Page last updated: 2024-08-21

oleanolic acid and Hyperglycemia

oleanolic acid has been researched along with Hyperglycemia in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.76)29.6817
2010's10 (58.82)24.3611
2020's5 (29.41)2.80

Authors

AuthorsStudies
Chen, J; Hua, W; Liu, J; Sun, H; Wu, G; Wu, X; Zhang, L1
Auwerx, J; Genet, C; Lobstein, A; Mioskowski, C; Saladin, R; Sato, H; Strehle, A; Thomas, C; Wagner, A1
Choi, JH; Choi, S; Choi, YJ; Chung, HY; Hyun, MK; Kim, DH; Lee, JY; Noh, SG; Park, CH; Park, D1
Cao, H; Fang, WS; Gao, X; Huan, Y; Niu, S; Shen, Z; Wang, S; Wang, X; Yang, M; Zhou, X1
Hu, R; Jois, SV; Xu, L; Zhang, L1
Dong, MJ; Liu, YY; Mao, L; Sun, MY; Tang, S; Yang, JL; Yuan, Q; Zhang, RD1
Arruri, VK; Gundu, C; Kalvala, AK; Kumar, A; Kumar, R; Sherkhane, B1
Chen, K; Kang, X; Liu, JB; Sheng, J; Xie, QY; Yang, Z; Zheng, W1
Bhattacharjee, N; Dewanjee, S; Dua, TK; Kalita, J; Khanra, R; Manna, P; Nandy, A; Saha, A1
An, Q; Cui, W; Ding, Y; Hu, Q; Wang, B; Wu, F1
Karan, SK; Mishra, SK; Mondal, A; Pal, D; Rout, KK1
Castellano, JM; Cayuela, JA; Delgado, T; Guinda, A; Rada, M1
Dinda, AK; Gupta, YK; Maulik, SK; Prabhakar, P; Reeta, KH1
Mapanga, RF; Musabayane, CT; Tufts, MA1
Cantley, J; Hegarty, BD; Iseli, TJ; Kraegen, EW; Molero, JC; Wang, YP; Ye, JM; Ye, Y; Zeng, XY1
Bourdon, E; Dlamini, N; Essop, MF; Fahim, MA; Hasan, MY; Kelly-Laubscher, R; Mapanga, RF; Rajamani, U; Rondeau, P; Shafiullah, M; Wahab, A; Zungu-Edmondson, M1
Adebajo, AC; Aladesanmi, AJ; Ayoola, MD; Odediran, SA; Schmidt, TJ; Verspohl, EJ1

Reviews

1 review(s) available for oleanolic acid and Hyperglycemia

ArticleYear
Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes.
    Diabetes, 2013, Volume: 62, Issue:6

    Topics: Humans; Hyperglycemia; Hypoglycemic Agents; Insulin-Secreting Cells; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes

2013

Other Studies

16 other study(ies) available for oleanolic acid and Hyperglycemia

ArticleYear
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
    Bioorganic & medicinal chemistry letters, 2006, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Blood Glucose; Cyclization; Enzyme Inhibitors; Glycogen Phosphorylase; Hyperglycemia; Mice; Molecular Structure; Muscles; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Triterpenes

2006
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea.
    Biochemical and biophysical research communications, 2007, Nov-03, Volume: 362, Issue:4

    Topics: Administration, Oral; Animals; Hyperglycemia; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Olea; Plant Extracts; Receptors, G-Protein-Coupled; Treatment Outcome

2007
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation.
    Journal of molecular medicine (Berlin, Germany), 2022, Volume: 100, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Experimental; Eriobotrya; Hyperglycemia; Inflammation; Mice; Oleanolic Acid; Plant Extracts; Ursolic Acid

2022
Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo.
    Bioorganic chemistry, 2022, Volume: 129

    Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Esters; Gluconeogenesis; Hyperglycemia; Hypoglycemic Agents; Liver; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Cytoplasmic and Nuclear

2022
Oleanolic acid and moderate drinking increase the pancreatic GLP-1R expression of the
    PeerJ, 2023, Volume: 11

    Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Hyperglycemia; Insulin; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger

2023
Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells.
    Aging, 2020, 06-02, Volume: 12, Issue:11

    Topics: Apoptosis; Blood Glucose; Diabetic Angiopathies; Drug Evaluation, Preclinical; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Signal Transduction

2020
Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy.
    Molecular neurobiology, 2020, Volume: 57, Issue:8

    Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperglycemia; Hypoglycemic Agents; Kelch-Like ECH-Associated Protein 1; Male; Mitochondria; Oleanolic Acid; Rats, Sprague-Dawley; Signal Transduction

2020
Oleanolic acid prevents cartilage degeneration in diabetic mice via PPARγ associated mitochondrial stabilization.
    Biochemical and biophysical research communications, 2017, 08-26, Volume: 490, Issue:3

    Topics: Animals; Cartilage; Cartilage Diseases; Cells, Cultured; Diabetes Complications; Diabetes Mellitus, Experimental; Hyperglycemia; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; Oleanolic Acid; PPAR gamma; Protective Agents

2017
Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 94

    Topics: Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Hyperglycemia; Inflammation; Malvaceae; Molecular Docking Simulation; Oleanolic Acid; Plant Leaves; Rats; Rats, Wistar; Streptozocin; Up-Regulation

2017
Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3 inflammasome signaling pathways.
    Molecular medicine reports, 2017, Volume: 16, Issue:6

    Topics: Animals; Biomarkers; Body Weight; Carotid Artery Injuries; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; Hyperglycemia; Inflammasomes; Inflammation Mediators; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Rats; Signal Transduction

2017
Antidiabetic effect of Streblus asper in streptozotocin-induced diabetic rats.
    Pharmaceutical biology, 2013, Volume: 51, Issue:3

    Topics: Animals; Antioxidants; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Ethnopharmacology; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; India; Liver; Male; Moraceae; Neutrophil Infiltration; Oleanolic Acid; Oxidative Stress; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats; Streptozocin; Toxicity Tests, Acute

2013
α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:1

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Antioxidants; Diet, Carbohydrate Loading; Dose-Response Relationship, Drug; Fructose; Gene Expression Regulation; Hyperglycemia; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Liver; Male; Metabolic Syndrome; Oleanolic Acid; Oxidative Stress; PPAR alpha; Random Allocation; Rats, Wistar

2017
Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats.
    Renal failure, 2010, Volume: 32, Issue:7

    Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Syzygium

2010
Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Animals; Base Sequence; Blood Glucose; Diabetes Mellitus, Type 2; DNA Primers; Forkhead Box Protein O1; Forkhead Transcription Factors; Gluconeogenesis; Glucose Tolerance Test; Hyperglycemia; Insulin; Insulin Secretion; Liver; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Triglycerides

2012
Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Heart; Hyperglycemia; Male; Myocardial Contraction; Myocardium; Oleanolic Acid; Plant Extracts; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Syzygium

2012
Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem.
    Journal of diabetes, 2013, Volume: 5, Issue:3

    Topics: Animals; Apocynaceae; Blood Glucose; Cell Line, Tumor; Chromatography, Liquid; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Glucose; Glyburide; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulinoma; Male; Methanol; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Plant Stems; Rats; Rats, Wistar; Treatment Outcome

2013