olanzapine and Drug-Hypersensitivity

Topics: Adult; Drug Hypersensitivity; Female; Humans; Olanzapine; Photosensitivity Disorders

Topics: Adult; Benzodiazepines; Carbamazepine; Cross Reactions; Drug Hypersensitivity; Drug Interactions; Humans; Male; Olanzapine

Olanzapine is a second-generation antipsychotic, which is also used as a mood stabilizer. We report a case of a 33-year-old psychiatric patient, with bipolar affective disorder, who developed anaphylaxis as a late reaction to olanzapine. This case report shows the possibility, although rare, of a severe late anaphylactic reaction to olanzapine.

Topics: Adult; Anaphylaxis; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Dopamine Antagonists; Drug Hypersensitivity; Female; Humans; Olanzapine; Serotonin Antagonists; Treatment Outcome

Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Lithium Carbonate; Liver Function Tests; Neutropenia; Olanzapine; Retreatment; Thrombocytopenia; Valproic Acid

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Male; Myocarditis; Olanzapine; Psychotic Disorders; Retreatment

Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Clomipramine; Drug Hypersensitivity; Female; Humans; Male; Olanzapine; Photosensitivity Disorders

Hypersensitivity syndrome is defined as a drug-induced complex of symptoms consisting of fever, rash, and internal organ involvement. The hypersensitivity syndrome is well recognized as being caused by anticonvulsants. Olanzapine is an atypical antipsychotic agent whose side effects include sedation, weight gain, and increased creatinine kinase and transaminase levels. To date, there have been no reports of hypersensitivity syndrome related to this drug. A 34-year-old man developed a severe generalized pruritic skin eruption, fever, eosinophilia, and toxic hepatitis 60 days after ingestion of olanzapine. After termination of olanzapine treatment, the fever resolved, the skin rash was reduced, eosinophil count was reduced to normal, and the transaminase levels were markedly reduced. Clinical features and the results of skin and liver biopsies indicated that the patient developed hypersensitivity syndrome caused by olanzapine.

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chemical and Drug Induced Liver Injury; Diagnostic Errors; Drug Eruptions; Drug Hypersensitivity; Dyspnea; Eosinophilia; Fever; Humans; Male; Olanzapine; Pirenzepine; Pruritus; Respiratory Hypersensitivity; Respiratory Insufficiency; Schizophrenia, Paranoid; Syndrome

Topics: Adult; Antipsychotic Agents; Benzodiazepines; Drug Hypersensitivity; Eccrine Glands; Humans; Male; Necrosis; Olanzapine; Pirenzepine; Schizophrenia; Skin Diseases, Vesiculobullous