okadaic-acid and Epilepsy--Temporal-Lobe

okadaic-acid has been researched along with Epilepsy--Temporal-Lobe* in 1 studies

Other Studies

1 other study(ies) available for okadaic-acid and Epilepsy--Temporal-Lobe

Article	Year
GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors. Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-26, Volume: 104, Issue:52 A study was made of the "rundown" of GABA(A) receptors, microtransplanted to Xenopus oocytes from surgically resected brain tissues of patients afflicted with drug-resistant human mesial temporal lobe epilepsy (mTLE). Cell membranes, isolated from mTLE neocortex specimens, were injected into frog oocytes that rapidly incorporated functional GABA(A) receptors. Upon repetitive activation with GABA (1 mM), "epileptic" GABA(A) receptors exhibited a GABA(A)-current (I(GABA)) rundown that was significantly enhanced by Zn(2+) ( Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Neurons; Okadaic Acid; Oocytes; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Temporal Lobe; Xenopus; Zinc	2007

Article

Year

GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.

Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-26, Volume: 104, Issue:52

A study was made of the "rundown" of GABA(A) receptors, microtransplanted to Xenopus oocytes from surgically resected brain tissues of patients afflicted with drug-resistant human mesial temporal lobe epilepsy (mTLE). Cell membranes, isolated from mTLE neocortex specimens, were injected into frog oocytes that rapidly incorporated functional GABA(A) receptors. Upon repetitive activation with GABA (1 mM), "epileptic" GABA(A) receptors exhibited a GABA(A)-current (I(GABA)) rundown that was significantly enhanced by Zn(2+) (

Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Neurons; Okadaic Acid; Oocytes; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sensitivity and Specificity; Temporal Lobe; Xenopus; Zinc

2007