olanzapine and Sjogren-s-Syndrome

A 54-year-old woman diagnosed with primary Sjögren's syndrome in 2007 presented with a 1-year history of visual hallucinations requiring admission to a psychiatric unit. The hallucinations resolved while on olanzapine and hydroxychloroquine but recurred when they were stopped. Despite restarting olanzapine, her visual hallucinations persisted. When she started a tapering dose of prednisolone, all the hallucinations resolved. This report adds to the small literature on psychiatric manifestations of Sjögren's syndrome and provides evidence that low-dose corticosteroids may be an effective treatment for this manifestation.

Topics: Antipsychotic Agents; Antirheumatic Agents; Benzodiazepines; Female; Glucocorticoids; Hallucinations; Humans; Hydroxychloroquine; Middle Aged; Olanzapine; Prednisolone; Sjogren's Syndrome; Treatment Outcome