olanzapine and Pleural-Effusion

Topics: Adult; Benzodiazepines; Biopsy; Dantrolene; Eosinophilia; Humans; Iatrogenic Disease; Male; Middle Aged; Muscle Relaxants, Central; Olanzapine; Paracentesis; Pericardial Effusion; Pleural Effusion; Selective Serotonin Reuptake Inhibitors; Tomography, X-Ray Computed

Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy.. We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE.. Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed.. Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed.. All symptoms-as well as the EPE-were resolved 6 months later.. This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice.

Topics: Aged; Antidepressive Agents; Benzodiazepines; Depression; Drainage; Eosinophilia; Humans; Male; Olanzapine; Pleural Effusion