ofloxacin has been researched along with Uremia in 2 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An open three-compartment body model was used to calculate ofloxacin pharmacokinetic parameters." | 1.27 | Ofloxacin pharmacokinetics in renal failure. ( Fillastre, JP; Humbert, G; Leroy, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, T | 1 |
| Takahashi, K | 1 |
| Sakumoto, M | 1 |
| Kumazawa, J | 1 |
| Fillastre, JP | 1 |
| Leroy, A | 1 |
| Humbert, G | 1 |
2 other studies available for ofloxacin and Uremia
| Article | Year |
|---|---|
Restorative effect of ofloxacin on inhibited chemiluminescence response of PMNs by sera from uraemic patients.
Topics: Adjuvants, Immunologic; Anti-Infective Agents; Female; Humans; In Vitro Techniques; Luminescent Meas | 1995 |
Ofloxacin pharmacokinetics in renal failure.
Topics: Adult; Aged; Anti-Infective Agents; Creatinine; Glomerular Filtration Rate; Half-Life; Humans; Kidne | 1987 |