oleanolic acid has been researched along with Breast Cancer in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (15.38) | 29.6817 |
| 2010's | 39 (60.00) | 24.3611 |
| 2020's | 16 (24.62) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, MM; El Diwani, HI; Galal, SA; Kerwin, SM; Li, J; Omar, MA; Ramadan, RA; Shaker, YM; Tokuda, H | 1 |
| Jeengar, MK; Mallavadhani, UV; Naidu, VG; Vanga, NR | 1 |
| Arya, GC; Jaitak, V; Kaur, K | 1 |
| Guo, Y; He, K; Liang, Z; Meng, X; Pan, R; Su, J; Wei, G; Zhang, Z | 1 |
| Bednarczyk-Cwynar, B; Kaczmarek, M; Kujawski, J; Lewicka, I; Lisiak, NM; Rubis, B; Zaprutko, L | 1 |
| Chan, CB; Chen, C; Chen, W; Cheng, M; Jiao, B; Nie, J; Wang, H; Xu, H; Yang, Q; Zhu, H; Zou, L | 1 |
| He, Y; Hong, L; Jiang, Z; Pan, Z; Zhang, J; Zhao, Y; Zhou, Y | 1 |
| Bednarczyk-Cwynar, B; Dzikowska, P; Kaczmarek, M; Lisiak, N; Rubis, B; Wisniewska, U; Zaprutko, L | 1 |
| Greige-Gerges, H; Hamade, A; Kayouka, M; Landy, D; Najjar, F; Saliba, E | 1 |
| Bao, Y; Chen, AT; Chen, J; Chen, Z; Deng, G; Ma, J; Xu, W; Yao, G; Yu, ZQ; Zhang, S; Zhou, J | 1 |
| Chen, J; Fu, R; Li, B; Li, Y; Li, Z; Ming, Y; Xing, H; Zhang, L | 1 |
| Cheng, J; Han, Y; Qiao, W; Wang, J; Yang, X; Zhao, H | 1 |
| Qiao, W; Wang, J; Yang, X; Zhao, H | 1 |
| Feng, B; Li, J; Tian, T; Yu, J; Zhang, X; Zhang, Y; Zhao, C; Zhao, L | 1 |
| Banala, VT; Gautam, S; Marwaha, D; Mishra, PR; Rai, N; Shukla, P; Shukla, RP; Singh, N; Tiwari, P; Urandur, S | 1 |
| An, LK; Kang, S; Li, D; Liu, K; Yu, Q; Zeng, H; Zhang, Y | 1 |
| Ahmed, R; Daniyal, M; Jiang, S; Li, B; Liu, B; Liu, Y; Long, Y; Wang, W; Wang, Z; Xie, Q | 1 |
| Ediriweera, MK; Muthoni, DK; Piyathilaka, PC; Rajagopalan, U; Samarakoon, SR; Tennekoon, KH | 1 |
| Bednarczyk-Cwynar, B; Lisiak, N; Pakuła, M; Paszel-Jaworska, A; Rubiś, B; Rybczyńska, M; Totoń, E; Zaprutko, L | 1 |
| Gai, X; Guan, X; Li, C; Wang, M; Wang, P; Xue, H | 1 |
| Chen, W; Cheng, L; Ding, Q; Shi, L; Xia, TS; Xu, L; Zhu, Y | 1 |
| Dong, L; Li, H; Liu, C; Sun, Z; Wang, L; Wang, Q; Wang, X; Zhang, J | 1 |
| Ding, L; Gao, FF; Gao, Y; He, X; He, YQ; Jiang, NH; Li, K; Ma, Q; Pan, WT; Song, WJ; Wei, L; Xu, XL; Zhang, JW | 1 |
| Huwiler, A; Rabi, T; Zangemeister-Wittke, U | 1 |
| Bhatia, D; Bishayee, A; Mandal, A | 1 |
| Bednarczyk-Cwynar, B; Kaczmarek, M; Lisiak, N; Paszel-Jaworska, A; Rybczyńska, M; Zaprutko, L | 1 |
| Cheng, L; Ding, Q; Liang, XQ; Shi, L; Wang, Y; Wang, YF; Xia, TS; Xue, JQ; Zhou, W | 1 |
| Lin, X; Liu, G; Liu, J; Liu, M; Ma, L; Wu, N; Zhang, Y | 1 |
| Choi, HS; Kang, KW; Lim, SI; Oh, WK; Sharma, G; Uddin, MN; Yang, JL | 1 |
| Cheng, L; Ding, Q; Liang, XQ; Shi, L; Wang, M; Wang, Y; Wang, YF; Xia, TS; Xue, JQ; Zhou, W | 1 |
| Akl, MR; Ebrahim, HY; El Sayed, KA; Elsayed, HE; Haggag, EG; Kamal, AM; Sallam, AA | 1 |
| Akl, MR; Ebrahim, HY; El Sayed, KA; Elsayed, HE; Haggag, EG; Kamal, AM | 1 |
| Lin, X; Liu, G; Liu, J; Ma, L; Wang, B; Wu, N; Zhao, Y; Zheng, L | 1 |
| Ahmed, A; Ahmed, VU; Ali, FI; Aslam, A; Hashmi, IA; Manzoor, S; Mustufa, MA; Naqvi, Nu; Ozen, C; Ozturk, M | 1 |
| Gaforio, JJ; López-Biedma, A; Sánchez-Quesada, C | 2 |
| Cardentey, A; Delgado, O; El-Ashmawy, M; Shay, JW; Wright, WE | 1 |
| Efferth, T; Kadioglu, O | 1 |
| Cho, H; Choi, KS; Jeong, SA; Kim, IY; Lee, AR; Lee, JS; Yoon, MJ | 1 |
| Chu, P; Gao, L; Han, G; Li, X; Lin, Y; Liu, S; Peng, J; Sun, B; Sun, Z; Tang, Z; Wang, S; Wang, Y; Wu, J; Xu, Z | 1 |
| Kim, B; Kim, JH; Park, B | 1 |
| Lei, B; Li, YW; Liang, XS; Pang, D; Xu, SP; Zhang, GQ; Zhang, JF | 1 |
| Chu, P; Guo, C; Han, G; Hang, H; Li, X; Lin, Y; Liu, S; Peng, J; Sun, B; Sun, Z; Tang, Z; Wang, S; Wu, J; Yang, C; Yang, N; Zhao, L | 1 |
| Ball, MS; Kim, H; Liby, KT; Pioli, PA; Shipman, EP | 1 |
| Amara, S; Tiriveedhi, V; Zheng, M | 1 |
| Kim, B; Kim, YC; Park, B | 1 |
| Cho, YY; Park, B; Park, JH; Yoon, SW | 1 |
| De Mieri, M; Hamburger, M; Mofidi Tabatabaei, S; Moridi Farimani, M; Nejad-Ebrahimi, S; Neuburger, M; Salehi, P | 1 |
| Chung, WY; Hwang, YS; Park, HJ; Park, KK; Park, SK; Seo, JY | 1 |
| Chu, R; Climent, J; Cohen, I; Fong, S; Griffin, C; Leitman, D; Shoemaker, M; Shtivelman, E; Staub, RE; Zhao, X | 1 |
| Ahmed, S; Bishayee, A; Brankov, N; Perloff, M | 1 |
| Deng, CX; Kim, EH; Liby, KT; Sporn, MB | 1 |
| Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Gelsomino, L; Giordano, C; Gu, G; Menichini, F; Statti, G | 1 |
| Cha, EY; Chang, ES; Kim, JR; Lee, JS; Lee, MS; Thuong, PT; Youn, SH | 1 |
| Bid, HK; Chakravarti, B; Konwar, R; Maurya, R; Rajendran, SM; Siddiqui, JA; Yadav, PP | 1 |
| He, X; Hu, H; Wang, Y; Zhang, Z | 1 |
| Badger, TM; Berhow, MA; Rowlands, JC | 1 |
| Chang, NW; Chen, JC; Chen, KC; Chung, JG | 1 |
| Andreeff, M; Gold, D; Konopleva, M; Lapillonne, H; Madden, T; McQueen, T; Sutherland, RL; Tsao, T | 1 |
| Anderson, AC; Couch, RD; Gribble, GW; Han, J; Honda, T; Honda, Y; Janosik, T; Liby, KT; Sporn, MB; Williams, CR | 1 |
| Chang, WW; Hsu, CC; Lin, TW; Lo, WH; Tsai, YC; Wang, PH; Wu, CY | 1 |
| Croxton, R; Cryns, VL; Hyer, ML; Krajewska, M; Krajewski, S; Kress, CL; Lu, M; Reed, JC; Sporn, MB; Suh, N; Zapata, JM | 1 |
| Abdelrahim, M; Andreeff, M; Hung, MC; Johansen, M; Konopleva, M; Madden, T; McQueen, T; Munsell, MF; Safe, SH; Shi, YX; Tsao, T; Yu, D; Zhang, W | 1 |
| Banerjee, S; Rabi, T | 1 |
| Ahmad, R; Kufe, D; Meyer, C; Raina, D | 1 |
2 review(s) available for oleanolic acid and Breast Cancer
| Article | Year |
|---|---|
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Isoxazoles | 2021 |
Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Chemoprevention; Glycosides; Humans; Mice; Oleanolic Acid; Triterpenes; Ursolic Acid | 2011 |
63 other study(ies) available for oleanolic acid and Breast Cancer
| Article | Year |
|---|---|
Synthesis and docking studies of novel antitumor benzimidazoles.
Topics: Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Herpesvirus 4, Human; Humans; Lung Neoplasms; MCF-7 Cells; Models, Molecular; Pyrroles; Structure-Activity Relationship; Tetracyclines; Virus Activation | 2012 |
Synthesis of novel ring-A fused hybrids of oleanolic acid with capabilities to arrest cell cycle and induce apoptosis in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oleanolic Acid | 2014 |
Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Oleanolic Acid; RNA-Seq; Transcriptome | 2021 |
Oleanolic Acid's Semisynthetic Derivatives HIMOXOL and Br-HIMOLID Show Proautophagic Potential and Inhibit Migration of HER2-Positive Breast Cancer Cells In Vitro.
Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Female; Humans; In Vitro Techniques; Oleanolic Acid; Receptor, ErbB-2; Tumor Cells, Cultured | 2021 |
Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk.
Topics: Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Neoplastic Stem Cells; Oleanolic Acid; rab GTP-Binding Proteins; Tumor Microenvironment | 2022 |
Epifriedelinol Ameliorates DMBA-Induced Breast Cancer in Albino Rats by Regulating the PI3K/AKT Pathway.
Topics: Animals; Apoptosis; Breast Neoplasms; Female; Oleanolic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger | 2022 |
Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Humans; Oleanolic Acid; Receptors, Estrogen | 2023 |
P-glycoprotein modulates oleanolic acid effects in hepatocytes cancer cells and zebrafish embryos.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Embryo, Nonmammalian; Female; Hep G2 Cells; Hepatocytes; Humans; Liver Neoplasms; Oleanolic Acid; Verapamil; Zebrafish | 2020 |
Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Humans; Mice; Mice, Nude; Nanoparticles; Oleanolic Acid; Paclitaxel | 2020 |
Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lysosomes; Microtubule-Associated Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Saponins | 2020 |
Nanomedicine-Cum-Carrier by Co-Assembly of Natural Small Products for Synergistic Enhanced Antitumor with Tissues Protective Actions.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Products; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Glycyrrhetinic Acid; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; Molecular Conformation; Nanomedicine; Nanoparticles; Oleanolic Acid; Paclitaxel; Particle Size; Stereoisomerism; Surface Properties | 2020 |
Paclitaxel and betulonic acid synergistically enhance antitumor efficacy by forming co-assembled nanoparticles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nanoparticles; Oleanolic Acid; Paclitaxel; Treatment Outcome; Xenograft Model Antitumor Assays | 2020 |
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Cell Proliferation; Cytochromes c; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Triterpenes; Ursolic Acid | 2020 |
Development of putrescine anchored nano-crystalsomes bearing doxorubicin and oleanolic acid: deciphering their role in inhibiting metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Humans; Mice; Mice, Inbred BALB C; Oleanolic Acid; Putrescine; Vascular Endothelial Growth Factor A | 2021 |
Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Selective Vascular Endothelial Growth Factor Promoter i-Motif Ligands.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Female; Humans; Nucleic Acid Conformation; Nucleotide Motifs; Oleanolic Acid; Promoter Regions, Genetic; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2021 |
Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Esters; Female; Humans; Nanoparticles; Oleanolic Acid; Photochemotherapy; Photosensitizing Agents; Porphyrins; Saponins | 2021 |
Identification of 3-
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Growth Inhibitors; Humans; Neoplastic Stem Cells; Oleanolic Acid; Saponins; Triterpenes | 2022 |
Semisynthetic oleanane triterpenoids inhibit migration and invasion of human breast cancer cells through downregulated expression of the ITGB1/PTK2/PXN pathway.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Focal Adhesion Kinase 1; Humans; Integrin beta1; Neoplasm Invasiveness; Oleanolic Acid; Paxillin; Signal Transduction | 2017 |
Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Oleanolic Acid; Rhodamine 123; Saponins; Time Factors | 2017 |
D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Saponins; Treatment Outcome | 2018 |
Esculentoside A suppresses breast cancer stem cell growth through stemness attenuation and apoptosis induction by blocking IL-6/STAT3 signaling pathway.
Topics: Aldehyde Dehydrogenase; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Interleukin-6; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Neoplastic Stem Cells; Oleanolic Acid; Saponins; Signal Transduction; STAT3 Transcription Factor | 2018 |
Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Topics: Adolescent; Adult; Animals; Breast Neoplasms; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Microfilament Proteins; Middle Aged; Oleanolic Acid; Phosphoproteins; Saponins; STAT3 Transcription Factor; Young Adult | 2019 |
AMR-Me inhibits PI3K/Akt signaling in hormone-dependent MCF-7 breast cancer cells and inactivates NF-κB in hormone-independent MDA-MB-231 cells.
Topics: Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mitochondria; Morpholines; NF-kappa B; Nuclear Proteins; Oleanolic Acid; Oncogene Proteins v-mos; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-rel; Transcription Factor RelA; Transcription Factor RelB | 2014 |
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Chemoprevention; Cyclooxygenase 2; Down-Regulation; Female; HSP90 Heat-Shock Proteins; I-kappa B Proteins; Inflammation; Mammary Neoplasms, Experimental; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Rats; Rats, Sprague-Dawley | 2014 |
Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1; Breast Neoplasms; Caspase 3; Caspase 8; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Female; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Oleanolic Acid; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Up-Regulation | 2014 |
The apoptotic effect of D Rhamnose β-hederin, a novel oleanane-type triterpenoid saponin on breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Breast Neoplasms; Caspase 3; Caspase 9; Chromones; Cytochromes c; Drug Screening Assays, Antitumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Female; Humans; MAP Kinase Signaling System; MCF-7 Cells; Membrane Potential, Mitochondrial; Morpholines; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Saponins | 2014 |
Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms.
Topics: Antineoplastic Agents; Breast Neoplasms; Carrier Proteins; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Male; MCF-7 Cells; Membrane Proteins; Mitochondria; Oleanolic Acid; Oxidative Phosphorylation; Prostatic Neoplasms; Protein Isoforms; Proto-Oncogene Proteins c-myc; Pyruvate Kinase; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica.
Topics: Breast Neoplasms; Camellia; Cell Line, Tumor; Cell Survival; Female; Humans; Molecular Structure; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Triterpenes | 2014 |
The anticancer effect and mechanism of α-hederin on breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Clematis; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Oleanolic Acid; Phytotherapy; Plant Extracts; Saponins | 2014 |
Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.
Topics: Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Discovery; Female; Humans; Models, Molecular; Neoplasm Invasiveness; Neoplasm Proteins; Oleanolic Acid; Paxillin; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; Signal Transduction; Terminalia | 2015 |
3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; ErbB Receptors; Estrogen Receptor alpha; Female; Humans; Oleanolic Acid; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Sulfonamides | 2014 |
Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy.
Topics: Animals; Autophagy; Breast; Breast Neoplasms; Cell Line, Transformed; Cell Proliferation; Female; Genes, ras; Humans; Mice; Neoplasm Invasiveness; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines.
Topics: Amino Acids; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Survival; Dose-Response Relationship, Drug; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; MCF-7 Cells; Oleanolic Acid; Periploca; Phytotherapy; Plant Bark; Plant Leaves; Plants, Medicinal | 2014 |
The differential localization of a methyl group confers a different anti-breast cancer activity to two triterpenes present in olives.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Female; Fruit; Humans; Methylation; Molecular Structure; Neoplasm Invasiveness; Olea; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Stereoisomerism; Triterpenes | 2015 |
CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.
Topics: Animals; Antioxidants; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; DNA Damage; Epithelial Cells; Female; Humans; Lung; Lung Neoplasms; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Radiation-Protective Agents; Signal Transduction | 2014 |
Pharmacogenomic Characterization of Cytotoxic Compounds from Salvia officinalis in Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Breast Neoplasms; Drug Resistance, Neoplasm; Genes, erbB-1; Humans; Leupeptins; Molecular Structure; NF-kappa B; Oleanolic Acid; Pharmacogenetics; Plants, Medicinal; Salvia officinalis; Signal Transduction; Triterpenes; Ursolic Acid | 2015 |
Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Calcium; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Cell Survival; Cytosol; Down-Regulation; Endoplasmic Reticulum; Female; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Electron, Transmission; Mitochondria; Oleanolic Acid; Reactive Oxygen Species; Superoxides | 2015 |
Oleanolic Acid, a Compound Present in Grapes and Olives, Protects against Genotoxicity in Human Mammary Epithelial Cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Proliferation; DNA Damage; Epithelial Cells; Female; Humans; Mammary Glands, Human; Olea; Oleanolic Acid; Vitis | 2015 |
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Female; G1 Phase; Humans; MCF-7 Cells; Oleanolic Acid; Reactive Oxygen Species; Resting Phase, Cell Cycle; Signal Transduction | 2015 |
Pomolic Acid Inhibits Invasion of Breast Cancer Cells Through the Suppression of CXC Chemokine Receptor Type 4 Expression.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Receptors, CXCR4 | 2016 |
Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic; Oleanolic Acid; Prognosis; Pyrrolidines; RNA, Long Noncoding | 2016 |
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Topics: Apoptosis; Autophagy; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; MCF-7 Cells; Molecular Conformation; Morpholines; Oleanolic Acid; Structure-Activity Relationship | 2016 |
CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cytokines; Female; Gene Expression Regulation, Neoplastic; Humans; Macrophage Activation; Macrophages; Mice; Oleanolic Acid; RNA, Messenger; T-Lymphocytes | 2016 |
Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex IV; Female; Flow Cytometry; Glycolysis; Humans; Lactic Acid; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Sodium Chloride | 2016 |
Pomolic acid inhibits metastasis of HER2 overexpressing breast cancer cells through inactivation of the ERK pathway.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Receptor, ErbB-2; Receptors, CXCR4 | 2016 |
Suppression of MMP-9 and FAK expression by pomolic acid via blocking of NF-κB/ERK/mTOR signaling pathways in growth factor-stimulated human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation | 2016 |
A nor-diterpene from Salvia sahendica leaves.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Diterpenes; Female; Flavones; Hexanes; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Leaves; Salvia; Sitosterols; Staphylococcus aureus | 2017 |
Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
Topics: Acetophenones; Animals; Antineoplastic Agents, Phytogenic; Benzopyrans; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasm Transplantation; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C-delta; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transplantation, Heterologous | 2009 |
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cholesterol; Cytochromes c; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fluorescent Antibody Technique; Gleditsia; Humans; Mechanistic Target of Rapamycin Complex 1; Membrane Microdomains; Membrane Potential, Mitochondrial; Multiprotein Complexes; Oleanolic Acid; Plant Extracts; Proteins; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured | 2010 |
CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; DNA Damage; Enzyme Inhibitors; Fibroblasts; Genes, BRCA1; Humans; Imidazoles; Mice; Mutation; Oleanolic Acid; Reactive Oxygen Species | 2011 |
Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; Oldenlandia; Oleanolic Acid; Plant Extracts; Promoter Regions, Genetic; Tamoxifen; Transcriptional Activation; Triterpenes; Tumor Suppressor Protein p53; Up-Regulation; Ursolic Acid | 2012 |
Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Fatty Acid Synthases; Fatty Acids; Female; G1 Phase; Gene Expression; Genes, p53; Humans; Oleanolic Acid; Phytotherapy; Plant Extracts; Poly(ADP-ribose) Polymerases; Protein Biosynthesis; Ribonucleotides; RNA, Messenger | 2012 |
In vitro anti-breast cancer activity of ethanolic extract of Wrightia tomentosa: role of pro-apoptotic effects of oleanolic acid and urosolic acid.
Topics: Antineoplastic Agents; Apocynaceae; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Ethanol; HEK293 Cells; Humans; L-Lactate Dehydrogenase; Oleanolic Acid; Plant Extracts; Plant Leaves; Solvents; Triterpenes; Ursolic Acid | 2012 |
In vitro and in vivo antimammary tumor activities and mechanisms of the apple total triterpenoids.
Topics: Animals; Apoptosis; Breast Neoplasms; Caco-2 Cells; Cell Cycle; Cell Proliferation; Female; Fruit; Hep G2 Cells; Humans; Malus; Mammary Neoplasms, Animal; MCF-7 Cells; NF-kappa B; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Triterpenes; Ursolic Acid | 2012 |
Estrogenic and antiproliferative properties of soy sapogenols in human breast cancer cells in vitro.
Topics: Blotting, Northern; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Non-Steroidal; Female; Fulvestrant; Gene Expression; Glycine max; Humans; Isoflavones; Oleanolic Acid; Phytoestrogens; Plant Extracts; Plant Preparations; Receptors, Estrogen; RNA, Messenger; Saponins; Tumor Cells, Cultured | 2002 |
Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Genistein; Humans; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Saponins; Time Factors; Tumor Cells, Cultured | 2003 |
Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Immunocompromised Host; Mice; Mice, Nude; Oleanolic Acid; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2003 |
Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.
Topics: Biochemistry; Biotin; Breast Neoplasms; Cell Division; Chromatography, Affinity; Drug Design; Drug Evaluation, Preclinical; Female; Humans; Oleanolic Acid; Proteins; Streptavidin; Structure-Activity Relationship; Tumor Cells, Cultured | 2004 |
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.
Topics: beta-Galactoside alpha-2,3-Sialyltransferase; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Matrix; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Oleanolic Acid; Saponins; Sialic Acids; Sialyltransferases | 2005 |
Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caspase 8; Caspases; Down-Regulation; Drug Synergism; Female; Humans; Imidazoles; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation; Xenograft Model Antitumor Assays | 2005 |
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.
Topics: Animals; Breast Neoplasms; Caveolin 1; Cell Proliferation; Cyclin D1; Female; Humans; Mice; Mice, Mutant Strains; Oleanolic Acid; Phosphorylation; PPAR gamma; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; RNA, Messenger; Transcriptional Activation; Xenograft Model Antitumor Assays | 2006 |
Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate induces apoptosis through JNK and p38 MAPK pathways in human breast adenocarcinoma MCF-7 cells.
Topics: Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2008 |
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.
Topics: Biotin; Breast Neoplasms; Cell Line, Tumor; Dimerization; Female; Genes, Reporter; HeLa Cells; Humans; Interleukin-6; Janus Kinase 1; Oleanolic Acid; Protein Binding; STAT3 Transcription Factor | 2008 |