oleanolic acid has been researched along with Acute Liver Injury, Drug-Induced in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.28) | 18.7374 |
| 1990's | 15 (24.59) | 18.2507 |
| 2000's | 10 (16.39) | 29.6817 |
| 2010's | 30 (49.18) | 24.3611 |
| 2020's | 4 (6.56) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, C; Liu, F; Liu, J; Meng, C; Xia, C | 1 |
| Gao, ZH; Li, RF; Li, SQ; Li, YY; Liu, WY; Wang, HW; Wang, JG; You, M | 1 |
| Chen, CI; Chen, CY; Cheng, HY; Huang, HH; Kuo, SM; Shiu, LY | 1 |
| Chen, S; Han, S; He, T; Huang, J; Li, M; Li, W; Liu, C; Liu, N; Wang, M; Yuan, R; Zhang, D | 1 |
| Liu, S; Qu, H; Wang, Z; Xin, C | 1 |
| Li, S; Peng, S; Qiao, Y; Shen, C; Wang, S; Wu, Q; Yang, W; Yu, Y; Zhang, M; Zhang, Q; Zhang, Y | 1 |
| Liu, J; Lu, YF; Wan, XL; Wu, Q; Xu, SF | 1 |
| Guo, F; Jin, L; Jin, S; Li, Y; Lin, S; Liu, X; Lu, Y; Wei, Y; Zheng, W; Zhu, Y | 1 |
| Bao, WL; Guan, YY; Li, HL; Li, YX; Liu, LX; Shen, XY; Tang, HH; You, Y; Zhang, SL; Zhou, Y | 1 |
| Chen, Y; Li, Y; Lin, L; Que, R; Shen, Y; Yan, N | 1 |
| Klaassen, CD; Liu, J; Lu, YF; Shi, FG; Wu, Q; Xu, SF | 1 |
| Chen, X; Peng, X; Rao, X; Zheng, C; Zhu, Y | 1 |
| Gao, JJ; Han, LW; He, QX; Liu, KC; Tu, PF; Xia, Q; Zhang, SS; Zhang, Y | 1 |
| Sharma, M | 1 |
| Fan, F; Klaassen, CD; Liu, J; Lu, YF; Wu, KC; Zhang, Y | 1 |
| Feng, Y; Li, S; Li, X; Li, Y; Liu, L; Lv, S; Zhang, K | 1 |
| Kumar, N; Kumar, P; Parimoo, HA; Patil, RD; Sharma, OP; Sharma, R | 1 |
| Bi, H; Chen, P; Deng, R; Fan, X; Huang, M; Wang, Y; Xu, C; Zeng, H; Zhou, X | 1 |
| Fu, H; Hai, C; Liu, J; Liu, R; Liu, Y; Wang, X; Zhang, T | 1 |
| Fang, Z; Gonzalez, FJ; Guo, B; Jiang, C; Kim, JH; Krausz, KW; Liu, A; Sun, L; Tanaka, N; Yang, J | 1 |
| Klaassen, CD; Liu, J; Lu, YF; Wu, KC | 1 |
| Fang, H; Qiu, X; Sun, Y; Wang, J; Wang, X; Wang, Z; Xia, Z; Zhang, F | 1 |
| Baiev, DS; Biryukova, MS; Ivanova, EP; Nepomnyashchikh, GI; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA | 1 |
| Du, GH; Li, ZY; Qin, XM; Sun, HM; Xing, J | 1 |
| Chen, L; Jin, H; Lu, Y; Shao, J; Wu, L; Zhang, F; Zheng, S | 1 |
| Jiang, T; Li, G; Peng, W; Sun, W; Yu, R; Yu, Z | 1 |
| Egner, PA; Kaneko, T; Kensler, TW; Mashimo, T; Morita, M; Taguchi, K; Takaku, M; Yamamoto, M | 1 |
| Chao, JC; Chu, CC; Lin, YH; Tsai, YH; Wu, SJ | 1 |
| Buckley, DB; Klaassen, CD; Reisman, SA; Tanaka, Y | 1 |
| Alabugin, IV; Baev, DS; Govdi, AI; Shakirov, MM; Shults, EE; Sorokina, IV; Tolstikov, GA; Tolstikova, TG; Vasilevsky, SF | 1 |
| Chang, CC; Chao, JC; Tam, KW; Tsai, YH; Wu, SJ | 1 |
| Curti, C; da Costa, FB; Garcia, AF; Groppo, M; Lima, MC; Maioli, MA; Medeiros, HC; Mingatto, FE; Rocha, BA | 1 |
| Guo, ML; Sun, ZL; Wang, XK; Wang, Y; Xue, Q; Zhang, G | 1 |
| Chen, W; Hong, Z; Hu, J; Li, T; Wu, Z; Zhao, J; Zhou, J | 1 |
| Huang, W; Huang, Y; Lv, L; Sun, R; Wang, R | 1 |
| Baev, DS; Bessergeneva, EP; Glukhov, BM; Nepomnyaschikh, GI; Semenov, DE; Sorokina, IV; Tolstikova, TG; Zhukova, NA | 1 |
| Chen, Y; Grace-Lynn, C; Jothy, SL; Kanwar, JR; Latha, LY; Sasidharan, S; Vijayarathna, S | 1 |
| Hirakawa, T; Kinjo, J; Nagao, T; Nohara, T; Okabe, H; Okawa, M; Tsuchihashi, R | 1 |
| Chen, Y; Liu, J; Xu, H; Yang, X; Zhao, X | 1 |
| Basu, MK; Lala, S; Mahato, SB; Maitra, A; Nandy, AK; Tyagi, R; Verma, AK | 1 |
| Chen, J; Fang, F; Gao, J; Tang, XH; Xu, LZ; Xu, Q; Zhao, XN | 1 |
| Abdel-Rahman, MM; Abdel-Zaher, AO; Hafez, MM; Omran, FM | 1 |
| Chen, S; Dolan, PD; Kensler, TW; Liby, KT; Osburn, WO; Sporn, MB; Taguchi, K; Yamamoto, M; Yates, MS | 1 |
| Abe, H; Arichi, S; Odashima, S; Sakaguchi, M | 1 |
| Klaassen, CD; Liu, J; Liu, Y | 1 |
| Liu, GT; Shi, JZ | 1 |
| Bullock, P; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Choudhuri, S; Klaassen, CD; Kreppel, H; Liu, J; Liu, Y | 1 |
| Klaassen, CD; Liu, J; Liu, Y; Madhu, C | 1 |
| Ebashi, J; Furumoto, T; Isiguro, I; Nagamura, Y; Nishida, K; Saito, S; Sumita, S | 1 |
| Hirakawa, T; Kinjo, J; Nohara, T; Okawa, M; Shii, Y; Sohno, Y; Udayama, M | 1 |
| Bhat, TK; Dawra, RK; Sharma, OP; Sharma, S | 1 |
| Jeong, HG | 1 |
| Bhat, TK; Sharma, OP; Sharma, S; Singh, B | 1 |
| Hu, J; Li, C; Li, R; Su, Z; Tang, H; Wang, Z; Yi, Y | 1 |
| Gu, JQ; Lin, HW; Wang, ZZ; Xiao, K; Yi, YH | 1 |
| Heath, TJ; Lamberton, JA; Pass, MA; Seawright, AA | 1 |
| Bhutani, KK; Pattabhi, V; Sharma, OP; Vaid, J | 1 |
| Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Mao, Q | 1 |
| Jia, XS; Klaassen, CD; Liu, J; Liu, YP; Madhu, C; Mao, Q | 1 |
| Chuang, CH; Lin, CC; Liu, SY; Yen, MH | 1 |
1 review(s) available for oleanolic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Dose-Response Relationship, Drug; Humans; Liver; NF-E2-Related Factor 2; Oleanolic Acid; Protective Agents; Receptors, G-Protein-Coupled; Risk Assessment; Risk Factors; Signal Transduction; Time Factors | 2019 |
60 other study(ies) available for oleanolic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Homeostasis; Liver; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Receptors, Cytoplasmic and Nuclear; Tandem Mass Spectrometry | 2022 |
[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Energy Metabolism; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; NF-kappa B; Oleanolic Acid; Random Allocation; Saponins; Sirtuins | 2019 |
Reparative and toxicity-reducing effects of liposome-encapsulated saikosaponin in mice with liver fibrosis.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Compounding; Drug Liberation; Hepatic Stellate Cells; Humans; Inhibitory Concentration 50; Liposomes; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Oleanolic Acid; Protective Agents; Saponins; Thioacetamide | 2020 |
Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Databases, Nucleic Acid; Male; Metabolic Networks and Pathways; Metabolomics; Oleanolic Acid; Rats; Rats, Wistar; Saponins | 2021 |
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl
Topics: Administration, Oral; Animals; Biological Availability; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chitosan; Deoxycholic Acid; Gene Expression Regulation; Humans; Male; Mice; Nanocomposites; NF-kappa B; Oleanolic Acid; Oxidative Stress; Signal Transduction | 2021 |
Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri.
Topics: Acetic Acid; Animals; Animals, Newborn; Apoptosis; Bupleurum; Cardiotoxicity; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Hep G2 Cells; Hot Temperature; Humans; Male; Myocytes, Cardiac; Oleanolic Acid; Plant Preparations; Plant Roots; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2017 |
Oeanolic acid protects against the hepatotoxicity of D-galactosame plus endotoxin in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endotoxins; Galactosamine; Lipopolysaccharides; Male; Mice; NF-kappa B; Oleanolic Acid; Protective Agents; Tumor Necrosis Factor-alpha | 2017 |
Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity.
Topics: Animals; Anti-Inflammatory Agents; Celastrus; Chemical and Drug Induced Liver Injury; Circular Dichroism; HEK293 Cells; Humans; Ligands; Liver; Male; Mice; Molecular Structure; Mutagenesis; Oleanolic Acid; Plant Roots; Plant Stems; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled | 2018 |
Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-κB and Nrf2 signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Concanavalin A; Curcumin; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Enzymes; Inflammation Mediators; Liver; Male; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidative Stress; Signal Transduction | 2018 |
Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL‑7702 cell line.
Topics: Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytokines; Inflammasomes; Inflammation Mediators; Liver; Malondialdehyde; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Hep G2 Cells; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver X Receptors; Malondialdehyde; Mice, Inbred C57BL; Oleanolic Acid; Peroxidase; Saponins; Tumor Necrosis Factor-alpha | 2019 |
[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Fatty Liver, Alcoholic; Oleanolic Acid; Saponins; Zebrafish | 2019 |
Remarks on Sasidharan et al. "Evaluation of the hepatoprotective effects of lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage". Molecules 2012, 17, 13937-13947.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Humans; Oleanolic Acid | 2013 |
Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Oleanolic Acid | 2013 |
Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Female; Iridoid Glucosides; Lipids; Liver; Male; Mice; Nanostructures; Oleanolic Acid; Particle Size; Rats; Rats, Sprague-Dawley | 2013 |
Hepatoprotective effect of Ginkgo biloba leaf extract on lantadenes-induced hepatotoxicity in guinea pigs.
Topics: Animals; Apoptosis; Catalase; Chemical and Drug Induced Liver Injury; Ginkgo biloba; Glutathione; Guinea Pigs; Lipid Peroxidation; Liver; Oleanolic Acid; Oxidative Stress; Plant Extracts; Protective Agents; Superoxide Dismutase; Toxins, Biological | 2014 |
Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Dose-Response Relationship, Drug; Gene Expression; Hep G2 Cells; Hepatocytes; Humans; Lithocholic Acid; Liver Function Tests; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Oleanolic Acid; Primary Cell Culture; Up-Regulation | 2014 |
Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats.
Topics: Animals; Blotting, Western; Body Weight; Chemical and Drug Induced Liver Injury; Ethanol; Liver; Male; NF-E2-Related Factor 2; Oleanolic Acid; Organ Size; Rats; Rats, Sprague-Dawley; Triglycerides | 2014 |
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Bupleurum; Chemical and Drug Induced Liver Injury; Cytokines; Down-Regulation; Drugs, Chinese Herbal; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Oxidative Stress; Plants, Medicinal; PPAR alpha; RNA, Messenger; Saponins; Signal Transduction; STAT3 Transcription Factor | 2014 |
Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; Inflammation Mediators; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Liver; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Organic Anion Transporters, Sodium-Independent; Phalloidine; RNA, Messenger; Signal Transduction; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2015 |
The protective effect of Esculentoside A on experimental acute liver injury in mice.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Proliferation; Chemical and Drug Induced Liver Injury; Immunohistochemistry; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins; Signal Transduction; Sincalide | 2014 |
Hepatoprotective properties of betulonic acid amide and heptral in toxic liver injury induced by carbon tetrachloride in combination with ethanol.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; Female; Liver; Oleanolic Acid; Rats; Rats, Wistar | 2015 |
Chemical and biological comparison of raw and vinegar-baked Radix Bupleuri.
Topics: Acetic Acid; Animals; Bupleurum; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Female; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Oleanolic Acid; Plant Extracts; Saponins | 2015 |
Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Bupleurum; Caspase 8; Cell Line; Chemical and Drug Induced Liver Injury; fas Receptor; Hepatocytes; Humans; Male; MAP Kinase Signaling System; Mice; Mitochondria; Oleanolic Acid; Saponins; Signal Transduction | 2016 |
Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Male; Malondialdehyde; Oleanolic Acid; Prodrugs; Protective Agents; Rats; Rats, Wistar; Tissue Distribution | 2016 |
Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.
Topics: Aflatoxin B1; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Adducts; Gene Editing; Gene Expression Profiling; Genetic Predisposition to Disease; Imidazoles; Inactivation, Metabolic; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Mutation; NF-E2-Related Factor 2; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Phenotype; Rats, Inbred F344; Rats, Transgenic | 2016 |
Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Glutathione; Lipids; Liver; Liver Diseases; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Superoxide Dismutase | 2008 |
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
Topics: Acetaminophen; Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Imidazoles; Liver; Liver Diseases; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Necrosis; NF-E2-Related Factor 2; Nuclear Transfer Techniques; Oleanolic Acid; Response Elements; RNA, Messenger; Time Factors | 2009 |
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes; Inflammation; Male; Mice; Oleanolic Acid | 2009 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
Comparative effects of lantadene A and its reduced metabolite on mitochondrial bioenergetics.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Energy Metabolism; In Vitro Techniques; Lantana; Male; Membrane Potentials; Mitochondria, Liver; Oleanolic Acid; Osmotic Fragility; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar; Toxins, Biological; Uncoupling Agents | 2010 |
Two new compounds from Semen celosiae and their protective effects against CCl₄-induced hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Celosia; Chemical and Drug Induced Liver Injury; Mice; Molecular Structure; Oleanolic Acid; Saponins; Seeds | 2011 |
Hepatoprotective effects of Rubus aleaefolius Poir. and identification of its active constituents.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Nitric Oxide; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Rosaceae; Sitosterols; Superoxide Dismutase; Triterpenes | 2010 |
[Research on mechanism of energy metabolism disorders of rat's hepatoxicity induced by saikosaponins].
Topics: Animals; Antimetabolites; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Female; Liver; Male; Mitochondria, Liver; Oleanolic Acid; Organ Size; Rats; Saponins | 2011 |
Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amides; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cell Count; Cell Proliferation; Chemical and Drug Induced Liver Injury; Ethanol; Female; Hepatocytes; L-Lactate Dehydrogenase; Liver; Oleanolic Acid; Rats | 2012 |
Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Humans; Lantana; Liver; Mice; Oleanolic Acid; Plant Leaves; Protective Agents; Silymarin | 2012 |
Hepatoprotective constituents in plants. 14. Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells.
Topics: Carbohydrate Sequence; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Glucuronides; Glycyrrhizic Acid; Humans; Liver; Molecular Sequence Data; Oleanolic Acid; Saponins; tert-Butylhydroperoxide | 2003 |
Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect.
Topics: Administration, Oral; Alanine Transaminase; Animals; Calorimetry, Differential Scanning; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; China; Dosage Forms; Drug Evaluation, Preclinical; Hepatocytes; Injections, Subcutaneous; Liver Diseases; Malondialdehyde; Medicine, Chinese Traditional; Mice; Nanostructures; Oleanolic Acid; Particle Size; Solubility; Suspensions; Triterpenes; X-Ray Diffraction | 2005 |
Targeted delivery of arjunglucoside I using surface hydrophilic and hydrophobic nanocarriers to combat experimental leishmaniasis.
Topics: Animals; Antiparasitic Agents; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Creatinine; Cricetinae; Drug Carriers; Enzymes; Female; Gels; Glucosides; Kidney Diseases; Lactic Acid; Leishmania donovani; Leishmaniasis, Visceral; Light; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Microspheres; Oleanolic Acid; Particle Size; Pharmaceutic Aids; Plant Bark; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Terminalia; X-Ray Diffraction | 2005 |
Hepatoprotection of oleanolic acid is related to its inhibition on mitochondrial permeability transition.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Mitochondria, Liver; Mitochondrial Swelling; Oleanolic Acid | 2005 |
Role of nitric oxide and reduced glutathione in the protective effects of aminoguanidine, gadolinium chloride and oleanolic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Creatinine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gadolinium; Glutathione; Guanidines; Injections, Intramuscular; Kidney Diseases; Liver Diseases; Male; Nitric Oxide; Oleanolic Acid; Protective Agents; Rats; Rats, Wistar; Survival Analysis; Survival Rate | 2007 |
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
Topics: Aconitate Hydratase; Adaptor Proteins, Signal Transducing; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Cytoskeletal Proteins; Female; Gene Expression Profiling; Hepatocytes; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Peroxidation; Liver; Male; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oleanolic Acid; Signal Transduction | 2008 |
Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Lipid Peroxides; Male; Microsomes, Liver; Necrosis; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1982 |
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice.
Topics: Acetaminophen; Animals; Cadmium Poisoning; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Male; Mice; Necrosis; Oleanolic Acid | 1995 |
[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice].
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Glutathione; Liver; Liver Diseases; Male; Mice; Oleanolic Acid; Saponins | 1995 |
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Antagonism; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Liver Diseases; Male; Methylation; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1995 |
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein.
Topics: Alanine Transaminase; Animals; Blotting, Northern; Cadmium; Chemical and Drug Induced Liver Injury; Cytosol; Dose-Response Relationship, Drug; Isomerism; L-Iditol 2-Dehydrogenase; Liver; Liver Diseases; Male; Metallothionein; Mice; Mice, Inbred Strains; Oleanolic Acid; Organ Size; RNA Probes; RNA, Messenger; Subcellular Fractions; Tissue Distribution | 1993 |
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Animals; Biliary Tract; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Glucuronosyltransferase; Glutathione; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Oleanolic Acid; Subcellular Fractions; Uridine Diphosphate Glucuronic Acid | 1993 |
Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride Poisoning; Cell Survival; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1993 |
Hepatoprotective and hepatotoxic actions of oleanolic acid-type triterpenoidal glucuronides on rat primary hepatocyte cultures.
Topics: Animals; Carbohydrate Sequence; Cells, Cultured; Chemical and Drug Induced Liver Injury; Glucuronates; Immune Sera; Liver; Male; Molecular Sequence Data; Oleanolic Acid; Rats; Rats, Wistar; Structure-Activity Relationship; Triterpenes | 1999 |
Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs.
Topics: Aerobiosis; Anaerobiosis; Animals; Biotransformation; Cecum; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Female; Guinea Pigs; In Vitro Techniques; Intestine, Large; Liver; Oleanolic Acid; Tissue Distribution; Toxins, Biological; Triterpenes | 1999 |
Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Glutathione Transferase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid | 1999 |
Biotransformation of lantadenes, the pentacyclic triterpenoid hepatotoxins of lantana plant, in guinea pig.
Topics: Anaerobiosis; Animals; Bilirubin; Biotransformation; Cecum; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Guinea Pigs; Oleanolic Acid; Plant Leaves; Plants, Toxic | 2000 |
[Liver-protective activity of Aralia taibaiensis Z.Z. Wang et H.C. Zheng].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Liver; Magnoliopsida; Male; Mice; Oleanolic Acid; Saponins | 1997 |
[Studies on triterpenoids and their glycosides from Aralia dasyphylla Miq].
Topics: Animals; Aralia; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental; Glycosides; Hypoglycemic Agents; In Vitro Techniques; Male; Mice; Oleanolic Acid; Plants, Medicinal; Rats; Triterpenes | 1997 |
Lantadene A toxicity in sheep. A model for cholestasis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Liver Diseases; Necrosis; Oleanolic Acid; Plant Extracts; Sheep; Sheep Diseases; Triterpenes | 1979 |
Biological action of lantadene C, a new hepatotoxicant from Lantana camara var. aculeata.
Topics: Acid Phosphatase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Crystallization; Guinea Pigs; Liver; Liver Diseases; Male; Molecular Structure; Oleanolic Acid; Plant Extracts; Stereoisomerism; Toxins, Biological; X-Ray Diffraction | 1992 |
Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cadmium Poisoning; Chemical and Drug Induced Liver Injury; Liver; Male; Metallothionein; Mice; Oleanolic Acid; Saponins; Tissue Distribution | 1992 |
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Inactivation, Metabolic; Male; Mice; Microsomes, Liver; Oleanolic Acid; Saponins | 1992 |
Evaluation of root quality of Bupleurum species by TLC scanner and the liver protective effects of "xiao-chai-hu-tang" prepared using three different Bupleurum species.
Topics: Animals; Calibration; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Drugs, Chinese Herbal; Liver; Liver Diseases; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1991 |