oleanolic acid has been researched along with Inflammation in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (3.48) | 18.2507 |
| 2000's | 10 (8.70) | 29.6817 |
| 2010's | 79 (68.70) | 24.3611 |
| 2020's | 22 (19.13) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Li, S; Pan, S; Shi, Z; Wang, L | 1 |
| An, HJ; Kang, YM; Kim, HM; Lee, M | 2 |
| Khan, MI; Khan, MZ; Kim, JD; Kim, MY; Lee, YB; Shin, JH; Shin, TS | 1 |
| Chen, H; Chen, L; Fang, X; Lu, F; Song, X; Sun, J; Wu, X; Zhang, W; Zhao, K | 1 |
| Ahmed, H; Amin, U; Jia, Z; Li, Y; Pitts, DR; Sun, X; Zhu, H | 1 |
| Leehey, DJ | 1 |
| Dai, L; Feng, ZQ; Hu, KW; Qian, M; Sun, HB; Sun, JZ; Zheng, RN | 1 |
| Al-Gareeb, AI; Al-Kuraishy, HM; Alexiou, A; Batiha, GE; Negm, WA | 1 |
| Choi, JH; Choi, S; Choi, YJ; Chung, HY; Hyun, MK; Kim, DH; Lee, JY; Noh, SG; Park, CH; Park, D | 1 |
| Han, RY; Jia, J; Liu, XH; Tan, RZ; Wang, L; Xie, KH; Zhong, X | 1 |
| Chen, X; Hu, Z; Kang, L; Liu, B; Liu, Y; Niu, K; Xing, H | 1 |
| Gao, ZH; Li, RF; Li, SQ; Li, YY; Liu, WY; Wang, HW; Wang, JG; You, M | 1 |
| Chai, OH; Lee, EJ; Piao, CH; Song, CH | 1 |
| Jang, HJ; Kim, MH; Lee, S; Lee, SJ; Lee, SW; Lim, HJ; Rho, MC | 1 |
| Feng, J; Liu, L; Ou, CH; Ren, CH; Wang, JL | 1 |
| Duan, Q; Kang, T; Liu, M; Naqvi, S; Wang, Z; Xiao, S; Zhang, F; Zhang, G; Zheng, Y | 1 |
| Chen, H; Lei, H; Su, J; Xu, G; Yuan, Q | 1 |
| An, HJ; Kang, YM; Lee, M | 1 |
| Cao, G; Han, L; Hao, M; Lin, F; Ruan, J; Sun, F; Wang, L; Wang, T; Yu, H; Zhang, Y | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Genovese, T; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Bolat, I; Dokumacioglu, E; Hayirli, A; Iskender, H; Mohtare, B; Terim Kapakin, KA; Yenice, G | 1 |
| Chen, G; Fu, Y; Yao, L; Yao, T; Zhang, L; Zhou, C | 1 |
| Jannus, F; Lupiañez, JA; Marín, M; Martinez, A; Medina-O'Donnell, M; Neubrand, VE; Parra, A; Reyes-Zurita, FJ; Rivas, F; Rufino-Palomares, EE; Saez-Lara, MJ; Sepulveda, MR | 1 |
| Eo, SH; Kim, SJ; Phull, AR | 1 |
| Fu, L; Gribble, GW; Liby, KT; Lin, QX; Onyango, EO; Sporn, MB | 1 |
| Bhattacharjee, N; Dewanjee, S; Dua, TK; Kalita, J; Khanra, R; Manna, P; Nandy, A; Saha, A | 1 |
| da Silva Júnior, WF; da Veiga Júnior, VF; de Almeida, PDO; de Azevedo, EP; de Lima, ÁAN; de Menezes, DLB; E Silva, NES; Lima, ES; Pinheiro, JGO | 1 |
| Hu, Q; Ji, H; Lu, G; Wu, H; Yang, Z; Zhou, M | 1 |
| Ayi, K; Crowley, VM; Kain, KC; Liby, KT; Lu, Z; Sporn, M | 1 |
| Jia, J; Li, K; Li, Y; Wang, L; Xia, R; Zhang, J; Zhang, L | 1 |
| Dronamraju, SVL; Rajarathinam, G | 1 |
| Cheng, BF; Feng, ZW; Gao, YX; Guo, DD; Lian, JJ; Ma, SP; Xue, H; Zhang, BB; Zhang, YP | 1 |
| Belarbi, M; Benammar, C; Djeziri, FZ; Hichami, A; Khan, NA; Murtaza, B | 1 |
| Im, HT; Lee, KT; Shin, JS | 1 |
| Cheng, YD; Lan, WC; Lee, SC; Lin, LW; Tsai, FH; Wu, CR | 1 |
| Chen, HM; Pei, X; Zhang, XJ | 1 |
| Cao, X; Ge, X; Li, Z; Lu, Y; Qin, W; Shen, P; Sun, H; Tang, Q; Wang, D; Yang, N; Zhang, W | 1 |
| Chen, J; Chen, K; Dai, W; Fan, X; Feng, J; Guo, C; Ji, J; Li, J; Li, S; Liu, T; Mao, Y; Wang, F; Wang, W; Wu, J; Wu, L; Yu, Q; Zhang, J; Zhou, Y | 1 |
| Liu, J; Lu, YF; Wan, XL; Xu, Y | 1 |
| Bhatia, D; Bishayee, A; Mandal, A | 1 |
| Feng, DQ; Ji, KL; Li, Y; Liao, SG; Liu, B; Xu, YK; Zhang, MJ | 1 |
| Aminzadeh, MA; Khazaeli, M; Meyer, CJ; Reisman, SA; Vaziri, ND; Yuan, J | 1 |
| Aminzadeh, MA; Farzaneh, SH; Khazaeli, M; Meyer, CJ; Reisman, SA; Shelkovnikov, S; Vaziri, ND | 1 |
| Amaro-Luis, JM; Delaude, C; Delemasure, S; Dutartre, P; Lacaille-Dubois, MA; Mitaine-Offer, AC; Montes, EG; Paululat, T; Pouységu, L; Quideau, S; Rojas, LB | 1 |
| Córdova, C; Gallego-Muñoz, P; Gutiérrez, B; Hernández, M; Martín, R; Martínez-García, C; Nieto, ML | 1 |
| Fitzpatrick, LR; Liby, KT; Small, JS; Stonesifer, E | 1 |
| Cai, J; Cao, W; Chen, J; Chu, X; Deng, H; Li, X; Liu, Z; Mao, L; Sun, S; Zha, L | 1 |
| Helen, A; Krishnan, K; Mathew, LE; Vijayalakshmi, NR | 1 |
| He, ZX; Wang, YY; Yang, YX; Zhe, H; Zhou, SF | 1 |
| Fang, H; Qiu, X; Sun, Y; Wang, J; Wang, X; Wang, Z; Xia, Z; Zhang, F | 1 |
| Camer, D; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y | 4 |
| Jeon, SY; Kim, MR; Kim, SO; Park, JY; Yang, CH | 1 |
| Camer, D; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y; Zhang, Q | 1 |
| Li, L; Ning, Q; Qi, J; Wang, H; Wang, X; Wang, Y; Wu, T | 1 |
| Kang, MS; Kang, S; Kim, J; Oh, MS; Pak, CJ; Pak, YK; Park, WH; Piao, Y | 1 |
| Cao, Y; Fu, Y; Hu, X; Zhang, N; Zhang, Z | 1 |
| Bozeman, RG; Kaisani, A; Kim, SB; Kim, W; Richardson, JA; Shay, JW; Wright, WE; Zhang, L | 1 |
| An, WG; Cho, IJ; Chun, W; Jegal, KH; Ju, SA; Jung, JY; Kim, SC; Kim, SH; Kim, YW; Ku, SK; Lee, C; Lee, CW; Park, SM; Son, Y; Zhao, R | 1 |
| Dinh, CH; Huang, XF; Szabo, A; Yu, Y; Zhang, P; Zhang, Q | 1 |
| Nesi, RT; Pinho, RA; Silveira, PC; Thirupathi, A | 1 |
| Beutler, JA; Cho, N; Hong, J; Kim, HW; Moon, EH; Sung, SH | 1 |
| Olender, D; Pawełczyk, A; Sowa-Kasprzak, K; Zaprutko, L | 1 |
| Ji, JA; Jiang, ZY; Lu, MC; You, QD | 1 |
| He, X; Huang, J; Li, C; Wang, X; Wang, Y | 1 |
| Fu, Y; Liu, W; Shi, M; Wang, J; Wei, Z; Yang, Z | 1 |
| Aremu, OO; Nkeh-Chungag, BN; Oyedeji, AO; Oyedeji, OO; Rali, S | 1 |
| Kashyap, D; Punia, S; Sharma, A; Sharma, AK; Tuli, HS | 1 |
| Leal, AS; Liby, KT; Pioli, PA; Sporn, MB | 1 |
| Masullo, M; Piacente, S; Pizza, C | 1 |
| Dun, Y; Han, G; Liu, J; Liu, Z; Song, L; Wang, T; Wang, Y; Yuan, D; Zhang, C; Zhao, H; Zhou, Z | 1 |
| An, JH; Chung, KH; Kim, GJ; Lee, KJ; Song, DH; Yoo, HS | 1 |
| Bhattacharjee, N; Dewanjee, S; Dua, TK; Khanra, R | 1 |
| Mabandla, MV; Musabayane, CT; Sibiya, H | 1 |
| Dharmappa, KK; Kumar, RV; Mohamed, R; Nataraju, A; Shivaprasad, HV; Vishwanath, BS | 1 |
| Alabugin, IV; Baev, DS; Govdi, AI; Shakirov, MM; Shults, EE; Sorokina, IV; Tolstikov, GA; Tolstikova, TG; Vasilevsky, SF | 1 |
| Davis, PB; Eastman, JF; Nichols, DP; Shank, SL; Ziady, AG | 1 |
| Chang, CC; Chao, JC; Tam, KW; Tsai, YH; Wu, SJ | 1 |
| Aleksunes, LM; Goedken, MJ; Klaassen, CD; Manautou, JE; Rockwell, CE; Thomale, J | 1 |
| Jiang, ZZ; Liu, JP; Liu, L; Wang, H; Wang, T; Xue, M; Zhang, LY; Zhou, ZX | 1 |
| Alabran, JL; Auletta, JJ; Kim, BG; Letterio, JJ; Meyer, CJ | 1 |
| Bai, F; Li, HQ | 2 |
| Beal, MF; Calingasan, NY; Damiano, M; Kiaei, M; Liby, KT; Naseri, N; Neymotin, A; Petri, S; Risingsong, R; Sporn, M; Wille, E | 1 |
| Ching, H; Lin, LW; Lin, WH; Lin, YT; Wen, CL; Wu, CR | 1 |
| Cartagena, C; Cassels, BK; Delporte, C; González, P; León, F; Rodríguez-Díaz, M; Silva, X; Wessjohann, LA | 1 |
| Ferguson, DA; Huff, JW; Krauth, M; Meyer, CJ; Pergola, PE; Ruiz, S; Warnock, DG | 1 |
| Fusco, MR; Juárez, A; Pelzer, L; Petenatti, E; Robles, S; Rossomando, P; Sosa, A | 1 |
| Bento, AF; Calixto, JB; Meotti, FC; Passos, GF; Paszcuk, AF; Silva, ES; Simão da Silva, KAB | 1 |
| Cruz, FF; Fernandes, J; Gattass, CR; Lanzetti, M; Morales, MM; Oliveira, GP; Ornellas, DS; Pelosi, P; Rocco, PR; Santos, RS; Silva, PL; Valença, SS | 1 |
| Ahn, KS; Kwon, OK; Lee, HK; Lee, KY; Lee, MY; Lim, HS; Oh, SR; Yuk, JE | 1 |
| Baggio, CH; da Silva, CF; das Neves, TL; Horst, H; Kanazawa, LK; Pizzolatti, MG; Rodrigues, MR; Santos, AR; Werner, MF | 1 |
| Crunkhorn, S | 1 |
| Bai, L; Belkadi, A; Cohen, ML; Kesavapany, S; Letterio, JJ; Liby, KT; Loh, SL; Meyer, C; Miller, RH; Pareek, TK; Sporn, MB; Zaremba, A | 1 |
| Bargman, J; Burkart, J; Chertow, GM; Davies, S; Finkelstein, FO; Hebbar, S; Mehrotra, R; Ronco, C; Teitelbaum, I; Urakpo, K; Warnock, DG | 1 |
| Chang, YS; Ho, YL; Lai, SC; Liao, CR; Peng, WH | 1 |
| Bae, JS; Ku, SK; Lee, W; Song, KS; Yang, EJ | 1 |
| Jeong, JJ; Joh, EH; Kim, DH | 1 |
| Pergola, PE; Ruiz, S; Vaziri, ND; Zager, RA | 1 |
| Bai, Q; Li, G; Lü, C; Xu, H; Yao, X | 1 |
| Aquino, RP; Brkic, D; Fkih-Tetouani, S; Ilidrissi, A; Ismaili, H; Sosa, S; Touati, D; Tubaro, A | 1 |
| Sabir, AW; Saeed, MA | 1 |
| Gribble, GW; Honda, T; Honda, Y; Leesnitzer, LM; Place, AE; Risingsong, R; Rosen, E; Sporn, MB; Stimmel, JB; Suh, N; Williams, CR; Willson, TM | 1 |
| Biswal, S; Kensler, TW; Liby, KT; Scollick, C; Sporn, MB; Thimmulappa, RK; Traore, K; Trush, MA; Yamamoto, M; Yates, M | 1 |
| Biswal, S; Bream, JH; Fuchs, RJ; Kensler, TW; Liby, KT; Malhotra, D; Scollick, C; Sporn, MB; Thimmulappa, RK; Traore, K; Trush, MA | 1 |
| Akihisa, T; Takido, M; Tamura, T; Yasukawa, K | 1 |
| Liu, J | 1 |
| Masuda, K; Oshika, T; Shoji, N | 1 |
| Alcaraz, MJ; Garcia-Pastor, P; Gomez-Paloma, L; Paya, M; Randazzo, A | 1 |
| Cerdá-Nicolás, M; Giner, RM; Giner-Larza, EM; Máñez, S; Prieto, JM; Recio, MC; Ríos, JL | 1 |
| Jiang, YY; Xiao, ZY; Yi, YH; Zhang, JP; Zheng, QY | 1 |
9 review(s) available for oleanolic acid and Inflammation
| Article | Year |
|---|---|
Targeting Inflammation in Diabetic Kidney Disease: Is There a Role for Pentoxifylline?
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Humans; Inflammation; Multicenter Studies as Topic; Oleanolic Acid; Pentoxifylline; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective.
Topics: Acute Lung Injury; Anti-Inflammatory Agents; Antioxidants; Antiviral Agents; COVID-19 Drug Treatment; Cytokines; Humans; Inflammation; Oleanolic Acid; Reactive Oxygen Species; Respiratory Distress Syndrome; SARS-CoV-2; Ursolic Acid | 2022 |
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.
Topics: Animals; Humans; Hypertension, Pulmonary; Inflammation; Neoplasms; Oleanolic Acid; Renal Insufficiency, Chronic | 2014 |
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Topics: Animals; Anti-Inflammatory Agents; Antioxidant Response Elements; Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction | 2016 |
Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities.
Topics: Animals; Anti-Inflammatory Agents; Drug Discovery; Humans; Inflammation; Inflammation Mediators; Molecular Targeted Therapy; Oleanolic Acid; Patents as Topic; Signal Transduction; Triterpenes; Ursolic Acid | 2016 |
Oleanane derivatives for pharmaceutical use: a patent review (2000-2016).
Topics: Animals; Cell Proliferation; Drug Design; Humans; Inflammation; Oleanolic Acid; Oxidative Stress; Patents as Topic | 2017 |
Prospective safety study of bardoxolone methyl in patients with type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Inflammation; Kidney Failure, Chronic; Oleanolic Acid; Peritoneal Dialysis; Prospective Studies; Research Design; Sample Size | 2012 |
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Anti-Infective Agents; Antioxidants; Disease Progression; Humans; Inflammation; Kidney; Kidney Failure, Chronic; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome | 2013 |
Pharmacology of oleanolic acid and ursolic acid.
Topics: Antineoplastic Agents, Phytogenic; Humans; Hyperlipidemias; Inflammation; Liver; Oleanolic Acid; Triterpenes; Ursolic Acid | 1995 |
1 trial(s) available for oleanolic acid and Inflammation
| Article | Year |
|---|---|
Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD.
Topics: Adult; Aged; Antioxidants; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oleanolic Acid; Oxidative Stress; Placebos; Time Factors | 2011 |
105 other study(ies) available for oleanolic acid and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Topical gel based nanoparticles for the controlled release of oleanolic acid: design and in vivo characterization of a cubic liquid crystalline anti-inflammatory drug.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Delayed-Action Preparations; Gels; Inflammation; Liquid Crystals; Oleanolic Acid; Plant Extracts; Rats; Rats, Wistar; Skin Absorption | 2021 |
Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro.
Topics: Animals; Cell Line; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Humans; In Vitro Techniques; Inflammation; Irritants; Keratinocytes; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Signal Transduction | 2021 |
Pharmacological Approaches to Attenuate Inflammation and Obesity with Natural Products Formulations by Regulating the Associated Promoting Molecular Signaling Pathways.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Angiogenesis Inhibitors; Animals; Biological Products; Disease Models, Animal; Diterpenes, Kaurane; Drug Compounding; Drug Synergism; Female; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipogenesis; Lipolysis; Mice; Mice, Inbred ICR; Obesity; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins; Signal Transduction; Stevia; Tea | 2021 |
Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway.
Topics: Animals; Anti-Inflammatory Agents; Bone Resorption; Cell Differentiation; Cells, Cultured; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteoclasts; Osteogenesis; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Saponins | 2021 |
Triterpenoid CDDO-IM protects against lipopolysaccharide-induced inflammatory response and cytotoxicity in macrophages: The involvement of the NF-κB signaling pathway.
Topics: Cytokines; Humans; Inflammation; Lipopolysaccharides; Macrophages; NF-kappa B; Oleanolic Acid; Shock, Septic; Signal Transduction; Triterpenes | 2022 |
Effects of Echinocystic Acid on Atopic Dermatitis and Allergic Inflammation of the Skin and Lungs.
Topics: Animals; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Humans; Inflammation; Keratinocytes; Lung; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pyroglyphidae; Skin | 2022 |
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Topics: Animals; Apoptosis; Fibrosis; Heart Failure; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Oleanolic Acid | 2022 |
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Experimental; Eriobotrya; Hyperglycemia; Inflammation; Mice; Oleanolic Acid; Plant Extracts; Ursolic Acid | 2022 |
Hederagenin ameliorates cisplatin-induced acute kidney injury via inhibiting long non-coding RNA A330074k22Rik/Axin2/β-catenin signalling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; beta Catenin; Cisplatin; Disease Models, Animal; Inflammation; Kidney; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering; Saponins | 2022 |
Renoprotective effects of oleanolic acid and its possible mechanisms in rats with diabetic kidney disease.
Topics: AMP-Activated Protein Kinases; Animals; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Inflammation; Kidney; Lipids; Male; NF-kappa B; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4; Transforming Growth Factor beta1 | 2022 |
[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Energy Metabolism; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; NF-kappa B; Oleanolic Acid; Random Allocation; Saponins; Sirtuins | 2019 |
Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis.
Topics: Animals; Cytokines; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nasal Mucosa; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Oleanolic Acid; Ovalbumin; Rhinitis, Allergic; Saponins; Signal Transduction; STAT3 Transcription Factor; Th17 Cells; Th2 Cells | 2020 |
Oleanolic Acid Acetate Exerts Anti-Inflammatory Activity via IKKα/β Suppression in TLR3-Mediated NF-κB Activation.
Topics: Acetates; Anti-Inflammatory Agents; Cell Line; Cytokines; Down-Regulation; Gene Expression; Humans; I-kappa B Kinase; Inflammation; Macrophages; Mitogen-Activated Protein Kinases; NF-kappa B; Oleanolic Acid; Signal Transduction; Toll-Like Receptor 3 | 2019 |
Oleanolic acid inhibits mouse spinal cord injury through suppressing inflammation and apoptosis via the blockage of p38 and JNK MAPKs.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cytokines; Inflammation; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Models, Animal; Motor Activity; NF-kappaB-Inducing Kinase; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Spinal Cord; Spinal Cord Injuries | 2020 |
Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Humans; Imiquimod; Immunosuppression Therapy; Inflammation; Keratinocytes; Mice; NF-kappa B; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction | 2020 |
Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway.
Topics: Animals; Dinoprostone; Humans; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Macrophages; Mice; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
Oleanolic acid protects against mast cell-mediated allergic responses by suppressing Akt/NF-κB and STAT1 activation.
Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Calcimycin; Cell Line; Cytokines; Histamine Release; Humans; Inflammation; Inflammation Mediators; Male; Mast Cells; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; p-Methoxy-N-methylphenethylamine; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Proto-Oncogene Proteins c-akt; STAT1 Transcription Factor | 2021 |
Structurally diverse triterpenes obtained from the fruits of Ziziphus jujuba Mill. as inflammation inhibitors by NF-κB signaling pathway.
Topics: Animals; Fruit; Inflammation; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Phosphorylation; Plant Extracts; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha; Ziziphus | 2021 |
The Methyl Ester of 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid Reduces Endometrial Lesions Development by Modulating the NFkB and Nrf2 Pathways.
Topics: Animals; Apoptosis; Cellular Microenvironment; Cyclooxygenase 2; Cytokines; Endometriosis; Female; Fibrosis; Inflammation; Neovascularization, Physiologic; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Effects of oleanolic acid on inflammation and metabolism in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Inflammation; Oleanolic Acid; Oxidative Stress; Rats; Streptozocin | 2022 |
Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Disease Models, Animal; Epithelial Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; Inflammation; Kidney; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Saponins; Sepsis | 2021 |
Efficient In Vitro and In Vivo Anti-Inflammatory Activity of a Diamine-PEGylated Oleanolic Acid Derivative.
Topics: Animals; Anti-Inflammatory Agents; Ear Diseases; Edema; Inflammation; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; RAW 264.7 Cells | 2021 |
Oleanolic acid (OA) regulates inflammation and cellular dedifferentiation of chondrocytes via MAPK signaling pathways.
Topics: Animals; Cell Differentiation; Cell Proliferation; Chondrocytes; Collagen Type II; Cyclooxygenase 2; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fluorescence; Inflammation; MAP Kinase Signaling System; Models, Biological; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Rabbits; Up-Regulation | 2017 |
Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.
Topics: Animals; Anti-Inflammatory Agents; Drug Design; Female; Inflammation; Mice; Molecular Conformation; Nitric Oxide; Oleanolic Acid; RAW 264.7 Cells | 2017 |
Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats.
Topics: Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Hyperglycemia; Inflammation; Malvaceae; Molecular Docking Simulation; Oleanolic Acid; Plant Leaves; Rats; Rats, Wistar; Streptozocin; Up-Regulation | 2017 |
Development, Physicochemical Characterization and In Vitro Anti-Inflammatory Activity of Solid Dispersions of α,β Amyrin Isolated from Protium Oilresin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Burseraceae; Cell Line; Cell Survival; Humans; Hypromellose Derivatives; Inflammation; Lipopolysaccharides; Macrophages; Nitric Oxide; Oleanolic Acid; Plant Oils; Polyethylene Glycols; Povidone; Resins, Plant; Suspensions | 2017 |
Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.
Topics: Animals; Blood Urea Nitrogen; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-1beta; Kidney; Kidney Diseases; Male; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Signal Transduction; Uric Acid | 2017 |
Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.
Topics: Animals; Antimalarials; Blood-Brain Barrier; Endothelium; Female; Inflammation; Longevity; Malaria, Cerebral; Male; Mice, Inbred C57BL; Oleanolic Acid; Rats | 2017 |
Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by blocking secretory phospholipase A2 IIA-activated calcium signals.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cognitive Dysfunction; Culture Media, Conditioned; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Neurons; Neurotoxicity Syndromes; Oleanolic Acid; Peptide Fragments; Phospholipases A2, Secretory; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Anti-inflammatory activity of dimethyl octenol and oleanene tetrol isolated from Trianthema decandra L.
Topics: Aizoaceae; Animals; Anti-Inflammatory Agents; Arthritis; Cyclooxygenase 2; Disease Models, Animal; Inflammation; Macrophages; Male; Mice; Molecular Docking Simulation; Nitric Oxide; Octanols; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Leaves; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2018 |
[Inhibitory effect of oleanolic acid on inflammatory response in IL-1β-stimulated human synovial sarcoma SW982 cells].
Topics: Anti-Inflammatory Agents; Cell Line; Cytokines; Extracellular Signal-Regulated MAP Kinases; Humans; I-kappa B Proteins; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 1; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Sarcoma, Synovial; Signal Transduction; Transcription Factor RelA | 2016 |
Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice.
Topics: Adipose Tissue; Animals; Calcium; CD36 Antigens; Diet, High-Fat; Diet, Mediterranean; Female; Glucose Tolerance Test; Inflammation; Inflammation Mediators; Insulin; Interleukin-1beta; Interleukin-6; Lipogenesis; Lipopolysaccharides; Liver; Mice, Inbred C57BL; Obesity; Oleanolic Acid; RNA, Messenger; Taste Buds; Weight Gain | 2018 |
Saikosaponin B2 Suppresses Inflammatory Responses Through IKK/IκBα/NF-κB Signaling Inactivation in LPS-Induced RAW 264.7 Macrophages.
Topics: Animals; Anti-Inflammatory Agents; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction | 2019 |
Steroid-Enriched Fraction of Achyranthes bidentata Protects Amyloid β Peptide 1-40-Induced Cognitive Dysfunction and Neuroinflammation in Rats.
Topics: Acetylcholinesterase; Achyranthes; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Behavior, Animal; Brain; Cognitive Dysfunction; Cytokines; Ecdysterone; Glutathione; Hippocampus; Inflammation; Male; Malondialdehyde; MAP Kinase Signaling System; Maze Learning; Memory; Microglia; Neuroprotective Agents; NF-kappa B; Oleanolic Acid; Peptide Fragments; Rats, Sprague-Dawley; Steroids; Triterpenes; Ursolic Acid | 2019 |
Bardoxolone treatment alleviates lipopolysaccharide (LPS)-induced acute lung injury through suppressing inflammation and oxidative stress regulated by Nrf2 signaling.
Topics: Acute Lung Injury; Animals; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; RAW 264.7 Cells; Signal Transduction | 2019 |
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization.
Topics: Adipose Tissue; Animals; Cell Polarity; China; Diet, High-Fat; Disease Models, Animal; Humans; Inflammation; Macrophages; Male; Mice; Mice, Obese; Obesity; Oleanolic Acid; Pentacyclic Triterpenes; Signal Transduction | 2019 |
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Topics: Animals; Apoptosis; Autophagy; Hepatectomy; HMGB1 Protein; Inflammation; Liver; Liver Transplantation; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Oleanolic Acid; Phosphorylation; Reperfusion Injury; Signal Transduction; Transplantation Conditioning; Tumor Necrosis Factor-alpha | 2019 |
Repeated oral administration of oleanolic acid produces cholestatic liver injury in mice.
Topics: Acute-Phase Proteins; Administration, Oral; Animals; Bile Acids and Salts; Biomarkers; Body Weight; Cholestasis; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation; Liver; Male; Mice; Oleanolic Acid; Organ Size; Organic Anion Transport Protein 1 | 2013 |
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Chemoprevention; Cyclooxygenase 2; Down-Regulation; Female; HSP90 Heat-Shock Proteins; I-kappa B Proteins; Inflammation; Mammary Neoplasms, Experimental; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Rats; Rats, Sprague-Dawley | 2014 |
Uncarilic acid and secouncarilic acid, two new triterpenoids from Uucaria sessilifructus.
Topics: Cell Line; Humans; Inflammation; Lipopolysaccharides; Macrophages; Molecular Structure; Nitric Oxide; Oleanolic Acid; Secosteroids; Structure-Activity Relationship; Triterpenes; Uncaria | 2013 |
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.
Topics: Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Expression Regulation; Inflammation; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; Male; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta | 2014 |
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease.
Topics: Animals; Aorta; Endothelial Cells; Gene Expression Regulation; Inflammation; Male; Nephrectomy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2013 |
Acylated oleanane-type saponins from Ganophyllum giganteum.
Topics: Acylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Biological Products; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Hydrolysis; Inflammation; Mice; Molecular Conformation; Oleanolic Acid; Plant Roots; Sapindaceae; Saponins; Structure-Activity Relationship | 2014 |
Oleanolic acid controls allergic and inflammatory responses in experimental allergic conjunctivitis.
Topics: Allergens; Animals; Anti-Allergic Agents; Cell Proliferation; Conjunctiva; Conjunctivitis, Allergic; Cytokines; Eosinophils; Female; Flow Cytometry; Immunization; Immunoglobulin E; Inflammation; Mast Cells; Mice; Mice, Inbred BALB C; Models, Animal; Oleanolic Acid; Pollen | 2014 |
The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Inhibitory Concentration 50; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Spleen; STAT3 Transcription Factor; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway.
Topics: Animals; Cell Line; Chromones; Cyclooxygenase 2; Dinoprostone; Glycine max; I-kappa B Kinase; Inflammation; Lipopolysaccharides; Macrophages; Malondialdehyde; Mice; Morpholines; Nitriles; Oleanolic Acid; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction; Sulfones; Superoxide Dismutase; Transcription Factor RelA | 2014 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; India; Inflammation; Interleukin-6; Leukocytes, Mononuclear; Male; Medicine, Traditional; NF-kappa B; Oleanolic Acid; Plant Leaves; Rats; Rats, Sprague-Dawley | 2014 |
The protective effect of Esculentoside A on experimental acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins; Signal Transduction; Sincalide | 2014 |
Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Diet, High-Fat; Inflammation; Intra-Abdominal Fat; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Oxidative Stress; Tumor Necrosis Factor-alpha | 2015 |
Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Inflammation; Inflammation Mediators; Mice; NF-kappa B; Nitric Oxide; Oleanolic Acid; Saponins; Signal Transduction | 2015 |
Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet.
Topics: Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents; Brain Stem; Diet, Fat-Restricted; Diet, High-Fat; Energy Metabolism; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; PPAR gamma; Receptors, Adrenergic, beta-3; Transcription Factors; Tyrosine 3-Monooxygenase | 2015 |
Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Saponins; Signal Transduction | 2015 |
Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Plant Roots; Saponins | 2015 |
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts.
Topics: Anti-Inflammatory Agents; Blotting, Western; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Membrane Microdomains; Oleanolic Acid; Oxidative Stress; Protein Transport; Reactive Oxygen Species; RNA, Small Interfering; Saponins; Signal Transduction; Toll-Like Receptor 4; Transfection | 2015 |
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
Topics: Adenomatous Polyposis Coli; Aging; Animals; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mutation; Oleanolic Acid; Oxidative Stress; Proton Therapy; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Tumor Suppressor Protein p53; Whole-Body Irradiation | 2016 |
Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Clematis; Cytokines; Dose-Response Relationship, Drug; Edema; Foot; Inflammation; Lipopolysaccharides; Mice; Oleanolic Acid; Plant Roots; RAW 264.7 Cells; Skin | 2015 |
Bardoxolone methyl prevents the development and progression of cardiac and renal pathophysiologies in mice fed a high-fat diet.
Topics: Animals; Anti-Inflammatory Agents; Cardiomegaly; Diet, High-Fat; Fats; Heart; Hypertrophy; Inflammation; Kidney; Male; Mice, Inbred C57BL; Myocardium; Oleanolic Acid | 2016 |
Bardoxolone Methyl Prevents Mesenteric Fat Deposition and Inflammation in High-Fat Diet Mice.
Topics: AMP-Activated Protein Kinases; Animals; Cytokines; Diet, High-Fat; Energy Metabolism; Extracellular Signal-Regulated MAP Kinases; Inflammation; Intra-Abdominal Fat; Ion Channels; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Oleanolic Acid; Oxidative Stress; PPAR gamma; Proto-Oncogene Proteins c-akt; Uncoupling Protein 2 | 2015 |
Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice.
Topics: Animals; Anti-Inflammatory Agents; Colon; Cytokines; Diet, High-Fat; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid | 2016 |
β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine-induced hepatic fibrosis in male rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Dimethylnitrosamine; Inflammation; Liver; Liver Cirrhosis; Male; Microscopy, Electron, Transmission; Oleanolic Acid; Oxidative Stress; Rats; Rats, Wistar | 2017 |
Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus.
Topics: Anti-Inflammatory Agents; Araliaceae; Cyclooxygenase 2; Cytokines; Gene Expression Regulation; Humans; Inflammation; Lipopolysaccharides; Microglia; Neurodegenerative Diseases; Nitric Oxide; Oleanolic Acid; Plant Extracts; Plant Leaves; Plants, Medicinal | 2016 |
Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Inflammation; Ketoprofen; Molecular Structure; Naproxen; Oleanolic Acid | 2016 |
Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns.
Topics: Animals; Humans; Inflammation; Interleukin-6; Interleukin-8; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Oleanolic Acid; Quercus; RAW 264.7 Cells; Triterpenes; Tumor Necrosis Factor-alpha | 2016 |
Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter 1; Cell Membrane; Cell Survival; Cholesterol; Cytokines; Endotoxemia; Female; Inflammation; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Membrane Microdomains; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction; Toll-Like Receptor 4; Treatment Outcome | 2016 |
Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti-Inflammatory Properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; Female; Flowers; Inflammation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Oleanolic Acid; Plant Extracts; Rats; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Syzygium; Temperature | 2016 |
Bardoxolone methyl prevents obesity and hypothalamic dysfunction.
Topics: Animals; Anti-Obesity Agents; Body Weight; Diet, High-Fat; Energy Intake; Energy Metabolism; Hypothalamus; Inflammation; Leptin; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Signal Transduction | 2016 |
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Topics: Animals; Granulocyte Colony-Stimulating Factor; Homeodomain Proteins; Humans; Imidazoles; Inflammation; Interleukin-6; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Knockout; Monocyte Chemoattractant Proteins; Neoplasms, Experimental; Oleanolic Acid; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Proto-Oncogene Proteins p21(ras); Trans-Activators; Vascular Endothelial Growth Factor A | 2016 |
Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-κB, p53 and p38 signalling pathways.
Topics: Animals; Apoptosis; DNA Damage; Down-Regulation; Germ Cells; Inflammation; Interleukin-1beta; Male; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Testis; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2017 |
Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats.
Topics: Alanine Transaminase; Alcohol Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Cholesterol; Cyclooxygenase 2; Dietary Supplements; Ethanol; Inflammation; Interleukin-6; Liver; Liver Diseases; Male; Oleanolic Acid; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Triglycerides; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2017 |
Taraxerol, a pentacyclic triterpene from Abroma augusta leaf, attenuates acute inflammation via inhibition of NF-κB signaling.
Topics: Animals; Carrageenan; Cytokines; Edema; Inflammation; Inflammation Mediators; Malvaceae; NF-kappa B; Oleanolic Acid; Plant Leaves; Rats, Wistar; Signal Transduction; Triterpenes | 2017 |
Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria.
Topics: Anemia; Animals; Cytokines; Gene Expression Regulation; Inflammation; Interleukin-10; Interleukin-6; Malaria; Male; Oleanolic Acid; Parasitemia; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2017 |
Anti-inflammatory activity of oleanolic acid by inhibition of secretory phospholipase A2.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Dose-Response Relationship, Drug; Edema; Hemolysis; Humans; Inflammation; Mice; Oleanolic Acid; Phospholipases A2, Secretory; Plant Extracts; Pleura; Snake Venoms; Synovial Fluid | 2009 |
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes; Inflammation; Male; Mice; Oleanolic Acid | 2009 |
The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease.
Topics: Animals; Antioxidants; Bronchi; Bronchoalveolar Lavage; Cell Line; Cell Proliferation; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Epithelial Cells; Flagellin; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Lipopolysaccharides; Mice; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Proteomics; Trachea; Triterpenes | 2009 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blood Urea Nitrogen; Blotting, Western; Cisplatin; DNA Adducts; Gene Expression; Gene Expression Regulation; Imidazoles; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Kidney; Kidney Diseases; Mice; Mice, Knockout; Necrosis; NF-E2-Related Factor 2; Nucleic Acid Amplification Techniques; Oleanolic Acid; Platinum; RNA, Messenger; Transcription Factors | 2010 |
Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Immunosuppressive Agents; Inflammation; Male; Mice; Molecular Structure; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Tripterygium; Xylenes | 2010 |
The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.
Topics: Animals; Cells, Cultured; Dendritic Cells; Female; Heme Oxygenase (Decyclizing); Immunomodulation; Inflammation; Inflammation Mediators; Interleukin-17; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; Spleen; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2010 |
[Effects of fulvotomentoside on inflammatory factors and antiinflammatory factors in intestine of ovalbumin-sensitized BALB/c mice].
Topics: Animals; Female; Food Hypersensitivity; Forkhead Transcription Factors; Inflammation; Interleukin-17; Interleukin-6; Intestinal Mucosa; Intestines; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovalbumin; Saponins; Transforming Growth Factor beta1 | 2010 |
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Nucleus; Disease Models, Animal; Inflammation; Major Histocompatibility Complex; Mice; Mice, Transgenic; Mitochondria; Neurodegenerative Diseases; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteins; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Vesicular Transport Proteins | 2011 |
Analgesic and anti-inflammatory property of the methanol extract from Ligustrum morrisonense leaves in rodents.
Topics: Abdomen; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability; Carrageenan; Cyclooxygenase 2 Inhibitors; Edema; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Inflammation Mediators; Ligustrum; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Triterpenes | 2011 |
Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Inflammation; Male; Mice; Mice, Inbred Strains; Oleanolic Acid; Phorbol Esters; Phytotherapy; Plant Extracts; Quillaja | 2011 |
Anti-inflammatory properties from isolated compounds of Cyclolepis genistoides.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Injections, Intraperitoneal; Lactones; Male; Medicine, Traditional; Mice; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Sesquiterpenes; Time Factors | 2011 |
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Area Under Curve; Body Weight; Cyclohexanols; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Enzyme-Linked Immunosorbent Assay; Freezing Reaction, Cataleptic; Hyperalgesia; Inflammation; Locomotion; Male; Mice; Neuralgia; Oleanolic Acid; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Pentacyclic Triterpenes; Peroxidase; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Tritium | 2011 |
Effects of oleanolic acid on pulmonary morphofunctional and biochemical variables in experimental acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Respiratory Mechanics | 2011 |
Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophilia; Female; Immunoglobulin E; Inflammation; Leukocyte Count; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovalbumin; Phytotherapy; Transcription Factor RelA; Triterpenes | 2012 |
Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice.
Topics: Abietanes; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Lethal Dose 50; Mice; Motor Activity; Narcotic Antagonists; Oleanolic Acid; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Plants, Medicinal; Salvia officinalis; Time Factors; Triterpenes; Ursolic Acid | 2012 |
Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress.
Topics: Antioxidants; Drug Industry; Humans; Inflammation; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress | 2012 |
Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.
Topics: Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Inflammation; Interleukin-17; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multiple Sclerosis; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oleanolic Acid; Oligodendroglia; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; RNA, Messenger; Th1 Cells; Triterpenes | 2011 |
Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Carrageenan; Cyclooxygenase 2 Inhibitors; Edema; Elaeagnaceae; Flavonoids; Flavonols; Formaldehyde; Inflammation; Inflammation Mediators; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Nitric Oxide; Oleanolic Acid; Pain; Phytotherapy; Plant Extracts; Polyphenols; Triterpenes; Ursolic Acid | 2012 |
Anti-inflammatory effects of oleanolic acid on LPS-induced inflammation in vitro and in vivo.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxymethylcellulose Sodium; Cell Adhesion; Cell Line; Cell Movement; Cell Survival; E-Selectin; Endothelium, Vascular; Enzyme Activation; Female; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2013 |
[Immune state in lung of BALB/c mice with ovalbumin allergy and the effects of fulvotomentoside on lungs of mice].
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; Female; Food Hypersensitivity; Immunohistochemistry; Inflammation; Interleukin-17; Interleukin-6; Lung Diseases; Mice; Mice, Inbred BALB C; Neutrophils; Oleanolic Acid; Ovalbumin; Saponins; Transforming Growth Factor beta1 | 2012 |
Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase.
Topics: Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Drugs, Chinese Herbal; Enzyme Activation; I-kappa B Kinase; Inflammation; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Microscopy, Confocal; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Oleanolic Acid; RNA Interference; Saponins; Toll-Like Receptor 4; Transfection; Tumor Necrosis Factor-alpha | 2012 |
Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Cytokines; Dinoprostone; Down-Regulation; Inflammation; Lipopolysaccharides; Macrophages; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Oleanolic Acid; Oncogene Protein v-akt; RNA, Messenger | 2013 |
Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii.
Topics: Administration, Topical; Animals; Biological Assay; Croton Oil; Dermatologic Agents; Flavonoids; Glycosides; Inflammation; Lamiaceae; Male; Mice; Oleanolic Acid; Plant Extracts; Triterpenes; Ursolic Acid | 2002 |
Irritant potential of some constituents from the seeds of Caesalpinia bonducella (L.) fleming.
Topics: Animals; Caesalpinia; Dose-Response Relationship, Drug; Inflammation; Irritants; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Seeds; Triterpenes | 2003 |
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; CD11b Antigen; CD36 Antigens; Cell Differentiation; Cell Division; Cell Line, Tumor; Cell Separation; Cholecalciferol; Dose-Response Relationship, Drug; Female; Fibroblasts; Flow Cytometry; Humans; Imidazoles; Inflammation; Inhibitory Concentration 50; Mice; Models, Chemical; Monocytes; Neoplasms; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oleanolic Acid; Receptors, Cytoplasmic and Nuclear; Time Factors; Transcription Factors; Transcriptional Activation; U937 Cells | 2003 |
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
Topics: Animals; Chemokines; Cytokines; Gene Expression; Imidazoles; Inflammation; Lipopolysaccharides; Lung; Mice; Mice, Knockout; Neutrophils; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species | 2006 |
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Topics: Cytokines; Drug Evaluation, Preclinical; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Leukocytes, Mononuclear; Lipopolysaccharides; Neutrophils; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; Receptors, Formyl Peptide; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Inhibitory effect of karounidiol on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Female; Inflammation; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 1994 |
[Anterior chamber inflammation after the injection of endothelin-1 into the vitreous and the effect of ETA receptor antagonist].
Topics: Animals; Anterior Chamber; Aqueous Humor; Caffeic Acids; Dinoprostone; Endothelin Receptor Antagonists; Endothelin-1; Female; Inflammation; Leukotriene B4; Male; Oleanolic Acid; Rabbits; Receptor, Endothelin A; Receptors, Endothelin; Vitreous Body | 1997 |
Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Survival; Dinoprostone; Edema; Enzyme Inhibitors; Exudates and Transudates; Humans; In Vitro Techniques; Inflammation; Leukocytes; Leukotriene B4; Male; Mice; Oleanolic Acid; Phospholipases A; Phospholipases A2; Porifera; Rats; Rats, Inbred Lew; Rats, Wistar; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Ear, External; Edema; Female; Foot; Humans; Hypersensitivity, Delayed; In Vitro Techniques; Inflammation; Leukotriene B4; Leukotrienes; Mice; Neutrophils; Oleanolic Acid; Oxidation-Reduction; Peroxidase; Pistacia; Rats; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Triterpenes | 2001 |
Effect of esculentoside A on autoimmunity in mice and its possible mechanisms.
Topics: Animals; Antibodies, Antinuclear; Apoptosis; Autoimmunity; Cell Line; Endothelium, Vascular; Humans; Inflammation; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred BALB C; Oleanolic Acid; Phytolacca; Plants, Medicinal; RNA, Messenger; Saponins; Thymus Gland; Umbilical Cord | 2002 |