olanzapine and Metaplasia

Eccrine squamous syringometaplasia is a histopathologic pattern that has mainly been described in patients receiving chemotherapy. Its association to nonchemotherapeutic agents is rare, with very few cases reported in the literature. We present the case of a 55-year-old patient with schizophrenia, who developed a skin eruption 5 weeks after initiating treatment with olanzapine. The histopathologic study revealed squamous syringometaplasia of the dermal eccrine ducts.

Topics: Antipsychotic Agents; Benzodiazepines; Biopsy; Dermatologic Agents; Drug Substitution; Eccrine Glands; Humans; Male; Metaplasia; Middle Aged; Olanzapine; Risperidone; Schizophrenia; Sweat Gland Neoplasms; Treatment Outcome