Page last updated: 2024-08-21

oleanolic acid and Chronic Kidney Diseases

oleanolic acid has been researched along with Chronic Kidney Diseases in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's43 (91.49)24.3611
2020's4 (8.51)2.80

Authors

AuthorsStudies
Iwano, M; Kasuno, K; Yodoi, J1
Fukiya, H; Horizono, J; Kai, H; Kamura, M; Kaseda, S; Koyama, Y; Kuwazuru, J; Nara, F; Niinou, S; Nishiyama, H; Ogi, S; Onuma, K; Sannomiya, Y; Sasaki, R; Shuto, T; Suico, MA; Sunamoto, H1
Avula, UMR; Harris, L; Hassanein, M1
Ito, M; Nangaku, M1
Gamede, M; Khathi, A; Mabuza, L; Ngubane, P1
Nezu, M; Suzuki, N; Yamamoto, M1
Toto, RD1
Baigent, C; Lennon, R1
An, HJ; Gu, H; Gwon, MG; Jang, KM; Kim, JY; Park, B; Park, JH; Park, KK1
Appel, GB; Block, GA; Chertow, GM; Chin, MP; Coyne, DW; Goldsberry, A; Kalantar-Zadeh, K; Meyer, CJ; Molitch, ME; Pergola, PE; Raskin, P; Rossing, P; Silva, AL; Spinowitz, B; Sprague, SM1
Chin, MP; Goldsberry, A; McCullough, PA; Meyer, CJ; O'Grady, M; Pergola, PE; Rizk, DV; Silva, AL; Toto, R; Warnock, DG1
Solomon, R1
Kalantar-Zadeh, K; Tayek, JA1
Agarwal, R; Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Chin, M; de Zeeuw, D; Krauth, M; Lambers Heerspink, HJ; McMurray, JJ; Meyer, CJ; Parving, HH; Pergola, PE; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Warnock, DG; Wittes, J1
Fu, L; Gribble, GW1
Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Christ-Schmidt, H; de Zeeuw, D; Goldsberry, A; Krauth, M; Lambers Heerspink, HJ; Linde, P; McMurray, JJ; Meyer, CJ; Parving, HH; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Wittes, J; Wrolstad, D1
Aminzadeh, MA; Khazaeli, M; Meyer, CJ; Reisman, SA; Vaziri, ND; Yuan, J1
Himmelfarb, J; Tuttle, KR2
Akizawa, T; Audhya, P; Bakris, GL; Chertow, GM; Chin, M; Christ-Schmidt, H; de Zeeuw, D; Goldsberry, A; Houser, M; Krauth, M; Lambers Heerspink, HJ; McMurray, JJ; Meyer, CJ; Parving, HH; Remuzzi, G; Toto, RD; Vaziri, ND; Wanner, C; Wittes, J; Wrolstad, D1
Aminzadeh, MA; Farzaneh, SH; Khazaeli, M; Meyer, CJ; Reisman, SA; Shelkovnikov, S; Vaziri, ND1
Attley, J; Cuzzocrea, S; Esposito, E; Impellizzeri, D1
Chertow, GM; de Zeeuw, D1
Chartoumpekis, DV; Sykiotis, GP1
Kovács, T; Molnár, GA; Wittmann, I1
Ellison, DH1
Bakris, GL; Chin, MP; Linde, PG; McCullough, PA; Meyer, CJ; O'Grady, M; Packham, D; Reisman, SA; Vaziri, ND; Ward, KW; Warnock, DG1
Van Biesen, W; Van Laecke, S; Vanholder, R1
de Zeeuw, D; Meyer, C1
Bakris, GL; Chertow, GM; Chin, MP; de Zeeuw, D; Goldsberry, A; Linde, PG; McCullough, PA; McMurray, JJ; Meyer, CJ; Wittes, J; Wrolstad, D1
He, ZX; Wang, YY; Yang, YX; Zhe, H; Zhou, SF1
Chan, JY; Khazaeli, M; Lau, WL; Liu, SM; Ni, Z; Pahlevan, S; Vaziri, ND; Yuan, J1
Chin, MP; Meyer, CJ1
Camer, D; Huang, XF1
Farzaneh, SH; Khazaeli, M; Liu, S; Nazertehrani, S; Vaziri, ND; Zhao, YY1
Breyer, MD; Susztak, K1
Audhya, P; Christ-Schmidt, H; Grossman, EB; Huff, JW; Krauth, M; Meyer, CJ; Pergola, PE; Raskin, P; Ruiz, S; Toto, RD; Warnock, DG; Wittes, J1
Van Laecke, S; Vanholder, R1
Bittenbring, JT; Fliser, D; Rogacev, KS1
Levey, AS; Sarnak, MJ; Upadhyay, A1
Forman, JP; McMahon, GM1
Abramowitz, MK; Bauer, C; Hostetter, TH; Melamed, ML; Turner, JM1
Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Ronco, P1
Merk, D; Schubert-Zsilavecz, M1
Zhang, DD1
Pergola, PE; Ruiz, S; Vaziri, ND; Zager, RA1
Saito, H1

Reviews

8 review(s) available for oleanolic acid and Chronic Kidney Diseases

ArticleYear
Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics.
    Antioxidants & redox signaling, 2022, Volume: 36, Issue:13-15

    Topics: Acute Kidney Injury; Biomarkers; Female; Humans; Male; Oleanolic Acid; Oxidation-Reduction; Renal Insufficiency, Chronic; Thioredoxins

2022
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.
    American journal of nephrology, 2017, Volume: 45, Issue:6

    Topics: Acute Kidney Injury; Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Glomerular Filtration Rate; Humans; Kelch-Like ECH-Associated Protein 1; Kidney Tubules; Mice; Molecular Targeted Therapy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Proteasome Endopeptidase Complex; Proteolysis; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Ubiquitination

2017
Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
    Pharmacological research, 2014, Volume: 81

    Topics: Amides; Animals; Anti-Inflammatory Agents; Endocannabinoids; Ethanolamines; Humans; Oleanolic Acid; Palmitic Acids; Renal Insufficiency, Chronic

2014
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Animals; Humans; Hypertension, Pulmonary; Inflammation; Neoplasms; Oleanolic Acid; Renal Insufficiency, Chronic

2014
Developing Treatments for Chronic Kidney Disease in the 21st Century.
    Seminars in nephrology, 2016, Volume: 36, Issue:6

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Atrasentan; Benzhydryl Compounds; Canagliflozin; Diabetic Nephropathies; Drug Discovery; Endothelin Receptor Antagonists; Glucosides; Glycosaminoglycans; Humans; Hypoglycemic Agents; Mineralocorticoid Receptor Antagonists; Oleanolic Acid; Oxidative Stress; Pyridoxamine; Pyrrolidines; Renal Insufficiency, Chronic; Sodium-Glucose Transporter 2 Inhibitors

2016
Treatment of chronic kidney disease.
    Kidney international, 2012, Volume: 81, Issue:4

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Diabetes Mellitus, Type 2; Disease Progression; Endothelin-1; Humans; Hypertension; Kidney Failure, Chronic; Oleanolic Acid; Pyridones; Renal Insufficiency, Chronic; Renin-Angiotensin System

2012
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease.
    Kidney international, 2013, Volume: 83, Issue:6

    Topics: Acute Kidney Injury; Animals; Anti-Infective Agents; Antioxidants; Disease Progression; Humans; Inflammation; Kidney; Kidney Failure, Chronic; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome

2013
Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases.
    Biochemical pharmacology, 2013, Apr-01, Volume: 85, Issue:7

    Topics: Acute Kidney Injury; Animals; Antioxidants; Chronic Disease; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency; Renal Insufficiency, Chronic; Signal Transduction

2013

Trials

8 trial(s) available for oleanolic acid and Chronic Kidney Diseases

ArticleYear
Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease.
    Journal of diabetes and its complications, 2018, Volume: 32, Issue:12

    Topics: Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Male; Middle Aged; Obesity; Oleanolic Acid; Renal Insufficiency, Chronic; Waist Circumference

2018
Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.
    Cardiorenal medicine, 2019, Volume: 9, Issue:5

    Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Electrocardiography; Female; Glomerular Filtration Rate; Humans; Magnesium; Male; Middle Aged; Oleanolic Acid; Renal Insufficiency, Chronic

2019
Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON).
    American journal of nephrology, 2013, Volume: 37, Issue:3

    Topics: Anti-Inflammatory Agents; Clinical Trials Data Monitoring Committees; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Early Termination of Clinical Trials; Glomerular Filtration Rate; Humans; Oleanolic Acid; Renal Insufficiency, Chronic; Treatment Outcome

2013
Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: the Occurrence of renal eveNts (BEACON) trial.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2013, Volume: 28, Issue:11

    Topics: Adolescent; Adult; Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Oleanolic Acid; Prognosis; Renal Insufficiency, Chronic; Young Adult

2013
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.
    The New England journal of medicine, 2013, 12-26, Volume: 369, Issue:26

    Topics: Aged; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic; Treatment Failure; Weight Loss

2013
Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.
    American journal of nephrology, 2014, Volume: 39, Issue:6

    Topics: Animals; Diabetes Mellitus, Type 2; Double-Blind Method; Early Termination of Clinical Trials; Heart Failure; Humans; Macaca fascicularis; Male; Oleanolic Acid; Rats; Renal Insufficiency, Chronic; Sodium; Urine; Water-Electrolyte Imbalance

2014
Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.
    Journal of cardiac failure, 2014, Volume: 20, Issue:12

    Topics: Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Early Termination of Clinical Trials; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Oleanolic Acid; Patient Safety; Predictive Value of Tests; Reference Values; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index; Survival Rate; Treatment Outcome

2014
Bardoxolone methyl and kidney function in CKD with type 2 diabetes.
    The New England journal of medicine, 2011, Jul-28, Volume: 365, Issue:4

    Topics: Aged; Antioxidants; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Oleanolic Acid; Renal Insufficiency, Chronic; Spasm

2011

Other Studies

31 other study(ies) available for oleanolic acid and Chronic Kidney Diseases

ArticleYear
Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model.
    Kidney360, 2022, 04-28, Volume: 3, Issue:4

    Topics: Animals; Disease Models, Animal; Kelch-Like ECH-Associated Protein 1; Mice; Nephritis, Hereditary; NF-E2-Related Factor 2; Oleanolic Acid; Phenotype; Renal Insufficiency, Chronic

2022
Bardoxolone for CKD: The Paradox of Confusion and Dogma.
    Kidney360, 2022, 11-24, Volume: 3, Issue:11

    Topics: Humans; Oleanolic Acid; Renal Insufficiency, Chronic

2022
Increased albuminuria in bardoxolone methyl-treated type 2 diabetes patients: mere reflection of eGFR improvement?
    Kidney international, 2019, Volume: 96, Issue:4

    Topics: Albumins; Albuminuria; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Glomerular Filtration Rate; Humans; Oleanolic Acid; Renal Insufficiency, Chronic; Retrospective Studies

2019
Preventing the onset of diabetes-induced chronic kidney disease during prediabetes: The effects of oleanolic acid on selected markers of chronic kidney disease in a diet-induced prediabetic rat model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Animals; Biomarkers; Diabetic Nephropathies; Diet; Diet, High-Fat; Dietary Carbohydrates; Glomerular Filtration Rate; Hypoglycemic Agents; Kidney Function Tests; Male; Metformin; Oleanolic Acid; Oxidative Stress; Prediabetic State; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Syzygium

2021
Bardoxolone-the Phoenix?
    Journal of the American Society of Nephrology : JASN, 2018, Volume: 29, Issue:2

    Topics: Anti-Inflammatory Agents; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Glomerular Filtration Rate; Heart Failure; Humans; Nephritis, Hereditary; Oleanolic Acid; Renal Insufficiency, Chronic

2018
Should We Increase GFR with Bardoxolone in Alport Syndrome?
    Journal of the American Society of Nephrology : JASN, 2018, Volume: 29, Issue:2

    Topics: Albuminuria; Anti-Inflammatory Agents; Clinical Trials as Topic; Diabetic Nephropathies; Disease Progression; Glomerular Filtration Rate; Heart Failure; Humans; Nephritis, Hereditary; Oleanolic Acid; Renal Insufficiency, Chronic

2018
Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.
    Molecules (Basel, Switzerland), 2018, Sep-03, Volume: 23, Issue:9

    Topics: Animals; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice; Oleanolic Acid; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; STAT Transcription Factors; Transforming Growth Factor beta1

2018
New Approach to Slowing the Progression of Chronic Kidney Disease.
    Cardiorenal medicine, 2019, Volume: 9, Issue:5

    Topics: Disease Progression; Healthy Volunteers; Humans; Oleanolic Acid; Renal Insufficiency, Chronic

2019
The extinguished BEACON of bardoxolone: not a Monday morning quarterback story.
    American journal of nephrology, 2013, Volume: 37, Issue:3

    Topics: Anti-Inflammatory Agents; Diabetic Nephropathies; Early Termination of Clinical Trials; Humans; Oleanolic Acid; Proteinuria; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Spasm; Weight Loss

2013
Efficient and scalable synthesis of bardoxolone methyl (cddo-methyl ester).
    Organic letters, 2013, Apr-05, Volume: 15, Issue:7

    Topics: Anti-Inflammatory Agents; Chromatography; Diabetes Mellitus, Type 2; Esters; Humans; Molecular Structure; Oleanolic Acid; Renal Insufficiency, Chronic

2013
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.
    Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:6

    Topics: Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Expression Regulation; Inflammation; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; Male; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta

2014
New therapies for diabetic kidney disease.
    The New England journal of medicine, 2013, Dec-26, Volume: 369, Issue:26

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2013
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease.
    Redox biology, 2013, Volume: 1

    Topics: Animals; Aorta; Endothelial Cells; Gene Expression Regulation; Inflammation; Male; Nephrectomy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic

2013
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
    The New England journal of medicine, 2014, 05-01, Volume: 370, Issue:18

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2014
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
    The New England journal of medicine, 2014, 05-01, Volume: 370, Issue:18

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2014
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
    The New England journal of medicine, 2014, 05-01, Volume: 370, Issue:18

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2014
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
    The New England journal of medicine, 2014, 05-01, Volume: 370, Issue:18

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2014
Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease.
    The New England journal of medicine, 2014, 05-01, Volume: 370, Issue:18

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2014
The paradox of bardoxolone methyl: a call for every witness on the stand?
    Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:1

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2015
The paradox created by commenting on large clinical trial results.
    Diabetes, obesity & metabolism, 2015, Volume: 17, Issue:1

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2015
Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.
    Digestive diseases and sciences, 2015, Volume: 60, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Case-Control Studies; Colitis; Colon; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; Male; Nephrectomy; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction; Tight Junction Proteins; Tight Junctions; Uremia

2015
Reply: To PMID 25307295.
    Journal of cardiac failure, 2015, Volume: 21, Issue:3

    Topics: Diabetes Mellitus, Type 2; Early Termination of Clinical Trials; Female; Heart Failure; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2015
Is B-type natriuretic peptide a risk factor for heart failure in patients treated with bardoxolone methyl?
    Journal of cardiac failure, 2015, Volume: 21, Issue:3

    Topics: Diabetes Mellitus, Type 2; Early Termination of Clinical Trials; Female; Heart Failure; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2015
Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease.
    Free radical biology & medicine, 2015, Volume: 86

    Topics: Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; Male; NF-E2-Related Factor 2; Oleanolic Acid; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Signal Transduction

2015
Bardoxolone methyl, chronic kidney disease, and type 2 diabetes.
    The New England journal of medicine, 2011, 11-03, Volume: 365, Issue:18

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2011
Bardoxolone methyl, chronic kidney disease, and type 2 diabetes.
    The New England journal of medicine, 2011, 11-03, Volume: 365, Issue:18

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2011
Bardoxolone methyl, chronic kidney disease, and type 2 diabetes.
    The New England journal of medicine, 2011, 11-03, Volume: 365, Issue:18

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2011
Bardoxolone methyl, chronic kidney disease, and type 2 diabetes.
    The New England journal of medicine, 2011, 11-03, Volume: 365, Issue:18

    Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Male; Oleanolic Acid; Renal Insufficiency, Chronic

2011
[Chronic kidney disease, new therapeutic approaches].
    La Revue du praticien, 2012, Volume: 62, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Disease Progression; Drug Therapy, Combination; Endothelin Receptor Antagonists; Humans; Oleanolic Acid; Prognosis; Protein Kinase Inhibitors; Renal Insufficiency, Chronic; Treatment Outcome

2012
New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?
    Future medicinal chemistry, 2012, Volume: 4, Issue:3

    Topics: Anti-Inflammatory Agents; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Kidney; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic

2012
Bardoxolone brings Nrf2-based therapies to light.
    Antioxidants & redox signaling, 2013, Aug-10, Volume: 19, Issue:5

    Topics: Clinical Trials, Phase III as Topic; Humans; NF-E2-Related Factor 2; Oleanolic Acid; Renal Insufficiency, Chronic

2013