oleanolic acid has been researched along with Disease Models, Animal in 164 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (5.49) | 18.2507 |
| 2000's | 21 (12.80) | 29.6817 |
| 2010's | 107 (65.24) | 24.3611 |
| 2020's | 27 (16.46) | 2.80 |
| Authors | Studies |
|---|---|
| An, HJ; Kang, YM; Kim, HM; Lee, M | 2 |
| Khan, MI; Khan, MZ; Kim, JD; Kim, MY; Lee, YB; Shin, JH; Shin, TS | 1 |
| Eisch, AJ; Guzman, CS; Kiffer, FC; Luitel, K; Patel, RA; Shay, JW; Soler, I; Tran, FH; Xiao, R; Yun, S | 1 |
| Cao, Y; Chen, X; Huang, C; Huang, D; Liu, J; Tao, Y; Wang, Y | 1 |
| Fukiya, H; Horizono, J; Kai, H; Kamura, M; Kaseda, S; Koyama, Y; Kuwazuru, J; Nara, F; Niinou, S; Nishiyama, H; Ogi, S; Onuma, K; Sannomiya, Y; Sasaki, R; Shuto, T; Suico, MA; Sunamoto, H | 1 |
| Han, RY; Jia, J; Liu, XH; Tan, RZ; Wang, L; Xie, KH; Zhong, X | 1 |
| Cai, J; Fan, Y; Jiang, M; Liu, H; Nie, H; Sun, H; Wang, L; Wei, X; Xing, Z; Yang, D; Zhao, C; Zhou, L | 1 |
| Amirova, KM; Dimitrova, PA; Dinkova-Kostova, AT; Georgiev, MI; Koycheva, IK; Leseva, MN | 1 |
| Kang, NX; Khan, IA; Li, KP; Liu, YL; Wang, YE; Xu, QM; Yang, S; Zhao, JP | 1 |
| Chen, Z; Hu, B; Huang, H; Jie, Z; Ma, Y; Pan, X; Shi, P; Sun, X; Wang, J; Xie, Z; Zhang, B; Zhao, X | 1 |
| Akahane, T; Fujinaga, Y; Kaji, K; Kawaratani, H; Kaya, D; Kitagawa, K; Moriya, K; Namisaki, T; Ozutsumi, T; Takaya, H; Tsuji, Y; Yamashita, S; Yoshiji, H | 1 |
| Ali, H; Ali, J; Islam, SU; Khan, AU; Khan, S; Kim, YS; Shah, FA | 1 |
| Chai, OH; Lee, EJ; Piao, CH; Song, CH | 1 |
| Gao, J; Guan, X; Guo, J; Liu, B; Liu, S; Qin, Z; Tang, K; Wang, X; Zhang, F | 1 |
| Du, Y; Li, J; Liu, J; Lu, N; Ouyang, B; Xia, J; Yang, Y | 1 |
| Gao, Y; Lu, S; Luo, Y; Sun, G; Sun, X; Wu, D; Xu, X; Yang, K | 1 |
| Claro-Cala, CM; de Sotomayor, MA; Herrera, MD; Miñano, J; Pérez-Montero, M; Quintela, JC; Rodríguez-Rodríguez, AR | 1 |
| An, Y; Li, J; Li, M; Li, P; Ren, J; Wu, M; Xie, Y; Xiong, W; Xue, H; Yan, D; Zhong, G | 1 |
| Abdelaziz, S; El-Fattah, A; Elgaml, SA; Hashish, EA; Shalaby, SI | 1 |
| Chang, SL; Chen, YI; Hsu, TH; Hung, PH; Lin, CM; Tsai, JC; Tzeng, CY | 1 |
| Fakhoury, M; Fouani, M; Lawand, N; Salman, I | 1 |
| Han, Y; Li, X; Liang, G; Tong, Z; Wang, C | 1 |
| Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M | 1 |
| Hu, MZ; Li, YB; Liu, B; Mi, LF; Wang, AR; Zhang, ZL; Zhao, ZY; Zheng, S | 1 |
| Hou, X; Jiang, X; Liu, H; Ping, Y; Song, C; Song, J; Zhang, F; Zhang, Z; Zhi, L | 1 |
| Kim, J; Lee, H; Mikami, T; Park, J; Suidasari, S; Yaicharoen, P; Yamauchi, K; Yokozawa, M | 1 |
| Aslam, B; Faisal, MN; Muhammad, F; Siddique, R | 1 |
| Chen, G; Fu, Y; Yao, L; Yao, T; Zhang, L; Zhou, C | 1 |
| Guo, Q; Liu, Z; Smith, WW; Wang, B; Wang, X; Zhu, Y | 1 |
| Li, T; Liu, J; Luo, H; Ouyang, Q; Wang, L; Xuan, C | 1 |
| González-Chávez, MM; Pérez-González, C; Pérez-Gutiérrez, S; Ramos-Velázquez, CS; Sánchez-Mendoza, E; Serrano-Vega, R | 1 |
| Dun, Y; He, Y; Liu, C; Ren, D; Wang, J; Wang, T; Yuan, C; Yuan, D; Zhang, C; Zhao, H; Zhou, Z | 1 |
| Bhindi, R; Birgisdottir, AB; Bubb, KJ; Figtree, GA; Hansen, T; Karimi Galougahi, K; Kok, C; Meyer, C; Rasko, NB; Reisman, SA; Ritchie, R; Tang, O; Ward, K | 1 |
| Nezu, M; Suzuki, N; Yamamoto, M | 1 |
| Afzal, A; Bashir, S; Khan, MW; Ma, X; Madni, A; Raza, SM; Sarfraz, M; Xiang, G | 1 |
| Cho, S; Khan, A; Kim, YJ; Lee, S; Pan, JH; Park, YH | 1 |
| Chen, DZ; Chen, LQ; Gong, YQ; Lin, MX; Wei, DZ; Ying, BY | 1 |
| de Leon, RD; Estrada, C; Hinahon, E; Tong, L; Won, DS | 1 |
| Bi, Y; Ding, L; Gao, W; Ye, M; Zhu, W | 1 |
| Hisamichi, M; Hoshino, S; Kamijo-Ikemori, A; Kimura, K; Shibagaki, Y; Sugaya, T | 1 |
| Du, ZA; Hu, ZS; Sun, MN | 1 |
| Chang, CH; Liao, VH; Wei, CC | 1 |
| Bao, WL; Guan, YY; Li, HL; Li, YX; Liu, LX; Shen, XY; Tang, HH; You, Y; Zhang, SL; Zhou, Y | 1 |
| Cao, S; Dong, XL; Ho, MX; Wong, KC; Wong, MS; Yao, XS; Yu, WX | 1 |
| Han, JY; Jeon, D; Kim, HY; Kim, MS; Kim, SH; Lee, K; Lee, SW; Rho, MC | 1 |
| Chen, J; Chen, Y; Huang, H; Jia, Y; Pan, Y; Shen, Y; Song, Z; Zhou, F | 1 |
| Guo, W; Liu, S; Sun, W; Wang, K; Xu, J; Zhang, L; Zhang, Y; Zhou, Z | 1 |
| Dronamraju, SVL; Rajarathinam, G | 1 |
| An, HJ; Gu, H; Gwon, MG; Jang, KM; Kim, JY; Park, B; Park, JH; Park, KK | 1 |
| Han, YW; Li, XM; Liu, XJ; Zhao, Y | 1 |
| Gamede, M; Khathi, A; Mabuza, L; Ngubane, P | 1 |
| Huang, XT; Li, XH; Li, Y; Luo, ZQ; Peng, XP | 1 |
| Adhikari, N; An, CH; An, SY; Aryal, YP; Choi, M; Choi, SY; Ha, JH; Jung, JK; Kim, JY; Kim, SH; Lee, TH; Lee, Y; Neupane, S; Rho, MC; Sohn, WJ; Suh, JY; Yamamoto, H | 1 |
| Hara, H; Hida, Y; Horai, N; Inoue, Y; Masuda, T; Nakagami, Y; Nakamura, S; Nishinaka, A; Noguchi, T; Sakurai, S; Shimazawa, M; Tsusaki, H | 1 |
| Bai, C; Chen, H; He, X; Huang, Z; Liang, J; Liu, Z; Su, Q; Tian, X; Wei, F; Yin, M; Yu, B; Zhao, Q; Zhou, X | 1 |
| Álvarez de Cienfuegos, L; Blanco-Cabra, N; Moya-Andérico, L; Parra, A; Torrents, E; Vega-Granados, K; Vukomanovic, M | 1 |
| Cao, X; Ge, X; Li, Z; Lu, Y; Qin, W; Shen, P; Sun, H; Tang, Q; Wang, D; Yang, N; Zhang, W | 1 |
| Choi, JK; Khang, D; Kim, SH; Lee, S; Lee, SW; Lee, WS; Oh, HM; Park, JW; Rho, MC | 1 |
| Distler, JH; Doniparthi, S; Hinchcliff, M; Komura, K; Lord, G; Tamaki, Z; Tomcik, M; Varga, J; Wang, W; Wei, J; Zhu, H | 1 |
| Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP | 1 |
| Lee, HB; Sharma, M; Tailor, NK | 1 |
| Ci, XX; Jiang, LX; Qiao, AN; Soromou, LW; Wang, DC; Wei, JY; Wei, MM; Xie, XX; Zhong, WT; Zhou, X | 1 |
| Capelozzi, VL; Cruz, FF; de Assis, EF; de Castro-Faria-Neto, HC; de Oliveira, GP; Gattass, CR; Morales, MM; Pelosi, P; Rocco, PR; Santos, CL; Santos, RS; Silva, PL | 1 |
| Han, M; Heo, H; Hong, SW; Kim, DH; Kwon, YK; Yang, JH | 1 |
| Chen, W; Fan, J; Feng, X; Liu, X; Wang, J; Wu, J; Yang, X; Yu, X; Zeng, Y | 1 |
| Gu, T; Li, Y; Wang, J; Yamahara, J | 1 |
| Fitzpatrick, LR; Liby, KT; Small, JS; Stonesifer, E | 1 |
| Hara, H; Iwama, T; Iwawaki, T; Kitashoji, A; Shimazawa, M; Takagi, T; Tsuruma, K; Yoshimura, S | 1 |
| Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK | 1 |
| Ahn, YJ; Jang, DS; Jung, JW; Kwon, G; Lee, HE; Lee, Y; Oh, SR; Park, SJ; Ryu, JH; Woo, H | 1 |
| Cheong, JH; Kim, B; Ko, SY; Lee, HE; Lee, Y; Oh, HK; Park, SJ; Ryu, JH; Shin, CY | 1 |
| Andreeff, M; Hemachandran, S; Khobahy, E; Min, SY; Mohan, C; Pathak, S; Wu, T; Yan, M; Ye, Y; Zhou, J; Zhou, XJ; Zhu, J | 1 |
| Geng, D; Li, J; Liu, BB; Liu, Q; Luo, L; Yi, LT | 1 |
| Cheng, H; Cheng, L; Song, S; Wang, L; Xu, D; Yin, Q; Zhang, M; Zhou, X | 1 |
| Klaassen, CD; Liu, J; Lu, YF; Wu, KC | 1 |
| Helen, A; Krishnan, K; Mathew, LE; Vijayalakshmi, NR | 1 |
| Chan, JY; Khazaeli, M; Lau, WL; Liu, SM; Ni, Z; Pahlevan, S; Vaziri, ND; Yuan, J | 1 |
| Cao, C; Ding, H; Liu, Y | 1 |
| Cheng, YF; Guo, HB; Huang, F; Liang, BF; Wang, GH; Wang, HT; Xu, JP; Yuan, X; Zhang, MZ | 1 |
| Camer, D; Dinh, CHL; Fernandez, F; Huang, XF; Szabo, A; Yu, Y | 1 |
| Biswal, S; Cho, H; Duh, EJ; Gong, J; Hartsock, MJ; Mitchell, KL; Sporn, MB; Thimmulappa, RK; Wang, S; Wei, Y; Welsbie, DS; Wu, L; Xu, Z | 1 |
| Abdelkader, D; Chen, Y; Hassan, W; Liu, J; Sun, H; Wang, X | 1 |
| Arora, S; Blaufuss, TA; Blomenkamp, KS; Jain, AK; Long, JP; Neuschwander-Tetri, BA; Rodrigues, J; Teckman, JH; Wen, JX | 1 |
| Wang, S; Xu, Y; Yang, H; Yu, L; Zhu, X | 1 |
| He, ZX; Ma, YQ; Wang, YY; Zhang, CY; Zhe, H; Zhou, SF | 1 |
| Castañeda-Sanchez, JI; Castro-Mussot, ME; Domínguez-López, L; Hernández-Sanchéz, J; Jiménez-Arellanes, A; López-García, S; Luna-Herrera, J | 1 |
| Daniels, WM; Mabandla, MV; Ndlovu, BC | 1 |
| Bozeman, RG; Kaisani, A; Kim, SB; Kim, W; Richardson, JA; Shay, JW; Wright, WE; Zhang, L | 1 |
| Ci, X; Li, D; Peng, L; Ren, H; Wen, Z; Zhong, W | 1 |
| Ahn, YJ; Kwon, HW; Na, YE; Perumalsamy, H; Wang, X | 1 |
| Chen, J; Chen, W; Duan, M; Li, B; Li, Q; Liao, M; Ling, F; Liu, Y; Lu, C; Qi, W; Xiao, K; Zeng, Z; Zhao, Y | 1 |
| Campos, BL; Jesus, JA; Kallás, EG; Lago, JH; Laurenti, MD; Levy, D; Passero, LF; Rafael-Fernandes, M; Ribeiro, SP; Santos-Gomes, G; Sessa, DP; Silva, MS; Yamamoto, ES | 1 |
| Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG | 1 |
| Honkura, Y; Katori, Y; Kawase, T; Matsuo, H; Mizutari, K; Morita, I; Motohashi, H; Murakami, S; Sakiyama, M; Shinomiya, N; Shiotani, A; Yamamoto, M | 1 |
| de Haan, JB; Deliyanti, D; Lee, JY; Meyer, CJ; Petratos, S; Ward, KW; Wilkinson-Berka, JL | 1 |
| Egner, PA; Kaneko, T; Kensler, TW; Mashimo, T; Morita, M; Taguchi, K; Takaku, M; Yamamoto, M | 1 |
| Cichewicz, RH; Du, L; Dunn, DE; He, DN; Kaltenbach, LS; Lo, DC; McCoy, DD; Newman, RA; Peng, J; Shah, B; Shen, L; Van Kanegan, MJ; Yang, P | 1 |
| Cao, W; Guo, Z; Han, B; Han, Z; Zhao, S | 1 |
| Bian, Y; Gao, D; Li, L; Liu, Y; Luo, L; Wang, M; Xing, S; Zhang, X | 1 |
| Fan, Y; Hao, BB; Lu, L; Pan, XX; Qian, XF; Rao, JH; Wang, XH; Zhang, F | 1 |
| Law, BY; Liu, L; Lo, AC; Wong, VK; Wu, AG; Zeng, W; Zhu, YZ | 1 |
| Fussenegger, M; Shao, J; Wang, Y; Xie, M; Xue, S; Yang, L; Ye, H; Yin, J; Yu, Y | 1 |
| Adcott, J; Bertrand, HC; Callard, R; Castillo-Quan, JI; Cochemé, HM; Gatliff, J; Gomez Perez-Nievas, B; Ivanov, DK; Kerr, F; Khericha, M; Martinez, P; Noble, W; Partridge, L; Snoeren, I; Sofola-Adesakin, O; Thornton, J; Wells, G | 1 |
| Calingasan, NY; Dumont, M; Flint Beal, M; Gouras, GK; Liby, K; Lin, MT; Nathan, C; Sporn, M; Tampellini, D; Wille, E; Williams, C | 1 |
| Baggio, CH; Dos Santos, AC; Dos Santos, EP; Freitas, CS; Luiz, AP; Marcon, R; Marques, MC; Mayer, B; Pizzolatti, MG; Santos, AR; Soldi, C; Twardowschy, A | 1 |
| Kordower, JH; Masliah, E; McKay, H; Merrill, DA; Mufson, EJ; Roberts, JA; Tuszynski, MH | 1 |
| Buckley, DB; Klaassen, CD; Reisman, SA; Tanaka, Y | 1 |
| Maurya, R; Singh, AB; Srivastava, AK; Yadav, DK | 1 |
| Bento, AF; Calixto, JB; Figueiredo, CP; Hara, DB; Mazzuco, TL; Vitor, CE | 1 |
| Arnés, M; Carvalho-Tavares, J; Hernández, M; Martín, R; Nieto, ML; Ruiz-Gutiérrez, V | 1 |
| Hassoun, PM; Kensler, TW; Kleeberger, SR; Liby, KT; Reddy, NM; Reddy, SP; Sporn, MB; Suryanaraya, V; Yamamoto, M; Yates, MS | 1 |
| Davis, PB; Eastman, JF; Nichols, DP; Shank, SL; Ziady, AG | 1 |
| Feng, H; Guo, C; Hu, Z; Li, J; Qiu, L; Wang, J; Xiao, Z; Yu, Q; Zhang, J | 1 |
| Mapanga, RF; Musabayane, CT; Shode, FO; Tufts, MA | 1 |
| Beal, MF; Calingasan, NY; Dumont, M; Ho, D; Liby, K; Sporn, M; Stack, C; Wille, E; Williams, C | 1 |
| Brouillet, E; Escartin, C | 1 |
| Boller, S; Cabrini, DA; Marques, MC; Otuki, MF; Pizzolatti, MG; Santos, EP; Soldi, C; Zampronio, AR | 1 |
| Gong, XJ; Ji, H; Li, YM; Rong, ZT; Sun, HB | 1 |
| Huang, W; Sun, R | 1 |
| Hruban, RH; Liby, KT; Maitra, A; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Abe, H; Asai, K; Chayama, K; Hayes, CN; Hiraga, N; Imamura, M; Kawaoka, T; Maekawa, T; Matsuhira, T; Mitsui, F; Murakami, S; Ochi, H; Takahashi, S; Tateno, C; Tsuge, M; Yamashita, N; Yoshizato, K | 1 |
| Ahn, KS; Cai, XF; Jang, HY; Kwon, OK; Lee, HK; Lee, MY; Oh, SR; Yuk, JE | 1 |
| Joh, EH; Kim, DH | 1 |
| Agarwal, A; Chen, B; Chen, J; Ferguson, DA; Grossman, E; Hartono, J; Lu, CY; Meyer, C; Senitko, M; Wang, Y; Wigley, WC; Winterberg, P; Wu, QQ; Zhou, XJ | 1 |
| Ma, L; Qin, LP; Wei, YJ; Wu, JG; Yan, XQ; Zhang, H | 1 |
| Brito, GA; Chaves, MH; Melo, CM; Morais, TC; Rao, VS; Santos, FA; Tomé, AR | 1 |
| Beal, MF; Calingasan, NY; Damiano, M; Kiaei, M; Liby, KT; Naseri, N; Neymotin, A; Petri, S; Risingsong, R; Sporn, M; Wille, E | 1 |
| Fusco, MR; Juárez, A; Pelzer, L; Petenatti, E; Robles, S; Rossomando, P; Sosa, A | 1 |
| Bento, AF; Calixto, JB; Meotti, FC; Passos, GF; Paszcuk, AF; Silva, ES; Simão da Silva, KAB | 1 |
| Cruz, FF; Fernandes, J; Gattass, CR; Lanzetti, M; Morales, MM; Oliveira, GP; Ornellas, DS; Pelosi, P; Rocco, PR; Santos, RS; Silva, PL; Valença, SS | 1 |
| Chaves, MH; Ferreira, EL; Gomes, BS; Oliveira, FA; Oliveira, JP; Silva, LL; Sousa-Neto, BP | 1 |
| Ahn, KS; Kwon, OK; Lee, HK; Lee, KY; Lee, MY; Lim, HS; Oh, SR; Yuk, JE | 1 |
| Baggio, CH; da Silva, CF; das Neves, TL; Horst, H; Kanazawa, LK; Pizzolatti, MG; Rodrigues, MR; Santos, AR; Werner, MF | 1 |
| Huang, W; Huang, Y; Lv, L; Sun, R; Wang, R | 1 |
| Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Bai, F; Li, HQ | 1 |
| Bourdon, E; Dlamini, N; Essop, MF; Fahim, MA; Hasan, MY; Kelly-Laubscher, R; Mapanga, RF; Rajamani, U; Rondeau, P; Shafiullah, M; Wahab, A; Zungu-Edmondson, M | 1 |
| Abbate, M; Benigni, A; Carrara, F; Corna, D; Gaspari, F; Locatelli, M; Nava, V; Remuzzi, G; Sangalli, F; Zoja, C | 1 |
| Jyothi Kumari, P; Lakshmi, BS; Sangeetha, KN; Shilpa, K | 1 |
| Huang, XT; Li, N; Li, YY; Liu, CH; Mi, SQ; Wang, NS; Zheng, X | 1 |
| Rossing, P | 1 |
| Delgado, R; Delporte, C; García, D; Garrido, G; González, D; Lemus, Y; Lodeiro, L; Núñez-Sellés, AJ; Quintero, G | 1 |
| Almeida, FR; Brito, GA; Chaves, MH; Lima, RC; Maia, JL; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM | 1 |
| Kuzuhara, H; Minowa, N; Nishiyama, S; Sasaki, K | 1 |
| Almeida, FR; Campos, AR; Cavalcante, IJ; Chaves, MH; Costa, CL; Lima, AF; Lima, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM | 1 |
| Avellar, MC; Calixto, JB; Medeiros, R; Otuki, MF | 1 |
| Andreeff, M; Frolova, O; Konoplev, S; Konopleva, M; Kornblau, SM; Li, M; Ma, W; Murphy, WJ; Stephens, LC; Sun, K; Welniak, LA; Wilkins, DE | 1 |
| Cheng, WJ; Cheng, XL; Chu, KD; Liu, JZ; Liu, QB; Pan, XD; Shi, YL; Tan, YH; Yu, KY; Zhang, MJ; Zheng, S | 1 |
| Andreeff, M; Hyer, ML; Konopleva, M; Krajewska, M; Kress, CL; Lefebvre, S; Martínez-García, V; McQueen, T; Reed, JC; Zapata, JM | 1 |
| Chaves, MH; Cunha, GM; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA | 1 |
| Luiz, AP; Marcon, R; Meotti, FC; Mioto, LA; Pizzolatti, MG; Santos, AR; Soldi, C | 1 |
| Aragão, GF; Cunha Pinheiro, MC; de Barros Viana, GS; Gomes Lemos, TL; Nogueira Bandeira, P | 1 |
| Indranie, C; Jagan, P; Janakiram, NB; Malisetty, SV; Rao, CV; Steele, VE | 1 |
| Ambrose, R; Bird, D; Carroll, AR; Field, B; Kweifio-Okai, G; Smith, P; Valdes, R | 1 |
| Kapil, A; Sharma, S | 1 |
| Dai, Y; Ido, Y; Kubo, M; Matsuda, H; Yoshikawa, M | 1 |
| Cao, X; Fang, J; Ju, DW; Wang, HB; Zheng, QY | 1 |
| Fujimoto, M; Hiramatsu, K; Kita, T; Kubo, K; Nakashima, T; Sakaki, T; Sato, S; Yonetani, Y | 1 |
| Kirby, GC; Simmonds, MS; Steele, JC; Warhurst, DC | 1 |
| Kozai, K; Nagasaka, N; Okada, M; Suzuki, J | 1 |
| Li, Y; Matsuda, H; Yoshikawa, M | 1 |
| Kita, T; Kubo, K; Momochi, C; Nakashima, T; Narushima, I; Shimada, K; Yonetani, Y; Yoshikawa, I | 1 |
| Fujimoto, M; Matsuo, Y; Ninomiya, M | 1 |
1 review(s) available for oleanolic acid and Disease Models, Animal
| Article | Year |
|---|---|
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.
Topics: Acute Kidney Injury; Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Glomerular Filtration Rate; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Tubules; Mice; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteasome Endopeptidase Complex; Proteolysis; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Ubiquitination | 2017 |
1 trial(s) available for oleanolic acid and Disease Models, Animal
| Article | Year |
|---|---|
Oleanolic acid improves pulmonary morphofunctional parameters in experimental sepsis by modulating oxidative and apoptotic processes.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Catalase; Dexamethasone; Disease Models, Animal; Gene Expression Regulation; Glutathione Peroxidase; Lung; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Oleanolic Acid; Oxidative Stress; Sepsis; Superoxide Dismutase | 2013 |
162 other study(ies) available for oleanolic acid and Disease Models, Animal
| Article | Year |
|---|---|
Oleanolic Acid Alleviates Atopic Dermatitis-like Responses In Vivo and In Vitro.
Topics: Animals; Cell Line; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Humans; In Vitro Techniques; Inflammation; Irritants; Keratinocytes; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Signal Transduction | 2021 |
Pharmacological Approaches to Attenuate Inflammation and Obesity with Natural Products Formulations by Regulating the Associated Promoting Molecular Signaling Pathways.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Angiogenesis Inhibitors; Animals; Biological Products; Disease Models, Animal; Diterpenes, Kaurane; Drug Compounding; Drug Synergism; Female; Glucosides; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipid Metabolism; Lipogenesis; Lipolysis; Mice; Mice, Inbred ICR; Obesity; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins; Signal Transduction; Stevia; Tea | 2021 |
Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Cosmic Radiation; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Radiation Exposure; Recognition, Psychology; Social Behavior | 2022 |
Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Polarity; Cells, Cultured; Cytokines; Disease Models, Animal; Disease Progression; Inflammation Mediators; Macrophage Activation; Macrophages; Male; Mice, Inbred DBA; NF-kappa B; Oleanolic Acid; Phytotherapy; Signal Transduction; Synovial Membrane; Toll-Like Receptor 4 | 2022 |
Effects of Echinocystic Acid on Atopic Dermatitis and Allergic Inflammation of the Skin and Lungs.
Topics: Animals; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Humans; Inflammation; Keratinocytes; Lung; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pyroglyphidae; Skin | 2022 |
Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model.
Topics: Animals; Disease Models, Animal; Kelch-Like ECH-Associated Protein 1; Mice; Nephritis, Hereditary; NF-E2-Related Factor 2; Oleanolic Acid; Phenotype; Renal Insufficiency, Chronic | 2022 |
Hederagenin ameliorates cisplatin-induced acute kidney injury via inhibiting long non-coding RNA A330074k22Rik/Axin2/β-catenin signalling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; beta Catenin; Cisplatin; Disease Models, Animal; Inflammation; Kidney; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering; Saponins | 2022 |
Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Hepatocytes; Humans; Liposomes; Liver Neoplasms; Mice; Mice, Inbred Strains; Oleanolic Acid | 2023 |
The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage.
Topics: Animals; Disease Models, Animal; Mice; Necrosis; Neutrophils; NF-E2-Related Factor 2; Oleanolic Acid | 2023 |
Hederacolchiside C inhibits Enterovirus 71 propagation through activating innate immunity.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Enterovirus A, Human; Hand, Foot and Mouth Disease; Host-Pathogen Interactions; Humans; Immunity, Innate; Mice; Oleanolic Acid; Pulsatilla; Saponins; Virus Replication | 2019 |
The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.
Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Macrophages; Male; Membrane Proteins; Mesenchymal Stem Cells; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Osteoporosis; Ovariectomy; RANK Ligand; Reactive Oxygen Species; Signal Transduction; Time Factors | 2020 |
TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats.
Topics: Administration, Oral; Animals; Cell Line; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Disease Models, Animal; Drug Synergism; Dysbiosis; Feces; Humans; Lipid Peroxidation; Liver Cirrhosis; Male; Oleanolic Acid; Pyrimidines; Rats; Receptors, G-Protein-Coupled | 2019 |
Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cytokines; Diarrhea; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred BALB C; Mucositis; Oleanolic Acid; Saponins | 2019 |
Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis.
Topics: Animals; Cytokines; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nasal Mucosa; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Oleanolic Acid; Ovalbumin; Rhinitis, Allergic; Saponins; Signal Transduction; STAT3 Transcription Factor; Th17 Cells; Th2 Cells | 2020 |
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of Saikosaponin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dopamine; Male; Oleanolic Acid; Proteome; Rats; Rats, Sprague-Dawley; Saponins; Stress, Psychological | 2020 |
Sophoradiol inhibits the growth of drug resistant Mycobacterium tuberculosis in vitro and murine models of tuberculosis.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oleanolic Acid; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2020 |
Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Autophagy; Biomarkers; Diet, High-Fat; Disease Models, Animal; Gene Expression; Immunophenotyping; Lipoproteins, LDL; Macrophage Activation; Macrophages; Mice; Mice, Knockout; Models, Biological; Models, Molecular; Oleanolic Acid; Protein Binding; Sirtuin 1; Structure-Activity Relationship | 2020 |
Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice.
Topics: Adiposity; Animals; Aorta, Thoracic; Biomarkers; Blood Glucose; Diet, High-Fat; Diet, Mediterranean; Disease Models, Animal; Disease Progression; Insulin Resistance; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Olive Oil; Triterpenes; Vasoconstriction; Vasodilation; Weight Gain | 2020 |
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Mucins; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2020 |
β-Amyrin supplementation ameliorates the toxic effect of glycerol in the kidney of rat model.
Topics: Acute Kidney Injury; Animals; Creatinine; Dietary Supplements; Disease Models, Animal; Female; Glycerol; Kidney; Oleanolic Acid; Protective Agents; Rats, Sprague-Dawley; Urea | 2020 |
Acetylsalicylic acid-like analgesic effects of Trametes versicolor in Wistar rats.
Topics: Analgesics; Animals; Aspirin; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Down-Regulation; Male; Oleanolic Acid; Pain; Pain Threshold; Polyporaceae; Rats, Wistar | 2020 |
Peripheral Anti-nociceptive and Anti-inflammatory Effect of Oleanolic Acid in a Rat Model of Osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Injections, Intra-Articular; Knee Joint; Oleanolic Acid; Osteoarthritis; Rats | 2021 |
Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Apoptosis; Blood-Brain Barrier; Brain; Brain Edema; Capillary Permeability; Disease Models, Animal; HMGB1 Protein; Male; Neuroprotective Agents; Oleanolic Acid; Protein Processing, Post-Translational; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Subarachnoid Hemorrhage | 2021 |
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7.
Topics: Analgesics; Angelica; Animals; Bupleurum; CHO Cells; Cricetulus; Disease Models, Animal; Drugs, Chinese Herbal; Female; Formaldehyde; Furocoumarins; Hot Temperature; Male; Medicine, Chinese Traditional; Mice; NAV1.7 Voltage-Gated Sodium Channel; Oleanolic Acid; Pain; Plant Roots; Saponins; Sodium | 2021 |
Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Depression; Disease Models, Animal; Hippocampus; Ischemic Stroke; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Recovery of Function; Saponins | 2021 |
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Topics: Animals; Antidepressive Agents; Antioxidant Response Elements; Cell Death; Depressive Disorder; Disease Models, Animal; Hippocampus; Imidazoles; Lipid Peroxidation; Malondialdehyde; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Signal Transduction; Stroke | 2021 |
Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice.
Topics: Animals; Cognitive Dysfunction; Depression; Diet, High-Fat; Disease Models, Animal; Exercise Tolerance; Humans; Iridoid Glucosides; Male; Mice; Mitochondria; Obesity; Olea; Oleanolic Acid; Oxidative Stress; Physical Conditioning, Animal; Plant Extracts; Plant Leaves; Receptors, G-Protein-Coupled | 2021 |
Characterization and in vivo evaluation of nanoformulations in FCA induced rheumatoid arthritis in rats.
Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Catechols; Celecoxib; Disease Models, Animal; Fatty Alcohols; Nanoparticle Drug Delivery System; Oleanolic Acid; Rats | 2021 |
Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Disease Models, Animal; Epithelial Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; Inflammation; Kidney; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Saponins; Sepsis | 2021 |
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Autophagy; Behavior, Animal; Dihydroxyphenylalanine; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Male; Motor Activity; Nerve Degeneration; NF-E2-Related Factor 2; Oleanolic Acid; Parkinsonian Disorders; Phenotype; Rats, Sprague-Dawley; Repressor Proteins; Rotenone; Signal Transduction; Sirolimus | 2021 |
The effects of oleanolic acid on atherosclerosis in different animal models.
Topics: Animals; Atherosclerosis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Gene Expression; Lipid Metabolism; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Oleanolic Acid; PPAR gamma; Rabbits; Receptors, Adiponectin; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity | 2017 |
Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Flavonoids; Gas Chromatography-Mass Spectrometry; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophage Activation; Macrophages; Magnetic Resonance Spectroscopy; Male; Methylene Chloride; Mice; Oleanolic Acid; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Salvia; Solvents; Tetradecanoylphorbol Acetate; Triterpenes; Tumor Necrosis Factor-alpha; Ursolic Acid | 2017 |
Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling.
Topics: Adenosine Triphosphate; Adipose Tissue; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Homeostasis; Inflammasomes; Lipid Metabolism; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Panniculitis; Saponins; Signal Transduction | 2017 |
The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Disease Models, Animal; Fibronectins; Glutaredoxins; Heart; Humans; Male; Myocardial Infarction; NF-E2-Related Factor 2; Nitric Oxide Synthase Type III; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Ventricular Remodeling | 2017 |
Liposomal co-delivered oleanolic acid attenuates doxorubicin-induced multi-organ toxicity in hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cardiotoxicity; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Doxorubicin; Drug Liberation; Drug Stability; Drug Synergism; Female; Humans; Liposomes; Liver Neoplasms; Mice; Models, Biological; Myocytes, Cardiac; Oleanolic Acid; Protective Agents; Xenograft Model Antitumor Assays | 2017 |
Investigation of the Hepatoprotective Effect of Prunus mume Sieb. et Zucc Extract in a Mouse Model of Alcoholic Liver Injury Through High-Resolution Metabolomics.
Topics: Animals; Antioxidants; Chromatography, Liquid; Disease Models, Animal; Ethanol; Fatty Liver, Alcoholic; Humans; Liver; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Oleanolic Acid; Phosphatidylcholines; Prunus; Saponins | 2017 |
Esculentoside A inhibits LPS-induced acute kidney injury by activating PPAR-γ.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Disease Models, Animal; Interleukin-1beta; Interleukin-6; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; PPAR gamma; Saponins; Tumor Necrosis Factor-alpha | 2017 |
Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Female; Hindlimb; Motor Activity; Neuronal Plasticity; Oleanolic Acid; Rats, Sprague-Dawley; Recovery of Function; Robotics; Saponins; Spinal Cord; Spinal Cord Injuries; Synaptophysin | 2017 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; MicroRNAs; Oleanolic Acid; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats, Wistar; Saponins; Transcription Factor AP-1 | 2017 |
Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury.
Topics: Aldosterone; Angiotensinogen; Animals; Blood Pressure; Disease Models, Animal; Fatty Acid-Binding Proteins; Hypertension, Renal; Kidney; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Renin-Angiotensin System; Sodium Chloride; Up-Regulation | 2018 |
Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Caspase 1; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Neutrophil Infiltration; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pulmonary Edema; Saponins; Tumor Necrosis Factor-alpha | 2018 |
Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Autophagy; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Dopaminergic Neurons; Microtubule-Associated Proteins; Neurodegenerative Diseases; Oleanolic Acid; Oxidative Stress; Parkinson Disease | 2017 |
Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-κB and Nrf2 signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Concanavalin A; Curcumin; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Enzymes; Inflammation Mediators; Liver; Male; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidative Stress; Signal Transduction | 2018 |
Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Calcitriol; Calcium; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Duodenum; Female; Humans; Kidney Tubules, Proximal; Mice, Inbred C57BL; Oleanolic Acid; Osteoporosis, Postmenopausal; Ovariectomy; Rats, Sprague-Dawley; Vitamin D; Vitamin D3 24-Hydroxylase; X-Ray Microtomography | 2018 |
Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Fibronectins; Guanidines; Inflammasomes; Lung; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pneumonia; Pulmonary Fibrosis; Random Allocation; Transforming Growth Factor beta1; Triterpenes | 2018 |
Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1-7) upregulation.
Topics: Angiotensins; Animals; Apoptosis; Atherosclerosis; Cell Cycle; Cell Survival; Cytokines; Diet, High-Fat; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Oleanolic Acid; Protective Agents; Rabbits; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2018 |
Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Memory Deficit in Alzheimer's Disease Model Rats by Maintaining Synaptic Plasticity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antipsychotic Agents; Avoidance Learning; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Electric Stimulation; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Microscopy, Electron, Transmission; Oleanolic Acid; Peptide Fragments; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptic Potentials | 2018 |
Anti-inflammatory activity of dimethyl octenol and oleanene tetrol isolated from Trianthema decandra L.
Topics: Aizoaceae; Animals; Anti-Inflammatory Agents; Arthritis; Cyclooxygenase 2; Disease Models, Animal; Inflammation; Macrophages; Male; Mice; Molecular Docking Simulation; Nitric Oxide; Octanols; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Leaves; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2018 |
Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.
Topics: Animals; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice; Oleanolic Acid; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; STAT Transcription Factors; Transforming Growth Factor beta1 | 2018 |
Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK/VEGF/Src signaling pathway in rat model of subarachnoid hemorrhage.
Topics: Animals; Blood-Brain Barrier; Body Weight; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase-1; Male; MAP Kinase Signaling System; Microglia; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Permeability; Rats; Rats, Sprague-Dawley; src-Family Kinases; Subarachnoid Hemorrhage; Vascular Endothelial Growth Factor A | 2018 |
Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors.
Topics: Animals; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Fasting; Inflammation Mediators; Oleanolic Acid; Oxidative Stress; Plant Extracts; Prediabetic State; Rats; Risk Factors | 2019 |
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Topics: Acetylation; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; NF-kappa B; Oleanolic Acid; Oxidative Stress; Respiratory Mucosa; Sirtuin 1 | 2019 |
Effects of oleanolic acid acetate on bone formation in an experimental periodontitis model in mice.
Topics: Acetates; Alveolar Bone Loss; Animals; Disease Models, Animal; Male; Mice; Oleanolic Acid; Osteoclasts; Osteogenesis; Periodontitis | 2019 |
Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.
Topics: Animals; Cell Membrane Permeability; Cell Movement; Cell Proliferation; Cells, Cultured; Choroidal Neovascularization; Disease Models, Animal; Endothelial Cells; Fluorescein Angiography; Fundus Oculi; Humans; Immunoblotting; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Retinal Neovascularization; Retinal Vessels; Tomography, Optical Coherence; Triterpenes | 2019 |
3
Topics: Animals; Antibodies, Antinuclear; Biopsy; Cell Differentiation; Cell Survival; Cell-Free Nucleic Acids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Inflammation Mediators; Lupus Nephritis; Mice; Nuclear Receptor Subfamily 1, Group F, Member 3; Oleanolic Acid; Terpenes; Th17 Cells; Transcription, Genetic | 2019 |
Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study.
Topics: Animals; Bacterial Outer Membrane; Biofilms; Cross Infection; Disease Models, Animal; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Lepidoptera; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes | 2019 |
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization.
Topics: Adipose Tissue; Animals; Cell Polarity; China; Diet, High-Fat; Disease Models, Animal; Humans; Inflammation; Macrophages; Male; Mice; Mice, Obese; Obesity; Oleanolic Acid; Pentacyclic Triterpenes; Signal Transduction | 2019 |
Oleanolic acid acetate inhibits atopic dermatitis and allergic contact dermatitis in a murine model.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Antigens, Dermatophagoides; Cell Line; Cytokines; Dermatitis, Allergic Contact; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Eosinophils; Female; Gene Expression Regulation; Humans; Inflammation Mediators; Keratinocytes; Local Lymph Node Assay; MAP Kinase Signaling System; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Skin; T-Lymphocytes; Time Factors | 2013 |
A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses.
Topics: Adipogenesis; Adult; Animals; Biopsy; Cells, Cultured; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibroblasts; Fibrosis; Humans; Infant, Newborn; Mice; Mice, Inbred C57BL; Oleanolic Acid; Organ Culture Techniques; PPAR gamma; Proto-Oncogene Proteins c-akt; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta | 2014 |
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2013 |
Effective melanoma inhibition by synthetic pentacyclic triterpenoid 2-(3-phenylprop-2-en-1-ylidene)-22β-hydroxy-3-oxoolean-12-en-28-oic acid: an in vitro and in vivo study.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Chlorocebus aethiops; Disease Models, Animal; DNA Fragmentation; In Vitro Techniques; Male; Melanoma; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Skin Neoplasms; Survival Rate; Transplantation, Homologous; Vero Cells | 2013 |
Protective effect of esculentoside A on lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; I-kappa B Proteins; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-KappaB Inhibitor alpha; Oleanolic Acid; Pulmonary Edema; Saponins | 2013 |
Soyasaponin I improved neuroprotection and regeneration in memory deficient model rats.
Topics: Animals; Behavior, Animal; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Hippocampus; Ibotenic Acid; Male; Memory; Memory Disorders; Microglia; Nerve Regeneration; Neural Stem Cells; Neurons; Neuroprotective Agents; Oleanolic Acid; Pregnancy; Rats; Rats, Sprague-Dawley; Saponins | 2013 |
Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; Cryoprotective Agents; Disease Models, Animal; Heme Oxygenase-1; Kidney; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oleanolic Acid | 2014 |
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats.
Topics: Adipose Tissue; Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Fatty Acids, Nonesterified; Fructose; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Oleanolic Acid; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors | 2014 |
The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Inhibitory Concentration 50; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Spleen; STAT3 Transcription Factor; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.
Topics: Animals; Astrocytes; Blotting, Western; Brain Ischemia; Disease Models, Animal; Humans; Immunohistochemistry; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reperfusion Injury | 2014 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Hippocampus; Imipramine; Male; Mice; Monoamine Oxidase; Motor Activity; Oleanolic Acid; Pentylenetetrazole; Piperazines; Pyridines | 2014 |
Amyrin attenuates scopolamine-induced cognitive impairment in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; MAP Kinase Signaling System; Memory; Mice, Inbred ICR; Muscarinic Antagonists; Oleanolic Acid; Scopolamine | 2014 |
Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice.
Topics: Animals; Antipsychotic Agents; Attention; Disease Models, Animal; Dizocilpine Maleate; Frontal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hyperkinesis; Male; Memory Disorders; Mice, Inbred ICR; Oleanolic Acid; Phosphorylation; Prepulse Inhibition; Proto-Oncogene Proteins c-akt; Recognition, Psychology; Reflex, Startle; Schizophrenia | 2014 |
Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid.
Topics: Animals; Apoptosis; Autoantibodies; Blood Urea Nitrogen; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Lupus Nephritis; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Mutant Strains; NF-kappa B; Oleanolic Acid; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor | 2014 |
BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Disease; Cyclic AMP Response Element-Binding Protein; Depressive Disorder; Disease Models, Animal; Disks Large Homolog 4 Protein; Extracellular Signal-Regulated MAP Kinases; Guanylate Kinases; Hippocampus; Male; Membrane Proteins; Mice, Inbred ICR; MicroRNAs; Neurogenesis; Neurons; Oleanolic Acid; Random Allocation; Signal Transduction; Stress, Psychological; Uncertainty; Up-Regulation | 2014 |
Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury.
Topics: Animals; Chronic Disease; Constriction; Disease Models, Animal; Male; Neuralgia; NF-kappa B; Oleanolic Acid; Rats, Sprague-Dawley; Saponins; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; Inflammation Mediators; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Liver; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Organic Anion Transporters, Sodium-Independent; Phalloidine; RNA, Messenger; Signal Transduction; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2015 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; India; Inflammation; Interleukin-6; Leukocytes, Mononuclear; Male; Medicine, Traditional; NF-kappa B; Oleanolic Acid; Plant Leaves; Rats; Rats, Sprague-Dawley | 2014 |
Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Case-Control Studies; Colitis; Colon; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; Male; Nephrectomy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Tight Junction Proteins; Tight Junctions; Uremia | 2015 |
Pharmacological experimental study of the anti-depressant effect of total saikosaponins.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hindlimb Suspension; Humans; Male; Mice; Motor Activity; Oleanolic Acid; Saponins | 2014 |
Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression.
Topics: Animals; Antidepressive Agents; Chronic Disease; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Psychological; Treatment Outcome | 2015 |
Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory.
Topics: Animals; Autoradiography; Diet, High-Fat; Disease Models, Animal; Dizocilpine Maleate; Drug Administration Schedule; Exploratory Behavior; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oleanolic Acid; Prefrontal Cortex; Protein Binding; Recognition, Psychology; Signal Transduction; Statistics, Nonparametric; Tritium | 2015 |
Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Down-Regulation; Imidazoles; In Vitro Techniques; Ischemia; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2; Oleanolic Acid; Reactive Oxygen Species; Reperfusion Injury; Retina; Retinal Ganglion Cells; RNA, Small Interfering; tert-Butylhydroperoxide | 2015 |
Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.
Topics: Animals; Biomarkers; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Glucose; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Insulin; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Oleanolic Acid; Organ Size; Phosphorylation; RNA | 2015 |
Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition.
Topics: Animals; Animals, Newborn; Atrophy; Disease Models, Animal; Female; Gastrointestinal Tract; Oleanolic Acid; Organ Size; Parenteral Nutrition; Receptors, G-Protein-Coupled; Swine | 2016 |
Esculentoside A suppresses Aβ(1-42)-induced neuroinflammation by down-regulating MAPKs pathways in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Astrocytes; Disease Models, Animal; Down-Regulation; Encephalitis; Hippocampus; Inflammation Mediators; Male; MAP Kinase Signaling System; Memory; Mice; Mice, Inbred C57BL; Microglia; Oleanolic Acid; Peptide Fragments; Saponins | 2015 |
Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Collagen; Cytokines; Cytoprotection; Disease Models, Animal; Female; Gene Expression Regulation; Hydroxyproline; Inflammation Mediators; Lung; Lung Injury; Mice, Inbred C57BL; Oleanolic Acid; Pulmonary Fibrosis; Radiation Pneumonitis; RNA, Messenger | 2015 |
Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection.
Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Macrophage Activation; Macrophages; Mice; Mycobacterium tuberculosis; Nitric Oxide; Oleanolic Acid; Reactive Oxygen Species; Transforming Growth Factor beta1; Triterpenes; Tuberculosis; Tumor Necrosis Factor-alpha; Ursolic Acid | 2015 |
Amelioration of L-Dopa-Associated Dyskinesias with Triterpenoic Acid in a Parkinsonian Rat Model.
Topics: Adrenergic Agents; Age Factors; Animals; Animals, Newborn; Antiparkinson Agents; Catalase; Disease Models, Animal; Dyskinesia, Drug-Induced; Extremities; Female; Glutathione; Levodopa; Male; Movement; Oleanolic Acid; Oxidopamine; Parkinsonian Disorders; Pregnancy; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric | 2016 |
Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
Topics: Adenomatous Polyposis Coli; Aging; Animals; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mutation; Oleanolic Acid; Oxidative Stress; Proton Therapy; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Tumor Suppressor Protein p53; Whole-Body Irradiation | 2016 |
Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway.
Topics: Active Transport, Cell Nucleus; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Cell Adhesion Molecules; Cell Line; Cytokines; Dexamethasone; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heme Oxygenase-1; Humans; Immunoglobulin E; Lung; Membrane Proteins; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oleanolic Acid; Ovalbumin; RNA, Small Interfering; Saponins; Signal Transduction | 2015 |
Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.
Topics: Agastache; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Drosophila; Eating; Eye; Flavones; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Humans; Longevity; Male; Oleanolic Acid; Phenotype; Triterpenes | 2015 |
Saikosaponin A inhibits influenza A virus replication and lung immunopathology.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoblotting; Influenza A virus; Influenza, Human; Lung; Mice; Mice, Inbred C57BL; Oleanolic Acid; Orthomyxoviridae Infections; Respiratory Tract Infections; Saponins; Virus Replication | 2015 |
The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Female; Leishmania; Leishmaniasis, Cutaneous; Macrophages, Peritoneal; Male; Mice; Nitric Oxide; Oleanolic Acid; Plant Extracts; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2015 |
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; Male; Mice, Inbred C57BL; Oleanolic Acid; Pain; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Reserpine; Serotonin | 2016 |
NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.
Topics: Animals; Cochlea; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Genetic Predisposition to Disease; Glutathione; Hearing Loss, Noise-Induced; Imidazoles; Lipid Peroxidation; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protective Agents; Reactive Oxygen Species | 2016 |
A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy.
Topics: Angiogenic Proteins; Animals; Animals, Newborn; Antioxidants; Astrocytes; Capillary Permeability; Cells, Cultured; Cytokines; Disease Models, Animal; Ependymoglial Cells; Hyperoxia; Inflammation Mediators; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Retina; Retinal Neovascularization; Retinopathy of Prematurity; Signal Transduction | 2016 |
Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.
Topics: Aflatoxin B1; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Adducts; Gene Editing; Gene Expression Profiling; Genetic Predisposition to Disease; Imidazoles; Inactivation, Metabolic; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; NF-E2-Related Factor 2; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Phenotype; Rats, Inbred F344; Rats, Transgenic | 2016 |
Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.
Topics: Animals; Antineoplastic Agents; Brain; Chemical Fractionation; Disease Models, Animal; Female; Glucose; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Nerium; Neurodegenerative Diseases; Neuroprotective Agents; Oleanolic Acid; Organ Culture Techniques; Oxygen; Plant Extracts; Rats, Sprague-Dawley; Stroke | 2016 |
Protection against 1-methyl-4-phenyl pyridinium-induced neurotoxicity in human neuroblastoma SH-SY5Y cells by Soyasaponin I by the activation of the phosphoinositide 3-kinase/AKT/GSK3β pathway.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Neuroprotective Agents; Oleanolic Acid; Parkinson Disease; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction | 2016 |
Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect.
Topics: Animals; Antineoplastic Agents; Chitosan; Disease Models, Animal; Female; Gold; Hydrogen-Ion Concentration; Hyperthermia, Induced; Liposomes; Mice; Nanoshells; Oleanolic Acid; Spectroscopy, Fourier Transform Infrared | 2016 |
Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway.
Topics: Animals; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Heme Oxygenase-1; Liver; Liver Diseases; Male; Membrane Proteins; Mice, Inbred C57BL; Nuclear Proteins; Oleanolic Acid; Peroxidases; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Protoporphyrins; Reperfusion Injury; Signal Transduction; Time Factors | 2016 |
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenylate Kinase; alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hedera; Huntingtin Protein; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Oleanolic Acid; PC12 Cells; Rats; Saponins; TOR Serine-Threonine Kinases | 2017 |
A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.
Topics: Animals; Cell Engineering; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Design; Gene Expression Regulation; Gene Regulatory Networks; Genetic Engineering; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Liver Diseases; Male; Mice; Mice, Transgenic; Oleanolic Acid; Synthetic Biology | 2017 |
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Expression Profiling; Glycogen Synthase Kinase 3; Humans; Kelch-Like ECH-Associated Protein 1; Lithium Chloride; Longevity; Mice; Microscopy, Confocal; Neurons; NF-E2-Related Factor 2; Oleanolic Acid; Peptide Fragments; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Thiadiazoles; Triazoles | 2017 |
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cricetinae; Disease Models, Animal; Female; Memory; Memory Disorders; Mice; Mice, Transgenic; Oleanolic Acid; Plaque, Amyloid; Triterpenes | 2009 |
Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in mice.
Topics: Analgesics; Animals; Baccharis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mice; Oleanolic Acid; Pain; Pain Measurement; Plant Components, Aerial; Plant Extracts; Receptors, Glutamate; Solvents; Stigmasterol; Triterpenes | 2009 |
Association of early experience with neurodegeneration in aged primates.
Topics: Aging; Animals; Disease Models, Animal; Environment; Macaca mulatta; Neocortex; Neurodegenerative Diseases; Oleanolic Acid; Synaptophysin | 2011 |
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Imidazoles; Liver; Liver Diseases; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Necrosis; NF-E2-Related Factor 2; Nuclear Transfer Techniques; Oleanolic Acid; Response Elements; RNA, Messenger; Time Factors | 2009 |
Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Ficus; Glucose Tolerance Test; Hypoglycemic Agents; Lipids; Male; Mice; Molecular Structure; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2009 |
Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Therapy, Combination; Male; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Trinitrobenzenesulfonic Acid | 2009 |
Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role.
Topics: Animals; Antibody Formation; Blood-Brain Barrier; Chemokines; Cytokines; Disease Models, Animal; Humans; Multiple Sclerosis; Oleanolic Acid | 2010 |
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Antioxidants; Disease Models, Animal; Hyperoxia; Imidazoles; In Situ Nick-End Labeling; Lung; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease.
Topics: Animals; Antioxidants; Bronchi; Bronchoalveolar Lavage; Cell Line; Cell Proliferation; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Epithelial Cells; Flagellin; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Lipopolysaccharides; Mice; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Proteomics; Trachea; Triterpenes | 2009 |
Effects of esculentoside A on autoimmune syndrome induced by Campylobacterjejuni in mice and its modulation on T-lymphocyte proliferation and apoptosis.
Topics: Animals; Antigens, CD; Apoptosis; Apoptosis Regulatory Proteins; Autoimmune Diseases; Campylobacter jejuni; Cell Movement; Cell Proliferation; Disease Models, Animal; Immunomodulation; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Phytolacca; Saponins; T-Lymphocytes | 2010 |
Renal effects of plant-derived oleanolic acid in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Filtration Rate; Kidney Function Tests; Male; Oleanolic Acid; Phytotherapy; Plant Extracts; Potassium; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sodium; Streptozocin | 2009 |
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease.
Topics: Animals; Antioxidants; Behavioral Symptoms; Brain; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice, Transgenic; Motor Activity; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction; Transcriptional Activation | 2010 |
The Nrf2 pathway as a potential therapeutic target for Huntington disease A commentary on "Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease"
Topics: Animals; Brain; Cytoprotection; Disease Models, Animal; Drug Discovery; Heme Oxygenase-1; Humans; Huntington Disease; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Signal Transduction; Transcriptional Activation | 2010 |
Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Baccharis; Capsaicin; Dermatitis, Contact; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Ear; Edema; Male; Mice; Neutrophil Infiltration; Oleanolic Acid; Plant Leaves; Plant Preparations; Stigmasterol; Tetradecanoylphorbol Acetate | 2010 |
Protective effects of oleanolic acid on cerebral ischemic damage in vivo and H(2)O(2)-induced injury in vitro.
Topics: Animals; Antioxidants; Brain Ischemia; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stroke; Survival Rate | 2011 |
[Study on hepatotoxicity on rats caused by crude extracts of total saikosaponins and correlation with oxidative damage mechanism].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Liver; Male; Malondialdehyde; Oleanolic Acid; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins; Superoxide Dismutase | 2010 |
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Mice; Mice, Transgenic; Nicotinic Acids; Oleanolic Acid; Pancreatic Neoplasms; Signal Transduction; Tetrahydronaphthalenes | 2010 |
ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo.
Topics: Animals; Antiviral Agents; Base Sequence; Cell Line; Disease Models, Animal; Drug Synergism; Hepacivirus; Hepatitis C, Chronic; Hepatocytes; Humans; In Vitro Techniques; Interferon Type I; Mice; Mice, SCID; Oleanolic Acid; Recombinant Proteins; Replicon; RNA, Viral; Transplantation Chimera; Virus Replication | 2011 |
Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Mice; Mice, Inbred BALB C; Molecular Structure; Oleanolic Acid; Respiratory System; Saxifragaceae; T-Lymphocytes, Helper-Inducer | 2011 |
Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1 Receptor-Associated Kinases; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; Oleanolic Acid; Saponins; Sulfasalazine | 2011 |
Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Capillaries; Cisplatin; Disease Models, Animal; Fluorescent Antibody Technique; Heme Oxygenase-1; Ischemia; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; PPAR gamma; RNA, Messenger; Time Factors; Up-Regulation | 2011 |
Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model.
Topics: Animals; Cicatrix, Hypertrophic; Collagen Type I; Collagen Type III; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ear, External; Female; Matrix Metalloproteinase 1; Oleanolic Acid; Rabbits; Severity of Illness Index; Transforming Growth Factor beta1 | 2011 |
Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice.
Topics: Amylases; Animals; Anti-Inflammatory Agents; Burseraceae; Ceruletide; Disease Models, Animal; Immunosuppressive Agents; Interleukin-6; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Pancreatitis; Peroxidase; Random Allocation; Thalidomide; Tumor Necrosis Factor-alpha | 2011 |
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Line; Cell Nucleus; Disease Models, Animal; Inflammation; Major Histocompatibility Complex; Mice; Mice, Transgenic; Mitochondria; Neurodegenerative Diseases; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteins; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Vesicular Transport Proteins | 2011 |
Anti-inflammatory properties from isolated compounds of Cyclolepis genistoides.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Injections, Intraperitoneal; Lactones; Male; Medicine, Traditional; Mice; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Sesquiterpenes; Time Factors | 2011 |
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Area Under Curve; Body Weight; Cyclohexanols; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Enzyme-Linked Immunosorbent Assay; Freezing Reaction, Cataleptic; Hyperalgesia; Inflammation; Locomotion; Male; Mice; Neuralgia; Oleanolic Acid; Oligodeoxyribonucleotides, Antisense; Pain Threshold; Pentacyclic Triterpenes; Peroxidase; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Tritium | 2011 |
Effects of oleanolic acid on pulmonary morphofunctional and biochemical variables in experimental acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Respiratory Mechanics | 2011 |
Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus.
Topics: Animals; Antipruritics; Behavior, Animal; Carrageenan; Cell Degranulation; Disease Models, Animal; Edema; Ethanol; Ether; Female; Lecythidaceae; Male; Mast Cells; Medicine, Traditional; Mice; Motor Activity; Oleanolic Acid; p-Methoxy-N-methylphenethylamine; Phytotherapy; Plant Extracts; Plant Leaves; Pruritus; Rats; Rats, Wistar; Solvents; South America; Triterpenes; Ursolic Acid | 2012 |
Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophilia; Female; Immunoglobulin E; Inflammation; Leukocyte Count; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovalbumin; Phytotherapy; Transcription Factor RelA; Triterpenes | 2012 |
Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice.
Topics: Abietanes; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Lethal Dose 50; Mice; Motor Activity; Narcotic Antagonists; Oleanolic Acid; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Plants, Medicinal; Salvia officinalis; Time Factors; Triterpenes; Ursolic Acid | 2012 |
[Research on mechanism of energy metabolism disorders of rat's hepatoxicity induced by saikosaponins].
Topics: Animals; Antimetabolites; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Female; Liver; Male; Mitochondria, Liver; Oleanolic Acid; Organ Size; Rats; Saponins | 2011 |
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2013 |
[Immune state in lung of BALB/c mice with ovalbumin allergy and the effects of fulvotomentoside on lungs of mice].
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drugs, Chinese Herbal; Female; Food Hypersensitivity; Immunohistochemistry; Inflammation; Interleukin-17; Interleukin-6; Lung Diseases; Mice; Mice, Inbred BALB C; Neutrophils; Oleanolic Acid; Ovalbumin; Saponins; Transforming Growth Factor beta1 | 2012 |
Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Heart; Hyperglycemia; Male; Myocardial Contraction; Myocardium; Oleanolic Acid; Plant Extracts; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Syzygium | 2012 |
Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Chromatography, Liquid; Diabetic Nephropathies; Disease Models, Animal; Diuresis; Drinking; Hemodynamics; Kidney; Liver; Male; Mass Spectrometry; Oleanolic Acid; Ramipril; Rats; Rats, Zucker; Renal Circulation; Triterpenes | 2013 |
Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Glucose; Glucose Transporter Type 4; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Mangifera; Mice; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; Rosiglitazone; Thiazolidinediones | 2013 |
[The anti-portal hypertension effect of oleanolic acid in CCl4-induced cirrhosis rats].
Topics: Animals; Body Weight; Carbon Tetrachloride; Disease Models, Animal; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Oleanolic Acid; Phytotherapy; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley | 2012 |
Diabetic nephropathy: Could problems with bardoxolone methyl have been predicted?
Topics: Animals; Clinical Trials, Phase III as Topic; Diabetic Nephropathies; Disease Models, Animal; Early Termination of Clinical Trials; Glomerular Filtration Rate; Humans; Oleanolic Acid | 2013 |
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cuba; Dexamethasone; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ear, External; Edema; Eicosanoids; Indomethacin; Interferon-gamma; Leukotriene B4; Lipopolysaccharides; Macrophages; Male; Mangifera; Mice; Oleanolic Acid; Peroxidase; Phospholipases A; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Plants, Medicinal; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Water; Xanthones | 2004 |
Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Burseraceae; Disease Models, Animal; Drug Administration Schedule; Drug Synergism; Glutathione; Injections, Intraperitoneal; Liver Failure, Acute; Male; Mice; Necrosis; Oleanolic Acid; Pentobarbital; Phytotherapy; Plant Bark; Plants, Medicinal; Protective Agents; Resins, Plant; Sleep; Triterpenes | 2005 |
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model.
Topics: Animals; Concanavalin A; Crystallography, X-Ray; Disease Models, Animal; Hepatitis, Animal; Liver; Liver Function Tests; Male; Mice; Mice, Inbred BALB C; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins | 2005 |
Attenuation of capsaicin-induced acute and visceral nociceptive pain by alpha- and beta-amyrin, a triterpene mixture isolated from Protium heptaphyllum resin in mice.
Topics: Administration, Oral; Analgesics; Animals; Behavior, Animal; Burseraceae; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Hypothermia; Mice; Motor Activity; Oleanolic Acid; Pain; Postural Balance; Resins, Plant; Sleep | 2005 |
Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Dermatitis, Contact; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; I-kappa B Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; NF-kappa B; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-alpha; Skin; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor RelA | 2007 |
The synthetic triterpenoid, CDDO, suppresses alloreactive T cell responses and reduces murine early acute graft-versus-host disease mortality.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oleanolic Acid; T-Lymphocytes; Transplantation, Homologous | 2007 |
[Aike mixture has good anti-inflammatory and analgesic effects on mice].
Topics: Animals; Chronic Disease; Disease Models, Animal; Drug Combinations; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Phytotherapy; Prostatitis; Saponins | 2007 |
Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.
Topics: Animals; B-Lymphocytes; Cell Survival; Disease Models, Animal; Female; Flow Cytometry; Gene Deletion; Humans; Immunoenzyme Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; T-Lymphocytes; TNF Receptor-Associated Factor 2 | 2007 |
Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents; Burseraceae; Dexamethasone; Diclofenac; Disease Models, Animal; Gingiva; Gingivitis; Isomerism; Male; Molecular Structure; Neutrophil Infiltration; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Periodontitis; Peroxidase; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2008 |
Synthetic derivatives of the alpha- and beta-amyrin triterpenes and their antinociceptive properties.
Topics: Analgesics; Animals; Disease Models, Animal; Mice; Molecular Structure; Oleanolic Acid; Pain; Structure-Activity Relationship; Triterpenes | 2008 |
Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) march.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dextrans; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Mice; Oleanolic Acid; Pain; Pain Measurement; Phytotherapy | 2007 |
Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; HT29 Cells; Humans; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 2008 |
Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III.
Topics: Acute Disease; Administration, Oral; Anemia; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Bone Marrow; Bone Marrow Cells; Cartilage, Articular; Cell Division; Chronic Disease; Disease Models, Animal; Ghana; Granulocytes; Hyaluronic Acid; Leukocytes; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Synovial Fluid; Synovial Membrane; Tarsal Joints; Triterpenes | 1995 |
Effect of oleanolic acid on complement in adjuvant- and carrageenan-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Complement Inactivator Proteins; Disease Models, Animal; Edema; Freund's Adjuvant; Hindlimb; Injections, Intraperitoneal; Male; Oleanolic Acid; Rats | 1995 |
[Studies on Kochiae Fructus. I. Antipruritogenic effect of 70% ethanol extract from kochiae fructus and its active component].
Topics: Animals; Antipruritics; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Histamine; Male; Mice; Oleanolic Acid; p-Methoxy-N-methylphenethylamine; Pruritus | 1997 |
Esculentoside A inhibits tumor necrosis factor, interleukin-1, and interleukin-6 production induced by lipopolysaccharide in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Interleukin-1; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Regression Analysis; Saponins; Shock, Septic; Thymus Gland; Tumor Necrosis Factor-alpha | 1998 |
Profiles of an intravenously available endothelin A-receptor antagonist, S-0139, for preventing cerebral vasospasm in a canine two-hemorrhage model.
Topics: Animals; Basilar Artery; Caffeic Acids; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Female; Infusions, Intravenous; Ischemic Attack, Transient; Male; Oleanolic Acid; Spine; Subarachnoid Hemorrhage | 1998 |
In vitro and in vivo evaluation of betulinic acid as an antimalarial.
Topics: Animals; Antimalarials; Betulinic Acid; Disease Models, Animal; Euphorbiaceae; Malaria; Mice; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plant Roots; Plasmodium berghei; Plasmodium falciparum; Random Allocation; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 1999 |
Effect of oleanolic acid-cyclodextrin inclusion compounds on dental caries by in vitro experiment and rat-caries model.
Topics: Animals; Anti-Bacterial Agents; Cyclodextrins; Dental Caries; Disease Models, Animal; Glucans; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Solubility; Streptococcus; Streptococcus mutans; Streptococcus sobrinus | 1999 |
Effects of oleanolic acid glycosides on gastrointestinal transit and ileus in mice.
Topics: Animals; Capsaicin; Disease Models, Animal; Gastrointestinal Transit; Glucuronates; Glycosides; Intestinal Obstruction; Laparotomy; Male; Mice; Oleanolic Acid; Saponins; Streptozocin; Triterpenes | 1999 |
Contribution of endothelin-1 to disruption of blood-brain barrier permeability in dogs.
Topics: Analysis of Variance; Animals; Blood; Blood-Brain Barrier; Caffeic Acids; Cell Membrane Permeability; Cisterna Magna; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Female; Fluorescein; Injections, Intraventricular; Male; Oleanolic Acid; Receptor, Endothelin A; Subarachnoid Hemorrhage | 1999 |
Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Edema; Caffeic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neuroprotective Agents; Oleanolic Acid; Peroxidase; Rats; Rats, Wistar; Receptor, Endothelin A; Reperfusion Injury; Survival Rate; Time Factors; Water | 2001 |