olanzapine and Hepatolenticular-Degeneration

Topics: Adolescent; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Female; Hepatolenticular Degeneration; Humans; Lithium Chloride; Male; Olanzapine; Psychiatric Status Rating Scales; Young Adult

Wilson's disease (WD), or hepatolenticular degeneration, is a genetic neurodegenerative disorder of copper metabolism. It is an uncommon medical condition that produces psychiatric symptoms during the early phase in approximately 50% of patients. Reported herein is a case of WD in a young man presenting persistent delusional disorder of organic etiology, which resolved entirely after 4 months of combined pharmacotherapy. The present case demonstrates the importance of considering the occurrence of psychotic symptoms in WD patients given that psychiatric manifestations in WD are known to be uncommon as well as inhomogeneous. It also supports the hypothesis that psychopathologic features in WD have an organic foundation.

Topics: Adult; Antipsychotic Agents; Behavior; Benzodiazepines; Cerebrovascular Circulation; Copper; Female; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Neuropsychological Tests; Olanzapine; Psychiatric Status Rating Scales; Schizophrenia, Paranoid; Tomography, Emission-Computed, Single-Photon

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Dyskinesia, Drug-Induced; Hepatolenticular Degeneration; Humans; Male; Muscle Rigidity; Olanzapine; Parkinsonian Disorders; Pirenzepine; Psychotic Disorders; Risperidone