oleanolic acid has been researched along with Cancer of Pancreas in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 8 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Chun, KH; Kim, J; Kim, Y; Lim, JW; Yoon, Y | 1 |
| Awale, S; Dibwe, DF; Kim, MJ; Omar, AM; Sun, S; Tawila, AM; Toyooka, N; Ueda, JY | 1 |
| Baer-Dubowska, W; Kleszcz, R; Krajka-Kuźniak, V; Narożna, M | 1 |
| Chu, P; Dong, Y; Li, N; Niu, M; Sun, Z; Tang, Z; Wang, S; Zhou, Y; Zhou, Z | 1 |
| Akuetteh, PDP; Hong, W; Huang, H; Jin, G; Lan, L; Shangguan, F; Wu, S; Yang, H; Zhang, Q; Zhou, H | 1 |
| Behroozi, J; Chamanara, M; Esmaeili, H; Farhadi, A; Hadi, S; Hazrati, E; Heidari, MF; Mosaed, R; Nasrollahzadeh Sabet, M | 1 |
| Ahmad, N; Ai, J; Almoiliqy, M; Alshwmi, M; Awsh, M; Chu, P; Gamallat, Y; Jamalat, Y; Li, H; Li, X; Mousa, H; Niu, M; Qaed, E; Shobet, L; Shopit, A; Tang, Z; Tesfaldet, T; Wang, H; Wang, S | 1 |
| Al-Radhi, M; Awsh, M; Baldi, S; Chu, P; Fang, J; Jia, J; Li, X; Ma, X; Peng, J; Safi, M; Shopit, A; Shu, X; Tang, Z; Wang, F; Wang, S | 1 |
| Chu, P; Gao, L; Hu, M; Li, H; Ma, X; Peng, J; Qaed, E; Song, Y; Sun, B; Tang, Z; Wang, S | 1 |
| Han, L; Lu, J; Lv, C; Zhao, B; Zhao, Y | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Liu, Y; Varma, NR | 1 |
| Li, H; Liao, J; Yang, GY; Yang, Y; Zhang, W | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, P; Liu, Y; Shaw, J; Zhang, Y | 1 |
| Chen, X; Gong, Y; Liang, H; Liu, J; Ma, A; Ma, L; Wang, J; Yu, T; Zheng, L | 1 |
| Leal, AS; Liby, KT; Pioli, PA; Sporn, MB | 1 |
| Abdelrahim, M; Andreeff, M; Basha, MR; Chadalapaka, G; Jutooru, I; Konopleva, M; Safe, S; Samudio, I | 1 |
| Hruban, RH; Liby, KT; Maitra, A; Risingsong, R; Royce, DB; Sporn, MB; Williams, CR | 1 |
| Arbab, AS; Deeb, D; Gao, X; Gautam, SC; Kim, SH; Liu, Y; Pindolia, KR | 1 |
| Han, L; Lin, X; Liu, H; Liu, M; Wang, F; Wang, H; Wei, J; Zhang, Y | 1 |
| Chu, E; Han, L; Lin, X; Liu, H; Liu, M; Wei, J; Wu, N; Xiao, L; Zhao, J | 1 |
| Deeb, D; Gao, X; Gautam, SC; Liu, YB | 1 |
| Andreeff, M; Evans, R; Gilbert, HF; Gribble, GW; Hail, N; Honda, T; Hsu, T; Konopleva, M; McQueen, T; Safe, S; Samudio, I; Shi, YX; Sporn, M | 1 |
22 other study(ies) available for oleanolic acid and Cancer of Pancreas
| Article | Year |
|---|---|
Discovery of ursolic acid prodrug (NX-201): Pharmacokinetics and in vivo antitumor effects in PANC-1 pancreatic cancer.
Topics: Animals; Cell Line, Tumor; Humans; Mice, SCID; Pancreas; Pancreatic Neoplasms; Prodrugs; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2016 |
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line.
Topics: Antineoplastic Agents, Phytogenic; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Egypt; Humans; Molecular Structure; Myrtaceae; Pancreatic Neoplasms; Structure-Activity Relationship; Terpenes; Tumor Microenvironment | 2020 |
Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells.
Topics: Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Cyclooxygenase Inhibitors; Diclofenac; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Oleanolic Acid; Oximes; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2022 |
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chloroquine; ErbB Receptors; Humans; Oleanolic Acid; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction | 2022 |
Synthetic oleanane triterpenoid derivative CDDO-Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5.
Topics: Adenocarcinoma; Amino Acid Transport System ASC; Animals; Apoptosis; Cell Line, Tumor; Energy Metabolism; Humans; Mice; Mice, Nude; Minor Histocompatibility Antigens; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Triterpenes | 2022 |
Oleanolic acid increases the anticancer potency of doxorubicin in pancreatic cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Doxorubicin; Humans; Oleanolic Acid; Pancreatic Neoplasms | 2023 |
miR-421 up-regulation by the oleanolic acid derivative K73-03 regulates epigenetically SPINK1 transcription in pancreatic cancer cells leading to metabolic changes and enhanced apoptosis.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Energy Metabolism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; MicroRNAs; Mitochondria; Oleanolic Acid; Pancreatic Neoplasms; Signal Transduction; Transcription, Genetic; Trypsin Inhibitor, Kazal Pancreatic; Tumor Burden; Tumor Cells, Cultured; Up-Regulation; Xenograft Model Antitumor Assays | 2020 |
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; MicroRNAs; Oleanolic Acid; Pancreatic Neoplasms; Trypsin Inhibitor, Kazal Pancreatic | 2021 |
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 2; Mice; Mitochondria; Morpholines; NF-kappa B; Oleanolic Acid; Pancreatic Neoplasms; STAT3 Transcription Factor | 2018 |
New 23, 27-dihydroxy-oleanane-type triterpenoid saponins from
Topics: A549 Cells; Anemone; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Pancreatic Neoplasms; Plant Extracts; Rhizome; Saponins; Triterpenes | 2021 |
Inhibition of telomerase activity by oleanane triterpenoid CDDO-Me in pancreatic cancer cells is ROS-dependent.
Topics: Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Pancreatic Neoplasms; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Telomerase | 2013 |
Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Animals; Cadherins; CD18 Antigens; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, ras; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Pancreatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; RNA, Small Interfering; Signal Transduction; Transfection; Up-Regulation; Xenograft Model Antitumor Assays | 2014 |
CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mice; Mice, SCID; Neoplasm Recurrence, Local; Oleanolic Acid; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2015 |
ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.
Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-E2-Related Factor 2; Nitriles; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Topics: Animals; Granulocyte Colony-Stimulating Factor; Homeodomain Proteins; Humans; Imidazoles; Inflammation; Interleukin-6; Leukocyte Common Antigens; Lipopolysaccharides; Mice; Mice, Knockout; Monocyte Chemoattractant Proteins; Neoplasms, Experimental; Oleanolic Acid; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Proto-Oncogene Proteins p21(ras); Trans-Activators; Vascular Endothelial Growth Factor A | 2016 |
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cell Proliferation; DNA Primers; Humans; Male; Mice; Mice, Nude; MicroRNAs; Oleanolic Acid; Pancreatic Neoplasms; Polymerase Chain Reaction; Reactive Oxygen Species; Transcription Factors | 2010 |
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Mice; Mice, Transgenic; Nicotinic Acids; Oleanolic Acid; Pancreatic Neoplasms; Signal Transduction; Tetrahydronaphthalenes | 2010 |
Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Oleanolic Acid; Pancreatic Neoplasms; Suppression, Genetic; Telomerase | 2012 |
Oleanolic acid arrests cell cycle and induces apoptosis via ROS-mediated mitochondrial depolarization and lysosomal membrane permeabilization in human pancreatic cancer cells.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cytochromes c; DNA Fragmentation; Humans; Lysosomes; Mitochondria; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species | 2013 |
Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cathepsin D; Cell Proliferation; Cytochromes c; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Inhibitor of Apoptosis Proteins; Intracellular Membranes; Lysosomes; NF-kappa B; Oleanolic Acid; Pancreatic Neoplasms; Permeability; Proto-Oncogene Proteins c-bcl-2; Survivin; Tumor Cells, Cultured | 2012 |
Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides | 2012 |
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Binding Sites; Biotinylation; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytoplasm; DNA Fragmentation; Enzyme Activation; Flow Cytometry; Glutathione; Humans; Imidazoles; Membrane Potentials; Mitochondria; Models, Chemical; Oleanolic Acid; Pancreatic Neoplasms; Reactive Oxygen Species; Sulfhydryl Compounds; Time Factors | 2005 |