olanzapine and Thrombophilia

olanzapine has been researched along with Thrombophilia* in 2 studies

Other Studies

2 other study(ies) available for olanzapine and Thrombophilia

Article	Year
Coagulation and inflammation markers during atypical or typical antipsychotic treatment in schizophrenia patients and drug-free first-degree relatives. Schizophrenia research, 2008, Volume: 103, Issue:1-3 Clinical studies suggest that the second generation antipsychotics (APs) clozapine and olanzapine and to a lesser extent the typical antipsychotics may be associated with a procoagulant and proinflammatory state that promotes venous thromboembolism. We evaluated here several blood factors associated with coagulation and inflammation in AP-treated schizophrenia patients and their first-degree relatives.. Procoagulant factors (fibrinogen and plasminogen activator inhibitor [PAI-1]), the anticoagulant factor antithrombin III [AT-III], and inflammation-related factors (C-reactive protein [CRP] and leptin) were assessed in patients chronically treated with clozapine (n=29), olanzapine (n=29), typical APs (n=30) and first degree relatives of clozapine (n=23) and olanzapine subjects (n=11).. The typical AP group had the highest CRP level (p=0.013) in spite of having the lowest body mass index (BMI). Patients as a single group had higher CRP levels than relatives (p=0.003). The typical AP group also had the highest AT-III levels (p=0.021). Fibrinogen levels did not differ between the groups (p=0.13). Olanzapine patients displayed the highest PAI-1 and leptin levels among the drug-treated subjects, but values were similar to those observed in their relatives, and were significantly correlated with the BMI.. A homogeneous negative profile of high inflammation and procoagulant factors along with low levels of anticoagulants was not detected in any group. While preliminary, our results suggest that the observed abnormalities were not related to a direct drug effect, but to elevated BMI (high PAI-1 and leptin in olanzapine-treated patients). We speculate that the high CRP in the typical AP group might be related to poor lifestyle habits, but this must we confirmed in future studies. Topics: Adult; Antipsychotic Agents; Antithrombin III; Benzodiazepines; Body Mass Index; C-Reactive Protein; Clozapine; Dose-Response Relationship, Drug; Female; Fibrinogen; Humans; Inflammation Mediators; Leptin; Life Style; Male; Middle Aged; Olanzapine; Plasminogen Activator Inhibitor 1; Risk Factors; Schizophrenia; Thromboembolism; Thrombophilia	2008
Seizures, coma, and coagulopathy following olanzapine overdose. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:2 Topics: Adult; Antiphospholipid Syndrome; Antipsychotic Agents; Benzodiazepines; Coma; Drug Overdose; Epilepsy, Complex Partial; Humans; Male; Olanzapine; Pulmonary Embolism; Schizophrenia, Paranoid; Thrombophilia; Venous Thrombosis	2005

Article

Year

Coagulation and inflammation markers during atypical or typical antipsychotic treatment in schizophrenia patients and drug-free first-degree relatives.

Schizophrenia research, 2008, Volume: 103, Issue:1-3

Clinical studies suggest that the second generation antipsychotics (APs) clozapine and olanzapine and to a lesser extent the typical antipsychotics may be associated with a procoagulant and proinflammatory state that promotes venous thromboembolism. We evaluated here several blood factors associated with coagulation and inflammation in AP-treated schizophrenia patients and their first-degree relatives.. Procoagulant factors (fibrinogen and plasminogen activator inhibitor [PAI-1]), the anticoagulant factor antithrombin III [AT-III], and inflammation-related factors (C-reactive protein [CRP] and leptin) were assessed in patients chronically treated with clozapine (n=29), olanzapine (n=29), typical APs (n=30) and first degree relatives of clozapine (n=23) and olanzapine subjects (n=11).. The typical AP group had the highest CRP level (p=0.013) in spite of having the lowest body mass index (BMI). Patients as a single group had higher CRP levels than relatives (p=0.003). The typical AP group also had the highest AT-III levels (p=0.021). Fibrinogen levels did not differ between the groups (p=0.13). Olanzapine patients displayed the highest PAI-1 and leptin levels among the drug-treated subjects, but values were similar to those observed in their relatives, and were significantly correlated with the BMI.. A homogeneous negative profile of high inflammation and procoagulant factors along with low levels of anticoagulants was not detected in any group. While preliminary, our results suggest that the observed abnormalities were not related to a direct drug effect, but to elevated BMI (high PAI-1 and leptin in olanzapine-treated patients). We speculate that the high CRP in the typical AP group might be related to poor lifestyle habits, but this must we confirmed in future studies.

Topics: Adult; Antipsychotic Agents; Antithrombin III; Benzodiazepines; Body Mass Index; C-Reactive Protein; Clozapine; Dose-Response Relationship, Drug; Female; Fibrinogen; Humans; Inflammation Mediators; Leptin; Life Style; Male; Middle Aged; Olanzapine; Plasminogen Activator Inhibitor 1; Risk Factors; Schizophrenia; Thromboembolism; Thrombophilia

2008

Seizures, coma, and coagulopathy following olanzapine overdose.

Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:2

Topics: Adult; Antiphospholipid Syndrome; Antipsychotic Agents; Benzodiazepines; Coma; Drug Overdose; Epilepsy, Complex Partial; Humans; Male; Olanzapine; Pulmonary Embolism; Schizophrenia, Paranoid; Thrombophilia; Venous Thrombosis

2005