ofloxacin has been researched along with Tendinopathy in 27 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Tendinopathy: Clinical syndrome describing overuse tendon injuries characterized by a combination of PAIN, diffuse or localized swelling, and impaired performance.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In light of the mounting concerns surrounding fluoroquinolone-associated toxicities, the purpose of this clinical review is to provide a comprehensive summary of the risk of tendinopathy associated with levofloxacin, one of the most widely prescribed antibiotics in the United States, across in vitro, animal, and clinical studies, relative to other antibiotics." | 8.93 | Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk? ( Bidell, MR; Lodise, TP, 2016) |
| "To describe what we believe to be the first reported possible case of tendinopathy of the hip in a patient receiving levofloxacin." | 7.78 | Levofloxacin-induced tendinopathy of the hip. ( Ganske, CM; Horning, KK, 2012) |
| "Levofloxacin was administered and 3 days later, he complained of pain in the left Achilles tendon and revealed redness and swelling in the area." | 5.36 | Levofloxacin-induced Achilles tendinitis in a young adult in the absence of predisposing conditions. ( Baek, YS; Cheong, MH; Durey, A; Lee, JS; Lee, K; Park, JS; Ryu, JS, 2010) |
| "Levofloxacin is a recently introduced fluoroquinolone." | 5.31 | [Achilles tendinitis associated to levofloxacin: report of 4 cases]. ( Aros, C; Flores, C; Mezzano, S, 2002) |
| " There is limited evidence for nine risk factors: (1) prior lower limb tendinopathy or fracture, (2) use of ofloxacin (quinolone) antibiotics, (3) an increased time between heart transplantation and initiation of quinolone treatment for infectious disease, (4) moderate alcohol use, (5) training during cold weather, (6) decreased isokinetic plantar flexor strength, (7) abnormal gait pattern with decreased forward progression of propulsion, (8) more lateral foot roll-over at the forefoot flat phase and (9) creatinine clearance of <60 mL/min in heart transplant patients." | 5.01 | Clinical risk factors for Achilles tendinopathy: a systematic review. ( Breda, SJ; de Vos, RJ; Oei, EHG; van der Vlist, AC; Verhaar, JAN, 2019) |
| " In light of the mounting concerns surrounding fluoroquinolone-associated toxicities, the purpose of this clinical review is to provide a comprehensive summary of the risk of tendinopathy associated with levofloxacin, one of the most widely prescribed antibiotics in the United States, across in vitro, animal, and clinical studies, relative to other antibiotics." | 4.93 | Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk? ( Bidell, MR; Lodise, TP, 2016) |
| "To describe what we believe to be the first reported possible case of tendinopathy of the hip in a patient receiving levofloxacin." | 3.78 | Levofloxacin-induced tendinopathy of the hip. ( Ganske, CM; Horning, KK, 2012) |
| "A 72-year-old female dialysis patient with insulin-dependent diabetes mellitus who was under long-term medication with oral prednisolone due to chronic obstructive pulmonary disease was given levofloxacin for one week to treat an acute bronchitis (one 500 mg dose on the first day, 125 mg/day orally from second day onwards)." | 3.74 | [Fluoroquinolone-induced Achilles tendon rupture]. ( Maurin, N, 2008) |
| " We report the first case of tendinitis after treatment with moxifloxacin, and of recurrent tendinitis after treatment with 2 different fluoroquinolones." | 3.72 | Recurrent tendinitis after treatment with two different fluoroquinolones. ( Burkhardt, O; Köhnlein, T; Pap, T; Welte, T, 2004) |
| "Levofloxacin was found to be very safe with a low rate of hepatic abnormalities (1/650,000)." | 2.41 | Comparison of side effects of levofloxacin versus other fluoroquinolones. ( Carbon, C, 2001) |
| "Levofloxacin was administered and 3 days later, he complained of pain in the left Achilles tendon and revealed redness and swelling in the area." | 1.36 | Levofloxacin-induced Achilles tendinitis in a young adult in the absence of predisposing conditions. ( Baek, YS; Cheong, MH; Durey, A; Lee, JS; Lee, K; Park, JS; Ryu, JS, 2010) |
| "We report five cases of tendinitis induced by fluoroquinolones, three caused by levofloxacin and two by ciprofloxacin." | 1.34 | [Fluoroquinolone-induced tendon diseases]. ( Bruscas Izu, C; Mauri Llerda, JA; Medrano San Ildefonso, M, 2007) |
| " A dosage of 750 mg q." | 1.34 | Safety of prolonged high-dose levofloxacin therapy for bone infections. ( Beltrand, E; Caillaux, M; Dehecq, C; Legout, L; Loïez, C; Migaud, H; Mouton, Y; Poissy, J; Senneville, E; Valette, M; Yazdanpanah, Y, 2007) |
| "Levofloxacin is a recently introduced fluoroquinolone." | 1.31 | [Achilles tendinitis associated to levofloxacin: report of 4 cases]. ( Aros, C; Flores, C; Mezzano, S, 2002) |
| "We describe 7 Achilles tendinitis occurring during fluoroquinolone treatment." | 1.28 | Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy. ( Audisio, F; De Bandt, M; Hayem, G; Jorgensen, C; Kahn, MF; Meyer, O; Palazzo, E; Ribard, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 17 (62.96) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Huruba, M | 1 |
| Farcas, A | 1 |
| Leucuta, DC | 1 |
| Bucsa, C | 1 |
| Sipos, M | 1 |
| Mogosan, C | 1 |
| van der Vlist, AC | 1 |
| Breda, SJ | 1 |
| Oei, EHG | 1 |
| Verhaar, JAN | 1 |
| de Vos, RJ | 1 |
| Grandvuillemin, A | 1 |
| Contant, E | 1 |
| Fedrizzi, S | 1 |
| Gras, V | 1 |
| Dautriche, A | 1 |
| Bidell, MR | 1 |
| Lodise, TP | 1 |
| London, L | 1 |
| Durey, A | 1 |
| Baek, YS | 1 |
| Park, JS | 1 |
| Lee, K | 1 |
| Ryu, JS | 1 |
| Lee, JS | 1 |
| Cheong, MH | 1 |
| Kato, A | 1 |
| Ishigaki, S | 1 |
| Yasuda, H | 1 |
| Ganske, CM | 1 |
| Horning, KK | 1 |
| Takeda, S | 1 |
| Imai, T | 1 |
| Chaki, Y | 1 |
| Kusano, E | 1 |
| Tomás, ME | 1 |
| Pérez Carreras, M | 1 |
| Morillasa, JD | 1 |
| Castellano, G | 1 |
| Solís, JA | 1 |
| Aros, C | 1 |
| Flores, C | 1 |
| Mezzano, S | 1 |
| Schindler, C | 1 |
| Pittrow, D | 1 |
| Kirch, W | 1 |
| de La Red, G | 1 |
| Mejía, JC | 1 |
| Cervera, R | 1 |
| Lladó, A | 1 |
| Mensa, J | 1 |
| Font, J | 1 |
| Vergara Fernández, I | 1 |
| Gómez Rodríguez, N | 1 |
| Ibáñez Ruán, J | 1 |
| González Pérez, M | 1 |
| Burkhardt, O | 1 |
| Köhnlein, T | 1 |
| Pap, T | 1 |
| Welte, T | 1 |
| Alvarez Luque, I | 1 |
| Gomariz Santacecilia, M | 1 |
| Villamor Baliarda, E | 1 |
| Rando Matos, Y | 1 |
| García Fernández, Y | 1 |
| Beyer, J | 1 |
| Schellong, S | 1 |
| Sánchez Muñoz, LA | 1 |
| Sanjuán Portugal, FJ | 1 |
| Naya Machado, J | 1 |
| Castiella Herrero, J | 1 |
| Medrano San Ildefonso, M | 1 |
| Mauri Llerda, JA | 1 |
| Bruscas Izu, C | 1 |
| Senneville, E | 1 |
| Poissy, J | 1 |
| Legout, L | 1 |
| Dehecq, C | 1 |
| Loïez, C | 1 |
| Valette, M | 1 |
| Beltrand, E | 1 |
| Caillaux, M | 1 |
| Mouton, Y | 1 |
| Migaud, H | 1 |
| Yazdanpanah, Y | 1 |
| Maurin, N | 1 |
| Benizeau, I | 1 |
| Cambon-Michot, C | 1 |
| Daragon, A | 1 |
| Voisin, L | 1 |
| Mejjad, O | 1 |
| Thomine, JM | 1 |
| Le Loet, X | 1 |
| Casado Burgos, E | 1 |
| Viñas Ponce, G | 1 |
| Lauzurica Valdemoros, R | 1 |
| Olivé Marqués, A | 1 |
| Carbon, C | 1 |
| Ribard, P | 1 |
| Audisio, F | 1 |
| Kahn, MF | 1 |
| De Bandt, M | 1 |
| Jorgensen, C | 1 |
| Hayem, G | 1 |
| Meyer, O | 1 |
| Palazzo, E | 1 |
4 reviews available for ofloxacin and Tendinopathy
| Article | Year |
|---|---|
Clinical risk factors for Achilles tendinopathy: a systematic review.
Topics: Achilles Tendon; Alcohol Drinking; Cold Temperature; Foot; Gait; Heart Transplantation; Humans; Oflo | 2019 |
Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Topics: Animals; Anti-Bacterial Agents; Disease Management; Fluoroquinolones; Humans; Levofloxacin; Ofloxaci | 2016 |
Bilateral plantar tendinitis during levofloxacin therapy.
Topics: Anti-Bacterial Agents; Female; Foot Diseases; Humans; Levofloxacin; Middle Aged; Ofloxacin; Tendinop | 2006 |
Comparison of side effects of levofloxacin versus other fluoroquinolones.
Topics: Anti-Infective Agents; Cardiovascular System; Dermatitis, Phototoxic; Digestive System; Hepatocytes; | 2001 |
23 other studies available for ofloxacin and Tendinopathy
| Article | Year |
|---|---|
A VigiBase descriptive study of fluoroquinolone induced disabling and potentially permanent musculoskeletal and connective tissue disorders.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Adverse Drug Reaction Reporting Systems; Arthralgia; Cip | 2021 |
Tendinopathy after ofloxacin ear drops.
Topics: Anti-Bacterial Agents; Humans; Male; Middle Aged; Ofloxacin; Pharmaceutical Solutions; Tendinopathy | 2015 |
Cough... followed by calf pain.
Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Humans; Magnetic Resonance Imaging; Male; Ofloxacin; R | 2007 |
Levofloxacin-induced Achilles tendinitis in a young adult in the absence of predisposing conditions.
Topics: Achilles Tendon; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Disease Susceptibility | 2010 |
Levofloxacin-associated Achilles tendinitis in a patient with chronic kidney disease stage 5.
Topics: Achilles Tendon; Bronchitis; Female; Humans; Kidney Failure, Chronic; Levofloxacin; Magnetic Resonan | 2011 |
Levofloxacin-induced tendinopathy of the hip.
Topics: Anti-Bacterial Agents; Hip; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin; Tendinopathy | 2012 |
Four consecutive cases of Achilles tendon disorders associated with levofloxacin treatment in hemodialysis patients.
Topics: Achilles Tendon; Administration, Oral; Aged; Anti-Infective Agents, Urinary; Dose-Response Relations | 2012 |
Side effects of levofloxacin.
Topics: Anti-Infective Agents; Humans; Levofloxacin; Ofloxacin; Safety; Tendinopathy | 2002 |
[Rupture of the Achilles' tendon secondary to levofloxacin].
Topics: Achilles Tendon; Adult; Ceftriaxone; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Humans | 2003 |
[Achilles tendinitis associated to levofloxacin: report of 4 cases].
Topics: Achilles Tendon; Adult; Aged; Anti-Infective Agents; Female; Humans; Levofloxacin; Male; Middle Aged | 2002 |
Reoccurrence of levofloxacin-induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?
Topics: Achilles Tendon; Adverse Drug Reaction Reporting Systems; Aged; Anti-Bacterial Agents; Arthritis; Dr | 2003 |
Bilateral Achilles tendinitis with spontaneous rupture induced by levofloxacin in a patient with systemic sclerosis.
Topics: Achilles Tendon; Cyclophosphamide; Drug Therapy, Combination; Follow-Up Studies; Humans; Levofloxaci | 2003 |
[Muscle and tendon problems as a side-effect of levofloxacine: review of a case].
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Myositis; Ofloxacin; Tendinopathy | 2004 |
[Achilles bilateral tendonitis and levofloxacin].
Topics: Achilles Tendon; Anti-Infective Agents; Female; Humans; Levofloxacin; Middle Aged; Ofloxacin; Tendin | 2004 |
Recurrent tendinitis after treatment with two different fluoroquinolones.
Topics: Achilles Tendon; Aged; Anti-Infective Agents; Asthma; Aza Compounds; Female; Fluoroquinolones; Human | 2004 |
[Tendinitis associated with levofloxacin].
Topics: Achilles Tendon; Anti-Bacterial Agents; Follow-Up Studies; Humans; Levofloxacin; Male; Middle Aged; | 2005 |
[Levofloxacin-induced tendon rupture with fatal outcome].
Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Comorbidity; Fatal Outcome; Humans; Levofloxacin; Male | 2006 |
[Fluoroquinolone-induced tendon diseases].
Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; | 2007 |
Safety of prolonged high-dose levofloxacin therapy for bone infections.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluati | 2007 |
[Fluoroquinolone-induced Achilles tendon rupture].
Topics: Achilles Tendon; Aged; Anti-Bacterial Agents; Bronchitis; Diabetes Mellitus, Type 1; Female; Humans; | 2008 |
Tendinitis of the tibialis anterior with histologic documentation in a patient under fluoroquinolone therapy.
Topics: Anti-Infective Agents; Female; Humans; Middle Aged; Ofloxacin; Tendinopathy | 1997 |
[Levofloxacin-induced tendinitis].
Topics: Anti-Infective Agents, Urinary; Humans; Levofloxacin; Male; Middle Aged; Ofloxacin; Tendinopathy | 2000 |
Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy.
Topics: Achilles Tendon; Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Cystitis; Female; Human | 1992 |