olanzapine and Somatoform-Disorders

Various drugs have been suggested for treatment of Borderline Personality Disorder (BPD)-a disabling disease affecting two percent of the general population. If a drug could alleviate a wide range of symptoms, it would be more suitable. In these disorders drug addiction is very common. This fact makes the symptoms complicated and the treatment more difficult.. This study is designed to evaluate the effect of Olanzapine and Sertraline in patients suffering from personality disorders who are on methadone maintenance therapy. This study is a clinical trial. 120 males and females were chosen for methadone maintenance therapy through interview by a psychiatrist based on DSM-IV-TR diagnostic criteria for BPD. Afterwards they were randomly divided into two groups. These groups separately received Olanzapine (5-10 mg daily) and Sertraline (50-100 mg daily) therapy. The SCL-90 questionnaire was filled by all participants before treatment and at the 4th, 8th and 12th weeks of treatment.. According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and somatization disorders in patients with personality disorders on methadone maintenance therapy.. As result of this study it appears that Olanzapine and Sertraline are definitely effective in alleviating symptoms of patients with personality disorder, prescribing theses drugs are recommended for these patients.

Topics: Adult; Aggression; Analgesics, Opioid; Anxiety; Benzodiazepines; Borderline Personality Disorder; Depression; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Interpersonal Relations; Male; Methadone; Obsessive Behavior; Olanzapine; Sampling Studies; Selective Serotonin Reuptake Inhibitors; Sertraline; Severity of Illness Index; Somatoform Disorders; Surveys and Questionnaires; Treatment Outcome

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Double-Blind Method; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Olanzapine; Selective Serotonin Reuptake Inhibitors; Somatoform Disorders; Treatment Outcome

Delusional parasitosis (DP) is a rare delusional disorder in which patients believe that they are infected with parasites, worms, insects, or bacteria. Antipsychotics are the preferred treatment in these patients.. Case series in which we summarize six patients with DP treated with atypical antipsychotic medications including amisulpride, olanzapine, and risperidone.. One patient had a myocardial infarction after being given amisulpride, and several patients did not adjust well. Parenterally administered antipsychotics, particularly risperidone, were the most effective treatment in this series of patients with DP.. Patients with DP can be difficult to treat; however, parenterally administered antipsychotics appear to produce better results in these patients.

Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Female; Follow-Up Studies; Humans; Injections; Male; Middle Aged; Myocardial Infarction; Olanzapine; Parasitic Diseases; Paresthesia; Patient Compliance; Risperidone; Schizophrenia, Paranoid; Somatoform Disorders; Sulpiride; Treatment Outcome

Topics: Antipsychotic Agents; Benzodiazepines; Chest Pain; Clomipramine; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatigue; Humans; Male; Middle Aged; Olanzapine; Pain; Scalp; Somatoform Disorders

Topics: Age of Onset; Antipsychotic Agents; Benzodiazepines; Drug Administration Schedule; Female; Humans; Middle Aged; Obsessive-Compulsive Disorder; Olanzapine; Pirenzepine; Somatoform Disorders; Treatment Outcome