ofloxacin has been researched along with Tympanic Membrane Perforation in 13 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Tympanic Membrane Perforation: A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3% ofloxacin eardrops (OFLX), and Gelfoam patching on the healing of human moderate and large traumatic tympanic membrane perforations (TMPs)." | 9.22 | Healing Human Moderate and Large Traumatic Tympanic Membrane Perforations Using Basic Fibroblast Growth Factor, 0.3% Ofloxacin Eardrops, and Gelfoam Patching. ( Chang, J; Liu, YC; Lou, ZC; Lou, ZH, 2016) |
| "To investigate the effects of direct application of ofloxacin otic drops on human traumatic tympanic membrane perforations (TMPs)." | 7.83 | The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations. ( Lou, Z; Tang, Y; Xiao, J, 2016) |
| "3% ofloxacin eardrops (OFLX), and Gelfoam patching on the healing of human moderate and large traumatic tympanic membrane perforations (TMPs)." | 5.22 | Healing Human Moderate and Large Traumatic Tympanic Membrane Perforations Using Basic Fibroblast Growth Factor, 0.3% Ofloxacin Eardrops, and Gelfoam Patching. ( Chang, J; Liu, YC; Lou, ZC; Lou, ZH, 2016) |
| " growth factors, Ofloxacin Otic Solution, and insulin solutions) to the moist edges of traumatic tympanic membrane perforations shortened closure times and improved closure rates." | 4.95 | A moist edge environment aids the regeneration of traumatic tympanic membrane perforations. ( Lou, ZC; Lou, ZH, 2017) |
| "Objective Ciprofloxacin + dexamethasone ear drops have been associated with higher rates of tympanic membrane perforations than ofloxacin." | 3.88 | Effects of Common Ear Drops on Tympanic Membrane Healing in Rats. ( Antonelli, PJ; Dirain, CO; Kosko, B, 2018) |
| "To investigate the effects of direct application of ofloxacin otic drops on human traumatic tympanic membrane perforations (TMPs)." | 3.83 | The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations. ( Lou, Z; Tang, Y; Xiao, J, 2016) |
| "25 mL in children with chronic suppurative otitis media and perforated tympanic membrane, with serial sampling of otorrhea and serum up to 8 hours after dosing and middle ear mucosa up to 2 hours after dosing." | 1.30 | Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations. ( Furuta, S; Katsuda, K; Kiyota, R; Miyazaki, Y; Nobori, T; Ohyama, M; Ueno, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Dirain, CO | 2 |
| Karnani, DN | 1 |
| Antonelli, PJ | 3 |
| Lou, ZC | 2 |
| Lou, ZH | 2 |
| Lou, Z | 5 |
| Kosko, B | 1 |
| Wang, X | 1 |
| Winterstein, AG | 1 |
| Alrwisan, A | 1 |
| Tang, Y | 1 |
| Xiao, J | 1 |
| Bakshi, SS | 1 |
| Liu, YC | 1 |
| Chang, J | 1 |
| Filsoof, DM | 1 |
| Park, SY | 1 |
| Buyten, J | 1 |
| Kaufman, G | 1 |
| Ryan, M | 1 |
| Ohyama, M | 1 |
| Furuta, S | 1 |
| Ueno, K | 1 |
| Katsuda, K | 1 |
| Nobori, T | 1 |
| Kiyota, R | 1 |
| Miyazaki, Y | 1 |
| Tong, MC | 1 |
| Yue, V | 1 |
| Ku, PK | 1 |
| van Hasselt, CA | 1 |
1 review available for ofloxacin and Tympanic Membrane Perforation
| Article | Year |
|---|---|
A moist edge environment aids the regeneration of traumatic tympanic membrane perforations.
Topics: Epidermal Growth Factor; Fibroblast Growth Factor 2; Hyaluronic Acid; Intercellular Signaling Peptid | 2017 |
3 trials available for ofloxacin and Tympanic Membrane Perforation
| Article | Year |
|---|---|
A comparative study to evaluate the efficacy of EGF, FGF-2, and 0.3% (w/v) ofloxacin drops on eardrum regeneration.
Topics: Administration, Topical; Adult; Conservative Treatment; Epidermal Growth Factor; Female; Fibroblast | 2017 |
Healing Human Moderate and Large Traumatic Tympanic Membrane Perforations Using Basic Fibroblast Growth Factor, 0.3% Ofloxacin Eardrops, and Gelfoam Patching.
Topics: Adult; Anti-Bacterial Agents; Female; Fibroblast Growth Factor 2; Gelatin Sponge, Absorbable; Humans | 2016 |
Preoperative topical ofloxacin solution for tympanoplasty: a randomized, controlled study.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Female; Humans; Male; Myringoplasty; Ofloxacin; Otiti | 2002 |
9 other studies available for ofloxacin and Tympanic Membrane Perforation
| Article | Year |
|---|---|
Commercial Quinolone Ear Drops Cause Perforations in Intact Rat Tympanic Membranes.
Topics: Animals; Ciprofloxacin; Dexamethasone; Female; Hydrocortisone; Male; Methylprednisolone Hemisuccinat | 2019 |
Effects of Common Ear Drops on Tympanic Membrane Healing in Rats.
Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Dexamethasone; Glucocorticoids; Instillation, Drug; M | 2018 |
Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa.
Topics: Adult; Anti-Bacterial Agents; Child; Humans; Ofloxacin; Otitis Externa; Quinolones; Retrospective St | 2020 |
The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations.
Topics: Adolescent; Adult; Child; Female; Humans; Male; Middle Aged; Ofloxacin; Prospective Studies; Regener | 2016 |
Letter to the editor.
Topics: Humans; Ofloxacin; Tympanic Membrane Perforation; Wound Healing | 2016 |
Traumatic Tympanic Membrane Perforation Repair Using Gelfoam, Ofloxacin Drops, and FGF-2.
Topics: Fibroblast Growth Factor 2; Gelatin Sponge, Absorbable; Humans; Ofloxacin; Tympanic Membrane; Tympan | 2016 |
Eustachian tube foreign body undetected for 30 years: case report.
Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Eustachian Tube; Foreign Bodies; Hearing Loss, Conduct | 2009 |
Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ciprofloxacin; Dexamethasone; Ofloxacin; R | 2007 |
Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Child; Child, Preschool; Chronic | 1999 |