Page last updated: 2024-08-21

oleanolic acid and Obesity

oleanolic acid has been researched along with Obesity in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (15.63)	29.6817
2010's	20 (62.50)	24.3611
2020's	7 (21.88)	2.80

Authors

Authors	Studies
Hong, D; Hu, LH; Li, J; Li, JY; Shen, Q; Shi, L; Zhang, W; Zhang, YN	1
Chen, Y; Li, H; Qian, S; Wu, Y; Yang, S; Zhang, W	1
Bu, Y; Chen, H; Chen, Q; Cheng, H; Feng, G; Kong, G; Lu, Z; Meng, M; Shi, T; Tian, Y; Yao, X	1
Chang, YH; Hung, HY	1
Choi, CI; Han, HK; Lee, HS; Lim, SH	1
Khan, MI; Khan, MZ; Kim, JD; Kim, MY; Lee, YB; Shin, JH; Shin, TS	1
Claro-Cala, CM; Jiménez-Altayó, F; Rodriguez-Rodriguez, R; Zagmutt, S	1
Claro-Cala, CM; de Sotomayor, MA; Herrera, MD; Miñano, J; Pérez-Montero, M; Quintela, JC; Rodríguez-Rodríguez, AR	1
Akasaka, T; Jiang, Z; Katakura, Y; Nakamura, Y; Sato, M; Shirouchi, B; Tanaka, Y; Tsai, WT; Yuan, X	1
Kim, J; Lee, H; Mikami, T; Park, J; Suidasari, S; Yaicharoen, P; Yamauchi, K; Yokozawa, M	1
Chen, FF; Deng, SL; Tang, L; Wang, JT; Wang, K; Wang, YX; Wu, HS; Xing, SF; Zhang, JQ; Zhang, LX	1
Batista-Lima, FJ; Carvalho, KMMB; Chaves, MH; da Cruz Fonseca, SG; de Brito, TS; de Carvalho Almeida da Silva, AA; Magalhães, PJC; Nunes, PIG; Rao, VS; Santos, FA; Viana, AFSC	1
Kim, BM	1
Cao, M; Cheng, X; Fan, J; Hai, C; Hao, Y; Li, G; Li, S; Long, Z; Peng, J; Su, H; Su, S; Wang, X; Wu, G; Xu, Z	1
Belarbi, M; Benammar, C; Djeziri, FZ; Hichami, A; Khan, NA; Murtaza, B	1
Hwang, IH; Lee, MW; Seo, CS; Song, KH; Yin, J	1
Appel, GB; Block, GA; Chertow, GM; Chin, MP; Coyne, DW; Goldsberry, A; Kalantar-Zadeh, K; Meyer, CJ; Molitch, ME; Pergola, PE; Raskin, P; Rossing, P; Silva, AL; Spinowitz, B; Sprague, SM	1
Araújo, AJ; Barros Pereira, ED; Carvalho, AA; Chaves, MH; Costa Silva, RA; de Melo, KM; de Oliveira, FTB; Gomes Quinderé, AL; Marinho Filho, JDB; Rao, VS; Santos, FA	1
Cao, X; Ge, X; Li, Z; Lu, Y; Qin, W; Shen, P; Sun, H; Tang, Q; Wang, D; Yang, N; Zhang, W	1
Bumeister, R; Chin, M; Chuang, JC; Lee, CY; Meyer, C; Sonis, ST; Ward, KW; Wigley, WC	1
Liu, X; Lu, H; Wan, Q; Xiang, J; Yao, Z; Yie, S	1
Furusawa, Y; Higashi, C; Uruno, A; Yagishita, Y; Yamamoto, M	1
Camer, D; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y	3
Camer, D; Cheng, L; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y	1
Aida, K; Kinoshita, M; Naito, A; Ohnishi, M; Sasaki, G; Tokuji, Y; Yunoki, K	1
Aja, S; Dolan, PM; Kensler, TW; Liby, KT; Shin, S; Sporn, MB; Wakabayashi, J; Wakabayashi, N; Yamamoto, M; Yates, MS	1
Bizerra, AM; de Melo, CL; Fonseca, SG; Lemos, TL; Melo, TS; Queiroz, MG; Rao, VS; Santos, FA	1
Gong, JH; Han, SJ; Kang, SW; Kang, YH; Kim, JL; Lee, ES; Li, J; Sung, HY	1
Mitsuyoshi, H; Nakashima, T; Okanoue, T; Sumida, Y	1
Hasegawa, N; Mochizuki, M	1

Reviews

4 review(s) available for oleanolic acid and Obesity

Article	Year
Recent advances in natural anti-obesity compounds and derivatives based on in vivo evidence: A mini-review. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Animals; Anti-Obesity Agents; Drug Discovery; Obesity; Phytochemicals	2022
Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases. Nutrients, 2022, Apr-12, Volume: 14, Issue:8 Topics: Diet, Mediterranean; Humans; Metabolic Syndrome; Obesity; Oleanolic Acid; Olive Oil	2022
The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases. Oxidative medicine and cellular longevity, 2018, Volume: 2018 Topics: Apoptosis; Cardiovascular Diseases; Cell Cycle Checkpoints; Humans; Liver Diseases; Neoplasms; Neurodegenerative Diseases; Obesity; Oleanolic Acid; Oxidative Stress; Saponins	2018
[Treatment of nonalcoholic steatohepatitis (NASH)]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2004, Volume: 101, Issue:11 Topics: Cysteine; Diet; Drug Combinations; Fatty Liver; Glycine; Hepatitis; Humans; Insulin Resistance; Liver Transplantation; Obesity; Oleanolic Acid; Oxidative Stress; Ursodeoxycholic Acid; Vitamin E	2004

Trials

1 trial(s) available for oleanolic acid and Obesity

Article	Year
Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease. Journal of diabetes and its complications, 2018, Volume: 32, Issue:12 Topics: Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Oleanolic Acid; Renal Insufficiency, Chronic; Waist Circumference	2018

Article

Year

Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease.

Journal of diabetes and its complications, 2018, Volume: 32, Issue:12

Topics: Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Oleanolic Acid; Renal Insufficiency, Chronic; Waist Circumference

2018

Other Studies

27 other study(ies) available for oleanolic acid and Obesity

Article	Year
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities. Bioorganic & medicinal chemistry, 2008, Sep-15, Volume: 16, Issue:18 Topics: Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Insulin; Obesity; Oleanolic Acid; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, Insulin; Structure-Activity Relationship; T-Lymphocytes	2008
Synthesis and biological evaluation of oleanolic acid derivatives as inhibitors of protein tyrosine phosphatase 1B. Journal of natural products, 2010, Nov-29, Volume: 73, Issue:11 Topics: Diabetes Mellitus; Drugs, Chinese Herbal; Escherichia coli; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Obesity; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Structure-Activity Relationship	2010
A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Forsythia; Humans; Hypoglycemic Agents; Mice; Obesity; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 11	2011
Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes. International journal of molecular sciences, 2021, Oct-22, Volume: 22, Issue:21 Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipogenesis; Adiponectin; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Bupleurum; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Gene Expression; Lipogenesis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Oleanolic Acid; Phosphorylation; Plant Extracts; PPAR gamma; Saponins; Signal Transduction; Sterol Regulatory Element Binding Protein 1	2021
Pharmacological Approaches to Attenuate Inflammation and Obesity with Natural Products Formulations by Regulating the Associated Promoting Molecular Signaling Pathways. BioMed research international, 2021, Volume: 2021 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Angiogenesis Inhibitors; Animals; Biological Products; Disease Models, Animal; Diterpenes, Kaurane; Drug Compounding; Drug Synergism; Female; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipogenesis; Lipolysis; Mice; Mice, Inbred ICR; Obesity; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins; Signal Transduction; Stevia; Tea	2021
Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice. Nutrients, 2020, Jan-26, Volume: 12, Issue:2 Topics: Adiposity; Animals; Aorta, Thoracic; Biomarkers; Blood Glucose; Diet, High-Fat; Diet, Mediterranean; Disease Models, Animal; Disease Progression; Insulin Resistance; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Olive Oil; Triterpenes; Vasoconstriction; Vasodilation; Weight Gain	2020
Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high-fat diet-fed mice. Journal of food science, 2021, Volume: 86, Issue:5 Topics: 3T3-L1 Cells; Adipogenesis; Adipose Tissue; Animals; Anti-Obesity Agents; Cell Differentiation; Diet, High-Fat; Lipid Metabolism; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Saponins; Triglycerides	2021
Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice. Scientific reports, 2021, 06-14, Volume: 11, Issue:1 Topics: Animals; Cognitive Dysfunction; Depression; Diet, High-Fat; Disease Models, Animal; Exercise Tolerance; Humans; Iridoid Glucosides; Male; Mice; Mitochondria; Obesity; Olea; Oleanolic Acid; Oxidative Stress; Physical Conditioning, Animal; Plant Extracts; Plant Leaves; Receptors, G-Protein-Coupled	2021
Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells. British journal of pharmacology, 2017, Volume: 174, Issue:17 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Enteroendocrine Cells; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Lipid Metabolism; Liver; Male; Mice; Obesity; Oleanolic Acid; Pancreas; Protective Agents	2017
The triterpenoid alpha, beta-amyrin prevents the impaired aortic vascular reactivity in high-fat diet-induced obese mice. Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:10 Topics: Animals; Aorta, Thoracic; Body Weight; Diet, High-Fat; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mice; Obesity; Oleanolic Acid; Triterpenes; Vasoconstriction; Vasodilation	2017
Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling. Free radical biology & medicine, 2018, 08-20, Volume: 124 Topics: 3T3-L1 Cells; Adiposity; Animals; Antithyroid Agents; Cell Differentiation; Chlorodiphenyl (54% Chlorine); Diet, High-Fat; Gene Expression Regulation; Hepatocyte Nuclear Factor 1-beta; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Oxidation-Reduction; PPAR gamma; Signal Transduction	2018
Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice. Biochimie, 2018, Volume: 152 Topics: Adipose Tissue; Animals; Calcium; CD36 Antigens; Diet, High-Fat; Diet, Mediterranean; Female; Glucose Tolerance Test; Inflammation; Inflammation Mediators; Insulin; Interleukin-1beta; Interleukin-6; Lipogenesis; Lipopolysaccharides; Liver; Mice, Inbred C57BL; Obesity; Oleanolic Acid; RNA, Messenger; Taste Buds; Weight Gain	2018
Anti-Obesity Activities of Chikusetsusaponin IVa and Nutrients, 2018, Sep-03, Volume: 10, Issue:9 Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Dolichos; Fatty Acid Synthases; Fatty Acid-Binding Proteins; Functional Food; Mice; Obesity; Oleanolic Acid; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Saponins; Seeds	2018
α, β-Amyrin, a pentacyclic triterpenoid from Protium heptaphyllum suppresses adipocyte differentiation accompanied by down regulation of PPARγ and C/EBPα in 3T3-L1 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109 Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; Cell Survival; Down-Regulation; Fatty Acid-Binding Proteins; Glucose Transporter Type 4; Mice; Obesity; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; PPAR gamma	2019
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization. EBioMedicine, 2019, Volume: 45 Topics: Adipose Tissue; Animals; Cell Polarity; China; Diet, High-Fat; Disease Models, Animal; Humans; Inflammation; Macrophages; Male; Mice; Mice, Obese; Obesity; Oleanolic Acid; Pentacyclic Triterpenes; Signal Transduction	2019
Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity. American journal of physiology. Renal physiology, 2013, Jun-15, Volume: 304, Issue:12 Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Eating; Glucose; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oleanolic Acid; Rats; Rats, Zucker	2013
Study of oleanolic acid on the estrodiol production and the fat production of mouse preadipocyte 3T3-L1 in vitro. Human cell, 2015, Volume: 28, Issue:1 Topics: 3T3 Cells; Acetyl-CoA Carboxylase; Adipocytes; Animals; Down-Regulation; Estrogens; Female; Humans; Lipids; Menopause; Mice; Obesity; Oleanolic Acid; Steroid Hydroxylases; Up-Regulation	2015
Nrf2 induces fibroblast growth factor 21 in diabetic mice. Genes to cells : devoted to molecular & cellular mechanisms, 2014, Volume: 19, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Gene Knockdown Techniques; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Metabolism; Liver; Mice; Mice, Knockout; NF-E2-Related Factor 2; Obesity; Oleanolic Acid	2014
Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet. Chemico-biological interactions, 2015, Mar-05, Volume: 229 Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Diet, High-Fat; Inflammation; Intra-Abdominal Fat; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Oxidative Stress; Tumor Necrosis Factor-alpha	2015
Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet. Molecular and cellular endocrinology, 2015, Sep-05, Volume: 412 Topics: Animals; Cell Movement; Diet, High-Fat; Fatty Liver; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Macrophages; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid	2015
Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice. TheScientificWorldJournal, 2015, Volume: 2015 Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Diet, High-Fat; Energy Metabolism; Extracellular Signal-Regulated MAP Kinases; Inflammation; Intra-Abdominal Fat; Ion Channels; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Oleanolic Acid; Oxidative Stress; PPAR gamma; Proto-Oncogene Proteins c-akt; Uncoupling Protein 2	2015
Bardoxolone methyl prevents obesity and hypothalamic dysfunction. Chemico-biological interactions, 2016, Aug-25, Volume: 256 Topics: Animals; Anti-Obesity Agents; Body Weight; Diet, High-Fat; Energy Intake; Energy Metabolism; Hypothalamus; Inflammation; Leptin; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Signal Transduction	2016
Effect of dietary wine pomace extract and oleanolic acid on plasma lipids in rats fed high-fat diet and its DNA microarray analysis. Journal of agricultural and food chemistry, 2008, Dec-24, Volume: 56, Issue:24 Topics: Animals; Fats; Gene Expression; Gene Expression Profiling; Humans; Lipids; Liver; Male; Obesity; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Organ Size; Plant Extracts; Rats; Rats, Sprague-Dawley; Signal Transduction; Vitis	2008
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European journal of pharmacology, 2009, Oct-12, Volume: 620, Issue:1-3 Topics: Adipocytes; Animals; Anti-Obesity Agents; Body Weight; Dietary Fats; Energy Metabolism; Fatty Acids; Female; Gene Expression Regulation, Enzymologic; Imidazoles; Liver; Mice; NF-E2-Related Factor 2; Obesity; Oleanolic Acid; Oxidation-Reduction	2009
Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chemico-biological interactions, 2010, Apr-15, Volume: 185, Issue:1 Topics: Amylases; Animals; Blood Glucose; Body Weight; Drinking; Eating; Ghrelin; Glucose Tolerance Test; Intra-Abdominal Fat; Leptin; Lipase; Lipids; Male; Mice; Obesity; Oleanolic Acid; Phytotherapy; Sambucus	2010
Oleanolic acid reduces markers of differentiation in 3T3-L1 adipocytes. Nutrition research (New York, N.Y.), 2010, Volume: 30, Issue:12 Topics: 3T3-L1 Cells; Adipocytes; Anilides; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Blotting, Western; Cattle; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Dose-Response Relationship, Drug; Down-Regulation; Lipid Metabolism; Mice; Nicotinamide Phosphoribosyltransferase; Obesity; Oleanolic Acid; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Staining and Labeling	2010
Acceleration of lipid degradation by sericoside of Terminalia sericea roots in Fully differentiated 3T3-L1 cells. Phytotherapy research : PTR, 2006, Volume: 20, Issue:11 Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytosol; Dose-Response Relationship, Drug; Glucosides; Glycerol; Lipid Metabolism; Lipolysis; Mice; Obesity; Oleanolic Acid; Plant Roots; Terminalia; Time Factors; Triglycerides	2006