oleanolic acid has been researched along with Cirrhosis in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 16 (57.14) | 24.3611 |
| 2020's | 9 (32.14) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M | 1 |
| Chen, XM; Cheng, YF; Jiang, W; Li, X; Luo, D; Pi, JK; Wang, XJ; Wang, XX; Wu, SS; Wu, Z; Xu, JY; Zhang, Y; Zhang, YJ; Zhou, JH | 1 |
| He, L; Yang, W | 1 |
| Dai, L; Feng, ZQ; Hu, KW; Qian, M; Sun, HB; Sun, JZ; Zheng, RN | 1 |
| An, N; Cai, S; Pei, J; Peng, J; Wang, D; Wang, W; Wu, M; Zhan, X | 1 |
| Bahetibike, S; Huang, LT; Lu, YQ; Ma, HY; Mei, S; Qi, R; Wang, AH; Xiao, SL; Yang, RY; Yi, YL; Yu, ZW; Zhu, J; Zhu, SJ | 1 |
| Cheng, N; Li, Y; Liu, J; Luo, J; Ren, D; Xin, H; Yang, J; Zhang, J; Zhang, X | 1 |
| Cui, L; Cui, N; Li, C; Li, Y; Yang, L; Zhang, S; Zhuo, Y | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Genovese, T; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Cao, FY; Deng, HJ; Peng, HB; Tang, JD; Wang, JH; Wang, RX; Wang, YH | 1 |
| Chen, X; Cheng, Y; Gong, Y; Huang, Z; Kong, H; Li, H; Mou, Y; Qian, S; Wang, H; Xie, W; Zhang, Y | 1 |
| An, HJ; Gu, H; Gwon, MG; Jang, KM; Kim, JY; Park, B; Park, JH; Park, KK | 1 |
| Dong, J; Gao, L; Guo, S; Li, L; Li, R; Liang, C; Liu, Y; Yang, H; Zhao, X | 1 |
| Huang, N; Li, X; Liu, R; Sun, R | 1 |
| Cui, LH; Cui, NQ; Li, CX; Yang, L; Zhang, SK; Zhuo, YZ | 1 |
| He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z | 1 |
| Ku, SK; Kwak, MK; Lee, JH; Lee, SH; Ryoo, IG; Song, MK | 1 |
| Distler, JH; Doniparthi, S; Hinchcliff, M; Komura, K; Lord, G; Tamaki, Z; Tomcik, M; Varga, J; Wang, W; Wei, J; Zhu, H | 1 |
| Aminzadeh, MA; Khazaeli, M; Meyer, CJ; Reisman, SA; Vaziri, ND; Yuan, J | 1 |
| Chang, YS; Choi, BS; Chung, S; Hong, YA; Kim, EN; Kim, MY; Koh, ES; Lim, JH; Park, CW; Shin, SJ | 1 |
| Bian, ZY; Feng, H; Liao, HH; Ma, ZG; Tang, QZ; Yang, Z; Yuan, Y; Zhang, N | 1 |
| Allaway, G; Bhattachayya, M; Biswal, SS; Jones, BM; Korman, B; Lord, G; Marangoni, RG; Tourtellotte, WG; Varga, J; Wei, J; Zhu, H | 1 |
| Jeon, HY; Kim, YC; Lee, KY; Lee, MK; Sung, SH | 1 |
| Chang, CC; Chao, JC; Tam, KW; Tsai, YH; Wu, SJ | 1 |
| Bartolomé, MV; Cachofeiro, V; Cordova, C; Delgado, C; Gómez-Hurtado, N; Jurado-López, R; Lahera, V; Martín, R; Martínez-Martínez, E; Miana, M; Nieto, ML; San Román, JA | 1 |
| Cui, T; Janicki, JS; Li, J; Li, S; Meyer, CJ; Niu, T; Ruiz, S; Tang, D; Wang, W; Wang, XL; Xing, Y; Zhao, Y | 1 |
| Yamada, G | 1 |
| Fenton, BM; Okunieff, P; Su, Y; Wang, W; Xiao, Z; Yang, S; Yi, Y; Yin, L; Zhang, L | 1 |
2 review(s) available for oleanolic acid and Cirrhosis
| Article | Year |
|---|---|
A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Apoptosis; Bupleurum; China; Drugs, Chinese Herbal; Fibrosis; Humans; Liver; Oleanolic Acid; Oxidative Stress; Plant Extracts; Saponins | 2018 |
[Clinical aspects of type-C cirrhosis of liver--diagnosis, clinical course, treatment and prognosis].
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Cysteine; Disease Progression; Drug Combinations; Drug Therapy, Combination; Fibrosis; Glycine; Hepatitis C, Chronic; Humans; Interferons; Liver; Liver Cirrhosis; Liver Neoplasms; Oleanolic Acid; Prognosis; Ribavirin; Risk; Ursodeoxycholic Acid | 2004 |
26 other study(ies) available for oleanolic acid and Cirrhosis
| Article | Year |
|---|---|
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cells, Cultured; China; Fibrosis; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Estrogen; Receptors, G-Protein-Coupled; Saponins; Signal Transduction; Transforming Growth Factor beta | 2021 |
Saikosaponin D Alleviates DOX-induced Cardiac Injury In Vivo and In Vitro.
Topics: Antioxidants; Apoptosis; Cardiotoxicity; Doxorubicin; Fibrosis; Humans; Myocytes, Cardiac; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins | 2022 |
The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor.
Topics: Cell Line; Fibrosis; Humans; Kidney; Kidney Diseases; Oleanolic Acid; Pilocarpine; Receptors, Muscarinic; Transforming Growth Factor beta | 2022 |
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Topics: Animals; Apoptosis; Fibrosis; Heart Failure; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Oleanolic Acid | 2022 |
The Protective Effect of Ursolic Acid on Unilateral Ureteral Obstruction in Rats by Activating the Nrf2/HO-1 Antioxidant Signaling Pathway.
Topics: Animals; Antioxidants; Fibrosis; Heme Oxygenase (Decyclizing); Kidney Diseases; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Signal Transduction; Ureteral Obstruction; Ursolic Acid | 2022 |
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
Topics: AMP-Activated Protein Kinases; Animals; Fibrosis; Mice; Molecular Docking Simulation; Oleanolic Acid; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2023 |
Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway.
Topics: Animals; Fibroblasts; Fibrosis; Hedgehog Proteins; HEK293 Cells; Humans; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NIH 3T3 Cells; Oleanolic Acid; Rats; Saponins; Signal Transduction; Smoothened Receptor; Zinc Finger Protein Gli2 | 2020 |
Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Movement; Cell Proliferation; Cells, Cultured; Fibrosis; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pancreatic Stellate Cells; Rats; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
The Methyl Ester of 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid Reduces Endometrial Lesions Development by Modulating the NFkB and Nrf2 Pathways.
Topics: Animals; Apoptosis; Cellular Microenvironment; Cyclooxygenase 2; Cytokines; Endometriosis; Female; Fibrosis; Inflammation; Neovascularization, Physiologic; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats.
Topics: Animals; Collagen; Cytokines; Fibrosis; Glutathione Peroxidase; Lung; Male; Malondialdehyde; NF-kappa B; Oleanolic Acid; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Silicosis; Superoxide Dismutase; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2017 |
Identification of a Novel Hybridization from Isosorbide 5-Mononitrate and Bardoxolone Methyl with Dual Activities of Pulmonary Vasodilation and Vascular Remodeling Inhibition on Pulmonary Arterial Hypertension Rats.
Topics: Animals; Cardiomegaly; Drug Design; Fibrosis; Hypertension, Pulmonary; Isosorbide Dinitrate; Nitric Oxide Donors; Oleanolic Acid; Rats; Vascular Remodeling; Vasodilation | 2018 |
Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.
Topics: Animals; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice; Oleanolic Acid; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; STAT Transcription Factors; Transforming Growth Factor beta1 | 2018 |
Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Echocardiography; Endothelial Cells; Endothelium; Fibrosis; Hemodynamics; Male; Mice; Myocytes, Cardiac; Oleanolic Acid; Rats; Saponins; Signal Transduction | 2018 |
Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.
Topics: Animals; Autophagy; Cells, Cultured; Extracellular Matrix; Fibrosis; Male; Matrix Metalloproteinases; Oleanolic Acid; Organotin Compounds; Pancreas; Pancreatic Stellate Cells; Pancreatitis, Chronic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Saponins; Signal Transduction; Smad Proteins; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1 | 2019 |
Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiomyopathies; Fibrosis; Heart; Isoproterenol; Mice, Inbred BALB C; Myocardium; Myocytes, Cardiac; Oleanolic Acid; Phosphorylation; Saponins; Serine; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation.
Topics: Animals; Aristolochic Acids; Cell Line; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; HEK293 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Diseases; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; RNA, Small Interfering; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases | 2019 |
A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses.
Topics: Adipogenesis; Adult; Animals; Biopsy; Cells, Cultured; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibroblasts; Fibrosis; Humans; Infant, Newborn; Mice; Mice, Inbred C57BL; Oleanolic Acid; Organ Culture Techniques; PPAR gamma; Proto-Oncogene Proteins c-akt; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta | 2014 |
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.
Topics: Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Expression Regulation; Inflammation; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; Male; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta | 2014 |
Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Apoptosis; Biomarkers; Cell Nucleus; Cyclosporine; Cytoskeletal Proteins; Fibrosis; Heme Oxygenase-1; Kelch-Like ECH-Associated Protein 1; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Male; Malondialdehyde; Mice; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2014 |
Oleanolic acid alleviated pressure overload-induced cardiac remodeling.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Cardiomegaly; Diabetic Cardiomyopathies; Echocardiography; Fibrosis; Glucose; Hypertension; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oleanolic Acid; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2015 |
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.
Topics: Animals; Bleomycin; Cells, Cultured; Chalcones; Down-Regulation; Fibroblasts; Fibrosis; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; RNA, Messenger; Scleroderma, Systemic; Transforming Growth Factor beta | 2017 |
Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells.
Topics: Animals; Cell Line; Cell Proliferation; Fibrosis; Hepatic Stellate Cells; Magnoliopsida; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Plant Leaves; Plant Stems; Rats; Triterpenes | 2009 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Fibrosis; Male; Mice; Myofibroblasts; Oleanolic Acid; Rats; Triterpenes | 2012 |
Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Constriction; Fibrosis; Heart; Heart Failure; Hypertrophy; Male; Mice; Mice, Inbred C57BL; Myocardium; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Pressure; Up-Regulation; Ventricular Remodeling | 2012 |
Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis.
Topics: Animals; Cell Line, Tumor; Cytokines; Drugs, Chinese Herbal; Female; Fibroblasts; Fibrosis; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Oleanolic Acid; Radiodermatitis; Saponins; Skin; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |