oleanolic acid has been researched along with Lung Neoplasms in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.22) | 18.2507 |
| 2000's | 13 (28.89) | 29.6817 |
| 2010's | 26 (57.78) | 24.3611 |
| 2020's | 5 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, MM; El Diwani, HI; Galal, SA; Kerwin, SM; Li, J; Omar, MA; Ramadan, RA; Shaker, YM; Tokuda, H | 1 |
| Chen, Z; Cheng, YY; Duan, HQ; Goto, M; Huang, KY; Lee, KH; Ling, Y; Liu, YL; Morris-Natschke, SL; Tong, XH; Yang, PC; Yang, SL | 1 |
| Baek, SJ; Cha, S; Kim, A; Kim, NS; Lee, H; Park, M; Park, SM; Yi, JM | 1 |
| Ai, Y; Du, K; Jiang, X; Kang, F; Liu, W; Luo, Y; Ren, C; Wang, L; Xu, Y; Zhang, Y; Zhu, B; Zhu, H | 1 |
| Elwakeel, A; Kalra, RS; Kaul, SC; Omar, A; Putri, J; Wadhwa, R | 1 |
| Chan, MT; Chen, B; Du, B; Gu, J; Ho, IH; Liu, Q; Liu, X; Tan, Y; Wang, K; Wei, X; Wu, WK; Xiao, J; Yin, T; Zhan, Y; Zhang, L; Zhang, W | 1 |
| Chen, W; Liu, K; Ren, F; Wu, H; Wu, S; Xu, F; Zheng, D | 1 |
| Sun, HM; Wang, L; Wang, QW; Xu, YJ; Zhang, LX; Zhang, XK | 1 |
| Biradi, M; Hullatti, K | 1 |
| Cao, W; Gao, D; He, Y; Li, L; Wang, M; Wang, Q; Xing, S; Zhu, R | 1 |
| Ahsan, A; Chu, P; Gao, L; Kong, L; Lin, Y; Ma, X; Peng, J; Qaed, E; Song, Y; Sun, B; Tang, Z; Wang, S; Zhang, J | 1 |
| Chen, X; Liu, C; Wu, J; Ying, M; Zhao, P; Zhao, R; Zhou, N | 1 |
| Chen, B; Du, B; Gong, Q; Ho, HI; Li, Q; Liu, X; Lu, Y; Tan, Y; Wang, K; Wu, W; Xiao, J; Yin, T; Zhan, Y; Zhang, F; Zhang, Y; Zou, Y | 1 |
| Jin, W; Wang, J; Xiao, L; Xu, S; Yi, Q; Yu, M | 1 |
| Boon, HL; Sharma, M; Suthar, SK | 1 |
| Jin, W; Qi, R; Wang, J; Xu, S; Yi, Q; Yu, M | 1 |
| Aggarwal, V; Lee, HB; Sharma, A; Sharma, M; Suthar, SK | 1 |
| Li, D; Liu, M; Zhao, X | 1 |
| Cardentey, A; Delgado, O; El-Ashmawy, M; Shay, JW; Wright, WE | 1 |
| Liby, KT; Ringelberg, CS; Risingsong, R; Royce, DB; Sporn, MB; To, C; Williams, CR | 1 |
| Chen, X; Gong, Y; Liang, H; Liu, J; Ma, A; Ma, L; Wang, J; Yu, T; Zheng, L | 1 |
| Chen, J; Feng, Y; Gu, L; Guo, J; Jiang, H; Li, Y; Liao, S; Ma, L; Sun, M; Wang, H; Wen, H; Yu, X; Zeng, B; Zhou, Y | 1 |
| Khuri, FR; Sun, SY; Yue, P; Zou, W | 1 |
| Cai, Z; Hu, S; Hua, Y; Li, J; Li, Q; Sun, M; Zhang, Z | 1 |
| Liby, K; Ma, T; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR; Yore, MM | 1 |
| Qu, Y; Wang, X; Zhang, J; Zhang, Y | 1 |
| Arbab, AS; Deeb, D; Divine, GW; Dulchavsky, SA; Gao, X; Gautam, SC; Jiang, D; Liu, Y | 1 |
| Au-Yeung, W; Feng, L; Wang, SS; Xiang, P; Xu, YH; Zhu, Q | 1 |
| Lee, JH; Min, BS; Ryoo, S; Seo, J; Tae, N | 1 |
| Sun, ZL; Wan, AH; Wu, Y; Zhang, M; Zhang, R | 1 |
| Fernandes, J; Gattass, CR; Lúcio, KA; Monção-Ribeiro, LC; Rocha, Gda G; Takiya, CM | 1 |
| Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Cheng, MS; Chun, J; Han, L; Joo, EJ; Kim, YS; Liu, Y; Wang, B; Wang, YS | 1 |
| Gribble, GW; Honda, T; Hong, WK; Kim, KB; Lotan, R; Sporn, MB; Suh, N; Sun, SY; Wu, GS; Yue, P | 1 |
| Hsu, YL; Kuo, PL; Lin, CC | 1 |
| Khuri, FR; Liu, X; Lotan, R; Sporn, MB; Sun, SY; Yue, P; Zhou, Z; Zou, W | 1 |
| Chang, WW; Lin, TW; Tsai, YC; Wang, PH; Yu, CY | 1 |
| Khuri, FR; Sun, SY; Yue, P; Zhou, Z | 1 |
| Gribble, GW; Honda, T; Letterio, JJ; Liby, K; Risingsong, R; Royce, DB; Sporn, MB; Voong, N; Williams, CR | 1 |
| Dmitrovsky, E; Gribble, GW; Honda, T; Liby, K; Risingsong, R; Royce, DB; Sporn, MB; Sporn, TA; Williams, CR; Yore, MM | 1 |
| Andreeff, M; Dietrich, M; Konopleva, M; Ling, X; Madden, TL; McQueen, T; Ruvolo, V; Schober, W; Stephens, LC; Zeng, Z | 1 |
| Chen, S; Khuri, FR; Liu, X; Sporn, MB; Sun, SY; Yue, P; Zou, W | 1 |
| Black, CC; Dmitrovsky, E; Gribble, GW; Honda, T; Lamph, WW; Liby, K; Liu, X; Risingsong, R; Royce, DB; Sporn, MB; Sporn, TA; Williams, CR; Yore, MM | 1 |
| Abdel-Kader, M; Adams, H; Dalton, JM; Derveld, I; Hoch, J; Kingston, DG; Malone, S; Mamber, SW; Seo, Y; Werkhoven, MC; Wisse, JH | 1 |
| Iwashima, A; Kokumai, M; Konoshima, T; Kozuka, M; Nishino, H; Tokuda, H | 1 |
45 other study(ies) available for oleanolic acid and Lung Neoplasms
| Article | Year |
|---|---|
Synthesis and docking studies of novel antitumor benzimidazoles.
Topics: Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Herpesvirus 4, Human; Humans; Lung Neoplasms; MCF-7 Cells; Models, Molecular; Pyrroles; Structure-Activity Relationship; Tetracyclines; Virus Activation | 2012 |
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Design; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Nitric Oxide; Nitric Oxide Donors; Oleanolic Acid; Protein Kinase Inhibitors | 2019 |
Identification of a novel anticancer mechanism of Paeoniae Radix extracts based on systematic transcriptome analysis.
Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Aurora Kinase B; Gene Expression Profiling; Humans; Lung Neoplasms; Oleanolic Acid; Paeonia; Plant Extracts; Plant Roots | 2022 |
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Oleanolic Acid; Reactive Oxygen Species; Signal Transduction | 2019 |
Soyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Invasiveness; Oleanolic Acid; RNA-Binding Proteins; Saponins; Signal Transduction; Transcriptional Activation; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |
Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Cisplatin; Humans; Lung Neoplasms; Lysosomes; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Oleanolic Acid; Paclitaxel; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2020 |
Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Oleanolic Acid; Saponins; STAT3 Transcription Factor | 2020 |
Co-delivery of cisplatin and oleanolic acid by silica nanoparticles-enhanced apoptosis and reverse multidrug resistance in lung cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cisplatin; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasm Transplantation; Oleanolic Acid; Silicon Dioxide; Tetrazolium Salts; Thiazoles | 2021 |
Bioactivity guided isolation of cytotoxic terpenoids and steroids from Premna serratifolia.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Hep G2 Cells; Hexanes; Humans; Inhibitory Concentration 50; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methanol; Muscle Fibers, Skeletal; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Solvents; Stigmasterol; Verbenaceae | 2017 |
Targeted therapy of octreotide-modified oleanolic acid liposomes to somatostatin receptor overexpressing tumor cells.
Topics: A549 Cells; Animals; Drug Delivery Systems; Drug Liberation; Gene Expression Regulation; Humans; Liposomes; Lung Neoplasms; Mice; Octreotide; Oleanolic Acid; Receptors, Somatostatin; Xenograft Model Antitumor Assays | 2017 |
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Janus Kinase 2; Lung Neoplasms; Oleanolic Acid; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor | 2017 |
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Topics: A549 Cells; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Drug Synergism; Feedback, Physiological; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oleanolic Acid; Phosphorylation; Saponins; Tumor Suppressor Protein p53 | 2018 |
The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cathepsins; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogen-Ion Concentration; Lung Neoplasms; Lysosomes; Oleanolic Acid; Paclitaxel; Reactive Oxygen Species; Saponins; Tubulin Modulators | 2018 |
Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro.
Topics: Animals; Cell Death; Cell Line, Tumor; Dipeptides; DNA Damage; Down-Regulation; Glioma; Glutathione; Glutathione Synthase; Humans; Lung Neoplasms; Oleanolic Acid; Radiation Tolerance; Radiation-Sensitizing Agents; Rats | 2013 |
Novel lung adenocarcinoma and nuclear factor-kappa B (NF-κB) inhibitors: synthesis and evaluation of lantadene congeners.
Topics: Adenocarcinoma; Cell Line, Tumor; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; NF-kappa B; Oleanolic Acid; Phosphorylation; Spectrometry, Mass, Electrospray Ionization | 2014 |
Oleanolic acid enhances the radiosensitivity of tumor cells under mimetic hypoxia through the reduction in intracellular GSH content and HIF-1α expression.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; DNA Damage; Glioma; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Micronucleus Tests; Oleanolic Acid; Radiation Tolerance; Radiation-Sensitizing Agents; Rats | 2014 |
Synthesis of lantadene analogs with marked in vitro inhibition of lung adenocarcinoma and TNF-α induced nuclear factor-kappa B (NF-κB) activation.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Structure; NF-kappa B; Oleanolic Acid; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2014 |
Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis.
Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin G1; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MEF2 Transcription Factors; MicroRNAs; Oleanolic Acid | 2015 |
CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.
Topics: Animals; Antioxidants; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; DNA Damage; Epithelial Cells; Female; Humans; Lung; Lung Neoplasms; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Radiation-Protective Agents; Signal Transduction | 2014 |
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Dimethyl Fumarate; Female; Fumarates; Gene Expression Regulation, Neoplastic; Imidazoles; Lung Neoplasms; Mice, Inbred Strains; Mice, Knockout; Molecular Targeted Therapy; Neoplasms, Experimental; NF-E2-Related Factor 2; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Oxidative Stress | 2015 |
ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.
Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-E2-Related Factor 2; Nitriles; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Benzodioxoles; Carcinoma, Non-Small-Cell Lung; CDC2-CDC28 Kinases; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Follow-Up Studies; HSP90 Heat-Shock Proteins; Humans; Lung Neoplasms; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Nude; Middle Aged; Oleanolic Acid; Purines; Retrospective Studies; Tumor Burden; Tumor Cells, Cultured | 2017 |
Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Endoplasmic Reticulum; Enzyme Activation; Glutathione; Humans; Lung Neoplasms; MAP Kinase Kinase 4; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Transcription Factor CHOP; Transcription, Genetic; Up-Regulation | 2008 |
Oleanolic acid derivative Dex-OA has potent anti-tumor and anti-metastatic activity on osteosarcoma cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Oleanolic Acid; Osteosarcoma; S Phase | 2011 |
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Topics: Adenocarcinoma; Animals; Cell Proliferation; Fatty Acids, Unsaturated; Female; Ligands; Lung Neoplasms; Macrophages; Mice; Mice, Inbred A; Nicotinic Acids; Oleanolic Acid; Rats; Tetrahydronaphthalenes; Urethane | 2009 |
Ardipusilloside I purified from Ardisia pusilla competitively binds VEGFR and induces apoptosis in NCI-H460 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Ardisia; bcl-2-Associated X Protein; Binding, Competitive; Cell Line; Cell Nucleus; DNA Breaks; Humans; Lung Neoplasms; Microscopy, Electron, Transmission; Molecular Structure; Oleanolic Acid; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Receptors, Vascular Endothelial Growth Factor; Saponins | 2010 |
Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling.
Topics: Adenocarcinoma; Animals; Animals, Genetically Modified; Apoptosis; Blotting, Western; Cell Proliferation; Disease Progression; Female; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Oleanolic Acid; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2011 |
Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression.
Topics: Adenocarcinoma; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Blotting, Western; Cell Proliferation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Lung Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Prunella; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2011 |
3-Oxoolean-12-en-27-oic acid inhibits the proliferation of non-small cell lung carcinoma cells by inducing cell-cycle arrest at G0/G1 phase.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Cyclin E; Down-Regulation; G1 Phase; Humans; Lung Neoplasms; Oleanolic Acid; Resting Phase, Cell Cycle; Retinoblastoma Protein | 2011 |
Bioactive saponins from the fruits of Aesculus pavia L.
Topics: Aesculus; Amniotic Fluid; Antineoplastic Agents, Phytogenic; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Fruit; Humans; Lung Neoplasms; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins | 2011 |
Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Humans; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Neovascularization, Pathologic; Oleanolic Acid; Signal Transduction | 2011 |
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2013 |
Synthesis of novel diosgenyl saponin analogues and apoptosis-inducing activity on A549 human lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Caspase 8; Caspase 9; Cell Line, Tumor; DNA Fragmentation; Glycosylation; Humans; Lung; Lung Neoplasms; Oleanolic Acid; Saponins | 2012 |
Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Caspases; Cell Differentiation; Cell Division; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Humans; Lung Neoplasms; Mitochondria; Oleanolic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lung Neoplasms; Medicine, Chinese Traditional; Membrane Glycoproteins; Oleanolic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reagent Kits, Diagnostic; Saponins; Tumor Suppressor Protein p53 | 2004 |
c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Caspase 8; Caspases; Cell Line, Tumor; Drug Synergism; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Glycoproteins; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells.
Topics: Animals; Cell Adhesion; Cell Line, Tumor; Cell Membrane; Cell Movement; Extracellular Matrix; Flow Cytometry; Glycine max; Glycosylation; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; N-Acetylneuraminic Acid; Neoplasm Invasiveness; Neoplasm Metastasis; NIH 3T3 Cells; Oleanolic Acid; Saponins; Sialic Acids | 2006 |
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Topics: Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2006 |
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunoblotting; Interleukin-6; Lung Neoplasms; Multiple Myeloma; Oleanolic Acid; Phosphorylation; Signal Transduction; STAT Transcription Factors; STAT5 Transcription Factor; Time Factors; Transcription, Genetic | 2006 |
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Humans; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Oleanolic Acid; Phosphorylation; STAT3 Transcription Factor; Urethane | 2007 |
The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.
Topics: Animals; Apoptosis; Cell Growth Processes; Dendritic Cells; Female; Genetic Vectors; Lentivirus; Luciferases, Renilla; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Oleanolic Acid; Signal Transduction; Spleen; STAT3 Transcription Factor | 2007 |
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Humans; Lung Neoplasms; MAP Kinase Kinase 4; Oleanolic Acid; Proteasome Endopeptidase Complex; Terpenes; TNF-Related Apoptosis-Inducing Ligand; Ubiquitin | 2007 |
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Erlotinib Hydrochloride; Female; Lung; Lung Neoplasms; Mice; Nicotinic Acids; Oleanolic Acid; Protein Kinase Inhibitors; Quinazolines; Tetrahydronaphthalenes | 2008 |
Bioactive saponins from Acacia tenuifolia from the suriname rainforest.
Topics: Acacia; Animals; Antifungal Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Ovarian Neoplasms; Plants, Medicinal; Saponins; Stereoisomerism; Suriname; Triterpenes; Tumor Cells, Cultured; Yeasts | 2002 |
Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Isoflavones; Lung Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Plants, Medicinal; Saponins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1992 |