oleanolic acid has been researched along with Neoplasms in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (13.43) | 29.6817 |
| 2010's | 39 (58.21) | 24.3611 |
| 2020's | 19 (28.36) | 2.80 |
| Authors | Studies |
|---|---|
| Baba, K; Bastow, KF; Itokawa, H; Lee, KH; Morris-Natschke, SL; Nakagawa-Goto, K; Taniguchi, M; Tatsuzaki, J | 1 |
| Hamashima, Y; Hasegawa, J; Kajimoto, T; Node, M; Tanaka, R; Tokuda, H; Tsujii, H; Yamada, T | 1 |
| Abdelsamie, AS; Atta, MH; El Diwani, HI; Elhefnawi, MM; Galal, SA; Lida, A; Ramadan, RA; Suzuki, N; Tokuda, H | 1 |
| Ishikawa, M; Kanno, S; Nakazawa, T; Namikoshi, M; Sumilat, DA; Takahashi, O; Takahashi, S; Ukai, K; Yamazaki, H | 1 |
| Chau, VM; Do Thi, T; Doan Thi Mai, H; Litaudon, M; Nguyen, TT; Nguyen, VH; Pham, VC; Truong, BN | 1 |
| Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS | 1 |
| Borkova, L; Hodon, J; Kazakova, A; Pokorny, J; Urban, M | 1 |
| Ansari, MI; Coop, A; Johnson, CR; Kamil Hussain, M; Khatoon, S; Saquib, M | 1 |
| Daelemans, D; De Jonghe, S; Dehaen, W; Hu, H; Krasniqi, B; Li, Y; Luyten, W; Persoons, L; Wang, R | 1 |
| Chen, H; Gao, Y; Ke, L; Li, Z; Shi, H; Xie, H; Yang, Y; Zheng, Y; Zhu, F | 1 |
| Chen, H; Gao, Y; Li, Z; Shi, H; Yang, Y; Zheng, Y | 1 |
| Du, QY; Guo, J; He, XY; Shi, W; Wang, F; Zhou, P | 1 |
| Li, Y; Ma, XD; Tang, YT; Tang, ZY | 1 |
| Hu, R; Yin, X; Zhou, Y; Zhu, W | 1 |
| Chen, H; Du, K; Feng, W; Han, R; Li, M; Pan, R; Sun, Y; Wang, J; Xue, G; Zhao, C | 1 |
| Badalamenti, N; Bruno, M; Castiglione, D; Fontana, G; Labbozzetta, M; Notarbartolo, M; Poma, P; Spinella, A; Tutone, M | 1 |
| Ling, Y; Liu, GQ; Liu, Y; Meng, C; Qian, J; Ran, F; Wang, Y; Wu, H; Xu, Z; Yang, J; Zheng, H | 1 |
| Jiao, ZY; Xiao, LX; Zhou, HN | 1 |
| Özdemir, Z; Wimmer, Z | 1 |
| Chen, D; Chen, L; Gu, Z; He, B; Li, Y; Lin, S; Yan, W; Zeng, Z | 1 |
| Gidwani, B; Jain, V; Joshi, V; Namdeo, P; Pandey, RK; Shukla, SS; Tiwari, S; Vyas, A | 1 |
| Cordell, GA; Lim, YM; Ooi, KX; Poo, CL; Subramaniam, M | 1 |
| Abd-Alla, HI; Abourehab, MAS; Alsaggaf, AT; El-Beeh, ME; El-Mezayen, H; Fujita, M; Otsuka, M; Radwan, MO; Tateishi, H | 1 |
| Li, G; Muhseen, ZT | 1 |
| Guan, Q; Guo, Y; Li, Y; Lv, S; Shang, E; Shi, L; Sun, S; Xiao, H; Yu, X; Zhao, C | 1 |
| Avram, Ș; Coricovac, D; David, VL; Dehelean, C; Dumitrașcu, V; Macașoi, I; Mioc, A; Moacă, AE; Pavel, IZ; Șoica, C; Spandidos, DA; Tsatsakis, A | 1 |
| Csuk, R; Heise, N; Hoenke, S; Kazakova, O; Siewert, B; Ströhl, D | 1 |
| Han, SH; Jung, GH; Jung, JY; Jung, SH; Kim, SH; Lee, JH; Woo, JS; Yoo, ES | 1 |
| Kim, BM | 1 |
| Chaicharoenpong, C; Chunhakant, S | 1 |
| Gao, K; Lu, Y; Sun, X; Tang, H; Wang, X; Zhang, W | 1 |
| Hu, Y; Ma, G; Wang, S; Wei, H; Xu, X; Yang, J; Yu, S; Zhang, Y; Zhong, M | 1 |
| Lopez, C; Pertino, MW; Schmeda-Hirschmann, G; Theoduloz, C | 1 |
| Wang, YY; Zhao, R; Zhe, H | 1 |
| Lin, X; Liu, G; Liu, J; Wu, N; Zheng, L; Zhong, J | 1 |
| Albericio, F; Garcia-Granados, A; Lupiañez, JA; Martin-Fonseca, S; Martinez, A; Medina-O'Donnell, M; Parra, A; Reyes-Zurita, FJ; Rivas, F; Rufino-Palomares, EE | 1 |
| Lei, P; Men, X; Zhang, W | 1 |
| He, ZX; Wang, YY; Yang, YX; Zhe, H; Zhou, SF | 1 |
| Chu, F; Gong, Y; Gu, S; Lei, H; Li, G; Wang, M; Wang, P; Xu, B; Xu, K; Xu, X; Zhang, H; Zhang, Y | 1 |
| Bonacucina, G; Casettari, L; Cespi, M; Kwok, PC; Lam, JK; Leung, GP; Man, DK; Palmieri, GF; Sze, SC | 1 |
| Baumgartner, S; Estko, M; Heusser, P; Kunz, M; Regueiro, U; Urech, K; Weissenstein, U | 1 |
| Cao, M; Gribble, GW; Liby, KT; Onyango, EO; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Ferguson, DA; McCauley, L; Probst, BL; Trevino, I; Wigley, WC | 1 |
| Bartolomeo, R; Carnevale, G; Cormio, A; Cossarizza, A; De Biasi, S; De Pol, A; Gibellini, L; Musicco, C; Nasi, M; Pecorini, S; Pinti, M | 1 |
| Cai, X; Cao, P; Gao, SP; Hu, C; Lu, W; Qian, S; Sun, X; Yang, J; Yang, Y; Yu, Q | 1 |
| Chen, ZF; Cheng, KG; Huang, JY; Liu, J; Su, CH; Zheng, YT | 1 |
| Günther, G; Morales, J; Rodríguez, L; Valdés, K | 1 |
| Park, B; Park, JH; Yoon, J | 1 |
| Logashenko, EB; Markov, AV; Zenkova, MA | 1 |
| Bishayee, A; Farooqi, AA; Mocan, A; Nabavi, SF; Nabavi, SM; Šamec, D; Sureda, A; Žiberna, L | 1 |
| Kasai, R | 1 |
| Albini, A; Cammarota, R; Generoso, L; Lorusso, G; Noonan, DM; Sogno, I; Sporn, MB; Vannini, N | 1 |
| Bonesi, M; Conforti, F; Deguin, B; Loizzo, MR; Menichini, F; Tillequin, F; Tundis, R | 1 |
| Laszczyk, MN | 1 |
| Ashidi, JS; Efferth, T; Houghton, PJ; Hylands, PJ | 1 |
| Chalifa-Caspi, V; Feller, G; Kugel, A; Moonshine, D; Müller, KJ; Ofir, R; Prüfer, D; Rabinski, T; Scholz, M | 1 |
| Gao, LB; He, F; Lin, Y; Shi, F; Sun, H; Wang, Q; Wang, X; Yang, L; Zheng, XL; Zhong, YJ | 1 |
| Bau, DT; Chang, YH; Chen, YC; Kuo, CL; Lee, HZ; Tsai, RY | 1 |
| Cuddy, M; Kondaiah, P; Matsuzawa, S; Ogasawara, S; Rao, GS; Ravanan, P; Reed, JC; Sano, R; Singh, SK; Talwar, P | 1 |
| Barboni, L; Bramucci, M; Lupidi, G; Nguelefack, TB; Ponou, BK; Quassinti, L; Ricciutelli, M; Tapondjou, LA; Teponno, RB | 1 |
| Cao, L; Chen, A; Collins, J; Doroshow, JH; Gutierrez, ME; Kummar, S; Murgo, AJ; Parker, RJ; Speranza, G; Strong, JM; Yu, Y | 1 |
| Andreeff, M; Dezube, BJ; Eder, JP; Ferguson, DA; He, X; Hong, DS; Konoplev, S; Konopleva, M; Kufe, D; Kurzrock, R; Lawrence, D; Lazarus, H; Meyer, CJ; Mier, J; Naing, A; Shapiro, GI; Supko, JG; Wheler, J | 1 |
| Jaiswal, V; Lan, SS; Lee, HB; Sharma, M; Tailor, NK | 1 |
| Gribble, GW; Honda, T; Honda, Y; Leesnitzer, LM; Place, AE; Risingsong, R; Rosen, E; Sporn, MB; Stimmel, JB; Suh, N; Williams, CR; Willson, TM | 1 |
| Liby, KT; Sporn, MB; Yore, MM | 1 |
| Albini, A; Barberis, M; Cammarota, R; Lorusso, G; Noonan, DM; Sporn, MB; Vannini, N | 1 |
| Andreeff, M; Ansell, SM; Elsawa, SF; Grote, D; Konopleva, M; Novak, AJ; Witzig, TE | 1 |
22 review(s) available for oleanolic acid and Neoplasms
| Article | Year |
|---|---|
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2017 |
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferation; Drug Design; Humans; Neoplasms; Triterpenes; Viruses | 2019 |
Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.
Topics: Antineoplastic Agents; Cell Proliferation; DNA Ligase ATP; Enzyme Inhibitors; Humans; Neoplasms; Structure-Activity Relationship | 2019 |
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bupleurum; Cell Differentiation; Humans; Neoplasms; Oleanolic Acid; Saponins | 2021 |
Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Proliferation; Humans; Neoplasms; Oleanolic Acid; Signal Transduction | 2022 |
Present and Future Prospects of the Anti-cancer Activities of Saikosaponins.
Topics: Drugs, Chinese Herbal; Humans; Neoplasms; Oleanolic Acid; Saponins | 2022 |
Selected plant triterpenoids and their amide derivatives in cancer treatment: A review.
Topics: Amides; Humans; Neoplasms; Oleanolic Acid; Plants, Medicinal; Triterpenes | 2022 |
Enhanced Water Solubility and Anti-Tumor Activity of Oleanolic Acid through Chemical Structure Modification.
Topics: Humans; Neoplasms; Oleanolic Acid; Solubility; Triterpenes; Water | 2022 |
Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review.
Topics: Animals; Drug Compounding; Neoplasms; Oleanolic Acid; Solubility; Triterpenes; Ursolic Acid | 2023 |
Maslinic acid exerts anticancer effects by targeting cancer hallmarks.
Topics: Antineoplastic Agents; Humans; Neoplasms; Oleanolic Acid; Triterpenes | 2023 |
Gypsogenin Battling for a Front Position in the Pentacyclic Triterpenes
Topics: Humans; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Prospective Studies; Saponins; Triterpenes | 2023 |
The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases.
Topics: Apoptosis; Cardiovascular Diseases; Cell Cycle Checkpoints; Humans; Liver Diseases; Neoplasms; Neurodegenerative Diseases; Obesity; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment.
Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Oleanolic Acid | 2014 |
Review on anti-tumor effect of triterpene acid compounds.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Humans; Neoplasms; Oleanolic Acid; Triterpenes; Ursolic Acid | 2014 |
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.
Topics: Animals; Humans; Hypertension, Pulmonary; Inflammation; Neoplasms; Oleanolic Acid; Renal Insufficiency, Chronic | 2014 |
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Biological Availability; Drug Delivery Systems; Drug Liberation; Humans; Nanocapsules; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Triterpenes; Unilamellar Liposomes; Ursolic Acid; Water | 2016 |
Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives.
Topics: Antineoplastic Agents; Apoptosis; Humans; Neoplasms; NF-kappa B; Oleanolic Acid; Signal Transduction; Transforming Growth Factor beta; Triterpenes | 2017 |
Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy.
Topics: Animals; Antineoplastic Agents; Diet, Healthy; Humans; Neoplasms; Oleanolic Acid; Signal Transduction | 2017 |
[Studies on the constituents of cucurbitaceous plants].
Topics: Animals; Cell Division; Cucurbitaceae; Dammaranes; Dose-Response Relationship, Drug; Ecdysteroids; Glycosides; Humans; Micelles; Molecular Conformation; Neoplasms; Neovascularization, Physiologic; Oleanolic Acid; Solubility; Structure-Activity Relationship; Taste; Triterpenes; Tumor Cells, Cultured | 2008 |
Anti-angiogenic activity of a novel class of chemopreventive compounds: oleanic acid terpenoids.
Topics: Angiogenesis Inhibitors; Humans; Neoplasms; Neovascularization, Pathologic; Oleanolic Acid | 2009 |
Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.
Topics: Antineoplastic Agents, Phytogenic; Humans; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Triterpenes | 2009 |
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents; Dose-Response Relationship, Drug; Humans; Mice; Neoplasms; Oleanolic Acid; Retinoid X Receptors | 2007 |
2 trial(s) available for oleanolic acid and Neoplasms
| Article | Year |
|---|---|
Phase I study of the synthetic triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), in advanced solid tumors.
Topics: Anorexia; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Immunoblotting; Infusions, Intravenous; Jurkat Cells; Male; Metabolic Clearance Rate; Middle Aged; Mucositis; Nausea; Neoplasms; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Thromboembolism; Treatment Outcome; Vomiting | 2012 |
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Colorectal Neoplasms; Cyclin D1; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Janus Kinases; Kidney Neoplasms; Lymphoma; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Neoplasms; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; RNA, Messenger; STAT Transcription Factors; Thyroid Neoplasms; Young Adult | 2012 |
43 other study(ies) available for oleanolic acid and Neoplasms
| Article | Year |
|---|---|
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Topics: Antineoplastic Agents; Cytotoxins; Drug Screening Assays, Antitumor; Glycyrrhetinic Acid; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Styrenes; Tumor Cells, Cultured | 2007 |
Hybrids of 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Antioxidants; Cell Line; Drug Screening Assays, Antitumor; Female; Herpesvirus 4, Human; HIV Reverse Transcriptase; HIV-1; Humans; Mice; Mice, Inbred ICR; Neoplasms; Pyrones; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2010 |
Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives.
Topics: Animals; Antigens, Viral; Antineoplastic Agents; Binding Sites; Drug Design; Female; Hydrogen Bonding; Mice; Models, Molecular; Neoplasms; Protein Conformation; Proto-Oncogene Proteins c-kit; Quinoxalines; Reproducibility of Results | 2011 |
Absolute structures and bioactivities of euryspongins and eurydiene obtained from the marine sponge Euryspongia sp. collected at Iriomote Island.
Topics: Animals; Biological Products; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; Humans; Models, Molecular; Neoplasms; Porifera; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Sesquiterpenes | 2015 |
Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dammaranes; Drug Screening Assays, Antitumor; Humans; Neoplasms; Plant Leaves; Triterpenes; Viburnum | 2017 |
Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Proliferation; HL-60 Cells; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triterpenes | 2021 |
Convenient Tuning of the Elasticity of Self-Assembled Nano-Sized Triterpenoids to Regulate Their Biological Activities.
Topics: Animals; Antineoplastic Agents; Elastic Modulus; Endocytosis; Female; Mice; Mice, Inbred BALB C; Molecular Dynamics Simulation; Nanogels; Nanoparticles; Neoplasms; NIH 3T3 Cells; Oleanolic Acid; Tumor Microenvironment | 2021 |
A nanosensitizer self-assembled from oleanolic acid and chlorin e6 for synergistic chemo/sono-photodynamic cancer therapy.
Topics: Animals; Cell Line, Tumor; Chlorophyllides; Humans; Mice; Nanoparticles; Neoplasms; Oleanolic Acid; Photochemotherapy; Photosensitizing Agents; Porphyrins | 2021 |
Cytotoxic 13,28 Epoxy Bridged Oleanane-Type Triterpenoid Saponins from the Roots of
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Epoxy Compounds; Humans; Neoplasms; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Triterpenes; Tumor Cells, Cultured | 2022 |
Cytotoxic Polyhydroxylated Oleanane Triterpenoids from
Topics: Animals; Antineoplastic Agents, Phytogenic; Cissampelos; Cytotoxins; Humans; MCF-7 Cells; Mice; Neoplasms; Oleanolic Acid; RAW 264.7 Cells | 2022 |
Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway.
Topics: Cell Line; Humans; Leukemia; Neoplasms; NF-kappa B; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes | 2022 |
Redox-Activatable Theranostic Co-Prodrug for Precise Tumor Diagnosis and Selective Combination Chemotherapy.
Topics: Animals; Cell Line, Tumor; Drug Therapy, Combination; Glutathione; Mice; Nanoparticles; Neoplasms; Oleanolic Acid; Oxidation-Reduction; Precision Medicine; Prodrugs; Reactive Oxygen Species; Theranostic Nanomedicine | 2022 |
Promising Terpenes as Natural Antagonists of Cancer: An In-Silico Approach.
Topics: Computer Simulation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Molecular Dynamics Simulation; Neoplasms; Oleanolic Acid; Principal Component Analysis; Proto-Oncogene Proteins c-mdm2; Structure-Activity Relationship; Terpenes; Triterpenes; Up-Regulation | 2019 |
Hyaluronic acid-coated nanostructured lipid carriers for loading multiple traditional Chinese medicine components for liver cancer treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Carriers; Drug Liberation; Female; Ginsenosides; Hyaluronic Acid; Lipids; Mice; Nanostructures; Neoplasms; Oleanolic Acid; Particle Size; Static Electricity; Tissue Distribution; Triterpenes; Ursolic Acid | 2020 |
Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Mitochondria; Neoplasms; Neovascularization, Pathologic; Oleanolic Acid; Rhodamines; Tumor Microenvironment | 2020 |
A simple but unusual rearrangement of an oleanane to a taraxerane-28,14 β -olide.
Topics: Antineoplastic Agents; Cell Proliferation; Humans; Molecular Structure; Neoplasms; Oleanolic Acid; Triterpenes; Tumor Cells, Cultured | 2021 |
Anticancer effects of oleanolic acid on human melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Kidney; Liver; Mice, Inbred BALB C; Neoplasms; NF-kappa B p50 Subunit; Oleanolic Acid; Signal Transduction; Xenograft Model Antitumor Assays | 2021 |
Antityrosinase, Antioxidant, and Cytotoxic Activities of Phytochemical Constituents from
Topics: Antioxidants; Arbutin; Cell Line, Tumor; Cell Proliferation; Flavonoids; Humans; Hydroxybenzoates; Manilkara; Monophenol Monooxygenase; Neoplasms; Oleanolic Acid; Phytochemicals; Pyrones; Stigmasterol | 2019 |
Oleanane-type saponins from Anemone taipaiensis and their cytotoxic activities.
Topics: Anemone; Antineoplastic Agents, Phytogenic; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Rhizome; Saponins | 2013 |
Triterpene saponins from Tabellae Clinopodii.
Topics: Antineoplastic Agents, Phytogenic; HeLa Cells; Humans; Lamiaceae; MCF-7 Cells; Molecular Structure; Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Saponins | 2013 |
1,2,3-triazole-substituted oleanolic Acid derivatives: synthesis and antiproliferative activity.
Topics: Cell Proliferation; Drug Screening Assays, Antitumor; Fibroblasts; HL-60 Cells; Humans; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triazoles | 2013 |
Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways.
Topics: Autophagy; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; MCF-7 Cells; Neoplasms; Oleanolic Acid; Time Factors; TOR Serine-Threonine Kinases | 2014 |
Solid-phase library synthesis of bi-functional derivatives of oleanolic and maslinic acids and their cytotoxicity on three cancer cell lines.
Topics: Acylation; Antineoplastic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Humans; Neoplasms; Oleanolic Acid; Solid-Phase Synthesis Techniques; Triterpenes | 2014 |
Amino acid derivatives of ligustrazine-oleanolic acid as new cytotoxic agents.
Topics: Antineoplastic Agents; Apoptosis; Cytotoxins; HeLa Cells; Hep G2 Cells; Humans; Neoplasms; Oleanolic Acid; Pyrazines; Structure-Activity Relationship; Vasodilator Agents | 2014 |
Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells.
Topics: Apoptosis; Cell Line; Drug Carriers; Hep G2 Cells; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Nanoparticles; Neoplasms; Oleanolic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2015 |
Tumour cell derived effects on monocyte/macrophage polarization and function and modulatory potential of Viscum album lipophilic extract in vitro.
Topics: Biomarkers; Cell Differentiation; Cell Line, Tumor; Chemokine CCL2; Cytokines; Flow Cytometry; Humans; Interleukin-13; Interleukin-4; Macrophage Colony-Stimulating Factor; Macrophages; Monocytes; Neoplasms; Oleanolic Acid; Phenotype; Plant Extracts; Viscum album | 2015 |
Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Female; Heme Oxygenase-1; Humans; Imidazoles; Mice; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Nitric Oxide Synthase Type II; Oleanolic Acid; Oxidative Stress; RNA, Messenger; U937 Cells | 2015 |
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; MCF-7 Cells; Mice; Neoplasms; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2015 |
Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.
Topics: Aconitate Hydratase; Antineoplastic Agents; Apoptosis; ATP-Dependent Proteases; Cell Death; Cell Proliferation; DNA-Binding Proteins; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydrogen Peroxide; MCF-7 Cells; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Neoplasms; Oleanolic Acid; Oxidative Stress; Protease Inhibitors; Protein Carbonylation; Signal Transduction; Superoxides; Time Factors; Transcription Factors; Transfection | 2015 |
Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell Apoptosis.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Interleukin-6; MCF-7 Cells; Neoplasms; Oleanolic Acid; Receptors, Interleukin-6; Saponins; Signal Transduction; STAT3 Transcription Factor; TNF-Related Apoptosis-Inducing Ligand | 2016 |
Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Membrane Potential, Mitochondrial; Neoplasms; Oleanolic Acid; Uridine | 2016 |
Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Endothelial Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Magnoliopsida; MCF-7 Cells; Neoplasms; Neovascularization, Pathologic; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Real-Time Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Vascular Endothelial Growth Factor A | 2016 |
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apiaceae; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Macrophages; Mice; Neoplasms; Nitric Oxide; Oleanolic Acid; Plant Roots; Saponins; Triterpenes | 2009 |
Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves.
Topics: Cajanus; Cell Line, Tumor; Data Collection; Ethnobotany; Ethnopharmacology; Flavanones; Humans; Male; Neoplasms; Nigeria; Oleanolic Acid; Plant Leaves; Plants; Plants, Medicinal; Sitosterols | 2010 |
African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Black People; Cell Line, Tumor; Growth Inhibitors; Humans; Lymphocyte Activation; Mice; Neoplasms; Nigella; Oleanolic Acid; Pharmacogenetics; Phytotherapy; Plant Extracts; Polymorphism, Single Nucleotide; Saponins; Seeds; White People | 2010 |
Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Separation; Cisplatin; Flow Cytometry; Humans; Neoplasms; Oleanolic Acid; Reactive Oxygen Species; Saponins | 2010 |
Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Contamination; Hedyotis; Humans; Neoplasms; Oleanolic Acid; Phenotype; Phytotherapy; Plant Extracts; Quality Control; Species Specificity; Triterpenes; Ursolic Acid | 2011 |
Synthetic triterpenoid cyano enone of methyl boswellate activates intrinsic, extrinsic, and endoplasmic reticulum stress cell death pathways in tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Death; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Enzyme Activation; Humans; Neoplasms; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Triterpenes | 2011 |
Novel 3-oxo- and 3,24-dinor-2,4-secooleanane-type triterpenes from Terminalia ivorensis A. Chev.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neoplasms; Oleanolic Acid; Terminalia; Triterpenes | 2011 |
Synthesis, selective cancer cytotoxicity and mechanistic studies of novel analogs of lantadenes.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chlorocebus aethiops; Humans; Molecular Docking Simulation; Neoplasms; NF-kappa B; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Signal Transduction; Vero Cells | 2013 |
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; CD11b Antigen; CD36 Antigens; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Separation; Cholecalciferol; Dose-Response Relationship, Drug; Female; Fibroblasts; Flow Cytometry; Humans; Imidazoles; Inflammation; Inhibitory Concentration 50; Mice; Models, Chemical; Monocytes; Neoplasms; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oleanolic Acid; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcription Factors; Transcriptional Activation; U937 Cells | 2003 |
The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent.
Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cells, Cultured; Collagen; Drug Combinations; Humans; Laminin; Mice; Neoplasms; Oleanolic Acid; Proteoglycans; Sarcoma, Kaposi | 2007 |
CDDO-imidazolide mediated inhibition of malignant cell growth in Waldenström macroglobulinemia.
Topics: Actins; Apoptosis; B-Lymphocytes; Biopsy; Bone Marrow Cells; Caspase 8; Caspase 9; Cell Division; Cell Line; Cell Line, Tumor; Cell Survival; Enzyme Activation; Humans; Imidazoles; Neoplasms; Oleanolic Acid; Triterpenes; Waldenstrom Macroglobulinemia | 2008 |