oleanolic acid has been researched along with Melanoma in 26 studies
*Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 17 (65.38) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Assefa, H; Nimrod, A; Sindelar, R; Walker, L | 2 |
| Garcia-Granados, A; Martin-Fonseca, S; Martinez, A; Parra, A; Rivas, F | 1 |
| Hassan, M; Hwan Lee, K; Ja Kim, S; Raza, H; Seok Eom, Y; Vanjare, BD | 1 |
| Bhandari, R; Khatwani, N; Liby, KT; Park, C; Pioli, PA; Spezza, PA; Torres, GM; Yang, H | 1 |
| Eom, YS; Hassan, M; Hosseini Nasab, N; Kim, SJ; Kloczkowski, A; Raza, H | 1 |
| Al-Harrasi, A; Csuk, R; Deigner, HP; Heise, N; Hoenke, S; Simon, V | 1 |
| Chung, G; Golokhvast, KS; Izotov, BN; Kim, HS; Le, B; Sifaki, M; Spandidos, DA; Tsatsakis, AM; Tsukamoto, C; Tzanakakis, G; Yang, SH | 1 |
| Bojin, F; Caunii, A; Cristea, M; Drăghia, L; Ivan, A; Oprean, C; Paunescu, V; Soica, C; Tatu, C | 1 |
| Avram, S; Caunii, A; Cristea, M; Danciu, C; Dehelean, C; Ivan, A; Marti, D; Oprean, C; Paunescu, V; Soica, C; Spandidos, DA; Susan, R; Tatu, C; Tsatsakis, A; Tzanakakis, G | 1 |
| Li, TH; Yan, HX | 1 |
| Alvarado, HL; Calpena, AC; Clares, B; Garduño-Ramírez, ML; Melguizo, C; Ortiz, R; Prados, JC | 1 |
| Lee, HB; Sharma, M; Tailor, NK | 1 |
| Chatterjee, N; Das, S; Kumar, D; Mallick, S; Pal, BC; Saha, KD | 1 |
| Bishayee, A; Biswas, J; Dutta, K; Ganguly, KK; Sinha, D | 1 |
| Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR | 1 |
| Borcan, F; Coricovac, D; Crăiniceanu, Z; Danciu, C; Dehelean, CA; Munteanu, M; Oprean, C; Soica, C; Trandafirescu, C | 1 |
| Huang, L; Huo, M; Wang, Y; Xu, Z; Zhao, Y | 1 |
| Hu, SC; Lee, CW; Lee, IT; Lin, CC; Yen, FL; Yen, MH | 1 |
| Hayakawa, Y; Ma, H; Saiki, I; Yokoyama, S | 1 |
| Galanty, A; Michalik, M; Podolak, I; Sedek, L | 1 |
| Fernandes, J; Gattass, CR; Lúcio, KA; Monção-Ribeiro, LC; Rocha, Gda G; Takiya, CM | 1 |
| Andreeff, M; Dezube, BJ; Eder, JP; Ferguson, DA; He, X; Hong, DS; Konoplev, S; Konopleva, M; Kufe, D; Kurzrock, R; Lawrence, D; Lazarus, H; Meyer, CJ; Mier, J; Naing, A; Shapiro, GI; Supko, JG; Wheler, J | 1 |
| Deng, W; Ekmekcioglu, S; Grimm, EA; Qin, Y | 1 |
| Chang, HC; Chang, JJ; Chen, HT; Chen, YP; Cheng, CM; Kashiwada, Y; Lee, KH; Zhang, DC | 1 |
| Kim, DS; Kim, JY; Koo, HM | 1 |
1 trial(s) available for oleanolic acid and Melanoma
| Article | Year |
|---|---|
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Colorectal Neoplasms; Cyclin D1; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Janus Kinases; Kidney Neoplasms; Lymphoma; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Neoplasms; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; RNA, Messenger; STAT Transcription Factors; Thyroid Neoplasms; Young Adult | 2012 |
25 other study(ies) available for oleanolic acid and Melanoma
| Article | Year |
|---|---|
Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
Topics: Antineoplastic Agents; Apoptosis; Complement Inactivator Proteins; DNA Fragmentation; Drug Evaluation, Preclinical; Humans; Melanoma; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid.
Topics: Antineoplastic Agents; Complement Inactivator Proteins; Drug Screening Assays, Antitumor; Humans; Melanoma; Oleanolic Acid; Stereoisomerism; Tumor Cells, Cultured | 2001 |
Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Melanoma; Mice; Olea; Triterpenes | 2011 |
Elastase inhibitory activity of quinoline Analogues: Synthesis, kinetic mechanism, cytotoxicity, chemoinformatics and molecular docking studies.
Topics: alpha-Glucosidases; Cheminformatics; Glycoside Hydrolase Inhibitors; Humans; Melanoma; Molecular Docking Simulation; Oleanolic Acid; Pancreatic Elastase; Quinolines; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship | 2022 |
T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages.
Topics: Humans; Immunosuppressive Agents; Macrophages; Melanoma; Oleanolic Acid; T-Lymphocytes; Tumor Microenvironment | 2022 |
Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies.
Topics: Acetamides; Amides; Humans; Kinetics; Melanoma; Molecular Docking Simulation; Molecular Structure; Oleanolic Acid; Oxadiazoles; Pancreatic Elastase; Structure-Activity Relationship; Thiadiazoles | 2023 |
Type and position of linkage govern the cytotoxicity of oleanolic acid rhodamine B hybrids.
Topics: Antineoplastic Agents; Cell Proliferation; Humans; Melanoma; Oleanolic Acid; Rhodamines; Tumor Cells, Cultured | 2021 |
Soyasaponin Ag inhibits α‑MSH‑induced melanogenesis in B16F10 melanoma cells via the downregulation of TRP‑2.
Topics: alpha-MSH; Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Intramolecular Oxidoreductases; Melanins; Melanoma; Mice; Neoplasm Proteins; Oleanolic Acid; Saponins | 2017 |
Selective in vitro anti-melanoma activity of ursolic and oleanolic acids.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Melanoma; Mesenchymal Stem Cells; Oleanolic Acid; Triterpenes; Ursolic Acid | 2018 |
Effects of ursolic and oleanolic on SK‑MEL‑2 melanoma cells: In vitro and in vivo assays.
Topics: Angiogenesis Inhibitors; Animals; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Humans; Melanoma; Neovascularization, Physiologic; Oleanolic Acid; Skin Neoplasms; Triterpenes; Ursolic Acid | 2017 |
Antitumor‑ and apoptosis‑inducing effects of pomolic acid against SK‑MEL‑2 human malignant melanoma cells are mediated via inhibition of cell migration and sub‑G1 cell cycle arrest.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; G1 Phase Cell Cycle Checkpoints; Humans; Melanoma; Oleanolic Acid | 2018 |
Nanoemulsion Strategy for Ursolic and Oleanic Acids Isolates from
Topics: Animals; Antioxidants; Apocynaceae; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Emulsions; Melanoma; Mice; Molecular Conformation; Nanoparticles; Oleanolic Acid; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2018 |
Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: an in vitro and in vivo study.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Chlorocebus aethiops; Disease Models, Animal; DNA Fragmentation; In Vitro Techniques; Male; Melanoma; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Survival Rate; Transplantation, Homologous; Vero Cells | 2013 |
Effect of corchorusin-D, a saikosaponin like compound, on B16F10 melanoma cells (in vitro and in vivo).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Corchorus; Glycosides; Humans; Melanoma; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Structure; Oleanolic Acid; Saponins; Skin Neoplasms; Triterpenes | 2013 |
A novel synthetic oleanane triterpenoid suppresses adhesion, migration, and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Movement; Gelatinases; Gene Expression Regulation, Neoplastic; Melanoma; Mice; Neoplasm Invasiveness; Oleanolic Acid; Signal Transduction | 2015 |
Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: drug-DNA interaction and signaling cascade.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; DNA, Neoplasm; ErbB Receptors; Humans; Melanoma; Microscopy, Fluorescence; Oleanolic Acid; Phytolacca; Phytotherapy; Plant Extracts; Signal Transduction; Skin Neoplasms | 2014 |
The synergistic biologic activity of oleanolic and ursolic acids in complex with hydroxypropyl-γ-cyclodextrin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Synergism; Female; gamma-Cyclodextrins; Humans; Melanoma; Mice; Oleanolic Acid; Skin Neoplasms; Solubility; Triterpenes; Ultraviolet Rays; Ursolic Acid | 2014 |
Nanoparticle delivery of CDDO-Me remodels the tumor microenvironment and enhances vaccine therapy for melanoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cancer Vaccines; Cell Line, Tumor; Drug Synergism; Female; Melanoma; Membrane Proteins; Mice; Mice, Inbred C57BL; Nanocapsules; Oleanolic Acid; Particle Size; Peptide Fragments; Treatment Outcome; Tumor Microenvironment | 2015 |
Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d.
Topics: Apoptosis Regulatory Proteins; Bupleurum; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; Humans; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Nanoparticles; Oleanolic Acid; Particle Size; Plant Roots; Saponins; Solubility | 2016 |
Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Etoposide; Melanoma; Mice; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2017 |
The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells.
Topics: Animals; Cell Proliferation; Cell Shape; Cell Survival; Cells, Cultured; Cytoskeleton; Fibroblasts; Humans; Melanoma; Oleanolic Acid; Primulaceae; Saponins; Skin | 2008 |
Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Humans; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Neovascularization, Pathologic; Oleanolic Acid; Signal Transduction | 2011 |
Identification of unique sensitizing targets for anti-inflammatory CDDO-Me in metastatic melanoma by a large-scale synthetic lethal RNAi screening.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Neoplasm; High-Throughput Screening Assays; Humans; Melanoma; Neoplasm Metastasis; Oleanolic Acid; Reproducibility of Results; RNA Interference; RNA, Small Interfering; Signal Transduction; Skin Neoplasms; Treatment Outcome | 2013 |
Antitumor agents, 145. Cytotoxic asprellic acids A and C and asprellic acid B. new p-coumaroyl triterpenes, from Ilex asprella.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Coumaric Acids; Drug Screening Assays, Antitumor; Gastrointestinal Neoplasms; Humans; KB Cells; Leukemia P388; Melanoma; Mice; Oleanolic Acid; Plants, Medicinal; Tumor Cells, Cultured | 1993 |
Development of C-20 modified betulinic acid derivatives as antitumor agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Betulinic Acid; Drug Screening Assays, Antitumor; Humans; Male; Melanoma; Oleanolic Acid; Pentacyclic Triterpenes; Prostatic Neoplasms; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured | 2001 |