang, X1
Banno, A; Kiriyama, K; Matsuba, S; Mijiti, M; Mori, R; Nagaoka, S; Nakashima, Y; Sutoh, K; Takeuchi, A; Ye, Y1
Chen, D; Chen, X; Cheng, Y; Gu, R; Guan, C; Guo, C; Liang, J; Liang, Y; Qian, J; Qu, H; Shen, F; Wa, Y; Zhang, C1
Hu, Z; Li, B; Li, L; Liu, K; Ran, J; Wang, Y; Zhang, H1
Chen, H; Huang, J; Ma, C; Ren, J; Song, X; Sun, N; Tian, J; Wang, J; Wang, T; Wang, Z; Yang, B; Yu, Y; Zhan, T; Zhang, Y; Zhao, Y; Zhu, J1
Chen, Y; Gao, S; Lin, T; Liu, J; Wang, Z; Zeng, Z; Zhou, H; Zhou, W1
Dong, L; Gao, X; Ji, Y; Li, H; Liu, Y; Shi, H; Tian, H; Wang, Y; Xu, J; Yang, L1
Chen, Y; Fu, F; Li, X; Liu, W; Liu, X; Lu, Y; Su, S; Yuan, Y; Zeng, X; Zheng, Q; Zhu, M1
Chen, X; Ke, H; Liu, H; Liu, P; Shi, W; Wang, Y; Xie, Y; Xu, X; Yao, Q; Zhou, X1
Liu, Z; Wang, J; Yin, X1
Bai, X; Chen, L; Chen, Z; Dong, K; Du, Q; Wang, D; Xu, J; Yang, J; Zhang, M1
Aguennouz, M; Alanazi, AM; Amorini, AM; Barbagallo, IA; Distefano, A; Giallongo, S; Lazzarino, G; Longhitano, L; Macaione, V; Nicolosi, A; Orlando, L; Salomone, F; Saoca, C; Tibullo, D; Tropea, E; Volti, GL1
Deng, G; Gao, L; Huang, M; Li, J; Li, Y; Liao, Y; Liu, B; Liu, C; Qin, M; Shi, H; Wang, Y; Wu, C; Xu, Y; Yang, J; Yang, M; Zhang, Y; Zhao, J; Zhou, C1
Gao, J; Gao, S; Li, Q; Liang, C; Xu, Y1
Baixeras, E; Ciccocioppo, R; Cifani, C; de Ceglia, M; Decara, J; Gavito, A; Hernandez-Folgado, L; Jagerovic, N; Rodríguez de Fonseca, F; Rodríguez-Pozo, M; Rojo, G; Soverchia, L; Tovar, R; Ubaldi, M1
Huang, W; Li, Y; Liu, Y; Ma, K; Sheng, W; Song, J; Song, X1
Jin, L; Liu, J; Liu, Y; Wang, Q; Zhang, D1
Chen, Y; Le, WL; Shi, HB; Tang, QN1
Jiang, H; Jin, Y; Li, B; Li, D; Wang, Z; Xia, H; Zhang, X; Zhu, X1
Fan, JG; Hu, CX; Liu, XL; Pan, Q; Qiao, L; Xin, FZ; Xu, GW; Yang, RX; Zeng, J; Zhang, RN; Zhao, ZH; Zhou, D1
Hu, Y; Shi, LX; Ye, H1
Cao, Y; Fan, J; He, TC; Huang, A; Luo, J; Luo, Y; Peng, Q; Ran, L; Shi, Q; Shu, L; Wang, H; Weng, Y; Wu, J; Zhou, L; Zhu, Y; Zuo, G1
Li, J; Liu, P; Sun, W; Wang, T; Wang, X; Zheng, W1
Barshack, I; Cohen, H; Harari, A; Harats, D; Kamari, Y; Kandel Kfir, M; Leikin Frenkel, A; Sagee, A; Shaish, A1
Jiang, W; Wang, J1
Lu, W; Tang, E; Tang, Y; Zhang, M1
Cheng, B; Gao, W; Gao, Y; He, Y; Li, Y; Liu, C; Miao, W; Song, C; Wu, X; Yang, W; Yang, X; Yang, Z; Yu, Y; Zhang, F; Zheng, M1
Choi, YW; Guo, L; Hwang, DY; Je, BI; Kang, JS; Kang, NJ; Lee, YJ; Park, SY; Park, YH1
Bianchini, C; D'Ambrosio, R; Di Cesare Mannelli, L; Ghelardini, C; Lampertico, P; Micheli, L; Pacini, A; Trallori, E1
Cao, J; Chu, X; Li, L; Li, Q; Ma, H; Yao, Y1
Ding, L; Jiang, Q; Liu, J; Xie, T; Ye, Q; Zhang, D; Zhu, J1
He, LB; Huang, L; Li, N; Li, TT; Sun, YR; Tang, L; Wang, TY1
Li, W; Ou, R; Ren, Y; Xu, Y; Yang, W; Zhao, J; Zhao, L; Zhao, Y1
Dobrucki, JW; Górka, J; Jura, J; Korlatowicz, A; Kotlinowski, J; Kwapisz, O; Marona, P; Miekus, K; Pydyn, N; Waligórska, A1
Li, J; Liu, P; Song, X; Sun, W; Wang, M; Wang, T; Wang, X; Yang, B; Zheng, W1
Auer, N; Bruschi, FV; Claudel, T; Fuchs, CD; Kunczer, V; Ronda, OAHO; Scharnagl, H; Stojakovic, T; Tardelli, M; Trauner, M; Verkade, HJ1
Li, J; Liu, P; Sun, W; Wang, T; Wang, X; Yang, F; Zheng, W1
Chen, Y; Ding, Y; Luo, J; Niu, Y; Sun, P; Wang, Y; Xie, W; Xu, N; Zhang, Y1
Bandy, B; Omidian, K; Rafiei, H2
Al-Dhabi, NA; Balakrishna, K; Darvin, SS; Esakkimuthu, S; Ignacimuthu, S; Pandikumar, P; Sivasankaran, K; Stalin, A; Toppo, E1
Deng, KY; Guan, XH; Hu, L; Huang, CC; Qian, YS; Wang, LF; Wang, XN; Xiao, YF; Xin, HB1
Barola, C; Bartolini, D; Bellezza, G; Galarini, R; Galli, F; Giusepponi, D; Russo, A; Rychlicki, C; Sidoni, A; Svegliati-Baroni, G; Torquato, P1
Huang, X; Kobayashi, Y; Koike, K; Kojima-Yuasa, A; Li, W; Shirahata, T; Xu, M; Yuasa, I1
Cygal, M; Czajkowska-Bania, K; Dudka, J; Gawrońska-Grzywacz, M; Gieroba, R; Herbet, M; Izdebska, M; Korga, A; Korolczuk, A; Piątkowska-Chmiel, I; Sysa, M1
Sun, W; Tang, Y; Zhang, M; Zhou, M1
Chen, J; Ding, X; Jian, T; Li, W; Lv, H; Ma, L; Ren, B; Tong, B; Wu, Y; Zhao, L; Zuo, Y1
Choi, HK; Chung, MY; Hwang, JT; Kim, SH; Park, JH; Shin, EJ; Sung, MJ1
Chen, D; Liu, D; Liu, K; Lv, F; Pang, L; Shi, Y; Wang, Y; Xie, F; Yin, J; Zang, Y1
Bautista, JD; Del Campo, JA; Gallego, P; Gallego, R; García-Valdecasas, M; Gil-Gómez, A; Maldonado, R; Muñoz-Hernández, R; Rojas, Á; Rojas, L; Romero-Gómez, M1
Chen, JT; Chen, KY; Chen, YP; Ho, BY; Hsieh, MC; Hsu, AC; Hsu, RY; Lin, JA; Shen, TL; Tai, YT; Wang, GH; Wu, HT; Yao, HY1
Chen, X; Chen, Y; Cheng, J; Li, L; Liao, G; Liu, J; Liu, X; Lu, Y; Luo, R1
Gong, L; He, RR; Hong, M; Kurihara, H; Li, YF; Tian, JY; Wang, GE; Wu, YP; Yao, N; Zhai, YJ1
Bao, J; Cao, YR; Gao, HF; Huang, B; Jin, Y1
Lee, O; Lee, SJ; Yu, SM1
Chen, W; Hu, D; Ke, H; Li, Y; Su, H; Xie, L; Zheng, X1
Huang, B; Lin, S; Lin, Z; Wang, G; Xie, Z; Yang, B; Zhong, D; Zhou, H; Zhu, S1
Jung, DY; Jung, MH; Kim, JH; Nagappan, A1
Arantes Ferreira Peres, W; Cansanção, K; Carvalho Leite, N; Dávalos, A; Silva Monteiro, L; Tavares do Carmo, MDG1
Borlak, J; Breher-Esch, S; Sahini, N; Trincone, A; Wallstab, C1
Chen, S; Cheng, J; Cheng, Z; Deng, L; Liang, B; Liu, Y; Tang, X; Wang, Z; Wen, Y; Xin, H1
Kocarek, TA; Pant, A; Rondini, EA1
Xie, M; Xue, J; Zhao, X1
Berger, E; Géloën, A1
Chi, G; Feng, H; Han, L; Li, Z; Shen, B; Tian, Y; Wang, Y; Wu, L; Zhang, Q1
Fan, JG; Yang, RX1
Chen, Y; Han, F; Liao, L; Liu, Y1
Choi, JG; Choi, YJ; Choo, M; Chung, SJ; Jeong, YS; Jin, X; Koo, HR; Lee, BH; Lee, W; Oh, MS; Park, S1
Brown, MV; Cheatham, B; Compton, SA; Lawton, KA; Milburn, MV1
Abdirad, A; Ahmadian, S; Ghaffari, SM; Hassanzadeh, G; Khaghani, S; Nowrouzi, A; Vardasbi, S; Ziamajidi, N1
Chang, CJ; Hung, HC; Lu, FH; Ou, HY; Su, YC; Wu, CL; Wu, HT; Wu, JS; Yang, YC1
Huang, HP; Liao, CC; Ou, TT; Wang, CJ1
Jiang, Z; Kang, YJ; Lv, ZL; Wang, C; Wang, PL; Xiang, TX1
Alisi, A; Ceccarelli, S; Crudele, A; De Stefanis, C; Gaspari, S; Gnani, D; Locatelli, F; Marquez, VE; Nobili, V; Rota, R; Vella, S1
Anthérieu, S; Claude, N; de la Moureyre-Spire, C; Guillouzo, A; Rogue, A; Umbdenstock, T; Vluggens, A; Weaver, RJ1
Holm, C; Jones, HA; Motlagh, MK; Stenkula, KG; Winberg, ME1
Chen, YX; Fang, JQ; Qian, H; Sheng, X; Shi, J; Song, CY; Wang, Y; Zeng, X; Zhang, Y; Zheng, JM1
Chen, XF; Gu, LY; Lü, L; Mei, ZC; Qiu, LW1
Chen, D; Jia, L; Lin, M; Liu, Y; Meng, Q; Shi, Y; Xie, F; Yin, J1
Hammer, RE; Horton, JD; Mitsche, MA; Moon, YA; Ochoa, CR1
An, W; Xie, P; Zhan, Y; Zhang, L; Zhao, F; Zhu, C1
Wu, Y; Ye, Q; Zhang, L; Zhao, Y; Zheng, Q1
Cawthorne, M; Di Marzo, V; Guadagnino, I; Martella, A; Melck, D; Motta, A; Paris, D; Silvestri, C1
Claudel, T; Einarsson, C; Fauler, G; Hoesel, B; Jha, P; Koefeler, H; Lackner, C; Marschall, HU; Mueller, M; Stojakovic, T; Thorell, A; Trauner, M1
Grenert, JP; Maher, JJ; Pickens, MK; Pierce, AA; Siao, K1
Cho, SM; Kim, JS; Kim, SH; Lee, HJ; Lee, MS; Lee, SO1
Buechler, C; Eisinger, K; Krautbauer, S; Meier, EM; Pohl, R; Rein-Fischboeck, L; Weiss, TS1
Almeida, B; Baixeras, E; de la Torre, R; Decara, JM; Gavito, AL; Joglar, J; Pavón, FJ; Rivera, P; Rodríguez de Fonseca, F; Romero-Cuevas, M; Serrano, A; Suárez, J; Vázquez, M1
Dou, QL; Wang, Z; Wei, YY; Yan, D1
Červinková, Z; Kučera, O; Lotková, H; Mezera, V; Moravcová, A; Rychtrmoc, D1
Damiano, F; Gnoni, A; Rochira, A; Siculella, L; Testini, M; Tocci, R1
Kiyono, S; Kondo, T; Maruyama, H; Sekimoto, T; Yokosuka, O1
Chen, F; Chen, L; Li, C; Lin, K; Wang, J; Xu, Q; Zhou, X; Zhu, H; Zhu, M1
Di Mauro, S; Di Pino, A; Ferro, A; Filippello, A; Piro, S; Pulvirenti, A; Purrello, F; Purrello, M; Rabuazzo, AM; Ragusa, M; Scamporrino, A; Urbano, F1
An, S; Kim, B; Kim, JS; Kim, SH; Lee, SH; Park, CS; Woo, MJ1
Ai, DM; Cao, ZY; Pan, HP; Wang, L; Wang, Z; Zhang, N1
Chen, X; Guo, H; Jiang, X; Li, Y; Ling, W; Shen, T; Tang, X; Yu, C; Zheng, Y1
Chen, SH; Li, WP; Li, YM; Liu, J1
De Gottardi, A; Hadengue, A; Ravier-Dall'Antonia, F; Spahr, L1
Canesi, L; Cioffi, F; De Matteis, R; Fugassa, E; Gallo, G; Goglia, F; Grasselli, E; Vergani, L; Voci, A1
Ji, B; Li, M; Liu, Y; Lv, Y; Mao, T; Tang, M; Wang, D; Wei, Y; Wu, W; Zhang, D; Zhou, F1
Chavez-Tapia, NC; Rosso, N; Tiribelli, C1
Aransay, AM; Aspichueta, P; Banasik, K; Buque, X; Caballeria, J; Castro, A; Clement, K; Echevarria-Uraga, JJ; Garcia-Monzon, C; Garcia-Rodriguez, JL; Gonzalez-Lahera, A; Gual, P; Hansen, T; Joergensen, T; Justesen, JM; Lauritzen, T; Le Marchand-Brustel, Y; Lozano, JJ; Martin-Duce, A; Martinez-Arranz, I; Martinez-Chantar, ML; Mato, JM; Mendibil, I; Pedersen, O; Regueiro, MM; Rodriguez-Ezpeleta, N; Schlangen, KA; Tordjman, J; Tran, A; Vazquez-Chantada, M; Veyrie, N; Witte, DR1

Trials

2 trial(s) available for oleic acid and Fatty Liver, Nonalcoholic

ArticleYear
Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis.
    Lipids in health and disease, 2019, Oct-21, Volume: 18, Issue:1

    Topics: Adult; Animals; Autophagy; Carnitine O-Palmitoyltransferase; Case-Control Studies; Ceramides; Diet, High-Fat; Dyslipidemias; Fatty Acid-Binding Proteins; Fatty Acids, Monounsaturated; Female; Gene Expression Regulation; Hep G2 Cells; Hepatitis B, Chronic; Humans; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidoreductases; Palmitic Acid; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction

2019
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity.
    Journal of hepatology, 2015, Volume: 62, Issue:6

    Topics: Bile Acids and Salts; Humans; Intra-Abdominal Fat; Lipid Metabolism; Liver; Non-alcoholic Fatty Liver Disease; Obesity, Morbid; Oleic Acid; Receptors, Cytoplasmic and Nuclear; Stearoyl-CoA Desaturase; Ursodeoxycholic Acid

2015

Other Studies

119 other study(ies) available for oleic acid and Fatty Liver, Nonalcoholic

ArticleYear
Regulatory mechanisms of energy metabolism and inflammation in oleic acid-treated HepG2 cells from Lactobacillus acidophilus NX2-6 extract.
    Journal of food biochemistry, 2021, Volume: 45, Issue:10

    Topics: Endoplasmic Reticulum Chaperone BiP; Energy Metabolism; Hep G2 Cells; Humans; Inflammation; Lactobacillus acidophilus; Non-alcoholic Fatty Liver Disease; Oleic Acid; Probiotics

2021
[KLF9 regulates hepatic lipid metabolism via inducing CD36 expression].
    Sheng li xue bao : [Acta physiologica Sinica], 2021, Oct-25, Volume: 73, Issue:5

    Topics: Animals; CD36 Antigens; Diet, High-Fat; Kruppel-Like Transcription Factors; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oleic Acid

2021
Intracellular Exposure Dose-Associated Susceptibility of Steatotic Hepatocytes to Metallic Nanoparticles.
    International journal of molecular sciences, 2021, Nov-23, Volume: 22, Issue:23

    Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Lipid Metabolism; Metal Nanoparticles; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Particle Size; Reactive Oxygen Species; Silver; Titanium; Zirconium

2021
Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation.
    Life sciences, 2022, May-01, Volume: 296

    Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Enzyme Activation; Hep G2 Cells; Hesperidin; Humans; Lipid Metabolism; Lipids; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphorylation

2022
Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro.
    Scientific reports, 2022, 03-09, Volume: 12, Issue:1

    Topics: Animals; Diet, High-Fat; Diet, Western; Glycosides; Hep G2 Cells; Humans; Kaempferols; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Messenger

2022
Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids.
    International journal of molecular sciences, 2022, Mar-20, Volume: 23, Issue:6

    Topics: Fatty Acids; Fatty Acids, Nonesterified; Hepatocytes; Humans; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Proteome

2022
Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways.
    Journal of ethnopharmacology, 2022, Jun-28, Volume: 292

    Topics: AMP-Activated Protein Kinases; Dilleniaceae; Hep G2 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Lipid Metabolism; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Polyphenols; PPAR alpha; Reactive Oxygen Species; Signal Transduction; Sirtuins

2022
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
    Cells, 2022, 03-22, Volume: 11, Issue:7

    Topics: AMP-Activated Protein Kinases; Autophagy; Chloroquine; Ficusin; Humans; Insulin Resistance; Lipid Metabolism; Non-alcoholic Fatty Liver Disease; Oleic Acid

2022
Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.
    Journal of hepatology, 2022, Volume: 77, Issue:3

    Topics: Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Endopeptidase Clp; Fructose; Liver; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; Peptide Hydrolases

2022
DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation.
    Biochemical and biophysical research communications, 2022, 07-05, Volume: 612

    Topics: Animals; Carcinoma, Hepatocellular; DEAD-box RNA Helicases; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Lipogenesis; Liver; Liver Neoplasms; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid

2022
Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes.
    The Journal of nutritional biochemistry, 2022, Volume: 107

    Topics: Animals; Diet, High-Fat; Fructose; Hepatocytes; Liver; Mice; Mice, Inbred C57BL; Necroptosis; Non-alcoholic Fatty Liver Disease; Oleic Acid; Reactive Oxygen Species

2022
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
    Laboratory investigation; a journal of technical methods and pathology, 2022, Volume: 102, Issue:10

    Topics: Animals; Diet, High-Fat; Hepatocytes; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphatidate Phosphatase; Sterol Regulatory Element Binding Protein 1; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases

2022
Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway.
    Journal of food and drug analysis, 2021, 06-15, Volume: 29, Issue:2

    Topics: Apigenin; Autophagy; Fatty Acids; Humans; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha

2021
LncNONMMUG027912 alleviates lipid accumulation through AMPKα/mTOR/SREBP1C axis in nonalcoholic fatty liver.
    Biochemical and biophysical research communications, 2022, 08-27, Volume: 618

    Topics: AMP-Activated Protein Kinases; Animals; Lipid Metabolism; Liver; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Long Noncoding; Signal Transduction; Sterol Regulatory Element Binding Protein 1; TOR Serine-Threonine Kinases

2022
Andrographolide ameliorates hepatic steatosis by suppressing FATP2-mediated fatty acid uptake in mice with nonalcoholic fatty liver disease.
    Journal of natural medicines, 2023, Volume: 77, Issue:1

    Topics: Animals; Coenzyme A Ligases; Diet, High-Fat; Fatty Acids; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid

2023
Mapping Proteome and Lipidome Changes in Early-Onset Non-Alcoholic Fatty Liver Disease Using Hepatic 3D Spheroids.
    Cells, 2022, 10-13, Volume: 11, Issue:20

    Topics: Adenosine Triphosphate; Cadherins; Ceramides; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Lipidomics; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Proteome; Transforming Growth Factor beta; Triglycerides

2022
Red Pepper Seeds Inhibit Hepatic Lipid Accumulation by Inducing Autophagy via AMPK Activation.
    Nutrients, 2022, Oct-12, Volume: 14, Issue:20

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Capsicum; Diet, High-Fat; Fatty Liver; Glucose; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Seeds; TOR Serine-Threonine Kinases

2022
CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease.
    Lipids in health and disease, 2022, Nov-29, Volume: 21, Issue:1

    Topics: Animals; In Situ Hybridization, Fluorescence; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Sirtuin 1; Triglycerides

2022
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
    DNA and cell biology, 2022, Volume: 41, Issue:12

    Topics: Autophagy; Autophagy-Related Protein 5; Caspases; Hepatocytes; Humans; Non-alcoholic Fatty Liver Disease; Oleic Acid; Pyroptosis

2022
Protamine-derived peptide RPR (Arg-Pro-Arg) ameliorates oleic acid-induced lipogenesis via the PepT1 pathway in HepG2 cells.
    Bioscience, biotechnology, and biochemistry, 2023, Jan-24, Volume: 87, Issue:2

    Topics: Hep G2 Cells; Humans; Lipogenesis; Non-alcoholic Fatty Liver Disease; Oleic Acid; Peptide Transporter 1; Peptides; Proline; Protamines

2023
Beneficial effects of Lactobacillus rhamnosus hsryfm 1301 fermented milk on rats with nonalcoholic fatty liver disease.
    Journal of dairy science, 2023, Volume: 106, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; D-Aspartic Acid; Diet, High-Fat; Fatty Acids, Nonesterified; Glutamic Acid; Glycerides; Glycine; Lacticaseibacillus rhamnosus; Liver; Milk; Non-alcoholic Fatty Liver Disease; Oleic Acid; Rats; Reactive Oxygen Species; Rodent Diseases; Thymine

2023
Exercise activates Sirt1-mediated Drp1 acetylation and inhibits hepatocyte apoptosis to improve nonalcoholic fatty liver disease.
    Lipids in health and disease, 2023, Mar-07, Volume: 22, Issue:1

    Topics: Acetylation; Animals; Apoptosis; Dynamins; Hep G2 Cells; Hepatocytes; Humans; Non-alcoholic Fatty Liver Disease; Oleic Acid; Physical Conditioning, Animal; Rats; Sirtuin 1

2023
A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice.
    Free radical biology & medicine, 2023, Volume: 203

    Topics: AMP-Activated Protein Kinases; Animals; Cricetinae; Diet, High-Fat; Emodin; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Liver; Mice; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Oleic Acid

2023
Dihydrotrichodimerol Purified from the Marine Fungus
    Journal of natural products, 2023, 05-26, Volume: 86, Issue:5

    Topics: Animals; Lipid Metabolism; Liver; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha

2023
Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota.
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dysbiosis; Ferroptosis; Gastrointestinal Microbiome; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid

2023
Oleic acid improves hepatic lipotoxicity injury by alleviating autophagy dysfunction.
    Experimental cell research, 2023, Aug-15, Volume: 429, Issue:2

    Topics: Animals; Autophagy; Diet, High-Fat; Endoplasmic Reticulum Stress; Hepatocytes; Humans; Liver; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; Olive Oil; Palmitic Acid

2023
Hepatic Krüppel-like factor 14 regulates lipid metabolism in nonalcoholic steatohepatitis mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:8

    Topics: Animals; Kruppel-Like Transcription Factors; Lipid Metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha

2023
Tetrahydropalmatine ameliorates hepatic steatosis in nonalcoholic fatty liver disease by switching lipid metabolism via AMPK-SREBP-1c-Sirt1 signaling axis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 119

    Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Lipid Metabolism; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Oleic Acid; Sirtuin 1; Sterol Regulatory Element Binding Protein 1

2023
The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet.
    Molecules (Basel, Switzerland), 2023, Sep-20, Volume: 28, Issue:18

    Topics: Animals; CD36 Antigens; Diet, High-Fat; Disease Models, Animal; Fatty Acids, Nonesterified; Hepatocytes; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid

2023
(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis.
    International journal of molecular sciences, 2023, Sep-23, Volume: 24, Issue:19

    Topics: Energy Metabolism; Hepatocytes; Humans; Liver; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Palmitic Acid; Thioctic Acid

2023
Erchen decoction alleviates the progression of NAFLD by inhibiting lipid accumulation and iron overload through Caveolin-1 signaling.
    Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 3

    Topics: Animals; Caveolin 1; Diet, High-Fat; Iron; Iron Overload; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid

2024
Comparison of effects of HucMSCs, exosomes, and conditioned medium on NASH.
    Scientific reports, 2023, 10-27, Volume: 13, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Choline; Collagen; Culture Media, Conditioned; Exosomes; Humans; Liver; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; TOR Serine-Threonine Kinases

2023
Administration of Linoleoylethanolamide Reduced Weight Gain, Dyslipidemia, and Inflammation Associated with High-Fat-Diet-Induced Obesity.
    Nutrients, 2023, Oct-20, Volume: 15, Issue:20

    Topics: Animals; Cholesterol; Diet, High-Fat; Dyslipidemias; Humans; Inflammation; Liver; Male; Non-alcoholic Fatty Liver Disease; Obesity; Oleic Acid; Rats; Rats, Sprague-Dawley; Triglycerides; Weight Gain

2023
Chlorogenic Acid from Burdock Roots Ameliorates Oleic Acid-Induced Steatosis in HepG2 Cells through AMPK/ACC/CPT-1 Pathway.
    Molecules (Basel, Switzerland), 2023, Oct-25, Volume: 28, Issue:21

    Topics: AMP-Activated Protein Kinases; Arctium; Chlorogenic Acid; Fatty Acids; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid

2023
The Peptide AWRK6 Alleviates Lipid Accumulation in Hepatocytes by Inhibiting miR-5100 Targeting G6PC.
    International journal of molecular sciences, 2023, Nov-09, Volume: 24, Issue:22

    Topics: Animals; Hepatocytes; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Peptides; RNA, Messenger

2023
[Effect of calcium-independent phospholipase A2 on the expression of glycerol 3-phosphate dehydrogenase in human non-alcoholic fatty liver disease cells].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023, Oct-20, Volume: 31, Issue:10

    Topics: Glycerolphosphate Dehydrogenase; Humans; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phospholipases A2; Phospholipases A2, Calcium-Independent; Reactive Oxygen Species; RNA, Messenger; Triglycerides

2023
Alpha-naphthoflavone attenuates non-alcoholic fatty liver disease in oleic acid-treated HepG2 hepatocytes and in high fat diet-fed mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Animals; Benzoflavones; Catalase; Cell Proliferation; Diet, High-Fat; Glycogen; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Lipid Droplets; Lipid Metabolism; Liver; Male; Malondialdehyde; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Superoxide Dismutase

2019
MicroRNA-205 ameliorates lipid accumulation in non-alcoholic fatty liver disease through targeting NEU1.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:22

    Topics: Animals; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Hep G2 Cells; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Neuraminidase; Non-alcoholic Fatty Liver Disease; Oleic Acid

2019
Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:2

    Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Disease Models, Animal; Gene Silencing; HEK293 Cells; Hepatocytes; Humans; Lipid Metabolism; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Long Noncoding; Signal Transduction; Triglycerides; Up-Regulation

2020
Baicalein reduces hepatic fat accumulation by activating AMPK in oleic acid-induced HepG2 cells and high-fat diet-induced non-insulin-resistant mice.
    Food & function, 2020, Jan-29, Volume: 11, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diet, High-Fat; Flavanones; Hep G2 Cells; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred Strains; Non-alcoholic Fatty Liver Disease; Oleic Acid; Sterol Regulatory Element Binding Protein 1

2020
Addition of fish oil to atherogenic high fat diet inhibited atherogenesis while olive oil did not, in LDL receptor KO mice.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2020, 04-12, Volume: 30, Issue:4

    Topics: Animals; Atherosclerosis; Biomarkers; Chemokine CCL2; Cholesterol; Diet, High-Fat; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Female; Interleukin-6; Liver; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oleic Acid; Olive Oil; Plaque, Atherosclerotic; Receptors, LDL; Time Factors

2020
The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Feb-06, Volume: 26

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cholesterol; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; Hep G2 Cells; Humans; Insulin Resistance; Interleukin-6; Liver; Liver Neoplasms; Male; Malondialdehyde; Mice, Inbred ICR; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; rhoA GTP-Binding Protein; Signal Transduction; Superoxide Dismutase; Thiazoles; Triglycerides; Tumor Necrosis Factor-alpha; Urea

2020
MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1.
    Biochemical and biophysical research communications, 2020, 04-09, Volume: 524, Issue:3

    Topics: Animals; Base Sequence; Fatty Acid Synthases; Hepatocytes; Lipogenesis; Liver; Mice, Inbred C57BL; Mice, Obese; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Messenger; Stearoyl-CoA Desaturase

2020
Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1.
    Journal of agricultural and food chemistry, 2020, Apr-08, Volume: 68, Issue:14

    Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Body Weight; Diet, High-Fat; Gene Expression Regulation; Ginsenosides; Insulin Resistance; Lipid Metabolism; Lipogenesis; Liver; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Palmitic Acid; Sirtuin 1

2020
S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway.
    Food & function, 2020, Jun-24, Volume: 11, Issue:6

    Topics: AMP-Activated Protein Kinases; Cell Survival; Down-Regulation; Forkhead Box Protein O1; Hep G2 Cells; Humans; Lipid Accumulation Product; Lipogenesis; Lipolysis; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphorylation; Sesquiterpenes; Signal Transduction; Stearoyl-CoA Desaturase; Sterol Regulatory Element Binding Protein 1; Triglycerides; Up-Regulation

2020
Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation.
    Nutrients, 2020, Jun-18, Volume: 12, Issue:6

    Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Chlorogenic Acid; Choline; Coffee; Dietary Supplements; Disease Models, Animal; Docosahexaenoic Acids; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Silybum marianum; Tanacetum parthenium

2020
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
    Journal of agricultural and food chemistry, 2020, Oct-07, Volume: 68, Issue:40

    Topics: AMP-Activated Protein Kinases; Animals; Chickens; Citrates; Hepatocytes; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species

2020
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma.
    International journal of biological sciences, 2020, Volume: 16, Issue:15

    Topics: Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-alpha; Chromosomal Proteins, Non-Histone; Extracellular Matrix Proteins; Humans; Hyaluronan Receptors; Liver Neoplasms; Mice; Mice, Nude; Non-alcoholic Fatty Liver Disease; Oleic Acid; Ubiquitin-Conjugating Enzymes

2020
Amelioration by
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Acetates; Antioxidants; Biomarkers; Cell Survival; Cytokines; Flavonoids; Gene Expression Regulation; Hep G2 Cells; Humans; Inflammation Mediators; Lipid Metabolism; Lipogenesis; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phenols; Plant Extracts; RNA, Messenger; Salicaceae; Triglycerides

2020
Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling.
    Aging, 2020, 11-18, Volume: 12, Issue:23

    Topics: Apoptosis; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Liver; Membrane Potential, Mitochondrial; MicroRNAs; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Phospholipid Hydroperoxide Glutathione Peroxidase; Reactive Oxygen Species; RNA, Circular; Signal Transduction

2020
Fatty Acids and a High-Fat Diet Induce Epithelial-Mesenchymal Transition by Activating TGFβ and β-Catenin in Liver Cells.
    International journal of molecular sciences, 2021, Jan-28, Volume: 22, Issue:3

    Topics: Animals; beta Catenin; Cadherins; Cell Line, Tumor; Diet, High-Fat; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibronectins; Gene Expression Regulation; Hepatocytes; Humans; Interleukin-1; Liver; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Ribonucleases; Signal Transduction; Transforming Growth Factor beta; Vimentin; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1

2021
A network pharmacology approach: Inhibition of the NF-κB signaling pathway contributes to the NASH preventative effect of an Oroxylum indicum seed extract in oleic acid-stimulated HepG2 cells and high-fat diet-fed rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Jul-15, Volume: 88

    Topics: Animals; Bignoniaceae; Diet, High-Fat; Flavanones; Flavonoids; Hep G2 Cells; Humans; Lipid Metabolism; Liver Cirrhosis; Male; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Protein Interaction Maps; Rats, Sprague-Dawley; Seeds; Signal Transduction

2021
Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
    International journal of molecular sciences, 2021, Feb-20, Volume: 22, Issue:4

    Topics: Adipose Tissue; Animals; Cells, Cultured; Fatty Acids; Humans; Inflammation; Lipid Metabolism; Liver; Macrophages; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phenotype; U937 Cells; Weight Gain

2021
Hesperetin ameliorates hepatic oxidative stress and inflammation
    Food & function, 2021, May-11, Volume: 12, Issue:9

    Topics: Animals; Antioxidant Response Elements; Diet, High-Fat; Hep G2 Cells; Hepatocytes; Hesperidin; Humans; Interleukin-6; Lipid Metabolism; Liver; Liver Cirrhosis; Male; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha

2021
Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway.
    European journal of pharmacology, 2021, Sep-15, Volume: 907

    Topics: AMP-Activated Protein Kinases; Animals; Benzhydryl Compounds; Diet, High-Fat; Glucosides; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid

2021
Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:9

    Topics: Diet; Hep G2 Cells; Humans; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; Polyphenols; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Uncoupling Protein 2

2017
Antihyperlipidemic and hepatoprotective effects of Gardenin A in cellular and high fat diet fed rodent models.
    Chemico-biological interactions, 2017, May-01, Volume: 269

    Topics: Animals; Cell Survival; Diet, High-Fat; Flavones; Gardenia; Hep G2 Cells; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipids; Liver; Male; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Polyethylene Glycols; Protective Agents; Rats; Rats, Wistar

2017
Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway.
    Lipids in health and disease, 2017, Apr-27, Volume: 16, Issue:1

    Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Carbazoles; Cell Line; Cytokines; Diet, High-Fat; Enzyme Inhibitors; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease; Oleic Acid; Piperidines; Resveratrol; Signal Transduction; Sirtuin 1; Sterol Regulatory Element Binding Protein 1; Stilbenes

2017
Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E).
    The Journal of nutritional biochemistry, 2017, Volume: 47

    Topics: alpha-Tocopherol; Animals; Cytochrome P450 Family 4; Diet, Carbohydrate Loading; Diet, High-Fat; Diet, Western; Fatty Acids, Nonesterified; Fructose; Gene Expression Regulation; Hep G2 Cells; Humans; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; PPAR gamma; Sterol Regulatory Element Binding Protein 1

2017
Anti-steatosis compounds from leaves of Mallotus furetianus.
    Natural product research, 2018, Volume: 32, Issue:12

    Topics: Gallic Acid; Glucosides; Hep G2 Cells; Humans; Hydrolyzable Tannins; Mallotus Plant; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Leaves

2018
The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:12

    Topics: Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Palmitic Acid; Resveratrol; Stilbenes

2017
MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1.
    Scientific reports, 2017, 11-03, Volume: 7, Issue:1

    Topics: Animals; Cells, Cultured; Diet, High-Fat; fas Receptor; Genetic Therapy; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Mice, Inbred C57BL; Mice, Obese; MicroRNAs; Non-alcoholic Fatty Liver Disease; Obesity; Oleic Acid; Primary Cell Culture; Stearoyl-CoA Desaturase; Triglycerides

2017
A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Cholesterol; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Down-Regulation; Eriobotrya; Fatty Acids, Nonesterified; Glycosides; Hep G2 Cells; Humans; Malondialdehyde; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Plant Extracts; Plant Leaves; Sesquiterpenes; Superoxide Dismutase; Triglycerides

2018
Schisandra chinensis berry extract protects against steatosis by inhibiting histone acetylation in oleic acid-treated HepG2 cells and in the livers of diet-induced obese mice.
    Nutrition research (New York, N.Y.), 2017, Volume: 46

    Topics: Acetylation; Animals; Diet, Western; Dietary Supplements; Fatty Acids, Nonesterified; Freeze Drying; Fruit; Hep G2 Cells; Hepatocytes; Histones; Humans; Hypolipidemic Agents; Lipid Metabolism; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Oleic Acid; Organ Size; Plant Extracts; Protein Processing, Post-Translational; Schisandra

2017
Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease.
    Cell death & disease, 2018, 01-24, Volume: 9, Issue:2

    Topics: Apoptosis; Autophagy; bcl-2-Associated X Protein; Chromones; Cytoprotection; Down-Regulation; Endoplasmic Reticulum; Hep G2 Cells; Hepatocytes; Humans; Liver; Membrane Proteins; Mitophagy; Morpholines; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Suppressor Protein p53

2018
Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype.
    Annals of hepatology, 2018, Mar-01, Volume: 17, Issue:2

    Topics: Acetyl-CoA C-Acetyltransferase; Agaricales; Cell Line, Tumor; Cynara scolymus; Flowers; Genotype; Hepatocytes; Humans; Lipase; Lipogenesis; Lipolysis; Membrane Proteins; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phenotype; Plant Extracts; PPAR alpha; PPAR gamma; Quercetin; Sterol Regulatory Element Binding Protein 1

2018
Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways.
    Nutrition research (New York, N.Y.), 2018, Volume: 52

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Arctium; Carnitine O-Palmitoyltransferase; Fatty Liver; Furans; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukins; Lignans; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Sterol Regulatory Element Binding Protein 1

2018
Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis.
    Life sciences, 2018, Jun-15, Volume: 203

    Topics: Animals; Animals, Newborn; Apoptosis; Cell Proliferation; Cells, Cultured; Diet, High-Fat; Fatty Acids; Hep G2 Cells; Hepatocytes; Humans; Male; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley

2018
Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism.
    Metabolism: clinical and experimental, 2018, Volume: 85

    Topics: Animals; Apolipoproteins E; Carnitine; Diet, High-Fat; Energy Metabolism; Male; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Protective Agents; Signal Transduction; Uric Acid

2018
Cytochrome P450 1A1 (CYP1A1) Catalyzes Lipid Peroxidation of Oleic Acid-Induced HepG2 Cells.
    Biochemistry. Biokhimiia, 2018, Volume: 83, Issue:5

    Topics: Biocatalysis; Cytochrome P-450 CYP1A1; Hep G2 Cells; Humans; Lipid Peroxidation; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Small Interfering

2018
Determination of an Optimized Weighting Factor of Liver Parenchyma for Six-point Interference Dixon Fat Percentage Imaging Accuracy in Nonalcoholic Fatty Liver Disease Rat Model.
    Academic radiology, 2018, Volume: 25, Issue:12

    Topics: Adipose Tissue; Animals; Disease Models, Animal; Linoleic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phantoms, Imaging; Rats; Rats, Sprague-Dawley; Soybean Oil

2018
Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state.
    Free radical biology & medicine, 2018, Volume: 126

    Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biflavonoids; Catechin; Diet, High-Fat; Fatty Acids, Nonesterified; Fatty Liver; Hep G2 Cells; Hepatocytes; Humans; Lipogenesis; Liver; Lysosomes; Metabolic Networks and Pathways; Mice; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidation-Reduction; Oxidative Stress; Proanthocyanidins

2018
Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 49, Issue:3

    Topics: Animals; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Fibroblast Growth Factors; Fragile X Mental Retardation Protein; Hep G2 Cells; Hepatocytes; Humans; Lipid Droplets; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Oleic Acid; Proteoglycans; Receptors, Cytoplasmic and Nuclear; Reishi; Signal Transduction

2018
Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARγ2.
    Scientific reports, 2018, 09-13, Volume: 8, Issue:1

    Topics: Animals; Diet, High-Fat; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Liver; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acids; PPAR gamma; Triglycerides

2018
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
    Nutrients, 2018, Oct-29, Volume: 10, Issue:11

    Topics: Acetyltransferases; Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Delta-5 Fatty Acid Desaturase; Diet Records; Dietary Fats; Elasticity Imaging Techniques; Erythrocytes; Fatty Acid Desaturases; Fatty Acid Elongases; Fatty Acids, Monounsaturated; Female; Humans; Insulin; Liver; Liver Cirrhosis; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Stearic Acids

2018
Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease.
    BMC medical genomics, 2018, Dec-14, Volume: 11, Issue:1

    Topics: Carnitine O-Palmitoyltransferase; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Genomics; Hep G2 Cells; Hepatocytes; Humans; Lipid Droplets; Membrane Glycoproteins; Microscopy, Fluorescence; Mitochondria; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidoreductases Acting on Sulfur Group Donors; Palmitic Acid; Perilipin-2; Qb-SNARE Proteins; Qc-SNARE Proteins; Tumor Necrosis Factor-alpha; Vesicle-Associated Membrane Protein 3

2018
Gene expression profile-based drug screen identifies SAHA as a novel treatment for NAFLD.
    Molecular omics, 2019, 02-11, Volume: 15, Issue:1

    Topics: Diacylglycerol O-Acyltransferase; Drug Evaluation, Preclinical; Gene Expression Profiling; Hep G2 Cells; Hepatocytes; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Lipid Metabolism; Lipids; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Messenger; Vorinostat

2019
Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells.
    Toxicology and applied pharmacology, 2019, 02-15, Volume: 365

    Topics: Cell Line, Tumor; Constitutive Androstane Receptor; Farnesol; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidation-Reduction; PPAR alpha; Receptors, Cytoplasmic and Nuclear; Triglycerides

2019
Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes.
    Experimental gerontology, 2019, Volume: 119

    Topics: Animals; Coumarins; Cytokines; Gene Silencing; Hepatocytes; Inflammation Mediators; Lipid Metabolism; Lipopolysaccharides; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha; Rats; Signal Transduction

2019
Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function.
    Nutrients, 2019, Mar-03, Volume: 11, Issue:3

    Topics: Carnitine O-Palmitoyltransferase; Fatty Liver; Hep G2 Cells; Humans; Lipid Metabolism; Lipogenesis; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidation-Reduction; Polyphenols; Protective Agents

2019
Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier.
    Adipocyte, 2019, Volume: 8, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Caco-2 Cells; Cell Differentiation; Coculture Techniques; Fatty Acid-Binding Proteins; Hepatocytes; HT29 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Lipids; Lipogenesis; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; Protein Transport; Triglycerides

2019
Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.
    Journal of cellular physiology, 2019, Volume: 234, Issue:11

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinase Kinases; Animals; Flavonoids; Hep G2 Cells; Hepatocytes; Humans; Hyperlipidemias; Inflammation; Lipid Metabolism; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphorylation; Polyethylene Glycols; PPAR alpha; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Triglycerides

2019
Nitro-oleic acid as a new drug candidate for non-alcoholic steatohepatitis.
    EBioMedicine, 2019, Volume: 42

    Topics: Animals; Fibrosis; Hep G2 Cells; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid

2019
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells.
    Molecular medicine reports, 2019, Volume: 19, Issue:6

    Topics: AMP-Activated Protein Kinases; Cell Survival; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Lipase; Lipid Metabolism; Membrane Proteins; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sterol Regulatory Element Binding Protein 1; Triglycerides; Umbelliferones

2019
Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo.
    Planta medica, 2019, Volume: 85, Issue:9-10

    Topics: 4-Butyrolactone; Angelica; Animals; Diet, High-Fat; Drug Evaluation, Preclinical; Gene Expression Regulation; Hep G2 Cells; Humans; Lipid Metabolism; Lipogenesis; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phthalic Anhydrides; Plant Components, Aerial; Plant Extracts; Sterol Regulatory Element Binding Protein 1

2019
Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression.
    Obesity (Silver Spring, Md.), 2013, Volume: 21, Issue:12

    Topics: Bile Acids and Salts; Diglycerides; Disease Progression; Fatty Liver; HEK293 Cells; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Liver; Metabolome; Mitochondria; Monoglycerides; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Palmitic Acid; Phosphorylation; Reactive Oxygen Species

2013
Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 58

    Topics: Animals; Chromatography, High Pressure Liquid; Cichorium intybus; Diabetes Complications; Fatty Liver; Hep G2 Cells; Humans; Male; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; PPAR alpha; Rats; Rats, Wistar; Seeds; Sterol Regulatory Element Binding Protein 1

2013
The role of hepassocin in the development of non-alcoholic fatty liver disease.
    Journal of hepatology, 2013, Volume: 59, Issue:5

    Topics: Aged; Animals; Case-Control Studies; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Female; Fibrinogen; Gene Deletion; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Middle Aged; Neoplasm Proteins; Non-alcoholic Fatty Liver Disease; Oleic Acid

2013
The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase.
    Journal of the science of food and agriculture, 2014, Volume: 94, Issue:6

    Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Caffeic Acids; Cholesterol; Diet; Dietary Fats; Fatty Acid Synthesis Inhibitors; Fatty Liver; Gene Expression; Hep G2 Cells; Humans; Hypolipidemic Agents; Lipogenesis; Lipolysis; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphorylation; Plant Extracts; Sterol Regulatory Element Binding Protein 1; Triglycerides; Up-Regulation

2014
Aquaporin-9 downregulation prevents steatosis in oleic acid-induced non-alcoholic fatty liver disease cell models.
    International journal of molecular medicine, 2013, Volume: 32, Issue:5

    Topics: Aquaporins; Cell Line; Fatty Acids, Nonesterified; Fatty Liver; Glycerol; Humans; Non-alcoholic Fatty Liver Disease; Oleic Acid; Triglycerides

2013
EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD.
    International journal of molecular sciences, 2013, Dec-12, Volume: 14, Issue:12

    Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Fatty Liver; Hep G2 Cells; Histones; Humans; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Polycomb Repressive Complex 2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2013
PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells.
    Toxicology and applied pharmacology, 2014, Apr-01, Volume: 276, Issue:1

    Topics: Cell Line; Constitutive Androstane Receptor; Drug Evaluation, Preclinical; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Glycine; Humans; Lipid Metabolism; Lipogenesis; Lipotropic Agents; Liver; Liver X Receptors; Non-alcoholic Fatty Liver Disease; Oleic Acid; Orphan Nuclear Receptors; Oxazoles; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Receptors, Cytoplasmic and Nuclear; Triglycerides

2014
Adiponutrin: a multimeric plasma protein.
    Biochemical and biophysical research communications, 2014, Apr-18, Volume: 446, Issue:4

    Topics: Adult; Fatty Liver; Female; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Male; Membrane Proteins; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Protein Multimerization

2014
Sophocarpine attenuates toll-like receptor 4 in steatotic hepatocytes to suppress pro-inflammatory cytokines synthesis.
    Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:2

    Topics: Alkaloids; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression; Hepatocytes; Inflammation Mediators; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleic Acid; Polymerase Chain Reaction; Rats, Sprague-Dawley; Signal Transduction; Sophora; Toll-Like Receptor 4; Up-Regulation

2015
Oleic acid-induced hepatic steatosis is coupled with downregulation of aquaporin 3 and upregulation of aquaporin 9 via activation of p38 signaling.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2015, Volume: 47, Issue:4

    Topics: Aquaporin 3; Aquaporins; Down-Regulation; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; MAP Kinase Signaling System; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Messenger; Triglycerides; Up-Regulation

2015
ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease.
    Journal of cellular and molecular medicine, 2015, Volume: 19, Issue:1

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Survival; Cytoprotection; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Male; Mice, Inbred BALB C; Non-alcoholic Fatty Liver Disease; Oleic Acid; Triglycerides; Tumor Suppressor Proteins

2015
Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.
    Journal of lipid research, 2014, Volume: 55, Issue:12

    Topics: Acetyltransferases; Animals; Chimera; Clone Cells; Crosses, Genetic; Diabetes Mellitus, Experimental; Diet, Fat-Restricted; Diet, High-Fat; Dietary Carbohydrates; Embryonic Stem Cells; Fatty Acid Elongases; Gene Knockout Techniques; Insulin Resistance; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Non-alcoholic Fatty Liver Disease; Obesity; Oleic Acid; Oleic Acids

2014
Mechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterol.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:10

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cholesterol; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Signal Transduction

2014
[Study of synergistic effect of free fatty acid and iron on the establishment of nonalcoholic fatty liver disease model].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2014, Volume: 48, Issue:10

    Topics: Carnitine O-Palmitoyltransferase; Coenzyme A Ligases; Fatty Acid Synthase, Type I; Fatty Acids; Fatty Acids, Nonesterified; Hep G2 Cells; Humans; Iron; Non-alcoholic Fatty Liver Disease; Oleic Acid; RNA, Messenger; Triglycerides

2014
Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis.
    Journal of hepatology, 2015, Volume: 62, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cannabidiol; Cannabinoids; Cell Line; Dronabinol; Hepatocytes; Humans; Lipid Metabolism; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Oleic Acid; Receptor, Cannabinoid, CB1; Triglycerides; TRPV Cation Channels; Zebrafish

2015
Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.
    BMC gastroenterology, 2015, Jun-24, Volume: 15

    Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Dietary Carbohydrates; Disease Models, Animal; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Sucrose

2015
Fermented Rhus verniciflua Stokes Extract Exerts an Antihepatic Lipogenic Effect in Oleic-Acid-Induced HepG2 Cells via Upregulation of AMP-Activated Protein Kinase.
    Journal of agricultural and food chemistry, 2015, Aug-19, Volume: 63, Issue:32

    Topics: AMP-Activated Protein Kinases; Fermentation; Hep G2 Cells; Humans; Lipogenesis; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Rhus; Saccharomyces; Sterol Regulatory Element Binding Protein 1; Triglycerides

2015
Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease.
    Biochemical and biophysical research communications, 2015, Nov-13, Volume: 467, Issue:2

    Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Animals; Chemokines; Cytokines; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; GPI-Linked Proteins; Hepatocytes; Humans; Intercellular Signaling Peptides and Proteins; Lectins; Leptin; Lipopolysaccharides; Lipoproteins, HDL; Liver; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Primary Cell Culture; Scavenger Receptors, Class B; Signal Transduction; Transforming Growth Factor beta

2015
Treatment with a novel oleic-acid-dihydroxyamphetamine conjugation ameliorates non-alcoholic fatty liver disease in obese Zucker rats.
    Disease models & mechanisms, 2015, Oct-01, Volume: 8, Issue:10

    Topics: Adiposity; Animals; Body Weight; Deoxyepinephrine; Ether-A-Go-Go Potassium Channels; Feeding Behavior; Genotype; Lipid Metabolism; Liver; Male; Non-alcoholic Fatty Liver Disease; Obesity; Oleic Acid; PPAR alpha; Rats, Zucker; Receptor, Cannabinoid, CB1; RNA, Messenger; Transcription Factors

2015
Establishment of a hepatocyte steatosis model using Chang liver cells.
    Genetics and molecular research : GMR, 2015, Nov-26, Volume: 14, Issue:4

    Topics: Cell Line; Fatty Liver; Hepatocytes; Humans; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; Triglycerides

2015
The effect of oleic and palmitic acid on induction of steatosis and cytotoxicity on rat hepatocytes in primary culture.
    Physiological research, 2015, Volume: 64, Issue:Suppl 5

    Topics: Albumins; Animals; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hepatocytes; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Necrosis; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Primary Cell Culture; Rats, Wistar; Reactive Oxygen Species; Triglycerides

2015
Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5'-UTR in a cellular model of hepatic steatosis.
    Biochimica et biophysica acta, 2016, Volume: 1861, Issue:5

    Topics: 5' Untranslated Regions; Binding Sites; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Internal Ribosome Entry Sites; Lipogenesis; Liver; Non-alcoholic Fatty Liver Disease; Oleic Acid; p38 Mitogen-Activated Protein Kinases; Palmitic Acid; Protein Transport; RNA Interference; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection

2016
Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease.
    International journal of medical sciences, 2016, Volume: 13, Issue:3

    Topics: Animals; Cell Line; Disease Models, Animal; Gene Expression Regulation; Lipid Metabolism; Liver; Male; Mice, Inbred Strains; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Triglycerides; Up-Regulation

2016
Protective role of magnesium isoglycyrrhizinate in non-alcoholic fatty liver disease and the associated molecular mechanisms.
    International journal of molecular medicine, 2016, Volume: 38, Issue:1

    Topics: Apoptosis; Cell Line; Cell Survival; Fibroblast Growth Factor 2; Humans; Interleukin-6; Lipid Droplets; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oleic Acid; Protective Agents; RNA, Messenger; Saponins; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Unfolded Protein Response

2016
Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: Clinical implications.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016, Volume: 26, Issue:12

    Topics: CD36 Antigens; Cell Survival; Ceramides; Coenzyme A Ligases; Computational Biology; Diglycerides; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genetic Markers; Hep G2 Cells; Hepatocytes; Humans; Insulin Receptor Substrate Proteins; Liver; MicroRNAs; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oligonucleotide Array Sequence Analysis; Palmitic Acid; Phosphorylation; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors

2016
Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model.
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Carnitine O-Palmitoyltransferase; Disease Models, Animal; Humans; Hyperlipidemias; Lipid Metabolism; Lipoproteins, LDL; Liver; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; PPAR alpha; Rhamnaceae; Seeds

2017
Decreased MiR-155 Level in the Peripheral Blood of Non-Alcoholic Fatty Liver Disease Patients may Serve as a Biomarker and may Influence LXR Activity.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 39, Issue:6

    Topics: Animals; Base Sequence; Biomarkers; Case-Control Studies; Cell Line; Diet, High-Fat; Female; Gene Silencing; Humans; Lipogenesis; Liver X Receptors; Male; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitic Acid; Up-Regulation

2016
Interleukin-17A exacerbates high-fat diet-induced hepatic steatosis by inhibiting fatty acid β-oxidation.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:6

    Topics: Animals; Dietary Fats; Interleukin-17; Liver; Male; MAP Kinase Kinase 4; Mice; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidation-Reduction; PPAR alpha; Signal Transduction; Triglycerides

2017
[An in vitro hepatic steatosis cell model for study of non-alcoholic fatty liver disease].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2009, Volume: 38, Issue:6

    Topics: Culture Media; Fatty Acids, Nonesterified; Fatty Liver; Hep G2 Cells; Humans; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates

2009
Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.
    Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:10

    Topics: Apolipoproteins B; Arachidonic Acids; Biological Transport; Blotting, Western; Cannabinoids; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; Fatty Acid Synthase, Type I; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Non-alcoholic Fatty Liver Disease; Oleic Acid; Phosphatidylcholine-Sterol O-Acyltransferase; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Sterol Regulatory Element Binding Protein 1; Triglycerides; Up-Regulation

2010
Direct effects of iodothyronines on excess fat storage in rat hepatocytes.
    Journal of hepatology, 2011, Volume: 54, Issue:6

    Topics: Acyl-CoA Oxidase; Animals; Catalase; Cells, Cultured; Diiodothyronines; Fatty Liver; Gene Expression; Hepatocytes; Lipid Metabolism; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; PPAR alpha; PPAR delta; PPAR gamma; Rats; RNA, Messenger; Superoxide Dismutase; Triiodothyronine

2011
Inhibitory effect of blueberry polyphenolic compounds on oleic acid-induced hepatic steatosis in vitro.
    Journal of agricultural and food chemistry, 2011, Nov-23, Volume: 59, Issue:22

    Topics: Blueberry Plants; Fatty Liver; Hep G2 Cells; Humans; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Plant Extracts; Polyphenols; Protective Agents; Triglycerides

2011
Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease.
    BMC gastroenterology, 2012, Mar-01, Volume: 12

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Humans; In Vitro Techniques; Lipid Metabolism; Liver Neoplasms; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Palmitic Acid; Reactive Oxygen Species

2012
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 2; Fatty Liver; Female; Gene Frequency; Gene Silencing; Genetic Predisposition to Disease; Glucose Transporter Type 1; Humans; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Polymorphism, Single Nucleotide; Transcriptome

2013