olanzapine and Puerperal-Disorders

The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study.. Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery.. Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No-OLZ group did.. The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.

Topics: Adult; Affect; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Female; Humans; Olanzapine; Psychotic Disorders; Puerperal Disorders; Treatment Outcome

Topics: Adult; Antipsychotic Agents; Diabetic Ketoacidosis; Female; Humans; Olanzapine; Puerperal Disorders

Topics: Antipsychotic Agents; Asymptomatic Infections; COVID-19; Delusions; Female; Hallucinations; Haloperidol; Humans; India; Olanzapine; Psychotic Disorders; Puerperal Disorders; Restraint, Physical; Self-Injurious Behavior; Trihexyphenidyl; Young Adult

This article provides an introduction to the complex issues surrounding the management of women who have a history of psychosis and who become pregnant. Balancing the mental wellbeing of the woman and the safety and wellbeing of the baby is a complex task for both the expectant mother and the health professionals involved in her care.. Within this article the complexity of the issues will be outlined as a case report of a woman with a history of psychotic related disorders, who was also pregnant.. The woman was being case managed by a Mental Health Service in Victoria, Australia, and was included on the National Register of Antipsychotic Medications in Pregnancy Register (NRAMP) recently established at the Alfred Psychiatry Research Centre (APRC).. The profile of women with a history of previous mental illness, and who are pregnant, often includes a poor psychosocial history and involvement with child protection agencies with regard to custody of the children. Well meant but poorly coordinated decisions by health professionals result in sub-optimal outcomes for both mother and infant.. There is a need for the exploration of the management and experiences of women who have a history of psychosis and who are pregnant. This case example highlights the complexity of issues surrounding the management of this vulnerable group of women and their babies.

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Case Management; Child Custody; Cooperative Behavior; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Infant, Small for Gestational Age; Interprofessional Relations; Olanzapine; Pregnancy; Pregnancy Complications; Psychotic Disorders; Puerperal Disorders; Risperidone; Schizophrenia; Substance Withdrawal Syndrome; Treatment Outcome

Topics: Adult; Benzodiazepines; Breast Feeding; Chromatography, Gas; Drug Therapy, Combination; Female; Haloperidol; Humans; Infant, Newborn; Lactation; Methotrimeprazine; Milk, Human; Olanzapine; Psychotic Disorders; Puerperal Disorders