oleanolic acid has been researched along with Alloxan Diabetes in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.27) | 18.2507 |
| 2000's | 10 (18.18) | 29.6817 |
| 2010's | 34 (61.82) | 24.3611 |
| 2020's | 7 (12.73) | 2.80 |
| Authors | Studies |
|---|---|
| Bu, Y; Chen, H; Chen, Q; Cheng, H; Feng, G; Kong, G; Lu, Z; Meng, M; Shi, T; Tian, Y; Yao, X | 1 |
| Camici, G; Estrada-Soto, S; López-Martínez, S; López-Vallejo, F; Medina-Franco, JL; Navarrete-Vázquez, G; Ortiz-Andrade, R; Paoli, P; Ramírez-Espinosa, JJ; Rios, MY | 1 |
| Xu, J; Xu, W; Zhang, H; Zhang, Q | 1 |
| Choi, JH; Choi, S; Choi, YJ; Chung, HY; Hyun, MK; Kim, DH; Lee, JY; Noh, SG; Park, CH; Park, D | 1 |
| Cao, H; Fang, WS; Gao, X; Huan, Y; Niu, S; Shen, Z; Wang, S; Wang, X; Yang, M; Zhou, X | 1 |
| Chen, X; Hu, Z; Kang, L; Liu, B; Liu, Y; Niu, K; Xing, H | 1 |
| Ban, Y; Chu, Y; Guo, Z; Li, G; Pan, F; Qian, J; Tang, L; Wei, X; Yang, Y; Zhan, C; Zhang, J | 1 |
| Akahane, T; Fujinaga, Y; Kaji, K; Kawaratani, H; Kaya, D; Kitagawa, K; Moriya, K; Namisaki, T; Ozutsumi, T; Takaya, H; Tsuji, Y; Yamashita, S; Yoshiji, H | 1 |
| Baloyi, CM; Khathi, A; Ngubane, PS; Sibiya, NH | 1 |
| Arruri, VK; Gundu, C; Kalvala, AK; Kumar, A; Kumar, R; Sherkhane, B | 1 |
| Bolat, I; Dokumacioglu, E; Hayirli, A; Iskender, H; Mohtare, B; Terim Kapakin, KA; Yenice, G | 1 |
| Chen, FF; Deng, SL; Tang, L; Wang, JT; Wang, K; Wang, YX; Wu, HS; Xing, SF; Zhang, JQ; Zhang, LX | 1 |
| Chen, K; Kang, X; Liu, JB; Sheng, J; Xie, QY; Yang, Z; Zheng, W | 1 |
| Bhattacharjee, N; Dewanjee, S; Dua, TK; Kalita, J; Khanra, R; Manna, P; Nandy, A; Saha, A | 1 |
| Khathi, A; Luvuno, M; Mbongwa, HP | 1 |
| An, Q; Cui, W; Ding, Y; Hu, Q; Wang, B; Wu, F | 1 |
| Alrashdi, SF; de Haan, JB; Deliyanti, D; Meyer, C; Tan, SM; Ward, KW; Wilkinson-Berka, JL | 1 |
| Gamede, M; Khathi, A; Mabuza, L; Ngubane, P | 1 |
| Binnie, M; Estrada-Soto, S; García-Jiménez, S; Ibarra-Barajas, M; López-Vallejo, F; Medina-Franco, JL; Ortiz-Andrade, R; Ramírez-Espinosa, JJ; Rios, MY; Webster, SP | 1 |
| Bumeister, R; Chin, M; Chuang, JC; Lee, CY; Meyer, C; Sonis, ST; Ward, KW; Wigley, WC | 1 |
| Hai, C; Li, W; Liao, N; Liu, R; Qin, X; Wang, X; Wang, Z; Zhang, W; Zhang, X | 1 |
| Angaswamy, N; Banan, B; Benshoff, N; Chapman, W; Mohanakumar, T; Tiriveedhi, V | 1 |
| Arunkumar, R; Nair, SA; Radhika, J; Sabulal, B; Subramoniam, A | 1 |
| Cooper, ME; de Haan, JB; Karagiannis, TC; Meyer, C; Sharma, A; Stefanovic, N; Tan, SM; Ward, KW; Yuen, DY | 1 |
| Bhalla, V; Hall, ET | 1 |
| Furusawa, Y; Higashi, C; Uruno, A; Yagishita, Y; Yamamoto, M | 1 |
| Masola, B; Mukaratirwa, S; Mukundwa, A | 1 |
| Cui, J; Duan, J; Guan, Y; Guo, C; Wang, Y; Wei, G; Wen, A; Weng, Y; Wu, X; Xi, M; Yan, J; Yin, Y; Zhu, Y | 1 |
| Cui, J; Jia, N; Li, Y; Wen, A; Wu, Y; Xi, M; Zhang, T | 1 |
| Cao, SS; Cui, J; Duan, JL; Jia, N; Li, RL; Li, YW; Wang, C; Wang, L; Wen, AD; Weng, Y; Wu, Y; Xi, MM; Zhao, C | 1 |
| Abdelkader, D; Chen, Y; Hassan, W; Liu, J; Sun, H; Wang, X | 1 |
| Langa, SO; Masola, B; Mukaratirwa, S; Mukundwa, A | 1 |
| Camici, G; Cerón-Romero, L; Estrada-Soto, S; Flores-Morales, V; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Paoli, P; Ramírez-Espinosa, JJ; Rios, MY | 1 |
| Gutiérrez, RMP | 1 |
| Agarwal, SC; Chaturvedi, JP; Joshi, MD; Khaliq, T; Maurya, R; Mishra, P; Narender, T; Singh, AB; Srivastava, AK | 1 |
| Fan, Y; Gao, D; Han, Z; Li, J; Li, Q; Li, Y; Liu, Z; Zhao, H | 1 |
| Cai, L; Xi, S; Zhang, W; Zhang, X; Zhao, C; Zhou, G | 1 |
| Maurya, R; Singh, AB; Srivastava, AK; Yadav, DK | 1 |
| Mapanga, RF; Musabayane, CT; Shode, FO; Tufts, MA | 1 |
| Benshoff, N; Chapman, W; Liu, W; Mohanakumar, T; Nataraju, A; Ramachandran, S; Saini, D | 1 |
| Mapanga, RF; Musabayane, CT; Tufts, MA | 1 |
| Andreeff, M; Chan, L; Konopleva, M; Reddy, VT; Saha, PK | 1 |
| Cao, PP; Hai, CX; Hu, JX; Li, YL; Liang, X; Liao, N; Liu, JZ; Peng, J; Wang, X; Wu, H | 1 |
| Masola, B; Musabayane, CT; Ngubane, PS | 1 |
| Madlala, HP; Masola, B; Musabayane, CT; Singh, M | 1 |
| Arruda, BR; Brito, GA; Chaves, MH; da Silva, AA; de Melo, TS; Frota, JT; Rao, VS; Santos, FA | 1 |
| Khathi, A; Masola, B; Musabayane, CT | 1 |
| Choi, J; Jung, HJ; Lee, KT; Lee, MS; Park, HJ; Park, KY; Shin, MH | 1 |
| Delgado, G; Narváez-Mastache, JM; Soto, C | 1 |
| Fan, Y; Gao, D; Han, Z; Li, J; Li, K; Li, Q; Li, Y; Liu, Z | 1 |
| Matsuda, H; Matsumura, N; Murakami, T; Shimada, H; Yamahara, J; Yoshikawa, M | 1 |
| Bae, EA; Choi, JW; Kim, DH; Park, HJ; Yu, KW | 1 |
| Li, Y; Matsuda, H; Yamahara, J; Yoshikawa, M | 1 |
| Choi, JW; Kim, DH; Kwon, SH; Lee, KT; Park, HJ; Sohn, IC | 1 |
| Gu, JQ; Lin, HW; Wang, ZZ; Xiao, K; Yi, YH | 1 |
55 other study(ies) available for oleanolic acid and Alloxan Diabetes
| Article | Year |
|---|---|
A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Forsythia; Humans; Hypoglycemic Agents; Mice; Obesity; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 11 | 2011 |
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Male; Models, Molecular; Molecular Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Triterpenes | 2011 |
β-Amyrin ameliorates diabetic nephropathy in mice and regulates the miR-181b-5p/HMGB2 axis in high glucose-stimulated HK-2 cells.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; HMGB2 Protein; In Situ Hybridization, Fluorescence; Mice; MicroRNAs; Oleanolic Acid | 2022 |
Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Experimental; Eriobotrya; Hyperglycemia; Inflammation; Mice; Oleanolic Acid; Plant Extracts; Ursolic Acid | 2022 |
Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo.
Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Esters; Gluconeogenesis; Hyperglycemia; Hypoglycemic Agents; Liver; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Cytoplasmic and Nuclear | 2022 |
Renoprotective effects of oleanolic acid and its possible mechanisms in rats with diabetic kidney disease.
Topics: AMP-Activated Protein Kinases; Animals; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Inflammation; Kidney; Lipids; Male; NF-kappa B; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4; Transforming Growth Factor beta1 | 2022 |
Lipid-Based Nanocarriers Enabled Oral Delivery of Oleanolic Acid Derivative DKS26 for Diabetes Management.
Topics: Administration, Oral; Animals; Biological Availability; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Lipids; Mice; Nanoparticles; Oleanolic Acid | 2023 |
TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats.
Topics: Administration, Oral; Animals; Cell Line; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Disease Models, Animal; Drug Synergism; Dysbiosis; Feces; Humans; Lipid Peroxidation; Liver Cirrhosis; Male; Oleanolic Acid; Pyrimidines; Rats; Receptors, G-Protein-Coupled | 2019 |
The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocyte Count; Erythrocyte Indices; Erythropoietin; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Metformin; Oleanolic Acid; Oxidative Stress; Rats | 2019 |
Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperglycemia; Hypoglycemic Agents; Kelch-Like ECH-Associated Protein 1; Male; Mitochondria; Oleanolic Acid; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Effects of oleanolic acid on inflammation and metabolism in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Inflammation; Oleanolic Acid; Oxidative Stress; Rats; Streptozocin | 2022 |
Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Enteroendocrine Cells; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Lipid Metabolism; Liver; Male; Mice; Obesity; Oleanolic Acid; Pancreas; Protective Agents | 2017 |
Oleanolic acid prevents cartilage degeneration in diabetic mice via PPARγ associated mitochondrial stabilization.
Topics: Animals; Cartilage; Cartilage Diseases; Cells, Cultured; Diabetes Complications; Diabetes Mellitus, Experimental; Hyperglycemia; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; Oleanolic Acid; PPAR gamma; Protective Agents | 2017 |
Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats.
Topics: Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Hyperglycemia; Inflammation; Malvaceae; Molecular Docking Simulation; Oleanolic Acid; Plant Leaves; Rats; Rats, Wistar; Streptozocin; Up-Regulation | 2017 |
THE EFFECTS OF
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Gastrointestinal Tract; Ghrelin; Humans; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Syzygium; Triterpenes | 2016 |
Oleanolic acid alleviates diabetic rat carotid artery injury through the inhibition of NLRP3 inflammasome signaling pathways.
Topics: Animals; Biomarkers; Body Weight; Carotid Artery Injuries; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; Hyperglycemia; Inflammasomes; Inflammation Mediators; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Rats; Signal Transduction | 2017 |
Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy.
Topics: Angiopoietin-2; Animals; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Ependymoglial Cells; Gliosis; Interleukin-6; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2018 |
Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors.
Topics: Animals; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Fasting; Inflammation Mediators; Oleanolic Acid; Oxidative Stress; Plant Extracts; Prediabetic State; Rats; Risk Factors | 2019 |
Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Blood Glucose; Cholesterol; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Glucose Tolerance Test; HEK293 Cells; Humans; Hypoglycemic Agents; Molecular Docking Simulation; Oleanolic Acid; Rats; Rats, Wistar; Triglycerides; Triterpenes | 2013 |
Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.
Topics: Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Eating; Glucose; Kidney; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Oleanolic Acid; Rats; Rats, Zucker | 2013 |
Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gluconeogenesis; Hypolipidemic Agents; Injections, Intraperitoneal; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Transgenic; Mitochondrial Turnover; Oleanolic Acid; Organ Size; Reactive Oxygen Species | 2013 |
Synergism of a natural plant product, oleanolic acid with calcineurin inhibitor in prolonging islet allograft survival.
Topics: Allografts; Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Diabetes Mellitus, Experimental; Drug Synergism; Graft Survival; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Mice, Inbred BALB C; Oleanolic Acid; T-Lymphocytes | 2013 |
Promising anti-diabetes mellitus activity in rats of β-amyrin palmitate isolated from Hemidesmus indicus roots.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glycogen; Hemidesmus; Hypoglycemic Agents; Liver; Male; Oleanolic Acid; Organ Size; Plant Roots; Rats; Rats, Wistar | 2014 |
Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Rats | 2014 |
Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Male; Oleanolic Acid | 2014 |
Nrf2 induces fibroblast growth factor 21 in diabetic mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Gene Knockdown Techniques; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Metabolism; Liver; Mice; Mice, Knockout; NF-E2-Related Factor 2; Obesity; Oleanolic Acid | 2014 |
Effects of oleanolic acid on the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic male Sprague-Dawley rats.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glycogen; Glycogen Phosphorylase; Glycogen Synthase; Hypoglycemic Agents; Insulin; Male; Muscle, Skeletal; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oleanolic Acid; Reperfusion Injury; Saponins; Signal Transduction | 2016 |
Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects.
Topics: Animals; Aralia; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Oleanolic Acid; Oxidation-Reduction; Plant Bark; Plant Roots; Rats; Rats, Wistar; Saponins; Streptozocin; Triglycerides | 2015 |
Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells.
Topics: Animals; Calcium; Cell Line; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Oleanolic Acid; Protein Kinase C; Rats, Wistar; Receptors, G-Protein-Coupled; Saponins | 2015 |
Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.
Topics: Animals; Biomarkers; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Glucose; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Insulin; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Oleanolic Acid; Organ Size; Phosphorylation; RNA | 2015 |
In vivo effects of diabetes, insulin and oleanolic acid on enzymes of glycogen metabolism in the skin of streptozotocin-induced diabetic male Sprague-Dawley rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Glycogen; Glycogen Phosphorylase; Hexokinase; Insulin; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Skin; Streptozocin; Transferases | 2016 |
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Topics: Animals; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hypoglycemic Agents; Molecular Docking Simulation; Molecular Structure; Oleanolic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Structure-Activity Relationship | 2016 |
Hypolipidemic and hypoglycemic activities of a oleanolic acid derivative from Malva parviflora on streptozotocin-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Hypoglycemic Agents; Hypolipidemic Agents; Male; Malva; Mice; Molecular Conformation; Oleanolic Acid; Streptozocin | 2017 |
Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Oleanolic Acid; Rats; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Infrared; Streptozocin | 2009 |
Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum Ait in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Ligustrum; Oleanolic Acid; Phytotherapy; Rats; Rats, Wistar; Triglycerides | 2009 |
Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms.
Topics: Animals; Aralia; Calcium Channels, L-Type; Cardiomyopathies; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Heart; Hemodynamics; Male; Myocardium; Oleanolic Acid; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Saponins; Treatment Outcome | 2009 |
Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Ficus; Glucose Tolerance Test; Hypoglycemic Agents; Lipids; Male; Mice; Molecular Structure; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2009 |
Renal effects of plant-derived oleanolic acid in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Filtration Rate; Kidney Function Tests; Male; Oleanolic Acid; Phytotherapy; Plant Extracts; Potassium; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sodium; Streptozocin | 2009 |
Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograft.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Experimental; Graft Survival; Insulin; Islets of Langerhans Transplantation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oleanolic Acid; Reactive Oxygen Species; Subrenal Capsule Assay; Transplantation, Homologous | 2009 |
Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Syzygium | 2010 |
The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diet; Enzyme Activation; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Insulin; Mice; Mice, Mutant Strains; Muscle, Skeletal; Oleanolic Acid; Phosphorylation; Protein Serine-Threonine Kinases; Triglycerides | 2010 |
Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent.
Topics: Animals; Antioxidants; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Membrane Potential, Mitochondrial; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2011 |
The effects of Syzygium aromaticum-derived oleanolic acid on glycogenic enzymes in streptozotocin-induced diabetic rats.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Glucokinase; Glycogen; Hexokinase; Liver; Male; Muscle, Skeletal; Oleanolic Acid; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Syzygium | 2011 |
The effects of Syzygium aromaticum-derived oleanolic acid on kidney function of male Sprague-Dawley rats and on kidney and liver cell lines.
Topics: Analysis of Variance; Animals; Cell Line; Comet Assay; Creatinine; Diabetes Mellitus, Experimental; Electrophoresis, Agar Gel; Glomerular Filtration Rate; Kidney Tubules, Proximal; Liver; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Sodium; Syzygium; Tetrazolium Salts; Thiazoles | 2012 |
Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Discovery; Fenofibrate; Glyburide; Hypercholesterolemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin-Secreting Cells; Magnoliopsida; Male; Mice; Oleanolic Acid; Phytotherapy; Triglycerides | 2012 |
Effects of Syzygium aromaticum-derived oleanolic acid on glucose transport and glycogen synthesis in the rat small intestine.
Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Glycogen; Intestine, Small; Magnetic Resonance Spectroscopy; Male; Oleanolic Acid; Rats; Rats, Wistar; Streptozocin; Syzygium | 2013 |
Effect of kaikasaponin III obtained from Pueraria thunbergiana flowers on serum and hepatic lipid peroxides and tissue factor activity in the streptozotocin-induced diabetic rat.
Topics: Aldehyde Oxidase; Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Enzyme Induction; Flowers; Glutathione Peroxidase; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Peroxidation; Liver; Male; Oleanolic Acid; Oxidation-Reduction; Pueraria; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Superoxide Dismutase; Thromboplastin; Xanthine Oxidase | 2004 |
Antioxidant evaluation of Eysenhardtia species (Fabaceae): relay synthesis of 3-O-Acetyl-11alpha,12alpha-epoxy-oleanan-28,13beta-olide isolated from E. platycarpa and its protective effect in experimental diabetes.
Topics: Animals; Antioxidants; Biphenyl Compounds; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Epoxy Compounds; Fabaceae; Free Radical Scavengers; Glutathione; Glutathione Peroxidase; Indicators and Reagents; Male; Oleanolic Acid; Picrates; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2007 |
Antidiabetic potential of oleanolic acid from Ligustrum lucidum Ait.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Ligustrum; Lipids; Male; Oleanolic Acid; Organ Size; Rats; Rats, Wistar; Streptozocin; Thyroid Hormones | 2007 |
Inhibitory mechanisms of oleanolic acid 3-O-monodesmosides on glucose absorption in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gastric Emptying; Glucose; Glucuronates; Hypoglycemic Agents; Mice; Oleanolic Acid; Rats | 1997 |
Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry, Physical; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Intestinal Mucosa; Intestines; Lipids; Magnetic Resonance Spectroscopy; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 1998 |
Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system.
Topics: Animals; Blood Glucose; Capsaicin; Central Nervous System; Depression, Chemical; Diabetes Mellitus, Experimental; Diet; Gastric Emptying; Hypoglycemic Agents; Male; Mice; Neurons, Afferent; Oleanolic Acid; Sympathetic Nervous System | 1999 |
Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Hypoglycemic Agents; Hypolipidemic Agents; Isoflavones; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin | 2000 |
[Studies on triterpenoids and their glycosides from Aralia dasyphylla Miq].
Topics: Animals; Aralia; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Glycosides; Hypoglycemic Agents; In Vitro Techniques; Male; Mice; Oleanolic Acid; Plants, Medicinal; Rats; Triterpenes | 1997 |