oleanolic acid has been researched along with Cancer of Liver in 77 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (3.90) | 18.2507 |
| 2000's | 16 (20.78) | 29.6817 |
| 2010's | 46 (59.74) | 24.3611 |
| 2020's | 12 (15.58) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Huang, Z; Kaufman, DL; Kong, X; Lan, E; Peng, S; Tian, J; Zhang, Y | 1 |
| Dong, H; He, M; He, Y; Huang, M; Liu, D; Liu, X; Wei, Z; Zhang, M; Zheng, Z | 1 |
| Cao, L; Fang, Z; Jia, D; Mi, J; Pan, Z; Peng, P; Shi, Z; Zhang, Y | 1 |
| Cai, J; Fan, Y; Jiang, M; Liu, H; Nie, H; Sun, H; Wang, L; Wei, X; Xing, Z; Yang, D; Zhao, C; Zhou, L | 1 |
| Baer-Dubowska, W; Bednarczyk-Cwynar, B; Krajka-Kuźniak, V; Narożna, M; Szaefer, H | 1 |
| Greige-Gerges, H; Hamade, A; Kayouka, M; Landy, D; Najjar, F; Saliba, E | 1 |
| Chen, J; Chen, JS; Gough, NR; He, AR; Latham, PS; Li, S; Lin, P; Malta, TM; Mishra, B; Mishra, L; Mitra, A; Nguyen, BN; Noushmehr, H; Obias, V; Rashid, A; Shin, JH; Song, S; Su, X; Wu, RC; Yao, Z | 1 |
| Chen, BQ; Liu, QH; Liu, X; Liu, YM; Sun, L | 1 |
| Wu, X; Zeng, X; Zhou, W | 1 |
| Díaz-Ruiz, L; Jannus, F; Lupiáñez, JA; Medina-O'Donnell, M; Parra, A; Reyes-Zurita, FJ; Rivas, F; Rufino-Palomares, EE | 1 |
| Guo, J; Lin, S; Ma, Q; Min, W; Song, L; Wang, B; Yang, P | 1 |
| Huang, HY; Wu, YL; Zhu, YY | 1 |
| Liu, J; Liu, Q; Ren, S; Song, R; Xing, Y; Xu, J; Xue, Y; Yang, J; Zhang, Z | 1 |
| Cai, T; Chen, X; Cheng, J; Cheng, Z; Qi, S; Qi, Z; Wang, S; Wu, X | 1 |
| Biradi, M; Hullatti, K | 1 |
| Afzal, A; Bashir, S; Khan, MW; Ma, X; Madni, A; Raza, SM; Sarfraz, M; Xiang, G | 1 |
| Huang, ZJ; Liu, JC; Xu, JY; Yan, C; Zhang, HB; Zhang, YH; Zhou, JP; Zou, Y | 1 |
| Chen, S; Liang, Y; Liu, H; Liu, Y; Sun, T; Tian, Y; Wang, H; Yang, C; Zhang, H; Zhang, Q; Zhao, J; Zhong, W; Zhou, H; Zong, S | 1 |
| Cao, Y; Li, W; Wang, J; Wang, L; Wang, Y; Xu, G; Xu, J | 1 |
| Fulda, S; Hinrichs, TM; Lange, M; Liese, J | 1 |
| Chen, Y; Hou, X; Li, R; Lv, Y; Sun, R; Tian, Y; Xu, F; Xu, L; Zhang, Q; Zhang, Z | 1 |
| Bruno, M; Fontana, G; Labbozzetta, M; Notarbartolo, M; Poma, P; Rosselli, S; Spinella, A | 1 |
| Bai, H; Cao, P; Hai, C; Liao, N; Liu, J; Wang, X; Wang, Z; Zhang, W; Zhang, X | 1 |
| Fu, J; Huang, Z; Ji, H; Lai, Y; Liu, L; Peng, S; Tian, J; Zhang, Y | 1 |
| Bai, MH; Cheng, YA; Dai, ZJ; Lin, S; Ma, HB; Ma, XL; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, YL; Zan, Y | 1 |
| Ding, Y; Ji, H; Ling, J; Liu, L; Yang, L; Zhang, C; Zhang, Y; Zhang, Z; Zhao, Q | 1 |
| Bai, MH; Cheng, YA; Guan, HT; Kang, HF; Lin, S; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, ZW; Zan, Y | 1 |
| Bao, X; Chu, QC; Gao, M; Guan, X; Jiang, N; Liu, KX; Tian, Y; Xu, H; Zhang, CH | 1 |
| Bai, MH; Lin, S; Ma, HB; Min, WL; Song, LQ; Wang, BF; Wang, M; Wang, XJ; Yang, P | 1 |
| Chen, W; Ding, Y; Huang, C; Huang, T; Ma, C; Ma, H; Wang, Q; Yu, W | 1 |
| Ahmed, A; Ahmed, VU; Ali, FI; Aslam, A; Hashmi, IA; Manzoor, S; Mustufa, MA; Naqvi, Nu; Ozen, C; Ozturk, M | 1 |
| Chen, J; He, S; Hou, H; Lu, G; Lu, X; Wang, Z; Zhao, Z; Zhu, Z | 1 |
| Abhari, BA; Fulda, S; Liese, J | 1 |
| Du, Q; Liu, X; Mi, Y; Qi, G; Wu, W; Xiao, C | 1 |
| Chen, WL; Li, JZ; Liu, Y; Yang, SD; You, BG; Yuan, ZQ; Zhang, CG; Zhang, XN; Zhou, XF; Zhu, R; Zhu, WJ | 1 |
| Cao, X; Chen, J; Deng, W; Firempong, CK; Tong, SS; Wang, Q; Wang, Y; Xu, X; Yu, J; Zhang, HY; Zhou, J | 1 |
| Liu, L; Wang, JG; Zhao, JL | 1 |
| Ao, G; Pan, W; Wang, J; Wang, N; Wang, Q; Wu, F; Xu, G; Yang, J; Zhou, W | 1 |
| Huang, J; Li, J; Liu, Z; Luo, Y; Sun, X; Xiong, D; Yu, X; Zhang, X; Zhong, Z | 1 |
| Chen, F; Fang, L; Feng, M; Gou, S; Liu, X; Shen, H; Zhao, J | 1 |
| Abhari, BA; Fulda, S; Hinrichs, TM; Lange, M; Liese, J | 1 |
| Bao, X; Deng, S; Gao, D; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Wang, C; Xu, H; Zhang, C | 1 |
| Buitrago-Molina, LE; Cañón, JM; Finegold, M; Geffers, R; Grompe, M; Lamlé, J; Manns, MP; Marhenke, S; Sporn, M; Vogel, A; Yamamoto, M | 1 |
| Baumgartner, KJ; Dinkova-Kostova, AT; Egner, PA; Gribble, GW; Groopman, JD; Honda, T; Kensler, TW; Liby, K; Risingsong, R; Roebuck, BD; Royce, DB; Sporn, MB; Stephenson, KK; Sundararajan, C; Williams, CR; Yates, MS; Yore, MM; Yoshizawa, H | 1 |
| Popovich, DG; Tang, FY; Yeo, MC; Zhang, W | 1 |
| Huang, CY; Wu, ST; Yan, SL; Yin, MC | 1 |
| Kano, Y; Ma, CM; Masao, H; Wang, XJ; Wu, XH | 1 |
| Chen, L; Guo, Q; Huang, Z; Jing, Y; Lai, Y; Peng, S; Tian, J; Yuan, S; Zhang, J; Zhang, L; Zhang, Y; Zhao, L | 1 |
| Kao, TC; Shyu, MH; Yen, GC | 1 |
| Lushnikova, EL; Nepomnyashih, LM; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA | 1 |
| Chan, CY; Huang, CY; Lin, CC; Mong, MC; Yin, MC | 1 |
| Chambers, AF; Dales, DW; Foster, PJ; Hedley, BD; Liby, KT; Macdonald, IC; Mackenzie, L; Sporn, MB; Townson, JL | 1 |
| Chang, CI; Hsu, JL; Liao, MH; Lin, BW; Lin, PY; Shih, WL; Wu, HY; Yen, CH; Yu, FL | 1 |
| Arbab, AS; Deeb, D; Divine, GW; Dulchavsky, SA; Gao, X; Gautam, SC; Jiang, D; Liu, Y | 1 |
| Ding, L; Dong, W; Li, X; Liu, X; Yang, D | 1 |
| Gao, Y; Gong, Z; Su, F; Zhang, J; Zhang, Y | 1 |
| Chen, X; Chen, Y; Deng, A; He, J; Jin, L; Lou, L; Tao, X; Wang, J; Wu, S; Ye, W; Zhu, J | 1 |
| Li, MY; Pu, R; Wang, LT; Yuan, JK; Zhang, GP; Zhu, BH | 1 |
| Fu, J; Huang, Z; Ji, H; Knaus, EE; Lai, Y; Liu, L; Sun, Y; Tian, J; Zhang, Y | 1 |
| Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Cui, R; Fu, J; Ji, H; Li, T; Ling, J; Liu, L; Yu, X; Zhang, Y | 1 |
| Cao, L; Fan, H; Hu, JF; Liu, ST; Su, JJ; Xia, G; Xiong, J; Yang, GX; Ye, M; Zhao, Y | 1 |
| Cheng, Y; Dang, S; Jia, X; Li, M; Li, S; Li, Y; Zhang, X | 1 |
| Wen-Sheng, W | 1 |
| Chiang, LC; Hsu, YL; Kuo, PL; Lin, CC | 1 |
| Fujii, M; Hou, DX; Lin, S; Tong, X | 1 |
| Imazeki, F | 1 |
| Yamada, G | 1 |
| Choi, YM; Jeong, HG; Jeong, TC; Kim, DH; Kim, JY; Lee, ES; Lee, KJ | 1 |
| Bi, MR; Chen, LY; Ma, YJ; Wang, Y; Yang, BS | 1 |
| Grek, OR; Pozdnyakova, SV; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA | 1 |
| Peng, SX; Tian, JD; Zhang, YH | 1 |
| Popovich, DG; Zhang, W | 1 |
| Li, Q; Murakamio, T; Okita, K; Takahashi, M | 1 |
| Kimura, Y; Murakami, T; Okita, K; Qian, L; Takahashi, M | 1 |
| Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H | 1 |
| Hsu, HY; Wu, WS | 1 |
3 review(s) available for oleanolic acid and Cancer of Liver
| Article | Year |
|---|---|
[Alternative measures for patients with chronic hepatitis C unresponsive to interferon therapy].
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Clinical Trials as Topic; Cysteine; Drug Combinations; Drug Therapy, Combination; Genotype; Glycine; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Iron, Dietary; Liver Neoplasms; Oleanolic Acid; Phlebotomy; Prognosis; Ribavirin; Time Factors | 2004 |
[Clinical aspects of type-C cirrhosis of liver--diagnosis, clinical course, treatment and prognosis].
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Cysteine; Disease Progression; Drug Combinations; Drug Therapy, Combination; Fibrosis; Glycine; Hepatitis C, Chronic; Humans; Interferons; Liver; Liver Cirrhosis; Liver Neoplasms; Oleanolic Acid; Prognosis; Ribavirin; Risk; Ursodeoxycholic Acid | 2004 |
[Targeting of nitric oxide-donor and related drugs].
Topics: Animals; Apoptosis; Azo Compounds; Cell Line, Tumor; Drug Delivery Systems; Humans; Liver; Liver Neoplasms; Nitrates; Nitric Oxide Donors; Oleanolic Acid; Piperazines; Ursodeoxycholic Acid | 2006 |
74 other study(ies) available for oleanolic acid and Cancer of Liver
| Article | Year |
|---|---|
Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Drug Design; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Nitric Oxide; Oleanolic Acid | 2008 |
Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; MicroRNAs; Oleanolic Acid | 2021 |
α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Molecular Docking Simulation; Neoplasm Metastasis; Oleanolic Acid; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Saponins; Signal Transduction; STAT3 Transcription Factor | 2022 |
Hepatocyte-targeted delivery using oleanolic acid-loaded liposomes for enhanced hepatocellular carcinoma therapy.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Hepatocytes; Humans; Liposomes; Liver Neoplasms; Mice; Mice, Inbred Strains; Oleanolic Acid | 2023 |
Morpholide derivative of the novel oleanolic oxime and succinic acid conjugate diminish the expression and activity of NF-κB and STATs in human hepatocellular carcinoma cells.
Topics: bcl-2-Associated X Protein; bcl-X Protein; Carcinoma, Hepatocellular; Cell Survival; Cyclooxygenase 2; Hep G2 Cells; Humans; Liver Neoplasms; NF-kappa B; Oleanolic Acid; Oximes; Proto-Oncogene Proteins c-myc; STAT Transcription Factors; Succinic Acid; Transcription, Genetic | 2019 |
P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Embryo, Nonmammalian; Female; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Oleanolic Acid; Verapamil; Zebrafish | 2020 |
Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGFβ Signaling.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Down-Regulation; Exome Sequencing; Gene Deletion; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Heterografts; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplastic Stem Cells; Oleanolic Acid; Phosphorylation; RNA, Small Interfering; Smad Proteins; Smad2 Protein; Smad3 Protein; Spectrin; Stem Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases; Ubiquitination; Up-Regulation | 2020 |
Synthesis, Characterization and Anti-hepatoma Activity of New Hederagenin Derivatives.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2020 |
Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells.
Topics: Adenine; Adenosine Triphosphate; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Oleanolic Acid | 2020 |
A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells.
Topics: Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Diamines; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Polyethylene Glycols; Proto-Oncogene Proteins c-bcl-2; Receptors, Death Domain; Triterpenes; Tumor Suppressor Protein p53; Up-Regulation | 2020 |
Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemoradiotherapy; Humans; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Radiation Tolerance; Saponins; TOR Serine-Threonine Kinases | 2021 |
[Retracted] Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Oleanolic Acid | 2021 |
Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition.
Topics: Bupleurum; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Meridians; Microsomes, Liver; Oleanolic Acid; Pregnane X Receptor; Saponins; Time Factors | 2021 |
Calunduloside E inhibits HepG2 cell proliferation and migration via p38/JNK-HMGB1 signalling axis.
Topics: Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; HMGB1 Protein; Humans; Liver Neoplasms; MAP Kinase Signaling System; Oleanolic Acid; Phytotherapy; Saponins; Signal Transduction | 2021 |
Bioactivity guided isolation of cytotoxic terpenoids and steroids from Premna serratifolia.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Hep G2 Cells; Hexanes; Humans; Inhibitory Concentration 50; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Spectroscopy; Methanol; Muscle Fibers, Skeletal; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Solvents; Stigmasterol; Verbenaceae | 2017 |
Liposomal co-delivered oleanolic acid attenuates doxorubicin-induced multi-organ toxicity in hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Cardiotoxicity; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Doxorubicin; Drug Liberation; Drug Stability; Drug Synergism; Female; Humans; Liposomes; Liver Neoplasms; Mice; Models, Biological; Myocytes, Cardiac; Oleanolic Acid; Protective Agents; Xenograft Model Antitumor Assays | 2017 |
Synthesis and anti-hepatocellular carcinoma activity of novel O
Topics: Antineoplastic Agents; Apoptosis; Azo Compounds; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Drug Screening Assays, Antitumor; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Nitric Oxide; Nitric Oxide Donors; Oleanolic Acid | 2017 |
Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Hep G2 Cells; Humans; Liver Neoplasms; Models, Molecular; Molecular Docking Simulation; Neoplasm Invasiveness; Nitric Oxide Synthase Type II; Oleanolic Acid; Protein Multimerization; Xenograft Model Antitumor Assays | 2019 |
Molecular evidence for better efficacy of hypocrellin A and oleanolic acid combination in suppression of HCC growth.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cell Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Oleanolic Acid; Perylene; Phenol; Quinones; Transcription Factors | 2019 |
Cotreatment with sorafenib and oleanolic acid induces reactive oxygen species-dependent and mitochondrial-mediated apoptotic cell death in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Drug Therapy, Combination; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Sorafenib; Tumor Cells, Cultured | 2019 |
Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown.
Topics: Carcinoma, Hepatocellular; Cell Survival; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Metabolomics; Molecular Docking Simulation; Molecular Targeted Therapy; Neuropilin-1; Oleanolic Acid; Saponins | 2019 |
Cytotoxicity of oleanolic and ursolic acid derivatives toward hepatocellular carcinoma and evaluation of NF-κB involvement.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Humans; Liver Neoplasms; Malus; NF-kappa B; Olea; Oleanolic Acid; Plant Extracts; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2019 |
Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B1; Cyclooxygenase 2; Cytochromes c; Extracellular Signal-Regulated MAP Kinases; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mitochondria; Neoplasm Transplantation; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2013 |
Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azo Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; G2 Phase Cell Cycle Checkpoints; Glutathione; Glutathione S-Transferase pi; Humans; Isoenzymes; Lethal Dose 50; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Neoplasm Transplantation; Nitric Oxide; Nitric Oxide Donors; Oleanolic Acid; Prodrugs; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Structure-Activity Relationship | 2013 |
Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Liver Neoplasms; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; RNA, Messenger; Saponins; Tumor Suppressor Protein p53; X-Rays | 2013 |
The activation of p38 and JNK by ROS, contribute to OLO-2-mediated intrinsic apoptosis in human hepatocellular carcinoma cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Enzyme Activators; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species | 2014 |
Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1α.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Radiation Tolerance; Saponins; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
A novel oleanolic acid-loaded PLGA-TPGS nanoparticle for liver cancer treatment.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Coumarins; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Hep G2 Cells; Humans; Lactic Acid; Liver Neoplasms; Nanoparticles; Oleanolic Acid; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Thiazoles; Vitamin E | 2015 |
Effects of SSd combined with radiation on inhibiting SMMC-7721 hepatoma cell growth.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; In Vitro Techniques; Liver Neoplasms; Microscopy, Electron, Transmission; Oleanolic Acid; Radiation-Sensitizing Agents; Saponins; Tetrazolium Salts; Thiazoles | 2014 |
MEF2 transcription factors promotes EMT and invasiveness of hepatocellular carcinoma through TGF-β1 autoregulation circuitry.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MEF2 Transcription Factors; Neoplasm Invasiveness; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2014 |
Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines.
Topics: Amino Acids; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Survival; Dose-Response Relationship, Drug; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; MCF-7 Cells; Oleanolic Acid; Periploca; Phytotherapy; Plant Bark; Plant Leaves; Plants, Medicinal | 2014 |
Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Protein Processing, Post-Translational; Saponins; STAT3 Transcription Factor | 2014 |
Smac mimetic and oleanolic acid synergize to induce cell death in human hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Biomimetics; Carcinoma, Hepatocellular; Caspase 3; Cell Survival; Chick Embryo; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Hep G2 Cells; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Mitochondrial Proteins; Oleanolic Acid; Oligopeptides; Reactive Oxygen Species; RNA Interference; Time Factors; Transfection; Tumor Burden | 2015 |
Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways.
Topics: Apoptosis; Autophagy; Cell Proliferation; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; MAP Kinase Signaling System; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species | 2016 |
CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells.
Topics: Animals; Annexin A5; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Basigin; Chitosan; Endocytosis; Flow Cytometry; Fluorescence; Hep G2 Cells; Humans; Imaging, Three-Dimensional; Intracellular Space; Liver Neoplasms; Mice, Nude; Microscopy, Confocal; Nanoparticles; Oleanolic Acid; Particle Size; Propidium; Saponins; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Subcellular Fractions | 2015 |
Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lethal Dose 50; Liver Neoplasms; MCF-7 Cells; Mice; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Saponins; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
[Oleanolic acid induces G₂/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; M Phase Cell Cycle Checkpoints; Oleanolic Acid | 2015 |
YAP and 14-3-3γ are involved in HS-OA-induced growth inhibition of hepatocellular carcinoma cells: A novel mechanism for hydrogen sulfide releasing oleanolic acid.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogen Sulfide; Liver Neoplasms; Oleanolic Acid; Phosphoproteins; Transcription Factors; YAP-Signaling Proteins | 2016 |
Effect of a controlled-release drug delivery system made of oleanolic acid formulated into multivesicular liposomes on hepatocellular carcinoma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Emulsions; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Male; Mice; Oleanolic Acid; Particle Size; Rats, Sprague-Dawley; Reproducibility of Results; Solubility; Static Electricity | 2016 |
Oleanolic acid-NO donor-platinum(II) trihybrid molecules: Targeting cytotoxicity on hepatoma cells with combined action mode and good safety.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; G2 Phase; Humans; Liver Neoplasms; Nitric Oxide Donors; Oleanolic Acid; Organoplatinum Compounds | 2016 |
Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Death; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Humans; Liver Neoplasms; Niacinamide; Oleanolic Acid; Oxidative Stress; Phenylurea Compounds; Proteolysis; Reactive Oxygen Species; Sorafenib | 2016 |
Oleanolic acid-loaded PLGA-TPGS nanoparticles combined with heparin sodium-loaded PLGA-TPGS nanoparticles for enhancing chemotherapy to liver cancer.
Topics: Animals; Antineoplastic Agents; Hep G2 Cells; Heparin; Humans; Lactic Acid; Liver Neoplasms; Mice; Nanoparticles; Oleanolic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Vitamin E | 2016 |
Activation of nuclear factor E2-related factor 2 in hereditary tyrosinemia type 1 and its role in survival and tumor development.
Topics: Animals; Cyclohexanones; DNA Damage; Dose-Response Relationship, Drug; Glutathione; Hepatitis; Hydrolases; Imidazoles; Inactivation, Metabolic; Liver; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Mice; Mice, Knockout; NF-E2-Related Factor 2; Nitrobenzoates; Oleanolic Acid; Oxidative Stress; Tyrosinemias | 2008 |
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Topics: Administration, Oral; Aflatoxin B1; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; DNA Adducts; Heme Oxygenase-1; Humans; Imidazoles; Leukemia; Liver Neoplasms; Macrophages; Male; Mice; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Phenanthrenes; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2008 |
Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Hepatocytes; Humans; Liver Neoplasms; Oleanolic Acid; Plant Extracts; Saponins; Soybean Proteins; Spectrometry, Mass, Electrospray Ionization; Tetrazolium Salts; Thiazoles | 2009 |
Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspases; Cell Adhesion; Cell Line, Tumor; Cell Survival; Coloring Agents; DNA Fragmentation; Humans; Intercellular Adhesion Molecule-1; Liver Neoplasms; Membrane Potentials; Mitochondrial Membranes; Neoplasm Metastasis; Oleanolic Acid; Sodium-Potassium-Exchanging ATPase; Tetrazolium Salts; Thiazoles; Triterpenes; Ursolic Acid; Vascular Endothelial Growth Factor A | 2010 |
HCV protease inhibitory, cytotoxic and apoptosis-inducing effects of oleanolic acid derivatives.
Topics: Antineoplastic Agents; Antiviral Agents; Apoptosis; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hep G2 Cells; Hepacivirus; Humans; Inhibitory Concentration 50; Liver Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Viral Nonstructural Proteins | 2009 |
Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Discovery; Female; Glycosylation; Humans; Liver Neoplasms; Male; Mice; Nitric Oxide; Oleanolic Acid; Solubility; Structure-Activity Relationship; Water; Xenograft Model Antitumor Assays | 2010 |
Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Division; Cell Line, Tumor; Down-Regulation; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Oleanolic Acid; Triterpenes; Ursolic Acid; X-Linked Inhibitor of Apoptosis Protein | 2010 |
Structure of the liver in mice with transplanted Lewis carcinoma during polychemotherapy and correction with betulonic acid and its derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Drug Therapy, Combination; Hepatocytes; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Oleanolic Acid; Propionates | 2010 |
Antiangiogenic potential of three triterpenic acids in human liver cancer cells.
Topics: Angiogenesis Inhibitors; Cell Line, Tumor; Fibroblast Growth Factor 2; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-8; Liver Neoplasms; Oleanolic Acid; Triterpenes; Ursolic Acid | 2011 |
The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.
Topics: Animals; Cell Death; Female; Imidazoles; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Oleanolic Acid; Triterpenes | 2011 |
Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Line, Tumor; Flavones; Hepatocytes; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Oleanolic Acid; Signal Transduction; Trans-Activators; Transcriptional Activation; Transfection; Triterpenes; Ursolic Acid; Viral Regulatory and Accessory Proteins | 2011 |
Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling.
Topics: Adenocarcinoma; Animals; Animals, Genetically Modified; Apoptosis; Blotting, Western; Cell Proliferation; Disease Progression; Female; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Oleanolic Acid; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2011 |
A new triterpene saponin from Androsace integra.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Structure; Oleanolic Acid; Phytotherapy; Plant Extracts; Primulaceae; Saponins; Triterpenes | 2011 |
Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI₄-2, a new nitric oxide-releasing derivative of oleanolic acid.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cattle; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Nanostructures; Nitric Oxide; Oleanolic Acid; Protein Structure, Tertiary; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Temperature | 2011 |
Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Ardisia; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; cdc42 GTP-Binding Protein; Cell Movement; Cell Proliferation; Cell Survival; Collagenases; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Oleanolic Acid; Phytotherapy; Protein Serine-Threonine Kinases; rac1 GTP-Binding Protein; Saponins | 2012 |
[Effect of Saikosaponins-d on reversing malignant phenotype of HepG2 cells in vitro].
Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Oleanolic Acid; RNA, Messenger; Saponins | 2011 |
Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Female; Glycosylation; Humans; Liver Neoplasms; Male; Mice; Molecular Structure; Oleanolic Acid; Xenograft Model Antitumor Assays | 2012 |
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2013 |
NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway.
Topics: 4-Aminobenzoic Acid; Animals; Antineoplastic Agents; Apoptosis; Azo Compounds; Carcinoma, Hepatocellular; Cell Proliferation; Hep G2 Cells; Humans; Liver Neoplasms; Male; MAP Kinase Signaling System; Mice; Mitochondria; Nitric Oxide; Oleanolic Acid; Reactive Oxygen Species; Saponins; Xenograft Model Antitumor Assays | 2012 |
(24S)-ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Drug Screening Assays, Antitumor; Ergosterol; Hedyotis; Humans; Inhibitory Concentration 50; Liver Neoplasms; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Plants, Medicinal | 2013 |
Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Matrix Metalloproteinases; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Syndecan-2; Tissue Inhibitor of Metalloproteinase-2 | 2012 |
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Oleanolic Acid; Proteins; Receptors, Tumor Necrosis Factor; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Carrier Proteins; Caspases; Cell Division; Cell Line, Tumor; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Mitochondria; Mitogen-Activated Protein Kinases; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2004 |
Cytokine-mediated induction of metallothionein in Hepa-1c1c7 cells by oleanolic acid.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Interleukin-6; Liver Neoplasms; Macrophages; Metallothionein; Mice; Oleanolic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
[Molecular mechanisms of the protection of SNMC in HepG2 cell apoptosis].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cysteine; Drug Combinations; Glycine; Glycyrrhiza; Humans; Liver Neoplasms; Oleanolic Acid | 2005 |
Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma.
Topics: Animals; Liver; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Oleanolic Acid | 2005 |
Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Division; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Mass Spectrometry; Oleanolic Acid; Plant Extracts; Saponins | 2008 |
Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells.
Topics: alpha-Fetoproteins; Antineoplastic Agents; Astringents; Carcinoma, Hepatocellular; Cell Cycle; Cell Death; Cell Division; DNA, Neoplasm; Drugs, Chinese Herbal; Flavanones; Flavonoids; Ginsenosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Liver Neoplasms; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Tumor Cells, Cultured | 1993 |
Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; DNA, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Liver Neoplasms; Mitochondrial Swelling; Necrosis; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1995 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Female; Hyperplasia; Liver Neoplasms; Mice; Mice, Inbred ICR; Oleanolic Acid; Papilloma; Phenobarbital; Plants, Medicinal; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1997 |
Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Oleanolic Acid; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |