okadaic-acid and Fever

okadaic-acid has been researched along with Fever* in 2 studies

Other Studies

2 other study(ies) available for okadaic-acid and Fever

Article	Year
Outbreak of diarrhetic shellfish poisoning associated with consumption of mussels, United Kingdom, May to June 2019. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019, Volume: 24, Issue:35 We report on six cases of diarrhetic shellfish poisoning following consumption of mussels harvested in the United Kingdom. Topics: Abdominal Pain; Adult; Aged; Animals; Bivalvia; Diarrhea; Dinoflagellida; Disease Outbreaks; Environmental Monitoring; Female; Fever; Food Contamination; Humans; Male; Marine Toxins; Middle Aged; Nausea; Okadaic Acid; Seafood; Shellfish Poisoning; United Kingdom; Vomiting	2019
Effect of okadaic acid, a protein phosphatase inhibitor, on heat stress-induced HSP72 synthesis and thermotolerance. Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:4 Heat stress proteins (HSPs), in particular HSP72, seem to play a major role in cell protection against lethal stresses such as hyperthermia or ischemia. HSP synthesis is negatively regulated by protein phosphatases, which are implicated in dephosphorylation processes. In the present study, we have investigated the effect of okadaic acid (OA, a protein phosphatase inhibitor) on heat stress-induced HSP72 synthesis and thermotolerance in smooth muscle cells (SMC). SMC were heat stressed (42 degrees C for 20 minutes) in the presence of 250 nM OA (HS+OA cells) or its vehicle (HS+V cells). Control (OA or V) cells were not heat stressed. HSP72 mRNA expression was determined 1, 1.5, 3, and 6 hours after heat stress by RT-PCR, and HSP72 synthesis was determined 6, 12, 24, 48, and 72 hours after heat stress by Western blotting. SMC survival of lethal hyperthermia (47 degrees C for 90 minutes) was assessed 6, 24, and 48 hours after heat stress by a tetrazolium assay. The maximal expression of HSP72 mRNA was markedly prolonged in HS+OA cells (until 6 hours after heat stress) compared to HS+V cells (1 hour after heat stress). The kinetics of HSP72 synthesis and thermotolerance of SMC were not different between HS+OA and HS+V cells. Baseline HSP72 mRNA and protein expression were similar in control V and OA cells. In conclusion, okadaic acid treatment of SMC potentiated HSP72 mRNA expression without affecting heat stress-induced HSP72 synthesis and thermotolerance. Topics: Animals; Enzyme Inhibitors; Fever; Heat-Shock Proteins; Hot Temperature; Male; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction	2000

Article

Year

Outbreak of diarrhetic shellfish poisoning associated with consumption of mussels, United Kingdom, May to June 2019.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019, Volume: 24, Issue:35

We report on six cases of diarrhetic shellfish poisoning following consumption of mussels harvested in the United Kingdom.

Topics: Abdominal Pain; Adult; Aged; Animals; Bivalvia; Diarrhea; Dinoflagellida; Disease Outbreaks; Environmental Monitoring; Female; Fever; Food Contamination; Humans; Male; Marine Toxins; Middle Aged; Nausea; Okadaic Acid; Seafood; Shellfish Poisoning; United Kingdom; Vomiting

2019

Effect of okadaic acid, a protein phosphatase inhibitor, on heat stress-induced HSP72 synthesis and thermotolerance.

Cardiovascular drugs and therapy, 2000, Volume: 14, Issue:4

Heat stress proteins (HSPs), in particular HSP72, seem to play a major role in cell protection against lethal stresses such as hyperthermia or ischemia. HSP synthesis is negatively regulated by protein phosphatases, which are implicated in dephosphorylation processes. In the present study, we have investigated the effect of okadaic acid (OA, a protein phosphatase inhibitor) on heat stress-induced HSP72 synthesis and thermotolerance in smooth muscle cells (SMC). SMC were heat stressed (42 degrees C for 20 minutes) in the presence of 250 nM OA (HS+OA cells) or its vehicle (HS+V cells). Control (OA or V) cells were not heat stressed. HSP72 mRNA expression was determined 1, 1.5, 3, and 6 hours after heat stress by RT-PCR, and HSP72 synthesis was determined 6, 12, 24, 48, and 72 hours after heat stress by Western blotting. SMC survival of lethal hyperthermia (47 degrees C for 90 minutes) was assessed 6, 24, and 48 hours after heat stress by a tetrazolium assay. The maximal expression of HSP72 mRNA was markedly prolonged in HS+OA cells (until 6 hours after heat stress) compared to HS+V cells (1 hour after heat stress). The kinetics of HSP72 synthesis and thermotolerance of SMC were not different between HS+OA and HS+V cells. Baseline HSP72 mRNA and protein expression were similar in control V and OA cells. In conclusion, okadaic acid treatment of SMC potentiated HSP72 mRNA expression without affecting heat stress-induced HSP72 synthesis and thermotolerance.

Topics: Animals; Enzyme Inhibitors; Fever; Heat-Shock Proteins; Hot Temperature; Male; Muscle, Smooth, Vascular; Okadaic Acid; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction

2000