ofloxacin has been researched along with Tuberculosis, Meningeal in 7 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Tuberculosis, Meningeal: A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This trial is based on the hypothesis that current anti-mycobacterial treatment schedules for TBM are not potent enough and that outcomes will be improved by increasing the CSF penetrating power of this regimen by optimising dosage and using additional drugs with better CSF penetration." | 2.76 | Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial. ( Bang, ND; Caws, M; Chau, TT; Day, J; Dung, NH; Farrar, J; Heemskerk, D; Merson, L; Olliaro, P; Pouplin, T; Wolbers, M; Yen, NT, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heemskerk, D | 2 |
| Day, J | 2 |
| Chau, TT | 3 |
| Dung, NH | 1 |
| Yen, NT | 2 |
| Bang, ND | 1 |
| Merson, L | 1 |
| Olliaro, P | 1 |
| Pouplin, T | 1 |
| Caws, M | 3 |
| Wolbers, M | 2 |
| Farrar, J | 3 |
| Thwaites, GE | 1 |
| Bhavnani, SM | 1 |
| Hammel, JP | 1 |
| Török, ME | 1 |
| Van Wart, SA | 1 |
| Mai, PP | 1 |
| Reynolds, DK | 1 |
| Dung, NT | 1 |
| Hien, TT | 1 |
| Kulawy, R | 1 |
| Ambrose, PG | 1 |
| Rabar, D | 1 |
| Issartel, B | 1 |
| Petiot, P | 1 |
| Boibieux, A | 1 |
| Chidiac, C | 1 |
| Peyramond, D | 1 |
| Berning, SE | 1 |
| Cherry, TA | 1 |
| Iseman, MD | 1 |
| Takahara, M | 1 |
| Caparros-Lefebvre, D | 1 |
| Salomez, JL | 1 |
| Petit, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis[NCT03092817] | Phase 3 | 520 participants (Actual) | Interventional | 2017-05-25 | Active, not recruiting | ||
| A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype[NCT03100786] | Phase 3 | 640 participants (Anticipated) | Interventional | 2018-02-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for ofloxacin and Tuberculosis, Meningeal
| Article | Year |
|---|---|
Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial.
Topics: Adult; Antitubercular Agents; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; | 2011 |
Sample size requirements for separating out the effects of combination treatments: randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Data Interpretation, Statistical; Drug Synergism; Drug | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
Randomized pharmacokinetic and pharmacodynamic comparison of fluoroquinolones for tuberculous meningitis.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ciprofloxacin; Ethambutol; Female; Fluoroquinolones; | 2011 |
4 other studies available for ofloxacin and Tuberculosis, Meningeal
| Article | Year |
|---|---|
[Tuberculoma and tuberculous meningeal-radiculitis with paradoxical progression during treatment].
Topics: Aged; Anti-Inflammatory Agents; Antitubercular Agents; Confusion; Disease Progression; Drug Therapy, | 2005 |
Novel treatment of meningitis caused by multidrug-resistant Mycobacterium tuberculosis with intrathecal levofloxacin and amikacin: case report.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Humans; In | 2001 |
[A case of miliary tuberculosis complicated with SIADH, brain tuberculoma, and tuberculous meningitis].
Topics: Antitubercular Agents; Brain Diseases; Drug Therapy, Combination; Humans; Inappropriate ADH Syndrome | 2002 |
[Multiple intracranial tuberculomas. Aspects in magnetic resonance imaging and the therapeutic contribution of ofloxacin].
Topics: Adrenal Cortex Hormones; Adult; Humans; Magnetic Resonance Imaging; Male; Ofloxacin; Tuberculoma; Tu | 1989 |